Detailed information for compound 1146778

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.397 | Formula: C24H17NO3
  • H donors: 1 H acceptors: 2 LogP: 5.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c1c(o2)ncc(c1c1ccccc1)OCc1ccccc1
  • InChi: 1S/C24H17NO3/c26-18-11-12-20-19(13-18)23-22(17-9-5-2-6-10-17)21(14-25-24(23)28-20)27-15-16-7-3-1-4-8-16/h1-14,26H,15H2
  • InChiKey: MORGQZLXXVBLBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin E1 References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin E2 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin y 0.0026 0.0206 0.0113
Entamoeba histolytica cyclin C, putative 0.0026 0.0206 0.102
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0094 0.0243
Onchocerca volvulus 0.0167 0.2021 1
Trichomonas vaginalis cyclin B, putative 0.0167 0.2021 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0242 0.2976 0.3432
Onchocerca volvulus Protein CNPPD1 homolog 0.0026 0.0206 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0524
Brugia malayi SWIRM domain containing protein 0.002 0.0134 0.0105
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0626 0.6822
Echinococcus granulosus cyclin k 0.0026 0.0206 0.0133
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0445 0.0418
Giardia lamblia Hypothetical protein 0.0026 0.0206 0.0446
Echinococcus multilocularis cyclin b3 0.0107 0.125 0.1167
Loa Loa (eye worm) CYL-1 protein 0.0026 0.0206 0.0533
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0094 0.0243
Toxoplasma gondii cyclin dependent kinase binding protein 0.0026 0.0206 0.2244
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0134 0.2135
Loa Loa (eye worm) RecQ helicase 0.0019 0.0121 0.0314
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.055 0.2258
Echinococcus granulosus cyclin y 0.0026 0.0206 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0026 0.0206 0.0133
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0094 0.0243
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0094 0.0111
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0121 0.0027
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0206 0.0533
Giardia lamblia G2/mitotic-specific cyclin B 0.0167 0.2021 1
Leishmania major UDP-galactopyranose mutase 0.002 0.0134 0.0065
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0626 0.2659
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.055 0.1423
Echinococcus multilocularis cyclin G2 0.0026 0.0206 0.0113
Echinococcus granulosus G1:S specific cyclin D1 0.0026 0.0206 0.0133
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0626 0.2659
Entamoeba histolytica cyclin, putative 0.0107 0.125 0.6188
Toxoplasma gondii histone lysine-specific demethylase 0.002 0.0134 0.1457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0094 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0206 0.0446
Trypanosoma brucei mitotic cyclin 6 0.0167 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0536 0.1386
Plasmodium falciparum cyclin 1 0.0026 0.0206 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0206 0.0446
Schistosoma mansoni DNA helicase recq1 0.0019 0.0121 0.0143
Trypanosoma cruzi cyclin, putative 0.0167 0.2021 1
Entamoeba histolytica cyclin family protein 0.0107 0.125 0.6188
Loa Loa (eye worm) cyclin C 0.0026 0.0206 0.0533
Giardia lamblia Cyclin fold protein 1, putative 0.0026 0.0206 0.0446
Trichomonas vaginalis cyclin B3, putative 0.0026 0.0206 0.0446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.055 0.2258
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0626 0.2659
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0134 0.004
Schistosoma mansoni Cyclin fold protein 0.0026 0.0206 0.0243
Trichomonas vaginalis cyclin D, putative 0.0107 0.125 0.5944
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Echinococcus granulosus Cyclin L1 0.0026 0.0206 0.0133
Trypanosoma cruzi CYC2-like cyclin, putative 0.0167 0.2021 1
Entamoeba histolytica cyclin, domain containing protein 0.0026 0.0206 0.102
Onchocerca volvulus Cyclin L homolog 0.0026 0.0206 0.0581
Trypanosoma brucei cyclin 3 0.0026 0.0206 0.0446
Plasmodium vivax hypothetical protein, conserved 0.002 0.0134 0.2135
Brugia malayi hypothetical protein 0.002 0.0134 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Echinococcus granulosus cyclin A3 4 0.0026 0.0206 0.0133
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.002 0.0134 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0445 0.0354
Loa Loa (eye worm) hypothetical protein 0.0167 0.2021 0.5224
Schistosoma mansoni cyclin G2 0.0026 0.0206 0.0243
Trichomonas vaginalis cyclin B, putative 0.0107 0.125 0.5944
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.055 0.2258
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0626 0.0634
Toxoplasma gondii hypothetical protein 0.0081 0.0918 1
Schistosoma mansoni cyclin l 0.0026 0.0206 0.0243
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0134 0.0158
Echinococcus granulosus cyclin G2 0.0026 0.0206 0.0133
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0121 0.0027
Giardia lamblia Cyclin B-like protein 0.0026 0.0206 0.0446
