Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0038 | 0.0093 | 0.0342 | |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0049 | 0.016 | 0.2213 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0093 | 0.021 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0323 | 0.5874 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0671 | 0.3909 | 1 |
Brugia malayi | glutathione reductase | 0.0142 | 0.072 | 0.2057 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0026 | 0.002 | 0.0045 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.0304 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.016 | 0.0407 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0032 | 0.0078 |
Loa Loa (eye worm) | glutathione reductase | 0.0142 | 0.072 | 0.2057 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0042 | 0.0119 | 0.0337 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0049 | 0.016 | 0.0384 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0445 | 0.2546 | 0.2531 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.0141 |
Schistosoma mansoni | glutaminase | 0.0602 | 0.3495 | 0.7514 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0119 | 0.0337 |
Brugia malayi | hypothetical protein | 0.011 | 0.0524 | 0.1496 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.0712 | 0.1476 |
Schistosoma mansoni | rab6-interacting | 0.011 | 0.0524 | 0.1068 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0026 | 0.002 | 0.0279 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0011 | 0.0198 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0032 | 0.0078 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0078 | 0.1415 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0093 | 0.0265 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.006 | 0.1095 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.036 | 0.2035 | 1 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.006 | 0.0061 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0026 | 0.002 | 0.0279 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0093 | 0.021 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0049 | 0.016 | 0.0407 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0049 | 0.016 | 0.2213 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0147 | 0.025 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0079 | 0.0339 | 0.6173 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0093 | 0.0132 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.006 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0147 | 0.025 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0041 | 0.0116 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0079 | 0.0339 | 0.069 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.006 | 0.0835 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0093 | 0.0404 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0079 | 0.0339 | 0.097 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0049 | 0.016 | 0.0407 |
Leishmania major | glycosyl hydrolase-like protein | 0.0029 | 0.0041 | 0.0565 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0036 | 0.0082 | 0.023 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0093 | 0.0261 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0049 | 0.016 | 0.0407 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0093 | 0.0265 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0355 | 0.2006 | 0.5737 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0029 | 0.0041 | 0.0124 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0093 | 0.0261 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0011 | 0.0198 |
Brugia malayi | beta-NAC-like protein | 0.0036 | 0.0078 | 0.0219 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0029 | 0.0041 | 0.0547 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0041 | 0.0116 |
Trichomonas vaginalis | glutaminase, putative | 0.0602 | 0.3495 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.011 | 0.0524 | 0.109 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0323 | 0.5874 |
Mycobacterium tuberculosis | Probable reductase | 0.0324 | 0.1817 | 0.8923 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0029 | 0.0041 | 0.0565 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.2213 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0.016 | 0.0361 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.2213 |
Schistosoma mansoni | alpha glucosidase | 0.0079 | 0.0339 | 0.0666 |
Schistosoma mansoni | hypothetical protein | 0.0736 | 0.4304 | 0.9267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0078 | 0.0222 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0049 | 0.016 | 0.0739 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.006 | 0.0061 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0032 | 0.0078 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0079 | 0.0339 | 0.097 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.036 | 0.2035 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0324 | 0.1817 | 0.4634 |
Brugia malayi | glutaminase DH11.1 | 0.0602 | 0.3495 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.011 | 0.0524 | 0.0505 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0011 | 0.0151 |
Leishmania major | trypanothione reductase | 0.0142 | 0.072 | 1 |
Onchocerca volvulus | 0.0038 | 0.0093 | 0.0342 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0093 | 0.0265 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0033 | 0.006 | 0.0835 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0114 | 0.0549 | 0.1145 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0093 | 0.0404 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0355 | 0.2006 | 0.199 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0049 | 0.016 | 0.0459 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.1659 | 0.353 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0011 | 0.0027 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0079 | 0.0339 | 0.032 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.0712 | 0.1476 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0033 | 0.006 | 0.0817 |
Brugia malayi | Doublecortin family protein | 0.011 | 0.0524 | 0.1496 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0134 | 0.0671 | 0.1915 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.011 | 0.0524 | 0.0505 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0093 | 0.0404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0158 | 0.0451 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0049 | 0.016 | 0.0407 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0093 | 0.0404 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0323 | 0.5874 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0134 | 0.0671 | 0.1915 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Mycobacterium ulcerans | glutaminase | 0.0602 | 0.3495 | 0.8939 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0041 | 0.0116 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Echinococcus multilocularis | GPCR, family 2 | 0.0042 | 0.0119 | 0.0099 |
