Detailed information for compound 113080

Basic information

Technical information
  • TDR Targets ID: 113080
  • Name: 4-[(1,2,6,7-tetrahydroxycarbazol-9-yl)methyl] benzonitrile
  • MW: 346.336 | Formula: C20H14N2O4
  • H donors: 4 H acceptors: 5 LogP: 3.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)Cn1c2cc(O)c(cc2c2c1c(O)c(O)cc2)O
  • InChi: 1S/C20H14N2O4/c21-9-11-1-3-12(4-2-11)10-22-15-8-18(25)17(24)7-14(15)13-5-6-16(23)20(26)19(13)22/h1-8,23-26H,10H2
  • InChiKey: YJVYGHFORCXWDF-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[(1,2,6,7-tetrahydroxy-9-carbazolyl)methyl]benzonitrile
  • 4-[(1,2,6,7-tetrahydroxycarbazol-9-yl)methyl]benzenecarbonitrile
  • Carbazole deriv. 9j

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.247 1
Echinococcus granulosus agrin 0.002 0.0528 0.0839
Brugia malayi Cytochrome P450 family protein 0.0012 0.0159 0.0149
Onchocerca volvulus 0.003 0.0957 0.3703
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.1761 0.6851
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0213 0.0328
Schistosoma mansoni nuclear receptor 0.0022 0.0623 0.0828
Echinococcus granulosus organic anion transporting polypeptide 30B 0.003 0.0957 0.1533
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0012 0.0154 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0623 0.0828
Echinococcus granulosus death domain containing protein 0.0014 0.0252 0.0391
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0623 0.0623
Brugia malayi bZIP transcription factor family protein 0.0083 0.3375 0.3368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0012 0.0154 0.0195
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1857 0.7348
Onchocerca volvulus 0.003 0.0957 0.3703
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Brugia malayi SPARC precursor 0.002 0.0528 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.2911 0.4699
Loa Loa (eye worm) hypothetical protein 0.0016 0.0358 0.0358
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.182 0.2446
Brugia malayi hypothetical protein 0.003 0.0957 0.0947
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0252 0.0242
Brugia malayi nuclear receptor NHR-88 0.0047 0.1761 0.1753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Schistosoma mansoni follistatin 0.002 0.0528 0.07
Onchocerca volvulus 0.0016 0.0358 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.1761 0.1753
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0358 0.047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.1761 0.1753
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0623 0.0992
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.1761 0.2366
Entamoeba histolytica protein kinase, putative 0.0036 0.1273 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.1273 0.1706
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.1761 0.2366
Brugia malayi nuclear hormone receptor 0.0047 0.1761 0.1753
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.1761 0.2366
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 1 1
Echinococcus granulosus follistatin 0.002 0.0528 0.0839
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0358 0.0863
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0745 0.0735
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0358 0.2756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.182 0.2931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.1761 0.1753
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0623 0.0613
Schistosoma mansoni agrin 0.002 0.0528 0.07
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0358 0.5
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0528 0.2844
Echinococcus granulosus NCK adaptor protein 0.0012 0.0154 0.0233
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.1761 0.1761
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0358 0.1361
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0358 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.1761 0.1753
Plasmodium vivax vivapain-2 0.0016 0.0358 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0012 0.0154 0.0154
Toxoplasma gondii protease inhibitor PI2 0.002 0.0528 0.2844
Loa Loa (eye worm) sodium-independent organic anion transporter 0.003 0.0957 0.0957
Brugia malayi nuclear hormone receptor 0.0022 0.0623 0.0613
Brugia malayi sodium-independent organic anion transporter family protein 0.003 0.0957 0.0947
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0623 0.0613
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.182 0.2931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Schistosoma mansoni organic anion transporter 0.003 0.0957 0.1279
Leishmania major cathepsin L-like protease 0.0063 0.247 1
Brugia malayi hypothetical protein 0.003 0.0957 0.0947
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.247 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.1761 0.2366
Loa Loa (eye worm) hypothetical protein 0.002 0.0528 0.0528
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0623 0.0992
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.5256 0.8496
Loa Loa (eye worm) hypothetical protein 0.0025 0.0745 0.0745
Brugia malayi steroid hormone receptor 0.0047 0.1761 0.1753
Onchocerca volvulus 0.0047 0.1761 0.6851
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.182 0.2446
Brugia malayi tailless protein 0.0022 0.0623 0.0613
Echinococcus multilocularis thyroid hormone receptor alpha 0.0171 0.741 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0358 0.0358
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.5256 0.7089
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Brugia malayi Cathepsin L-like precursor 0.0011 0.011 0.01
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0623 0.2398
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.182 0.2446