Trichomonas vaginalis cyclin B, putative 0.0167 0.2021 1
Echinococcus granulosus microtubule associated protein 2 0.0671 0.8491 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0626 0.2659
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0206 0.0446
Entamoeba histolytica hypothetical protein 0.0026 0.0206 0.102
Treponema pallidum ATP-dependent DNA helicase 0.001 0 0.5
Trichomonas vaginalis cyclin D, putative 0.0107 0.125 0.5944
Schistosoma mansoni cyclin k 0.0026 0.0206 0.0243
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.055 0.046
Echinococcus multilocularis cyclin y 0.0026 0.0206 0.0113
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0626 0.31
Entamoeba histolytica protein kinase, putative 0.0059 0.0626 0.31
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0134 0.0105
Trichomonas vaginalis cyclin A, putative 0.0026 0.0206 0.0446
Echinococcus multilocularis cyclin t1 0.0026 0.0206 0.0113
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0121 0.1322
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.3564 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0626 0.2659
Trichomonas vaginalis cyclins, putative 0.0167 0.2021 1
Echinococcus granulosus cyclin t1 0.0026 0.0206 0.0133
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.055 0.2258
Echinococcus granulosus cyclins 0.0026 0.0206 0.0133
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0626 0.0537
Trichomonas vaginalis cyclins, putative 0.0167 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0533
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0121 0.0032
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0134 0.011
Echinococcus granulosus cyclin B3 1 0.0107 0.125 0.1377
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0167 0.2021 1
Schistosoma mansoni amine oxidase 0.002 0.0134 0.0158
Echinococcus multilocularis cyclin G2 0.0026 0.0206 0.0113
Giardia lamblia Hypothetical protein 0.0026 0.0206 0.0446
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0094 0.0111
Trypanosoma brucei protein kinase, putative 0.0059 0.0626 0.2659
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0206 0.0533
Trypanosoma brucei mitotic cyclin 0.0026 0.0206 0.0446
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0121 0.0601
Onchocerca volvulus 0.0026 0.0206 0.0581
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.002 0.0134 0.1457
Echinococcus granulosus cyclins 0.0107 0.125 0.1377
Schistosoma mansoni DNA helicase recq5 0.0019 0.0121 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0094 0.0111
Schistosoma mansoni g1/s-specific cyclin C 0.0026 0.0206 0.0243
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.055 0.046
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0134 0.0065
Schistosoma mansoni cyclin d 0.0026 0.0206 0.0243
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0094 0.0111
Trichomonas vaginalis cyclins, putative 0.0167 0.2021 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0311 0.3868 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.055 0.2258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0094 0.0243
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0206 0.0533
Plasmodium vivax cyclin 4, putative 0.0026 0.0206 0.3289
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0026 0.0206 0.0113
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.055 0.2258
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0206 0.0446
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.055 0.0543
Trichomonas vaginalis cyclins, putative 0.0107 0.125 0.5944
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.3564 1
Giardia lamblia Hypothetical protein 0.0107 0.125 0.5944
Trichomonas vaginalis cyclin B, putative 0.0167 0.2021 1
Schistosoma mansoni cyclin G 0.0026 0.0206 0.0243
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0121 0.0314
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.055 0.1423
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.055 0.0543
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0626 0.0537
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.055 0.0543
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0626 0.1619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0094 0.0243
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0094 0.0111
Trypanosoma cruzi mitotic cyclin, putative 0.0026 0.0206 0.0446
Giardia lamblia Kinase, CMGC CDK 0.0053 0.055 0.2258
Schistosoma mansoni hypothetical protein 0.0026 0.0206 0.0243
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.055 0.046
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0121 0.0032
Schistosoma mansoni coup transcription factor 0.0017 0.0094 0.0111
Echinococcus granulosus cyclin b3 0.0107 0.125 0.1377
Toxoplasma gondii cyclin 4, putative 0.0026 0.0206 0.2244
Loa Loa (eye worm) cyclin domain-containing protein 0.0242 0.2976 0.7694
Onchocerca volvulus 0.002 0.0134 0.0206
Trichomonas vaginalis cyclin B, putative 0.0026 0.0206 0.0446
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0134 0.0065
Brugia malayi Cyclin, N-terminal domain containing protein 0.0167 0.2021 0.5105
