Detailed information for compound 1151320

Basic information

Technical information
  • TDR Targets ID: 1151320
  • Name: 2-(4-methylpiperazin-1-yl)-2-thiophen-2-ylace tonitrile
  • MW: 221.322 | Formula: C11H15N3S
  • H donors: 0 H acceptors: 1 LogP: 1.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(c1cccs1)N1CCN(CC1)C
  • InChi: 1S/C11H15N3S/c1-13-4-6-14(7-5-13)10(9-12)11-3-2-8-15-11/h2-3,8,10H,4-7H2,1H3
  • InChiKey: NSNYAYMQDLBOQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methylpiperazin-1-yl)-2-(2-thienyl)acetonitrile
  • 2-(4-methyl-1-piperazinyl)-2-(2-thienyl)acetonitrile
  • 2-(4-methylpiperazin-1-yl)-2-thiophen-2-yl-ethanenitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.145 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 0.4477
Loa Loa (eye worm) beta-lactamase 0.0077 0.1303 0.2517
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.3158 0.7545
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0165 0.3144 1
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0188 0.081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1671 0.3904
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0229 0.1106
Loa Loa (eye worm) amidase 0.0026 0.0229 0.0441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1671 0.3904
Toxoplasma gondii ABC1 family protein 0.0077 0.1303 0.893
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1303 0.3002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0467 0.0902
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0188 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1671 0.3228
Loa Loa (eye worm) amidase 0.0026 0.0229 0.0441
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0026 0.0229 0.1106
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0296 0.1595
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.018 0.0338
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.3195 0.7635
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0026 0.0229 0.1238
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0467 0.7129
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0709 0.4607
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0026 0.0229 0.0163
Loa Loa (eye worm) hypothetical protein 0.0083 0.1425 0.2754
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0229 0.0372
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.018 0.0754
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0467 0.3184
Echinococcus multilocularis geminin 0.0166 0.3181 0.76
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0909 0.2037
Loa Loa (eye worm) acetyltransferase 0.0165 0.3158 0.6101
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1303 0.3788
Brugia malayi Amidase family protein 0.0026 0.0229 0.0441
Mycobacterium ulcerans beta-lactamase 0.0077 0.1303 0.3998
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1303 0.3002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0296 0.1595
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0269 0.052
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0909 0.1755
Mycobacterium ulcerans hypothetical protein 0.0077 0.1303 0.3998
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.3195 0.7635
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1303 0.1236
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0467 0.1273
Brugia malayi MAP kinase sur-1 0.0058 0.0909 0.1755
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0026 0.0229 0.0153
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0624 0.3988
Schistosoma mansoni alpha-glucosidase 0.0144 0.2707 0.644
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.018 0.0104
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0467 0.0902
Mycobacterium tuberculosis Conserved protein 0.0077 0.1303 0.1236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1671 0.3904
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0188 0.0363
Schistosoma mansoni hypothetical protein 0.0166 0.3181 0.76
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0165 0.3144 1
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1303 0.1236
Echinococcus multilocularis musashi 0.0028 0.0269 0.0472
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0188 0.0363
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.018 0.0254
Loa Loa (eye worm) hypothetical protein 0.013 0.2422 0.4679
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0909 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0262 0.5177 1
Mycobacterium ulcerans amidase 0.0026 0.0229 0.0495
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1303 0.3998
Brugia malayi hypothetical protein 0.013 0.2422 0.4679
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1303 0.3998
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1303 0.1236
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0188 0.0272
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0467 0.1273
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0467 0.1273
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.018 0.0254
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0624 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.1425 0.3302
Brugia malayi follicle stimulating hormone receptor 0.0251 0.4953 0.9567
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0909 0.2037
Trypanosoma brucei protein kinase, putative 0.0058 0.0909 0.6785
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0909 0.2713
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0077 0.0148
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1303 0.3998
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.1425 0.3302
Echinococcus granulosus Aminotransferase class III 0.0023 0.018 0.0254
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.145 0.4284
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0909 0.2037
Brugia malayi beta-lactamase family protein 0.0077 0.1303 0.2517
Brugia malayi beta-lactamase 0.0077 0.1303 0.2517
Loa Loa (eye worm) hypothetical protein 0.0084 0.145 0.2801
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0909 0.2037