Echinococcus granulosus growth factor receptor bound protein 2 0.0012 0.0154 0.0233
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0745 0.0993
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.1273 0.2044
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0016 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Onchocerca volvulus 0.0016 0.0358 0.1361
Onchocerca volvulus 0.0016 0.0358 0.1361
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.182 0.2931
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0623 0.0828
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0623 0.0613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0025 0.0745 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.1761 0.1753
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.1761 0.2366
Schistosoma mansoni tyrosine kinase 0.0009 0.0016 0.0007
Schistosoma mansoni netrin receptor unc5 0.0014 0.0252 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Brugia malayi nuclear receptor RXR 0.0022 0.0623 0.0613
Brugia malayi hypothetical protein 0.0022 0.0623 0.0613
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.1761 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Brugia malayi sodium-independent organic anion transporter family protein 0.003 0.0957 0.0947
Schistosoma mansoni hypothetical protein 0.0014 0.0252 0.0327
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.182 0.2931
Schistosoma mansoni organic anion transporter 0.003 0.0957 0.1279
Onchocerca volvulus Putative organic anion transporter 0.003 0.0957 0.3703
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.247 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0159 0.0159
Echinococcus multilocularis jun protein 0.0083 0.3375 0.4547
Trypanosoma cruzi MFS transporter, putative 0.003 0.0957 0.3452
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0957 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.002 0.0528 0.0528
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0528 0.0519
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0154 0.0195
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Schistosoma mansoni adapter molecule crk 0.0012 0.0154 0.0195
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.247 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.1761 0.6851
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.182 0.2446
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.002 0.0528 0.0528
Onchocerca volvulus Putative organic anion transporter 0.003 0.0957 0.3703
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Echinococcus multilocularis cysteine protease 0.0016 0.0358 0.047
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0213 0.0273
Loa Loa (eye worm) agrin synaptic family protein 0.002 0.0528 0.0528
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.1618 0.2172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.2221 0.8925
Echinococcus multilocularis Solute carrier organic anion transporter family 0.003 0.0957 0.1279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.1761 0.1753
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0154 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0119 0.5047 0.6806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.003 0.0957 0.1533
Schistosoma mansoni tyrosine kinase 0.0013 0.0213 0.0273
Onchocerca volvulus 0.0016 0.0358 0.1361
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0623 0.0623
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0745 0.0745
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0252 0.0391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0252 0.0252
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0745 0.119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0745 0.0993
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.003 0.0957 0.1279
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.1761 0.2366
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0144 0.6185 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.1761 0.6851
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.3375 0.545
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0623 0.0828
Brugia malayi hypothetical protein 0.0025 0.0745 0.0735
Echinococcus multilocularis NCK adaptor protein 0.0012 0.0154 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0171 0.741 1
Leishmania major cathepsin L-like protease 0.0016 0.0358 0.0863
Brugia malayi conserved hypotetical protein 0.0022 0.0623 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.1761 0.2835
Brugia malayi hypothetical protein 0.0025 0.0745 0.0735
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.182 0.2446
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.008 0.3272 0.3272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0745 0.0993
Schistosoma mansoni jun-related protein 0.0067 0.2669 0.3593
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0154 0.0144
Brugia malayi Sex muscle abnormal protein 5 0.0012 0.0154 0.0144
Onchocerca volvulus 0.0016 0.0358 0.1361
Onchocerca volvulus 0.0022 0.0623 0.2398
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Onchocerca volvulus 0.003 0.0957 0.3703
Brugia malayi nuclear receptor RXR 0.0025 0.0745 0.0735
Schistosoma mansoni zinc finger protein 0.0022 0.0623 0.0828
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0016 0.0009
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0623 0.0613
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0154 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.1761 0.1761
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.1761 0.2835
Brugia malayi hypothetical protein 0.0022 0.0623 0.0613
Onchocerca volvulus 0.003 0.0957 0.3703
Echinococcus granulosus tyrosine kinase 0.0044 0.1618 0.2603