Onchocerca volvulus 0.0059 0.0626 0.2763
Echinococcus granulosus protein kinase shaggy 0.0059 0.0626 0.0634
Loa Loa (eye worm) hypothetical protein 0.006 0.0644 0.1665
Echinococcus multilocularis 0.002 0.0134 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0094 0.0243
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0121 0.0027
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0026 0.0206 0.0133
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.055 0.2258
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.8491 1
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Echinococcus multilocularis cyclin B3 1 0.0107 0.125 0.1167
Giardia lamblia Cyclin A 0.0107 0.125 0.5944
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0134 0.0047
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0134 0.004
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0626 0.4473
Trichomonas vaginalis cyclin D, putative 0.0026 0.0206 0.0446
Plasmodium vivax protein kinase Crk2 0.0053 0.055 0.8785
Plasmodium falciparum protein kinase 5 0.0053 0.055 0.3799
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0626 0.2659
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Brugia malayi Cyclin, N-terminal domain containing protein 0.0311 0.3868 1
Brugia malayi intracellular kinase 0.0059 0.0626 0.141
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.055 0.1423
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.055 0.2723
Giardia lamblia Kinase, CMGC CDK 0.0053 0.055 0.2258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0121 0.1322
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0206 0.0533
Echinococcus granulosus cyclins 0.0107 0.125 0.1377
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Leishmania major cyclin 0.0167 0.2021 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.055 0.2258
Trichomonas vaginalis cyclin B, putative 0.0026 0.0206 0.0446
Schistosoma mansoni cyclins 0.0107 0.125 0.1473
Toxoplasma gondii hypothetical protein 0.0026 0.0206 0.2244
Echinococcus multilocularis Cyclin L1 0.0026 0.0206 0.0113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0445 0.093
Trichomonas vaginalis cyclins, putative 0.0026 0.0206 0.0446
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0445 0.0418
Trichomonas vaginalis cyclin A, putative 0.0167 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Echinococcus granulosus cyclin G2 0.0026 0.0206 0.0133
Echinococcus granulosus cyclin dependent kinase 0.0053 0.055 0.0543
Brugia malayi Cyclin, N-terminal domain containing protein 0.0167 0.2021 0.5105
Echinococcus granulosus cyclin y 0.0026 0.0206 0.0133
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0626 0.31
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.055 0.0648
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0206 0.0533
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0134 0.0158
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Trichomonas vaginalis cyclin B3, putative 0.0026 0.0206 0.0446
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.055 0.2258
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0094 0.0111
Echinococcus multilocularis cyclin 0.0026 0.0206 0.0113
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0626 0.1619
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0626 1
Trypanosoma cruzi cyclin, putative 0.0167 0.2021 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.055 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.125 0.5944
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.055 0.046
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0134 0.011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0094 0.0111
Loa Loa (eye worm) hypothetical protein 0.0167 0.2021 0.5224
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Echinococcus granulosus cyclins 0.0107 0.125 0.1377
Echinococcus granulosus cyclin 0.0026 0.0206 0.0133
Echinococcus granulosus bloom syndrome protein 0.0019 0.0121 0.0032
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0626 0.0738
Echinococcus granulosus cyclin B 0.0167 0.2021 0.2294
Leishmania major mitotic cyclin, putative 0.0026 0.0206 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0524
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.055 0.2258
Brugia malayi Cyclin, N-terminal domain containing protein 0.0242 0.2976 0.7637
Trichomonas vaginalis cyclin B, putative 0.0167 0.2021 1
Trichomonas vaginalis cyclins, putative 0.0086 0.0976 0.4501
Entamoeba histolytica cyclin, putative 0.0167 0.2021 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0134 0.011
Brugia malayi hypothetical protein 0.0026 0.0206 0.0297
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0134 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0206 0.3289
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0134 0.2135
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Echinococcus multilocularis G1:S specific cyclin D1 0.0026 0.0206 0.0113
Entamoeba histolytica cyclin, domain containing protein 0.0026 0.0206 0.102
Trypanosoma cruzi mitotic cyclin, putative 0.0026 0.0206 0.0446
