Detailed information for compound 1132998

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 374.428 | Formula: C21H26O6
  • H donors: 1 H acceptors: 4 LogP: 2.42 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@@]2([C@@]2([C@@H]1C(C)(C)CCC2)C)O
  • InChi: 1S/C21H26O6/c1-19(2)9-7-10-20(3)17(19)15(27-16(23)8-5-4-6-11-22)12-14-13-26-18(24)21(14,20)25/h4-6,8,11-12,15,17,25H,7,9-10,13H2,1-3H3/b6-4+,8-5+/t15-,17+,20+,21+/m1/s1
  • InChiKey: NTEIYTQTTHYBTI-BEFOBABASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peregrin 0.0031 0.009 0.0248
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0353
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0036 0.0086
Onchocerca volvulus 0.0488 0.247 0.2469
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0505 0.1405
Schistosoma mansoni kinase 0.0051 0.0197 0.0339
Toxoplasma gondii thioredoxin reductase 0.0037 0.0121 0.0403
Echinococcus granulosus dna polymerase eta 0.002 0.0032 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0033
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0291 0.1444 0.247
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0453 0.165
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.012 0.0809
Brugia malayi intermediate filament protein 0.0026 0.0066 0.009
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0314 0.0542
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0453 0.165
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0066 0.0113
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.009 0.0154
Leishmania major hypothetical protein, conserved 0.0023 0.0047 0.0128
Trypanosoma brucei polo-like protein kinase 0.0101 0.0453 0.1691
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0686 0.5083
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.012 0.0193
Echinococcus multilocularis protein dispatched 1 0.0049 0.0185 0.0512
Schistosoma mansoni hypothetical protein 0.0182 0.088 0.1522
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0032 0.007
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.012 0.0809
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Mycobacterium ulcerans hypothetical protein 0.0026 0.0065 0.0072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0459 0.0793
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0013 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0113
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0036 0.0048
Onchocerca volvulus 0.0026 0.0066 0.0065
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0133 0.0228
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0013 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0875 0.2436
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0055 0.0162
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.1657 0.2867
Trypanosoma brucei telomerase reverse transcriptase 0.0528 0.268 1
Brugia malayi hypothetical protein 0.045 0.2276 0.3139
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0414 0.5963
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0453 0.165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0257 0.0713
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0055 0.0055
Echinococcus multilocularis protein patched 0.0043 0.0153 0.0424
Schistosoma mansoni hypothetical protein 0.0136 0.0637 0.1101
Leishmania major hypothetical protein, conserved 0.0225 0.1103 0.4088
Brugia malayi Thioredoxin reductase 0.0037 0.0121 0.0165
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.0875 0.1513
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0065 0.0389
Plasmodium vivax hypothetical protein, conserved 0.0031 0.009 0.0289
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0253 0.0701
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0038
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0023 0.0038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0456 0.1269
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0453 0.126
Onchocerca volvulus 0.0133 0.0623 0.0621
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0036 0.0086
Brugia malayi SWIRM domain containing protein 0.002 0.0036 0.0048
Onchocerca volvulus 0.003 0.0088 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0456 0.1269
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0181
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0875 0.2436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0314 0.0529
Leishmania major protein kinase, putative 0.0017 0.0017 0.0016
Brugia malayi PHD-finger family protein 0.0031 0.009 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0316 0.0544
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0366 0.2663
Mycobacterium ulcerans hypothetical protein 0.0037 0.012 0.0169
Loa Loa (eye worm) RNA binding protein 0.0064 0.0265 0.0457
Echinococcus granulosus snurportin 1 0.0331 0.1657 0.4617
Echinococcus multilocularis microtubule associated protein 2 0.0702 0.3586 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0257 0.0443
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.0875 0.1205
Brugia malayi hypothetical protein 0.0071 0.0298 0.0409
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0414 0.3031
Brugia malayi RNA, U transporter 1 0.0088 0.039 0.0535
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0032 0.0042
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0013 0.0000085459
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0298 0.0827
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0032 0.007
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0001 0.0000083773
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0053
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0022 0.0046 0.0122
