Detailed information for compound 1126614

Basic information

Technical information
  • TDR Targets ID: 1126614
  • Name: 3,4-bis(3,4-dimethoxyphenyl)-5H-furan-2-one
  • MW: 356.369 | Formula: C20H20O6
  • H donors: 0 H acceptors: 1 LogP: 2.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1=C(C(=O)OC1)c1ccc(c(c1)OC)OC
  • InChi: 1S/C20H20O6/c1-22-15-7-5-12(9-17(15)24-3)14-11-26-20(21)19(14)13-6-8-16(23-2)18(10-13)25-4/h5-10H,11H2,1-4H3
  • InChiKey: FGMQIGBHXSBGMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Echinococcus granulosus fmrfamide receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis allatostatin A receptor 0.0316 0.5476 0.6324
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.0476 0.0549
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0201 0.0634
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.0476 0.0476
Schistosoma mansoni opsin-like receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis hypothetical protein 0.0055 0.0683 0.2156
Plasmodium vivax aspartyl protease, putative 0.0045 0.0493 0.1555
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0054 0.0655 0.0756
Onchocerca volvulus 0.0044 0.0476 0.0814
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Onchocerca volvulus Huntingtin homolog 0.0119 0.1848 0.3335
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1652 0.1907
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.002 0.0032 0.0037
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.0476 0.0476
Schistosoma mansoni histamine h1 receptor 0.0044 0.0476 0.0476
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0174 0.2866 0.9043
Onchocerca volvulus 0.0044 0.0476 0.0814
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0424 0.1338
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0174 0.2866 0.331
Schistosoma mansoni amine GPCR 0.0044 0.0476 0.0476
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.031 0.0977
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0045 0.0493 0.0846
Brugia malayi celfurPC protein 0.0231 0.3914 0.452
Brugia malayi hypothetical protein 0.0045 0.0493 0.0569
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.002 0.0032 0.0032
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.0476 0.0549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0361 0.2223
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1652 0.3281
Leishmania major protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0476 0.0549
Echinococcus granulosus mitogen activated protein kinase 14 0.0292 0.5033 0.5812
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0493 0.0569
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Brugia malayi larval opioid receptor 0.0044 0.0476 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1371 0.1371
Brugia malayi hypothetical protein 0.0045 0.0493 0.0569
Schistosoma mansoni hypothetical protein 0.0044 0.0476 0.0476
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Toxoplasma gondii aspartyl protease ASP1 0.0191 0.317 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0174 0.2866 0.9043
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0071 0.0223
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0476 0.0549
Echinococcus granulosus hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Brugia malayi Dopamine receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0071 0.0082
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0493 0.0569
Brugia malayi G protein-coupled receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1371 0.8299
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1461 0.1687
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1652 0.5
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0032 0.0199
Schistosoma mansoni biogenic amine receptor 0.0044 0.0476 0.0476
Trypanosoma brucei glucosidase, putative 0.0035 0.031 0.0615
Loa Loa (eye worm) TK/EPH protein kinase 0.0247 0.4202 0.4853
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0068 0.0909 0.0909
Echinococcus granulosus neuropeptide receptor 0.0044 0.0476 0.0549
Brugia malayi MH2 domain containing protein 0.0116 0.1796 0.2074
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.0476 0.0549
Brugia malayi endoprotease bli-4 precursor 0.0287 0.4933 0.5697
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0493 0.0569
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1652 0.521
Echinococcus multilocularis neuropeptide FF receptor 2 0.0489 0.866 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0191 0.317 0.317
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0032 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0476 0.0549
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.002 0.0032 0.0102
Schistosoma mansoni hypothetical protein 0.0036 0.0322 0.0322
Giardia lamblia Prenyltransferase 0.0054 0.0655 0.4037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Brugia malayi neuropeptide F receptor 0.0044 0.0476 0.0549
Brugia malayi Protein kinase domain containing protein 0.0024 0.011 0.0127
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.031 0.0358
Schistosoma mansoni amine GPCR 0.0044 0.0476 0.0476
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Trypanosoma brucei lanosterol synthase 0.0059 0.0751 0.1492
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0292 0.5033 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0196
Brugia malayi Serotonin receptor 0.0044 0.0476 0.0549
Brugia malayi ephrin receptor 1 precursor 0.0093 0.1367 0.1579
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0476 0.0549
Schistosoma mansoni hypothetical protein 0.0055 0.0683 0.0683
Trypanosoma cruzi protein farnesyltransferase, putative 0.0054 0.0655 0.1301
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.002 0.0032 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.031 0.0615
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0287 0.4933 0.4933
