Detailed information for compound 1149524

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 315.238 | Formula: C14H9N3O6
  • H donors: 0 H acceptors: 6 LogP: 3.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)/C=C/c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C14H9N3O6/c18-15(19)12-5-3-10(4-6-12)1-2-11-7-13(16(20)21)9-14(8-11)17(22)23/h1-9H/b2-1+
  • InChiKey: SNLKNNKBHAUTCL-OWOJBTEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0087 0.0144 0.0144
Brugia malayi follicle stimulating hormone receptor 0.0781 0.1633 0.4108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0536
Schistosoma mansoni alpha-glucosidase 0.014 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0162 0.0162
Brugia malayi hypothetical protein 0.0264 0.0524 0.1318
Schistosoma mansoni hypothetical protein 0.0118 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0087 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0362 0.2091
Entamoeba histolytica Ran family GTPase 0.0024 0.0009 0.0139
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0036 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0521 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.1319
Echinococcus granulosus RUN 0.0022 0.0006 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0047 0.0896
Loa Loa (eye worm) hypothetical protein 0.0118 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0343 0.0694 0.0694
Brugia malayi hypothetical protein 0.0022 0.0006 0.0015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.0674 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0308 0.0308
Schistosoma mansoni lamin 0.003 0.0023 0.0023
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0006 0.0006
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0118 0.0212 0.6721
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0047 0.0118
Echinococcus multilocularis neuropeptide s receptor 0.1039 0.2185 0.2185
Schistosoma mansoni na/ca exchanger 0.0118 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Echinococcus multilocularis GPCR, family 2 0.0087 0.0144 0.0144
Mycobacterium tuberculosis Conserved protein 0.0041 0.0047 0.0896
Schistosoma mansoni hypothetical protein 0.0531 0.1097 0.1097
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0047 0.027
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0209
Schistosoma mansoni lipoxygenase 0.0022 0.0006 0.0006
Trichomonas vaginalis ran, putative 0.0024 0.0009 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0006
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0101 0.452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0047 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0209
Schistosoma mansoni alpha glucosidase 0.0036 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0212 0.1226
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0091 0.0091
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0022
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0118 0.0212 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Loa Loa (eye worm) hypothetical protein 0.0118 0.0212 0.0212
Leishmania major GTP-binding protein, putative 0.0024 0.0009 0.0927
Treponema pallidum fructose-bisphosphate aldolase 0.0333 0.0674 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0023 0.0058
Brugia malayi intermediate filament protein 0.003 0.0023 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0209
Giardia lamblia Fructose-bisphosphate aldolase 0.0333 0.0674 1
Brugia malayi hypothetical protein 0.0022 0.0006 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Loa Loa (eye worm) hypothetical protein 0.0095 0.0162 0.0162
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0273 0.0545 0.0545
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0308 0.0308
Echinococcus granulosus geminin 0.0531 0.1097 0.1097
Schistosoma mansoni survival motor neuron protein 0.0054 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.0235
Loa Loa (eye worm) hypothetical protein 0.0118 0.0212 0.0212
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.0694 0.0694
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0212 0.1226
Loa Loa (eye worm) intermediate filament protein 0.003 0.0023 0.0023
Onchocerca volvulus 0.003 0.0023 0.0472
Plasmodium vivax importin-beta 2, putative 0.0032 0.0028 0.1056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0101 0.3281
Onchocerca volvulus 0.0054 0.0074 0.1855
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0144 0.0144
Echinococcus multilocularis musashi 0.003 0.0023 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0101 0.0101
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0006
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0118 0.0212 0.0212
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0118 0.0212 0.4069
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0144 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.1039 0.2185 0.2185
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0016 0.0304
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0015 0.311
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0047 0.0896
Echinococcus multilocularis RUN 0.0022 0.0006 0.0006
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0016 0.0515
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0047 0.027
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0016 0.0488
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0101 0.1938
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0118 0.0212 0.3149
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0118 0.0212 0.0212
Onchocerca volvulus 0.0094 0.0161 0.4214
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.0308 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0047 0.0896
Brugia malayi beta-lactamase 0.0041 0.0047 0.0118
Echinococcus granulosus neuropeptide s receptor 0.1039 0.2185 0.2185
Schistosoma mansoni hypothetical protein 0.0087 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0264 0.0524 0.0524
Schistosoma mansoni rab6-interacting 0.0022 0.0006 0.0006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.2005
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0028 0.59
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0144 0.0144
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.0345 0.9247
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0162 0.0162
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0047 0.0896
Echinococcus granulosus lamin dm0 0.003 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Echinococcus multilocularis neuropeptide receptor A26 0.1039 0.2185 0.2185
Mycobacterium ulcerans hypothetical protein 0.0041 0.0047 0.1517
Echinococcus granulosus GPCR family 2 0.0087 0.0144 0.0144
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0826 0.173 1
Brugia malayi RNA, U transporter 1 0.0091 0.0155 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Schistosoma mansoni hypothetical protein 0.0187 0.0359 0.0359
Trypanosoma brucei glucosidase, putative 0.0036 0.0036 0.773
Brugia malayi N-terminal motif family protein 0.018 0.0345 0.0869
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0016 0.0515
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0006 0.0006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.2005
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0028 0.0028
Brugia malayi Sodium/calcium exchanger protein 0.1874 0.3975 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0359 0.0359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0074 0.0186
Schistosoma mansoni hypothetical protein 0.0022 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0047 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0047 0.027
Mycobacterium tuberculosis Conserved protein 0.0041 0.0047 0.0896
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0273 0.0545 0.1371
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0209
Loa Loa (eye worm) beta-lactamase 0.0041 0.0047 0.0047
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.059 0.1485
Plasmodium vivax cation/H+ antiporter, putative 0.0118 0.0212 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0174
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.0674 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.0308 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0015 0.0084