Loa Loa (eye worm) TK protein kinase 0.0036 0.1273 0.1273
Brugia malayi prostaglandin transporter 0.003 0.0957 0.0947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Loa Loa (eye worm) DR-78 0.0022 0.0623 0.0623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.1761 0.2835
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.1761 0.2835
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0213 0.0273
Brugia malayi nuclear receptor NHR-88 0.0022 0.0623 0.0613
Brugia malayi Cathepsin L-like precursor 0.0011 0.011 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0358 0.047
Leishmania major cathepsin L-like protease 0.0063 0.247 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0745 0.0745
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.1761 0.2366
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.1761 0.2835
Brugia malayi nuclear receptor NHR-67 0.0022 0.0623 0.0613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.002 0.0528 0.0528
Echinococcus granulosus Ankyrin 0.0014 0.0257 0.04
Brugia malayi STAT protein, DNA binding domain containing protein 0.0163 0.703 0.7027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0623 0.0613
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0257 0.0334
Onchocerca volvulus 0.0011 0.011 0.0389
Brugia malayi ecdysone receptor 0.0022 0.0623 0.0613
Leishmania major cathepsin L-like protease 0.0016 0.0358 0.0863
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0358 0.0863
Echinococcus multilocularis expressed protein 0.002 0.0528 0.07
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0025 0.0745 0.0745
Onchocerca volvulus 0.003 0.0957 0.3703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus multilocularis agrin 0.002 0.0528 0.07
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.1761 0.1753
Echinococcus multilocularis cysteine protease 0.0016 0.0358 0.047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.1761 0.2366
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.1761 0.2835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0252 0.0946
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.2911 0.392
Onchocerca volvulus 0.0016 0.0358 0.1361
Loa Loa (eye worm) TK/ABL protein kinase 0.0009 0.001 0.001
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0528 0.2844
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.1761 0.1753
Onchocerca volvulus 0.002 0.0528 0.2027
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.002 0.0528 0.0528
Leishmania major cathepsin L-like protease 0.0016 0.0358 0.0863
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0358 0.2756
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.1761 0.1753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.182 0.2446
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0159 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0623 0.0828
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0623 0.2398
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0623 0.0828
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.182 0.2446
Schistosoma mansoni coup transcription factor 0.0047 0.1761 0.2366
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.182 0.2446
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.3375 0.4547
Schistosoma mansoni thyroid hormone receptor 0.0171 0.741 1
Schistosoma mansoni tyrosine kinase 0.0048 0.182 0.2446
Plasmodium vivax vivapain-2 0.0016 0.0358 0.5
Schistosoma mansoni tyrosine kinase 0.0013 0.0213 0.0273
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0623 0.0992
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.156 0.2094
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0623 0.0828
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0623 0.0828
Loa Loa (eye worm) cysteine protease 0.0016 0.0358 0.0358
Schistosoma mansoni tyrosine kinase 0.0048 0.182 0.2446
Schistosoma mansoni nuclear hormone receptor 0.0047 0.1761 0.2366
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0528 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.011
Brugia malayi sodium-independent organic anion transporter family protein 0.003 0.0957 0.0947
Onchocerca volvulus 0.0022 0.0623 0.2398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0048 0.182 0.2931
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0213 0.0203
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0623 0.0828
Schistosoma mansoni nck2/grb4 0.0012 0.0154 0.0195
Brugia malayi Protein kinase domain containing protein 0.0014 0.0252 0.0242
Schistosoma mansoni nuclear receptor 0.0022 0.0623 0.0828
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.182 0.2931
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.011 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.011 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0257 0.0257
Echinococcus multilocularis tyrosine protein kinase Abl 0.0013 0.0213 0.0273
Loa Loa (eye worm) STAT protein 0.0163 0.703 0.703
Echinococcus granulosus jun protein 0.0083 0.3375 0.545
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.156 0.2509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.1761 0.1753
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.182 0.2931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) fibroinase 0.0016 0.0358 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.1761 0.1753
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.1761 0.2835
Brugia malayi SRC-1 0.0048 0.182 0.1812
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Echinococcus multilocularis follistatin 0.002 0.0528 0.07
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0623 0.0992
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.1761 0.1753
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.1618 0.2603