Toxoplasma gondii hypothetical protein 0.002 0.0032 0.0102
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis 0.0231 0.3914 0.452
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.2248 0.2596
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0476 0.0549
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0201 0.0634
Loa Loa (eye worm) proprotein convertase 2 0.0068 0.0909 0.1049
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0192 0.3195 0.369
Onchocerca volvulus 0.0044 0.0476 0.0814
Echinococcus granulosus neuropeptide s receptor 0.0044 0.0476 0.0549
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1371 0.1583
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.011 0.0127
Echinococcus multilocularis serotonin receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1652 0.521
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Plasmodium falciparum plasmepsin III 0.0045 0.0493 0.1555
Loa Loa (eye worm) hypothetical protein 0.0112 0.1731 0.1999
Plasmodium falciparum plasmepsin VI 0.0191 0.317 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0032 0.0064
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0493 0.0569
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.0476 0.0549
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0361 0.2184
Onchocerca volvulus 0.0044 0.0476 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Brugia malayi P38 map kinase family protein 2 0.0292 0.5033 0.5812
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0476 0.0549
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.031 0.0977
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0174 0.2866 0.331
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0054 0.0655 0.0655
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.0476 0.0549
Echinococcus multilocularis neuroendocrine convertase 2 0.018 0.2975 0.3436
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0201 0.1217
Plasmodium vivax prenyltransferase alpha subunit, putative 0.002 0.0032 0.0102
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0424 0.1338
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0054 0.0655 0.3965
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0054 0.0655 0.2066
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0655 0.0756
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1796 0.2074
Onchocerca volvulus 0.0044 0.0476 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Brugia malayi neuroendocrine convertase 1 precursor 0.018 0.2975 0.3436
Echinococcus granulosus furin 0.0287 0.4933 0.5697
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0045 0.0493 0.0569
Plasmodium falciparum plasmepsin I 0.0191 0.317 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.2248 0.2596
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1371 0.1583
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus g protein coupled receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1371 0.2723
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.031 0.0615
Echinococcus granulosus ephrin type A receptor 4 A 0.0194 0.3234 0.3735
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0476 0.0549
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0054 0.0655 0.2066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2574 0.2972
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi phosphofructokinase 0.0108 0.1652 0.1907
Echinococcus multilocularis orexin receptor type 2 0.0044 0.0476 0.0549
Schistosoma mansoni memapsin-2 (A01 family) 0.0045 0.0493 0.0493
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0201 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.031 0.0977
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Plasmodium vivax aspartyl protease, putative 0.0045 0.0493 0.1555
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.1949
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.031 0.0358
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.002 0.0032 0.0037
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0424 0.049
Echinococcus granulosus mitogen activated protein kinase 11 0.0292 0.5033 0.5812
Loa Loa (eye worm) hypothetical protein 0.0119 0.1848 0.2134
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.031 0.0977
Schistosoma mansoni biogenic amine receptor 0.0044 0.0476 0.0476
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.0476 0.0549
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1652 1
Brugia malayi putative neuropeptide receptor 0.0044 0.0476 0.0549
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0201 0.124
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0655 0.2066
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0022 0.0071 0.007
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Schistosoma mansoni hypothetical protein 0.0044 0.0476 0.0476
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.2175 0.2512
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0055 0.0683 0.2156
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.031 0.0615
Schistosoma mansoni furin-1 (S08 family) 0.0125 0.1956 0.1956
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0201 0.1217
Plasmodium falciparum plasmepsin X 0.0045 0.0493 0.1555
Onchocerca volvulus 0.0044 0.0476 0.0814
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0493 0.0569
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.2248 0.2248
Onchocerca volvulus 0.0092 0.1347 0.2415
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.031 0.0358
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.002 0.0032 0.0102
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0424 0.1338
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0201 0.0634
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.0476 0.0549
Giardia lamblia Furin precursor putative serine protease 0.0055 0.0683 0.4213
Brugia malayi RE15519p 0.0044 0.0476 0.0549
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2574 0.2972