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0016 0.5
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0118 0.0212 0.0534
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0308 0.0774
Echinococcus multilocularis geminin 0.0531 0.1097 0.1097
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0016 0.032
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0028 0.0897
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0009 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0047 0.1517
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.0308 0.5906
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0036 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0101 0.3281
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0006 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0036 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0781 0.1633 0.1633
Schistosoma mansoni intermediate filament proteins 0.003 0.0023 0.0023
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0016 0.032
Loa Loa (eye worm) hypothetical protein 0.018 0.0345 0.0345
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0016 0.1569
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0308 0.0308
Mycobacterium ulcerans lipase LipD 0.0041 0.0047 0.1517
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0016 0.5
Treponema pallidum hypothetical protein 0.0118 0.0212 0.2984
Mycobacterium leprae Probable lipase LipE 0.0041 0.0047 0.1057
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0162 0.0408
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0308 0.0308
Leishmania major hypothetical protein, conserved 0.0041 0.0047 0.4625
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0144 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0101 0.3281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.0395 0.2286
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0047 0.1517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0028 0.59
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.0524 0.0524
Echinococcus granulosus intermediate filament protein 0.003 0.0023 0.0023
Trichomonas vaginalis esterase, putative 0.0041 0.0047 0.027
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0118 0.0212 0.5617
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.0395 0.2286
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0047 1
Schistosoma mansoni sodium/calcium exchanger 0.4684 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0047 0.027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0925 0.1942 0.1942
Onchocerca volvulus 0.0041 0.0047 0.1115
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0023 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0118 0.0212 0.0212
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0101 1
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0047 0.1057
Brugia malayi latrophilin 2 splice variant baaae 0.0187 0.0359 0.0904
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0118 0.0212 0.0212
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0118 0.0212 0.0212
Echinococcus multilocularis snurportin 1 0.0343 0.0694 0.0694
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.0373 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0047 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Plasmodium falciparum importin beta, putative 0.0032 0.0028 0.1056
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0091 0.0091
Schistosoma mansoni rab6-interacting 0.0022 0.0006 0.0006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0009
Echinococcus granulosus importin subunit beta 1 0.0032 0.0028 0.0028
Mycobacterium tuberculosis Conserved protein 0.0041 0.0047 0.0896
Onchocerca volvulus 0.0041 0.0047 0.1115
Echinococcus multilocularis sodium calcium exchanger 0.4684 1 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.059 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0144 0.0363
Leishmania major importin beta-1 subunit, putative 0.0026 0.0015 0.1438
Schistosoma mansoni alpha-glucosidase 0.014 0.0259 0.0259
Schistosoma mansoni lamin 0.003 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0047 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.059 0.3413
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0536
Schistosoma mansoni importin beta-1 0.0032 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.773
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0036 0.0036
Onchocerca volvulus 0.003 0.0023 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0087 0.0144 0.0144
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0016 0.0488
Onchocerca volvulus 0.0095 0.0162 0.4253
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0193 0.0373 0.0938
Schistosoma mansoni ran 0.0024 0.0009 0.0009
Mycobacterium ulcerans beta-lactamase 0.0041 0.0047 0.1517
Schistosoma mansoni lipoxygenase 0.0062 0.0091 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0101 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0144 0.0144
Brugia malayi Importin beta-1 subunit 0.0032 0.0028 0.0069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0144 0.0363
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0047 0.1984
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0373 0.2157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0015 0.0084
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0047 0.0047
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0036 0.3575
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.0273 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.1874 0.3975 0.3975
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0118 0.0212 0.0212
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.2005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0028
Loa Loa (eye worm) solute carrier family 8 0.4684 1 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0054 0.0074 0.0074
Schistosoma mansoni loxhd1 0.0022 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0212 0.1226
Onchocerca volvulus 0.0041 0.0047 0.1115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Brugia malayi Doublecortin family protein 0.0022 0.0006 0.0015
Schistosoma mansoni ran 0.0024 0.0009 0.0009
Schistosoma mansoni polycystin 1-related 0.0022 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0047
Echinococcus multilocularis lamin 0.003 0.0023 0.0023
Toxoplasma gondii manganese resistance 1 protein, putative 0.0118 0.0212 1
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0118 0.0212 0.0534
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0087 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0026 0.0015 0.0216
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0006 0.0006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0009 0.0174
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0101 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0016 0.3392
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0209
Schistosoma mansoni hypothetical protein 0.0531 0.1097 0.1097
Toxoplasma gondii ABC1 family protein 0.0041 0.0047 0.1842
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0047 0.0896
Echinococcus granulosus lamin 0.003 0.0023 0.0023
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0826 0.173 1
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0047 0.0896
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.773
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0015 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.0674 0.3894
Echinococcus granulosus snurportin 1 0.0343 0.0694 0.0694
Plasmodium falciparum cation/H+ antiporter 0.0118 0.0212 1
Echinococcus multilocularis lamin dm0 0.003 0.0023 0.0023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0024
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0036 0.0209
Brugia malayi beta-lactamase family protein 0.0041 0.0047 0.0118
Brugia malayi beta-lactamase family protein 0.0041 0.0047 0.0118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0273 0.0545 0.1371
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0047 0.0896

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 4.21 % Inhibition of human aromatase at 20 ug/ml preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins ChEMBL. 20558073

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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