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0358 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.1761 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0623 0.0623
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0358 0.0358
Echinococcus multilocularis Ankyrin 0.0014 0.0257 0.0334
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0528 0.0519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.1761 0.1761
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.182 0.2446
Onchocerca volvulus 0.0016 0.0358 0.1361
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.1761 0.1753
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0358 0.0563
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.011 0.0134
Brugia malayi Cytochrome P450 family protein 0.0012 0.0159 0.0149
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.1761 0.1753
Brugia malayi hypothetical protein 0.0065 0.2566 0.2558
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0358 0.047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.1761 0.1753
Brugia malayi secreted modular calcium-binding protein 1 0.002 0.0528 0.0519
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0213 0.0328
Onchocerca volvulus 0.0065 0.2566 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0358 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.1761 0.1761
Echinococcus granulosus cathepsin l1 0.0016 0.0358 0.0563
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0252 0.0327
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0623 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.1761 0.1753
Schistosoma mansoni hypothetical protein 0.0067 0.2669 0.3593
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0623 0.0828
Brugia malayi Death domain containing protein 0.0014 0.0252 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.1618 0.2172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Leishmania major cathepsin L-like protease 0.0016 0.0358 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0358 1
Brugia malayi cathepsin L-like precursor 0.0011 0.011 0.01
Loa Loa (eye worm) TK protein kinase 0.0044 0.1618 0.1618
Brugia malayi protein-tyrosine kinase 0.0044 0.1618 0.1609
Schistosoma mansoni retinoic acid receptor RXR 0.0144 0.6185 0.8344
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0358 0.0358
Echinococcus granulosus cathepsin l1 0.0011 0.011 0.0161
Schistosoma mansoni hypothetical protein 0.0124 0.5256 0.7089
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0528 0.0519
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Loa Loa (eye worm) SRC-1 0.0048 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0623 0.0992
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.1761 0.2366
Onchocerca volvulus Putative organic anion transporter 0.003 0.0957 0.3703
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0358 0.0563
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0528 0.2844
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0358 0.047
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0252 0.0391
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0358 0.047
Leishmania major cathepsin L-like protease 0.0016 0.0358 0.0863
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0623 0.0613
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.011
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.1618 0.2603
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0358 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0957 0.0957
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0623 0.0992
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0252 0.0327
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0358 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0358 0.1361
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.1618 0.2172
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0358 0.1361
Loa Loa (eye worm) hypothetical protein 0.0047 0.1761 0.1761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.247 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.182 0.2931
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.1761 0.2366
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0745 0.0735
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.1761 0.2366
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.1761 0.2366
Entamoeba histolytica cysteine protease, putative 0.0016 0.0358 0.2756
Leishmania major cathepsin L-like protease 0.0063 0.247 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.1761 0.1761
Brugia malayi ecdysteroid receptor 0.0047 0.1761 0.1753
Loa Loa (eye worm) hypothetical protein 0.0022 0.0623 0.0623
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0159 0.0159
Echinococcus granulosus FTZ F1 alpha 0.0047 0.1761 0.2835
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0528 0.2844
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.1761 0.2366
Brugia malayi Cathepsin L-like precursor 0.0016 0.0358 0.0348
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0213 0.0273
Brugia malayi Uncoordinated protein 44 0.0014 0.0252 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.1761 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0358 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.4 uM Tested for in vitro inhibitory activity against tyrosine protein kinase pp60 c-src ChEMBL. 7518523
IC50 (binding) = 0.4 uM Tested for in vitro inhibitory activity against tyrosine protein kinase pp60 c-src ChEMBL. 7518523
IC50 (binding) = 275 uM In vitro inhibitory activity against protein kinase A ChEMBL. 7518523
IC50 (binding) = 275 uM In vitro inhibitory activity against protein kinase A ChEMBL. 7518523

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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