Mycobacterium ulcerans hypothetical protein 0.0165 0.3144 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1303 0.3998
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0026 0.0229 0.0372
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0188 0.081
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0467 0.0956
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.145 1
Schistosoma mansoni alpha glucosidase 0.0037 0.0467 0.0956
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.3158 0.7545
Plasmodium falciparum ornithine aminotransferase 0.0023 0.018 0.0754
Echinococcus multilocularis lamin dm0 0.0028 0.0269 0.0472
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0909 0.6785
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0709 0.4607
Echinococcus multilocularis lamin 0.0028 0.0269 0.0472
Schistosoma mansoni alpha-glucosidase 0.0144 0.2707 0.644
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0188 0.0363
Brugia malayi intermediate filament protein 0.0028 0.0269 0.052
Echinococcus multilocularis Aminotransferase class III 0.0023 0.018 0.0254
Mycobacterium ulcerans amidase 0.0026 0.0229 0.0495
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0026 0.0229 0.0153
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0188 0.0272
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0467 0.1273
Brugia malayi Probable ClpP-like protease 0.0084 0.145 0.2801
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0188 0.0907
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0269 0.052
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0909 0.2713
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0909 0.6059
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0077 0.0148
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0467 0.0956
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0026 0.0229 0.0372
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0467 0.1273
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0213 0.4161 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1303 0.3002
Trypanosoma cruzi amidase, putative 0.0026 0.0229 0.1238
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.018 0.0104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.1425 0.3302
Trichomonas vaginalis chaperonin, putative 0.0024 0.0188 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0909 0.2713
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1303 0.1236
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0165 0.3144 1
Brugia malayi beta-lactamase family protein 0.0077 0.1303 0.2517
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 1
Leishmania major hypothetical protein, conserved 0.0026 0.0229 0.1238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1671 0.3904
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1303 0.3998
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0467 0.1273
Leishmania major hypothetical protein, conserved 0.0077 0.1303 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0467 0.2843
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0843 0.0773
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0188 0.0272
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.018 0.0338
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0188 0.0907
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.145 0.3362
Mycobacterium tuberculosis Probable aminotransferase 0.0165 0.3144 0.3091
Onchocerca volvulus 0.0077 0.1303 0.4801
Echinococcus multilocularis GPCR, family 2 0.0083 0.1425 0.3302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1671 0.3904
Schistosoma mansoni hypothetical protein 0.0083 0.1425 0.3302
Brugia malayi amidase 0.0213 0.4161 0.8038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.1425 0.3302
Trypanosoma cruzi amidase, putative 0.0026 0.0229 0.1238
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0296 0.039
Onchocerca volvulus 0.0097 0.1717 0.6724
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1303 0.3998
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1671 0.3904
Loa Loa (eye worm) hypothetical protein 0.0179 0.3441 0.6646
Echinococcus granulosus fatty acid amide hydrolase 1 0.0213 0.4161 1
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0229 0.0495
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1303 0.1236
Mycobacterium ulcerans amidase 0.0026 0.0229 0.0495
Toxoplasma gondii hypothetical protein 0.0029 0.0296 0.1595
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0909 0.6785
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0843 0.0773
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.3195 0.6172
Brugia malayi Calcitonin receptor-like protein seb-1 0.0262 0.5177 1
Brugia malayi Amidase family protein 0.0026 0.0229 0.0441
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.018 0.0754
Onchocerca volvulus Huntingtin homolog 0.013 0.2422 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.145 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Schistosoma mansoni fatty-acid amide hydrolase 0.0026 0.0229 0.0372
Mycobacterium ulcerans amidase 0.0026 0.0229 0.0495
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0709 0.2063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1303 0.2517
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0213 0.4161 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0188 0.081
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0213 0.4161 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.1425 0.2754
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1303 1
Trichomonas vaginalis esterase, putative 0.0077 0.1303 0.3998
Echinococcus granulosus fatty acid amide hydrolase 1 0.0213 0.4161 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.018 0.0338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0709 0.1549
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.4953 0.9567
Trypanosoma brucei glucosidase, putative 0.0037 0.0467 0.3184
Mycobacterium ulcerans lipase LipD 0.0077 0.1303 0.3998
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0188 0.0272
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0296 0.1595