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0424 0.1338
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1652 0.3281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.1949
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0071 0.0223
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Onchocerca volvulus 0.0192 0.3195 0.581
Echinococcus multilocularis serotonin receptor 0.0044 0.0476 0.0549
Schistosoma mansoni opsin-like receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0191 0.317 0.366
Echinococcus granulosus neuropeptide FF receptor 2 0.0489 0.866 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0316 0.5476 0.5476
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.0476 0.0549
Plasmodium falciparum plasmepsin II 0.0191 0.317 1
Echinococcus granulosus neuroendocrine convertase 2 0.018 0.2975 0.3436
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.0476 0.0549
Plasmodium falciparum plasmepsin V 0.0045 0.0493 0.1555
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.002 0.0032 0.0037
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1652 1
Schistosoma mansoni biogenic amine receptor 0.0044 0.0476 0.0476
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1652 0.1652
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0476 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Schistosoma mansoni hypothetical protein 0.0207 0.3464 0.3464
Echinococcus multilocularis geminin 0.0164 0.2685 0.31
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Trypanosoma cruzi lanosterol synthase, putative 0.0059 0.0751 0.1492
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trypanosoma brucei RNA helicase, putative 0.0207 0.3464 0.6882
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1652 1
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0032 0.0199
Schistosoma mansoni adenoreceptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0287 0.4933 0.5697
Loa Loa (eye worm) acetyltransferase 0.0141 0.2248 0.2596
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0044 0.0476 0.0814
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1371 0.2723
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0055 0.0683 0.2156
Plasmodium vivax plasmepsin IV, putative 0.0191 0.317 1
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.002 0.0032 0.0102
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0655 0.2066
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.0476 0.0549
Echinococcus granulosus neuropeptide receptor A26 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.0476 0.0549
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.031 0.0977
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0191 0.317 1
Echinococcus granulosus allatostatin A receptor 0.0316 0.5476 0.6324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.031 0.0358
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0476 0.0549
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0476 0.0549
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0059 0.0751 0.4548
Onchocerca volvulus 0.0044 0.0476 0.0814
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0045 0.0493 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.0476 0.0549
Brugia malayi G-protein coupled receptor 0.0044 0.0476 0.0549
Trypanosoma cruzi protein farnesyltransferase, putative 0.0054 0.0655 0.1301
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus multilocularis mitogen activated protein kinase 11 0.0292 0.5033 0.5812
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.031 0.0977
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0201 0.0634
Onchocerca volvulus Huntingtin homolog 0.0119 0.1848 0.3335
Brugia malayi Dopamine receptor protein 2 0.0044 0.0476 0.0549
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) endoprotease bli-4 0.0287 0.4933 0.5697
Toxoplasma gondii aspartyl protease ASP3 0.0045 0.0493 0.1555
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis mitogen activated protein kinase 14 0.0292 0.5033 0.5812
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Brugia malayi GnHR receptor homolog 0.0044 0.0476 0.0549
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0322 0.0372
Schistosoma mansoni cathepsin D (A01 family) 0.0562 1 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0655 0.0756
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.0476 0.0549
Trypanosoma brucei polo-like protein kinase 0.0093 0.1371 0.2723
Schistosoma mansoni amine GPCR 0.0044 0.0476 0.0476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.0476 0.0549
Schistosoma mansoni amine GPCR 0.0044 0.0476 0.0476
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0044 0.0476 0.0814
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Schistosoma mansoni neuropeptide receptor 0.0044 0.0476 0.0476
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.0476 0.0549
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0054 0.0655 0.2066
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0191 0.317 0.366
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0044 0.0476 0.0476
Onchocerca volvulus 0.0045 0.0493 0.0846
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2574 0.2972
Leishmania major farnesyltransferase beta subunit 0.0054 0.0655 0.1301
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0476 0.0549
Onchocerca volvulus Neuropeptide F receptor homolog 0.0044 0.0476 0.0814
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1652 0.1907
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.0476 0.0549
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.002 0.0032 0.0037
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0054 0.0655 0.2066
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1652 0.1907
Leishmania major lanosterol synthase, putative 0.0045 0.0482 0.0958
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.0476 0.0476
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.0476 0.0549