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0061 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Echinococcus granulosus chromobox protein 1 0.0074 0.0314 0.0872
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0965 0.1669
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0366 0.2663
Plasmodium falciparum phd finger protein, putative 0.0031 0.009 0.0289
Plasmodium falciparum glutathione reductase 0.0037 0.0121 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0253 0.0435
Leishmania major importin beta-1 subunit, putative 0.0025 0.0061 0.0178
Leishmania major DNA polymerase eta, putative 0.002 0.0032 0.007
Schistosoma mansoni lamin 0.0026 0.0066 0.0113
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0453 0.0623
Plasmodium vivax glutathione reductase, putative 0.0037 0.0121 0.0403
Brugia malayi hypothetical protein 0.002 0.0036 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Echinococcus multilocularis lamin dm0 0.0026 0.0066 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Plasmodium vivax SET domain protein, putative 0.0062 0.0253 0.0898
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0253 0.0898
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0265 0.0457
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0257 0.0713
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0032 0.0118
Echinococcus multilocularis dna polymerase eta 0.002 0.0032 0.0085
Brugia malayi beta-lactamase family protein 0.0037 0.012 0.0164
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0435
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0032 0.0053
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0366 0.5239
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0161 0.0264
Echinococcus granulosus geminin 0.0182 0.088 0.2452
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0366 0.2663
Schistosoma mansoni hypothetical protein 0.0182 0.088 0.1522
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.009 0.0248
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0036 0.0097
Toxoplasma gondii ABC1 family protein 0.0037 0.012 0.0401
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.009 0.0289
Leishmania major hypothetical protein, conserved 0.0037 0.012 0.0401
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0153 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0265 0.0457
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0153 0.0424
Schistosoma mansoni ran 0.0023 0.0049 0.0082
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0451 0.1255
Brugia malayi SET domain containing protein 0.0015 0.0008 0.0009
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0036 0.0086
Plasmodium falciparum thioredoxin reductase 0.0037 0.0121 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Loa Loa (eye worm) hypothetical protein 0.045 0.2276 0.3941
Plasmodium vivax hypothetical protein, conserved 0.002 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0038
Echinococcus multilocularis lamin 0.0026 0.0066 0.0181
Schistosoma mansoni amine oxidase 0.002 0.0036 0.006
Brugia malayi beta-lactamase 0.0037 0.012 0.0164
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0049
Onchocerca volvulus 0.0026 0.0066 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.1103 0.4117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0032 0.0053
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0013 0.0000085459
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.012 0.0206
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0314 0.0529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.012 0.0206
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0153 0.0424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0366 0.2663
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0291 0.1444 0.247
Loa Loa (eye worm) hypothetical protein 0.0031 0.009 0.0154
Echinococcus granulosus dna polymerase kappa 0.002 0.0032 0.0085
Onchocerca volvulus 0.0024 0.0055 0.0054
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0032 0.0085
Trichomonas vaginalis esterase, putative 0.0037 0.012 0.0193
Mycobacterium ulcerans putative regulatory protein 0.0046 0.0168 0.0251
Mycobacterium tuberculosis Conserved protein 0.0037 0.012 0.0809
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.012 0.0193
Trypanosoma brucei trypanothione reductase 0.0037 0.0121 0.045
Brugia malayi PAS domain containing protein 0.0062 0.0252 0.0345
Schistosoma mansoni tsg101-related 0.0059 0.0236 0.0407
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0091 0.0251
Loa Loa (eye worm) hypothetical protein 0.0053 0.0204 0.0351
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0032 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0055 0.0317
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0145 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0066 0.009
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0036 0.0097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0055 0.0623
Echinococcus granulosus expressed conserved protein 0.0094 0.042 0.1166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0875 0.1513
Brugia malayi MH2 domain containing protein 0.0121 0.0562 0.0774
Schistosoma mansoni hypothetical protein 0.0063 0.0257 0.0443
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0121 0.0403
Leishmania major telomerase reverse transcriptase, putative 0.0528 0.268 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0156
Brugia malayi RNA binding protein 0.0064 0.0265 0.0364
Loa Loa (eye worm) runx1 0.0057 0.0224 0.0385
Onchocerca volvulus 0.0037 0.012 0.0119
Mycobacterium leprae Probable lipase LipE 0.0037 0.012 0.1591
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0033