Mycobacterium ulcerans peptide amidase, GatA 0.0026 0.0229 0.0495
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0467 0.3184
Schistosoma mansoni hypothetical protein 0.0083 0.1425 0.3302
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0909 0.6785
Schistosoma mansoni amidase 0.0213 0.4161 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.018 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0269 0.052
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 0.4477
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0843 0.1877
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0909 0.6785
Mycobacterium tuberculosis Conserved protein 0.0077 0.1303 0.1236
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0843 0.2237
Schistosoma mansoni intermediate filament proteins 0.0028 0.0269 0.0472
Brugia malayi Latrophilin receptor protein 2 0.0083 0.1425 0.2754
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0624 0.6582
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0026 0.0229 0.0153
Mycobacterium leprae Probable lipase LipE 0.0077 0.1303 0.3788
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0229 0.1106
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1303 0.3998
Loa Loa (eye worm) hypothetical protein 0.0213 0.4161 0.8038
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0909 0.6785
Echinococcus granulosus lamin dm0 0.0028 0.0269 0.0472
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.3061 0.7307
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0909 0.2037
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0188 0.0907
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.018 0.0754
Echinococcus granulosus ornithine aminotransferase 0.0023 0.018 0.0254
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1303 0.1236
Schistosoma mansoni lamin 0.0028 0.0269 0.0472
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.018 0.0104
Schistosoma mansoni hypothetical protein 0.0083 0.1425 0.3302
Echinococcus granulosus fatty acid amide hydrolase 1 0.0026 0.0229 0.0372
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.145 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1303 1
Echinococcus granulosus GPCR family 2 0.0083 0.1425 0.3302
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0229 0.1106
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0467 0.1273
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.018 0.0348
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0909 0.6785
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0188 0.2032
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0467 0.3184
Echinococcus granulosus geminin 0.0166 0.3181 0.76
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.145 0.3362
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1303 0.1236
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0188 0.0272
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0467 0.7129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1671 0.3228
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.3195 0.7635
Onchocerca volvulus Huntingtin homolog 0.013 0.2422 1
Schistosoma mansoni hypothetical protein 0.0179 0.3441 0.8236
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.145 0.3362
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0467 0.1273
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1303 0.893
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0467 0.1273
Brugia malayi putative amidase 0.0026 0.0229 0.0441
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0909 0.6785
Onchocerca volvulus 0.0077 0.1303 0.4801
Brugia malayi latrophilin 2 splice variant baaae 0.0179 0.3441 0.6646
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0026 0.0229 0.0153
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0026 0.0229 0.0153
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0165 0.3144 0.3091
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.3195 0.6172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1671 0.3904
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0843 0.1877
Schistosoma mansoni hypothetical protein 0.0166 0.3181 0.76
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0026 0.0229 0.0163
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.05
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0026 0.0229 0.0372
Echinococcus granulosus intermediate filament protein 0.0028 0.0269 0.0472
Mycobacterium ulcerans amidase 0.0026 0.0229 0.0495
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.018 0.0338
Echinococcus granulosus lamin 0.0028 0.0269 0.0472
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.018 0.0104
Loa Loa (eye worm) hypothetical protein 0.0262 0.5177 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.1425 0.2754
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.018 0.0338
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0909 0.2713
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0262 0.5177 1
Loa Loa (eye worm) hypothetical protein 0.013 0.2422 0.4679
Onchocerca volvulus 0.0077 0.1303 0.4801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1303 0.3002
Schistosoma mansoni lamin 0.0028 0.0269 0.0472
Schistosoma mansoni hypothetical protein 0.0083 0.1425 0.3302
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0269 0.052
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0709 0.2063
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.018 0.0338
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0229 0.038
Mycobacterium tuberculosis Conserved protein 0.0077 0.1303 0.1236
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0188 0.1337
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.3158 0.6101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1303 0.2517
Loa Loa (eye worm) hypothetical protein 0.0077 0.1303 0.2517
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0709 0.4607
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1303 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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