Echinococcus multilocularis | geminin | 0.0736 | 0.4304 | 0.4292 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0079 | 0.0339 | 0.097 |
Plasmodium vivax | heat shock protein 86, putative | 0.0033 | 0.006 | 0.015 |
Echinococcus granulosus | geminin | 0.0736 | 0.4304 | 0.9269 |
Onchocerca volvulus | 0.0206 | 0.1103 | 0.4562 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0001 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0119 | 0.0189 |
Toxoplasma gondii | thioredoxin reductase | 0.0142 | 0.072 | 0.1839 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0143 | 0.0723 | 0.0705 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0032 | 0.0025 |
Schistosoma mansoni | lipoxygenase | 0.0445 | 0.2546 | 0.5455 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0079 | 0.0339 | 0.0966 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0142 | 0.072 | 0.1839 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0042 | 0.0119 | 0.0214 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0026 | 0.002 | 0.0024 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0049 | 0.016 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Onchocerca volvulus | 0.0421 | 0.2404 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0134 | 0.0671 | 0.1915 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0029 | 0.0041 | 0.074 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0079 | 0.0339 | 0.097 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0162 | 0.0843 | 0.1781 |
Schistosoma mansoni | lipoxygenase | 0.0248 | 0.1357 | 0.2876 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0011 | 0.0151 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0093 | 0.0404 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.0712 | 0.0693 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.006 | 0.1095 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0026 | 0.002 | 0.0279 |
Brugia malayi | Endoplasmin precursor | 0.0033 | 0.006 | 0.0168 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0324 | 0.1817 | 0.8923 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0216 | 0.1168 | 0.334 |
Echinococcus multilocularis | protein patched | 0.0049 | 0.0158 | 0.0138 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0216 | 0.1168 | 0.334 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0049 | 0.016 | 0.0384 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0093 | 0.0265 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.006 | 0.0835 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0041 | 0.0116 |
Schistosoma mansoni | patched 1 | 0.0049 | 0.0158 | 0.0273 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0323 | 0.0919 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0323 | 0.0303 |
Echinococcus granulosus | RUN | 0.011 | 0.0524 | 0.109 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0049 | 0.0158 | 0.0448 |
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0671 | 0.3909 | 1 |
Plasmodium falciparum | porphobilinogen synthase | 0.0671 | 0.3909 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0142 | 0.072 | 0.1839 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0032 | 0.0012 |
Treponema pallidum | NADH oxidase | 0.0049 | 0.016 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0049 | 0.016 | 0.2228 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0093 | 0.021 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0036 | 0.0078 | 0.0195 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0093 | 0.1287 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.0712 | 0.1497 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Trypanosoma brucei | trypanothione reductase | 0.0142 | 0.072 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0093 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0147 | 0.025 |
Schistosoma mansoni | rab6-interacting | 0.011 | 0.0524 | 0.1068 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.002 | 0.0057 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0033 | 0.006 | 0.2852 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0093 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0119 | 0.0189 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.0342 | 0.0975 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0079 | 0.0339 | 0.0966 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.037 | 0.2095 | 0.5993 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.0712 | 0.1497 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Schistosoma mansoni | transcription factor btf3 | 0.0036 | 0.0078 | 0.01 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0079 | 0.0339 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0011 | 0.0027 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0143 | 0.0723 | 0.1522 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Echinococcus multilocularis | expressed conserved protein | 0.0107 | 0.0508 | 0.0488 |
Echinococcus granulosus | expressed conserved protein | 0.0107 | 0.0508 | 0.1055 |
Schistosoma mansoni | alpha-glucosidase | 0.0306 | 0.1707 | 0.3635 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0093 | 0.0261 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0355 | 0.2006 | 0.199 |
Loa Loa (eye worm) | endoplasmin | 0.0033 | 0.006 | 0.0168 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Onchocerca volvulus | 0.011 | 0.0524 | 0.2144 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0339 | 0.4707 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Plasmodium falciparum | LCCL domain-containing protein | 0.011 | 0.0524 | 0.1338 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0049 | 0.0158 | 0.0298 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.0384 |
Brugia malayi | MH2 domain containing protein | 0.0216 | 0.1168 | 0.334 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0049 | 0.016 | 0.0459 |
Echinococcus granulosus | GPCR family 2 | 0.0042 | 0.0119 | 0.0214 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0093 | 0.0404 |
Loa Loa (eye worm) | glutaminase 2 | 0.0602 | 0.3495 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0001 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0184 | 0.0522 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.002 | 0.0057 |