Echinococcus multilocularis cyclin A3 4 0.0026 0.0206 0.0113
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0026 0.0206 0.2244
Leishmania major mitotic cyclin, putative 0.0026 0.0206 0.0446
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Trichomonas vaginalis cyclin B3, putative 0.0107 0.125 0.5944
Brugia malayi cyclin fold protein 1 variant b 0.0026 0.0206 0.0297
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0121 0.0072
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0026 0.0206 0.0243
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0121 0.0072
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0026 0.0206 0.0533
Echinococcus multilocularis cyclin B 0.0167 0.2021 0.1945
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0094 0.0111
Trichomonas vaginalis cyclins, putative 0.0026 0.0206 0.0446
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0445 0.1151
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0094 0.0111
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0026 0.0206 0.2244
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0026 0.0206 0.075
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.055 0.2258
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0094 0.0111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0094 0.0111
Schistosoma mansoni cyclin B 0.0167 0.2021 0.238
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0026 0.0206 0.3289
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0445 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0524
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Brugia malayi Cyclin C 0.0026 0.0206 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0346
Schistosoma mansoni cyclin B3 0.0242 0.2976 0.3505
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0206 0.075
Trypanosoma brucei cyclin 9 0.0026 0.0206 0.0446
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.8491 0.8477
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0314
Plasmodium vivax hypothetical protein, conserved 0.002 0.0134 0.2135
Trichomonas vaginalis cyclins, putative 0.0167 0.2021 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.055 0.5993
Trypanosoma cruzi cyclin 9, putative 0.0026 0.0206 0.0446
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0134 0.5
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0121 0.0072
Schistosoma mansoni amine oxidase 0.002 0.0134 0.0158
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0242 0.2976 0.2909
Plasmodium falciparum cyclin 0.0107 0.125 1
Onchocerca volvulus Cyclin L homolog 0.0026 0.0206 0.0581
Schistosoma mansoni hypothetical protein 0.0026 0.0206 0.0243
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0094 0.0111
Plasmodium vivax cyclin homologue, putative 0.0026 0.0206 0.3289
Brugia malayi hypothetical protein 0.0026 0.0206 0.0297
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0026 0.0206 0.0113
Entamoeba histolytica cyclin family protein 0.0107 0.125 0.6188
Echinococcus granulosus cyclins 0.0107 0.125 0.1377
Brugia malayi cell division control protein 2 homolog 0.0053 0.055 0.1209
Echinococcus multilocularis cyclin k 0.0026 0.0206 0.0113
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0026 0.0206 0.0446
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0533
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0206 0.0297
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.055 0.2723
Trypanosoma cruzi cyclin 6, putative 0.0167 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0094 0.0243
Echinococcus granulosus cyclins 0.0107 0.125 0.1377
Echinococcus multilocularis cyclins 0.0107 0.125 0.1167
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.055 0.0648
Leishmania major cyclin 9, putative 0.0026 0.0206 0.0446
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0267 0.3305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0094 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0206 0.0446

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of human recombinant GST-fused CDK1/cyclin B expressed in insect Sf9 cells using RBER-CHKtide as substrate assessed as incorporation of 33Pi after 60 mins by microplate scintillation counting analysis ChEMBL. No reference
Inhibition (binding) Inhibition of human recombinant GST-fused CDK5/P25 expressed in insect Sf9 cells using RBER-CHKtide as substrate assessed as incorporation of 33Pi after 60 mins by microplate scintillation counting analysis ChEMBL. No reference
Inhibition (binding) Inhibition of human recombinant GST-fused GSK-3beta expressed in insect Sf9 cells using RBER-CHKtide as substrate assessed as incorporation of 33Pi after 60 mins by microplate scintillation counting analysis ChEMBL. No reference
Ki (binding) = 2.3 uM Inhibition of CDK1/Cyclin B ChEMBL. 23039927
Ki (binding) = 5.8 uM Inhibition of GSK3beta ChEMBL. 23039927
Ki (binding) = 6.4 uM Inhibition of CDK2/Cyclin E ChEMBL. 23039927
Ki (binding) > 1000 uM Inhibition of CDK5/p25 ChEMBL. 23039927

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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