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.009 0.0248
Onchocerca volvulus 0.0032 0.0098 0.0097
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0023 0.0077
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0049 0.0133
Echinococcus granulosus chromobox protein 1 0.0074 0.0314 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0124 0.0343
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0036 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0032 0.0118
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0003 0.0002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0453 0.126
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0065
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0451 0.0621
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0032 0.014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.1478 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0265 0.0457
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0055 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0562 0.0971
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Entamoeba histolytica hypothetical protein 0.011 0.0505 0.3273
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0133
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0451 0.29
Mycobacterium tuberculosis Probable reductase 0.0084 0.0366 0.2663
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Schistosoma mansoni hypothetical protein 0.0041 0.0145 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Schistosoma mansoni cpg binding protein 0.0032 0.0097 0.0166
Schistosoma mansoni glutaminase 0.1122 0.5773 1
Schistosoma mansoni tsg101-related 0.0048 0.018 0.031
Brugia malayi hypothetical protein 0.011 0.0505 0.0695
Onchocerca volvulus 0.0046 0.0171 0.0169
Leishmania major protein kinase, putative 0.0017 0.0017 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0157
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0065 0.0097
Loa Loa (eye worm) glutaminase 2 0.1122 0.5773 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0013 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0121 0.0207
Schistosoma mansoni microtubule-associated protein tau 0.0702 0.3586 0.621
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0032 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0875 0.1513
Echinococcus multilocularis cpg binding protein 0.0032 0.0097 0.0267
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.012 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0453 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0133
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0136 0.0637 0.1101
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0505 0.0873
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.0162
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0249
Schistosoma mansoni intermediate filament proteins 0.0026 0.0066 0.0113
Loa Loa (eye worm) hypothetical protein 0.0154 0.073 0.1262
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0036 0.0086
Onchocerca volvulus Alhambra homolog 0.0031 0.009 0.0089
Schistosoma mansoni lamin 0.0026 0.0066 0.0113
Plasmodium falciparum importin beta, putative 0.0031 0.0091 0.0293
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0065 0.0193
Schistosoma mansoni hypothetical protein 0.0041 0.0145 0.0249
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.0055
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0675 0.1879
Giardia lamblia Kinase, PLK 0.0101 0.0453 0.1591
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.1478 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0257 0.0353
Entamoeba histolytica hypothetical protein 0.011 0.0505 0.3273
Mycobacterium ulcerans hypothetical protein 0.0026 0.0065 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0082 0.0127
Mycobacterium ulcerans glutaminase 0.1122 0.5773 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0253 0.0435
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0277 0.0478
Mycobacterium ulcerans dehydrogenase 0.002 0.0036 0.0022
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0017 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0265 0.0457
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0047 0.0128
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.002
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0074
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0265 0.0457
Loa Loa (eye worm) hypothetical protein 0.045 0.2276 0.3941
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0028 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Echinococcus multilocularis Protein lozenge 0.0057 0.0224 0.0621
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0121 0.0812
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0265 0.0457
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0016 0.0041
Schistosoma mansoni chromobox protein 0.0074 0.0314 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0091 0.034
Echinococcus granulosus lamin 0.0026 0.0066 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0037 0.012 0.0401
Echinococcus multilocularis peregrin 0.0031 0.009 0.0248
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0253 0.0701
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0133 0.0368
Brugia malayi Importin beta-1 subunit 0.0031 0.0091 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0875 0.2436
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0066 0.0113
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0675 0.1879
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0088 0.015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0033
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.002 0.0036 0.034
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0065 0.0072