Brugia malayi G-protein coupled receptor 0.0044 0.0476 0.0549
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0054 0.0655 0.2066
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0519 0.1637
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0493 0.1555
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0424 0.1338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1796 0.2074
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0039 0.0386 0.1218
Trypanosoma cruzi lanosterol synthase, putative 0.0059 0.0751 0.1492
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0102
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0201 0.0634
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi follicle stimulating hormone receptor 0.0044 0.0476 0.0549
Schistosoma mansoni alpha-glucosidase 0.0136 0.2168 0.2168
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.0476 0.0476
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0201 0.0634
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Leishmania major hypothetical protein, conserved 0.0022 0.0071 0.014
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0476 0.0549
Schistosoma mansoni hypothetical protein 0.0044 0.0476 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Echinococcus granulosus g-protein coupled receptor 0.0044 0.0476 0.0549
Echinococcus granulosus g protein coupled receptor 0.0044 0.0476 0.0549
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0493 0.1555
Echinococcus granulosus sex peptide receptor 0.0044 0.0476 0.0549
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.002 0.0032 0.0196
Onchocerca volvulus 0.0044 0.0476 0.0814
Brugia malayi AKH receptor 0.0044 0.0476 0.0549
Toxoplasma gondii aspartyl protease 0.0045 0.0493 0.1555
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1371 0.2723
Onchocerca volvulus 0.0316 0.5476 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0489 0.866 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1652 0.1907
Plasmodium vivax aspartyl proteinase, putative 0.0191 0.317 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0102
Schistosoma mansoni hypothetical protein 0.0164 0.2685 0.2685
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.031 0.0977
Brugia malayi ORL1-like opioid receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis ephrin type A receptor 4 A 0.0194 0.3234 0.3735
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.002 0.0032 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0054 0.0655 0.2066
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0071 0.014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0191 0.317 0.366
Brugia malayi Tachykinin-like peptides receptor 99D 0.0489 0.866 1
Schistosoma mansoni alpha-glucosidase 0.0136 0.2168 0.2168
Schistosoma mansoni neuropeptide receptor 0.0044 0.0476 0.0476
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0054 0.0655 0.1301
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.031 0.0977
Echinococcus granulosus Furin 1 0.0068 0.0909 0.1049
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0037
Echinococcus multilocularis sex peptide receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0119 0.1848 0.2134
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.0476 0.0549
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0361 0.1138
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0476 0.0476
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0064
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.0476 0.0476
Schistosoma mansoni myosin xvIII 0.0044 0.0476 0.0476
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.0476 0.0549
Plasmodium falciparum plasmepsin VII 0.0045 0.0493 0.1555
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0044 0.0476 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0201 0.0634
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0476 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0476 0.0549
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.1949
Echinococcus granulosus somatostatin receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Echinococcus multilocularis Furin 1 0.0068 0.0909 0.1049
Brugia malayi Pepsin A precursor 0.0045 0.0493 0.0569
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0519 0.1637
Brugia malayi proprotein convertase 2 0.018 0.2975 0.3436
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1371 0.1583
Plasmodium falciparum plasmepsin IV 0.0191 0.317 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.002 0.0032 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Brugia malayi hypothetical protein 0.0036 0.0322 0.0372
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.0476 0.0549
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.0476 0.0549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0032 0.0032
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0064
Plasmodium vivax plasmepsin V, putative 0.0045 0.0493 0.1555
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Echinococcus granulosus geminin 0.0164 0.2685 0.31
Plasmodium vivax aspartyl protease, putative 0.0045 0.0493 0.1555
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0476 0.0549
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.0476 0.0549
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0476 0.0549
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.1949
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0032 0.0102
Loa Loa (eye worm) hypothetical protein 0.0191 0.317 0.366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.031 0.0977
Schistosoma mansoni amine GPCR 0.0044 0.0476 0.0476
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0201 0.0634
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0476 0.0549
Schistosoma mansoni opsin-like receptor 0.0044 0.0476 0.0476
Schistosoma mansoni alpha glucosidase 0.0035 0.031 0.031
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.0476 0.0476