Trichomonas vaginalis | heat shock protein, putative | 0.0033 | 0.006 | 0.0172 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0323 | 0.0655 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0093 | 0.0404 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0093 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0415 | 0.1185 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0079 | 0.0339 | 0.097 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.011 | 0.0524 | 0.109 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0445 | 0.2546 | 0.5466 |
Loa Loa (eye worm) | doublecortin family protein | 0.011 | 0.0524 | 0.1496 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0079 | 0.0339 | 0.0864 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0079 | 0.0339 | 0.097 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.016 | 0.0407 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0049 | 0.016 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0049 | 0.0158 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0524 | 0.1496 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0078 | 0.0222 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0093 | 0.0234 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.002 | 0.0057 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0042 | 0.0119 | 0.0337 |
Brugia malayi | Pre-SET motif family protein | 0.0053 | 0.0184 | 0.0522 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0079 | 0.0339 | 0.4707 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0093 | 0.1271 |
Schistosoma mansoni | hypothetical protein | 0.0736 | 0.4304 | 0.9267 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0339 | 0.4707 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0011 | 0.0198 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.0712 | 0.0693 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0792 | 0.4641 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0026 | 0.002 | 0.0024 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0671 | 0.3909 | 0.3897 |
Plasmodium vivax | SET domain protein, putative | 0.0053 | 0.0184 | 0.0467 |
Schistosoma mansoni | porphobilinogen synthase | 0.0671 | 0.3909 | 0.8411 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0114 | 0.0549 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.0712 | 0.2034 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0184 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0011 | 0.0027 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0049 | 0.016 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0671 | 0.1915 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.011 | 0.0524 | 0.0505 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0049 | 0.016 | 0.0455 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0093 | 0.0404 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.0712 | 0.2034 |
Echinococcus multilocularis | transcription factor btf3 | 0.0036 | 0.0078 | 0.0058 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0079 | 0.0339 | 0.097 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0051 | 0.0172 | 0.0329 |
Brugia malayi | Pre-SET motif family protein | 0.037 | 0.2095 | 0.5993 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0355 | 0.2006 | 0.4297 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Plasmodium falciparum | glutathione reductase | 0.0142 | 0.072 | 0.1839 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0323 | 0.0631 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0042 | 0.0119 | 0.0099 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0199 | 0.018 |
Loa Loa (eye worm) | glutaminase | 0.0602 | 0.3495 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0033 | 0.006 | 0.015 |
Onchocerca volvulus | 0.0053 | 0.0184 | 0.0722 | |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0671 | 0.3909 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0033 | 0.006 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0041 | 0.0112 |
Onchocerca volvulus | 0.011 | 0.0524 | 0.2144 | |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0029 | 0.0041 | 0.0116 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0011 | 0.0151 |
Plasmodium vivax | endoplasmin, putative | 0.0033 | 0.006 | 0.015 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0324 | 0.1817 | 0.8923 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0033 | 0.006 | 0.0817 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0049 | 0.016 | 0.0407 |
Leishmania major | basic transcription factor 3a, putative | 0.0036 | 0.0078 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0549 | 0.1568 |
Brugia malayi | CHE-14 protein | 0.0049 | 0.0158 | 0.0448 |
Schistosoma mansoni | porphobilinogen synthase | 0.0671 | 0.3909 | 0.8411 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0671 | 0.3909 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0053 | 0.0184 | 0.0164 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0093 | 0.0261 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0036 | 0.0078 | 0.1062 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0524 | 0.1068 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0142 | 0.072 | 0.3503 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.1327 | 0.6502 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.011 | 0.0524 | 0.109 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0036 | 0.0078 | 0.0195 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0011 | 0.0027 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Brugia malayi | heat shock protein 90 | 0.0033 | 0.006 | 0.0168 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0.016 | 0.0361 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0092 | 0.0415 | 0.1185 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0792 | 0.4641 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0142 | 0.072 | 0.1839 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0029 | 0.0041 | 0.0565 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.006 | 0.0835 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0079 | 0.0339 | 0.6173 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0041 | 0.0116 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0147 | 0.025 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0142 | 0.072 | 0.2057 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0093 | 0.0404 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0053 | 0.0184 | 0.033 |
Brugia malayi | Thioredoxin reductase | 0.0142 | 0.072 | 0.2057 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0093 | 0.0265 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0033 | 0.006 | 0.0835 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0119 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0415 | 0.0832 |