Schistosoma mansoni cpg binding protein 0.0032 0.0097 0.0166
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0013 0.0007
Brugia malayi Protein kinase domain containing protein 0.0421 0.2123 0.2928
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0091 0.0293
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0055 0.0055
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.1478 0.5
Schistosoma mansoni hypothetical protein 0.0063 0.0257 0.0443
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.012 0.0332
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0637 0.0877
Loa Loa (eye worm) hypothetical protein 0.0117 0.0542 0.0936
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0168
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0065 0.0072
Brugia malayi jmjC domain containing protein 0.0039 0.0133 0.0182
Brugia malayi hypothetical protein 0.0016 0.0013 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0012 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0265 0.0457
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.002
Mycobacterium ulcerans monoamine oxidase 0.002 0.0036 0.0022
Brugia malayi Heterochromatin protein 1 0.0074 0.0314 0.0431
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.009 0.0289
Echinococcus multilocularis musashi 0.0026 0.0066 0.0181
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0061 0.0178
Toxoplasma gondii RNA-directed DNA polymerase 0.0528 0.268 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.002 0.0036 0.0022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0033
Onchocerca volvulus 0.0074 0.0316 0.0314
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0017 0.0016
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0033
Brugia malayi Pre-SET motif family protein 0.0428 0.2162 0.2981
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Schistosoma mansoni cpg binding protein 0.003 0.0088 0.015
Onchocerca volvulus 0.002 0.0036 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Mycobacterium leprae conserved hypothetical protein 0.0037 0.012 0.1591
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0063
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0013 0.0000085459
Trichomonas vaginalis glutaminase, putative 0.1122 0.5773 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0453 0.0452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.012 0.0193
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0047 0.0177
Brugia malayi Bromodomain containing protein 0.0031 0.009 0.0123
Loa Loa (eye worm) glutaminase 0.1122 0.5773 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0505 0.1405
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Entamoeba histolytica hypothetical protein 0.011 0.0505 0.3273
Loa Loa (eye worm) hypothetical protein 0.01 0.0451 0.0779
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Brugia malayi CHE-14 protein 0.0043 0.0153 0.021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1148 0.8575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0257 0.0443
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0032 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.012 0.0401
Schistosoma mansoni ran 0.0023 0.0049 0.0082
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0414 0.3031
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0036 0.0086
Echinococcus granulosus GPCR family 2 0.0063 0.0257 0.0713
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0153 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0082
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0451 0.1255
Echinococcus multilocularis GPCR, family 2 0.0063 0.0257 0.0713
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0032 0.0053
Brugia malayi glutaminase DH11.1 0.1122 0.5773 0.7964
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.012 0.0193
Loa Loa (eye worm) beta-lactamase 0.0037 0.012 0.0206
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0123 0.034
Schistosoma mansoni jumonji domain containing protein 0.008 0.0348 0.0601
Leishmania major DNA polymerase kappa, putative 0.002 0.0032 0.007
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0065 0.0177
Echinococcus granulosus single minded 2 0.0046 0.0168 0.0465
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0145 0.0249
Entamoeba histolytica hypothetical protein 0.0025 0.0061 0.02
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0121 0.0403
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0023 0.0038
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.018 0.1026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Schistosoma mansoni hypothetical protein 0.0063 0.0257 0.0443
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0528 0.268 1
Echinococcus multilocularis 0.002 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0093
Mycobacterium tuberculosis Conserved protein 0.0037 0.012 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0145 0.0236
Plasmodium vivax hypothetical protein, conserved 0.002 0.0036 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0253 0.0701
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0262 0.0451
Echinococcus granulosus tar DNA binding protein 0.0064 0.0265 0.0735
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0453 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0965 0.1329
Schistosoma mansoni single-minded 0.0062 0.0252 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.006
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0065 0.0193
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0032 0.007
Echinococcus granulosus microtubule associated protein 2 0.0702 0.3586 1
Echinococcus multilocularis chromobox protein 1 0.0074 0.0314 0.0872