Echinococcus granulosus serotonin receptor 0.0044 0.0476 0.0549
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0683 0.2156
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1652 0.3281
Onchocerca volvulus 0.0044 0.0476 0.0814
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0082
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.002 0.0032 0.0037
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.031 0.1876
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1652 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.031 0.1876
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1371 0.2458
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.002 0.0032 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1652 0.1907
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0476 0.0476
Brugia malayi neuropeptide F receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1371 0.4324
Brugia malayi Melatonin receptor type 1A 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.0476 0.0549
Echinococcus granulosus protein prenyltransferase alpha subunit 0.002 0.0032 0.0037
Brugia malayi 6-phosphofructokinase 0.0108 0.1652 0.1907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0071 0.0082
Echinococcus multilocularis neuropeptide receptor A26 0.0044 0.0476 0.0549
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2574 0.2972
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0292 0.5033 0.5812
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Giardia lamblia Kinase, PLK 0.0093 0.1371 0.845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0476 0.0476
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0032 0.0064
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0055 0.0683 0.2156
Brugia malayi hypothetical protein 0.0044 0.0476 0.0549
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0292 0.5033 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0909 0.2866
Brugia malayi Dopamine receptor protein 1 0.0044 0.0476 0.0549
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0476 0.0549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0071 0.0223
Schistosoma mansoni neuropeptide receptor 0.0044 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.0164 0.2685 0.2685
Toxoplasma gondii subtilisin SUB12 0.0027 0.0152 0.048
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1652 0.1652
Schistosoma mansoni neuropeptide receptor 0.0044 0.0476 0.0476
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0032 0.0064
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0292 0.5033 1
Brugia malayi Serotonin receptor 0.0044 0.0476 0.0549
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.0476 0.0549
Echinococcus granulosus neuropeptide receptor 0.0044 0.0476 0.0549
Schistosoma mansoni ephrin receptor 0.0194 0.3234 0.3234
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.002 0.0032 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0476 0.0549
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.031 0.0977
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.0476 0.0476
Schistosoma mansoni kinase 0.0048 0.0541 0.0541
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0476 0.0549
Echinococcus multilocularis mitogen activated protein kinase 14 0.0292 0.5033 0.5812
Loa Loa (eye worm) hypothetical protein 0.0316 0.5476 0.6324
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2574 0.2972
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0191 0.317 1
Echinococcus granulosus orexin receptor type 2 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0476 0.0549
Brugia malayi sulfakinin receptor protein 0.0044 0.0476 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Echinococcus granulosus g protein coupled receptor 0.0044 0.0476 0.0549
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0493 0.1555
Brugia malayi 6-phosphofructokinase 0.0108 0.1652 0.1907
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0201 0.5
Brugia malayi hypothetical protein 0.0119 0.1848 0.2134
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1652 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0201 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0322 0.0372
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0655 0.2066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0476 0.0476
Plasmodium falciparum plasmepsin IX 0.0045 0.0493 0.1555
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.0476 0.0549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0476 0.0476
Brugia malayi Kringle domain containing protein 0.0022 0.0071 0.0082
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.0476 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1652 0.521
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.0476 0.0549
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.0476 0.0476
Echinococcus multilocularis mitogen activated protein kinase 11 0.0292 0.5033 0.5812
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0292 0.5033 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.0476 0.0549
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0476 0.0549
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0476 0.0476
Giardia lamblia High cysteine membrane protein Group 2 0.0106 0.1622 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0032 0.0064
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1371 0.1583
Echinococcus multilocularis neuropeptide s receptor 0.0044 0.0476 0.0549
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.0476 0.0476
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0054 0.0655 0.0756
Echinococcus multilocularis somatostatin receptor 0.0044 0.0476 0.0549
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1652 0.521
Schistosoma mansoni hypothetical protein 0.0022 0.0071 0.0071

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 nM Inhibition of human placental microsome CYP19 ChEMBL. 20413308

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.