Brugia malayi | hypothetical protein | 0.011 | 0.0524 | 0.1496 |
Trypanosoma brucei | glucosidase, putative | 0.0079 | 0.0339 | 0.4697 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0093 | 0.021 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0355 | 0.2006 | 0.5737 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0324 | 0.1817 | 0.8923 |
Echinococcus multilocularis | RUN | 0.011 | 0.0524 | 0.0505 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0792 | 0.4641 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0032 | 0.0087 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.011 | 0.0524 | 0.1338 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0042 | 0.0119 | 0.0214 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0142 | 0.072 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0093 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0119 | 0.0189 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0162 | 0.0843 | 0.0825 |
Loa Loa (eye worm) | ICD-1 protein | 0.0036 | 0.0078 | 0.0219 |
Echinococcus multilocularis | heat shock protein | 0.0033 | 0.006 | 0.004 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.036 | 0.2035 | 0.5193 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0671 | 0.3909 | 0.8415 |
Mycobacterium tuberculosis | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) | 0.0342 | 0.1924 | 0.9449 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.036 | 0.2035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0011 | 0.0027 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0078 | 0.1079 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0323 | 0.5874 |
Onchocerca volvulus | 0.0038 | 0.0093 | 0.0342 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0158 | 0.0448 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0324 | 0.1817 | 0.8923 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0115 | 0.056 | 0.1145 |
Chlamydia trachomatis | delta-aminolevulinic acid dehydratase | 0.0671 | 0.3909 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0093 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0093 | 0.0265 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0032 | 0.0424 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0053 | 0.0184 | 0.0164 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0093 | 0.1287 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0114 | 0.0549 | 0.053 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0032 | 0.0424 |
Toxoplasma gondii | NAC domain-containing protein | 0.0036 | 0.0078 | 0.0195 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0324 | 0.1817 | 0.8923 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0261 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0032 | 0.0087 |
Echinococcus granulosus | heat shock protein 90 | 0.0033 | 0.006 | 0.0087 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0184 | 0.033 |
Schistosoma mansoni | polycystin 1-related | 0.011 | 0.0524 | 0.1068 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0671 | 0.3909 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0078 | 0.1079 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0093 | 0.021 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.006 | 0.0835 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0036 | 0.0082 | 0.023 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0298 | 0.1659 | 0.4745 |
Echinococcus granulosus | transcription factor btf3 | 0.0036 | 0.0078 | 0.0125 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0053 | 0.0184 | 0.0354 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0093 | 0.0261 |
Plasmodium falciparum | heat shock protein 90 | 0.0033 | 0.006 | 0.015 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0033 | 0.006 | 0.0817 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.016 | 0.2228 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0114 | 0.0549 | 0.1568 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.016 | 0.2228 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0049 | 0.016 | 0.2228 |
Echinococcus multilocularis | snurportin 1 | 0.0298 | 0.1659 | 0.1642 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0041 | 0.0116 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0093 | 0.0404 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0079 | 0.0339 | 0.097 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0029 | 0.0041 | 0.0112 |
Echinococcus granulosus | heat shock protein | 0.0033 | 0.006 | 0.0087 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0011 | 0.0027 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0033 | 0.006 | 0.0168 |
Schistosoma mansoni | alpha-glucosidase | 0.0306 | 0.1707 | 0.3635 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0041 | 0.0116 |
Schistosoma mansoni | loxhd1 | 0.011 | 0.0524 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0224 | 0.0637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0078 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0524 | 0.1496 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.0712 | 0.1476 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0001 | 0.0019 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0036 | 0.0078 | 0.1415 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0042 | 0.0119 | 0.0099 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0049 | 0.0158 | 0.0138 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0042 | 0.0119 | 0.0337 |
Echinococcus granulosus | snurportin 1 | 0.0298 | 0.1659 | 0.3547 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.006 | 0.0817 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0093 | 0.021 |
Trichomonas vaginalis | set domain proteins, putative | 0.0421 | 0.2404 | 0.6877 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0053 | 0.0184 | 0.0467 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0184 | 0.033 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.006 | 0.0061 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0323 | 0.0631 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0033 | 0.006 | 0.015 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0093 | 0.0157 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0093 | 0.1287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 17.02 ug ml-1 | Cytotoxicity against human HL60 cells after 24 hrs | ChEMBL. | 20303755 |
IC50 (functional) | = 18.61 ug ml-1 | Cytotoxicity against human MCF7 cells after 24 hrs | ChEMBL. | 20303755 |
IC50 (functional) | = 20.39 ug ml-1 | Cytotoxicity against human A375 cells after 24 hrs | ChEMBL. | 20303755 |
IC50 (functional) | = 39.87 ug ml-1 | Cytotoxicity against human A549 cells after 24 hrs | ChEMBL. | 20303755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.