Schistosoma mansoni amine oxidase 0.002 0.0036 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0157
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.1478 0.5461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0133
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0528 0.268 1
Brugia malayi jmjC domain containing protein 0.0101 0.0456 0.0628
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0032 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0237 0.0658
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.012 0.0809
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0133 0.0228
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0013 0.0049
Trypanosoma brucei unspecified product 0.002 0.0032 0.0118
Trichomonas vaginalis ran, putative 0.0023 0.0049 0.0069
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0036 0.0086
Onchocerca volvulus 0.0037 0.012 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.0016 0.0025
Echinococcus granulosus intermediate filament protein 0.0026 0.0066 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.012 0.0809
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0036 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.012 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0257 0.0713
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0049 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Schistosoma mansoni DNA polymerase eta 0.002 0.0032 0.0053
Toxoplasma gondii histone lysine-specific demethylase 0.002 0.0036 0.0086
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0023 0.4426
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0093
Mycobacterium tuberculosis Conserved protein 0.0026 0.0065 0.0389
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0013 0.0007
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0036 0.006
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.009 0.0154
Brugia malayi CHD4 protein 0.0014 0.0001 0.0000066714
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0036 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Schistosoma mansoni chromobox protein 0.0074 0.0314 0.0542
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0265 0.0735
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0049 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.005 0.019 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0875 0.1513
Schistosoma mansoni importin beta-1 0.0031 0.0091 0.0156
Mycobacterium ulcerans beta-lactamase 0.0037 0.012 0.0169
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0013 0.0007
Echinococcus multilocularis aryl hydrocarbon receptor 0.0134 0.0625 0.1741
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1103 0.4088
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0061 0.009
Leishmania major GTP-binding protein, putative 0.0023 0.0049 0.0133
Echinococcus granulosus lamin dm0 0.0026 0.0066 0.0181
Echinococcus granulosus importin subunit beta 1 0.0031 0.0091 0.0251
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0036 0.0173
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0013 0.0007
Echinococcus multilocularis expressed conserved protein 0.0094 0.042 0.1166
Giardia lamblia Telomerase catalytic subunit 0.0528 0.268 1
Entamoeba histolytica Ran family GTPase 0.0023 0.0049 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0253 0.0435
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0265 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Trichomonas vaginalis set domain proteins, putative 0.0488 0.247 0.4269
Brugia malayi Telomerase reverse transcriptase 0.1405 0.7249 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0032 0.007
Echinococcus multilocularis snurportin 1 0.0331 0.1657 0.4617
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0153 0.025
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.012 0.0809
Brugia malayi bHLH-PAS transcription factor 0.0046 0.0168 0.023
Schistosoma mansoni patched 1 0.0043 0.0153 0.0263
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0065 0.0072
Echinococcus multilocularis dna polymerase kappa 0.002 0.0032 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0453 0.0771
Schistosoma mansoni aryl hydrocarbon receptor 0.0179 0.0864 0.1494
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0686 1
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0161 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0032 0.0118
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0001 0.0000083773
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0032 0.0118
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0161 0.016
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0032 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0414 0.3031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0032 0.0085
Schistosoma mansoni hypothetical protein 0.0331 0.1657 0.2867
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1478 0.2549
Brugia malayi glutathione reductase 0.0037 0.0121 0.0165
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0032 0.0015
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0036 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0145 0.0236
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0366 0.2663
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0108
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0016 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0875 0.2436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.2162 0.3743
Echinococcus granulosus aryl hydrocarbon receptor 0.0134 0.0625 0.1741
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Onchocerca volvulus 0.0037 0.012 0.0119
Brugia malayi Pre-SET motif family protein 0.0062 0.0253 0.0347
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0298 0.0827
Giardia lamblia PHD finger protein 15 0.0031 0.009 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.012 0.0169
Schistosoma mansoni hypothetical protein 0.0041 0.0145 0.0249
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0012 0.0005
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0017 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0242 0.0856
Trichomonas vaginalis hypothetical protein 0.0034 0.0109 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.012 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0965 0.1329
Schistosoma mansoni tsg101-related 0.0059 0.0236 0.0407
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0033
Brugia malayi TAR-binding protein 0.0064 0.0265 0.0364
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0049 0.0133
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0013 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0257 0.0353
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0123 0.034
Onchocerca volvulus 0.045 0.2276 0.2275
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0133 0.0228
Schistosoma mansoni hypothetical protein 0.0031 0.009 0.0154
Echinococcus multilocularis geminin 0.0182 0.088 0.2452
Leishmania major trypanothione reductase 0.0037 0.0121 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.012 0.0449
Mycobacterium ulcerans oxidoreductase 0.002 0.0036 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.012 0.0193
Entamoeba histolytica hypothetical protein 0.011 0.0505 0.3273
Trichomonas vaginalis CAMK family protein kinase 0.005 0.019 0.0314
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.027 0.1337 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0528 0.268 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0091 0.0293
Schistosoma mansoni hypothetical protein 0.011 0.0505 0.0873
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1103 0.4088
Loa Loa (eye worm) hypothetical protein 0.0071 0.0298 0.0514
Echinococcus multilocularis chromobox protein 1 0.0074 0.0314 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0082 0.0127
Leishmania major UDP-galactopyranose mutase 0.002 0.0036 0.0086
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0153 0.0424
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0257 0.0713
Brugia malayi chromobox protein homolog 3 0.0041 0.0145 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.012 0.0206
Loa Loa (eye worm) hypothetical protein 0.0199 0.0965 0.1669
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0453 0.2914
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0042 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0562 0.0971
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.012 0.0169
Mycobacterium ulcerans lipase LipD 0.0037 0.012 0.0169
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0055 0.0317
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0032 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0206
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0091 0.034
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0065 0.0177
Onchocerca volvulus 0.0154 0.073 0.0728
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0033 0.0055
Plasmodium falciparum telomerase reverse transcriptase 0.0528 0.268 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0061 0.009
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0036 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0055
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0153 0.0263
Echinococcus granulosus cpg binding protein 0.0032 0.0097 0.0267
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0032 0.007
Schistosoma mansoni lozenge 0.0057 0.0224 0.0385
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0055 0.0623
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0093
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0032 0.0039
Mycobacterium tuberculosis Conserved protein 0.0037 0.012 0.0809
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0017 0.0016
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0036 0.0097
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0117 0.0539 0.0742
Loa Loa (eye worm) glutathione reductase 0.0037 0.0121 0.0207
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0686 0.1152
Brugia malayi CXXC zinc finger family protein 0.003 0.0088 0.0119
Brugia malayi beta-lactamase family protein 0.0037 0.012 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.012 0.0809
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0065 0.0193
Loa Loa (eye worm) hypothetical protein 0.0133 0.0623 0.1076
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0263
Loa Loa (eye worm) hypothetical protein 0.0117 0.0539 0.0931
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0421 0.2123 0.3677
Schistosoma mansoni hypothetical protein 0.0063 0.0257 0.0443
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.012 0.0401
Brugia malayi hypothetical protein 0.0154 0.073 0.1005
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.0168 0.0465

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.6 ug ml-1 Cytotoxicity against mouse L5178Y cells by MTT assay ChEMBL. 19778087
EC50 (functional) = 5.9 ug ml-1 Cytotoxicity against human HeLa cells by MTT assay ChEMBL. 19778087
IC50 (functional) = 9 uM Cytotoxicity against human HL60 cells after 72 hrs by MTT assay ChEMBL. 19769341
IC50 (functional) > 100 uM Cytotoxicity against human A549 cells after 24 hrs by SRB assay ChEMBL. 19769341

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19769341

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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