Detailed information for compound 1151607

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.416 | Formula: C20H23N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cccc1c1[nH]cc(n1)CN(Cc1ccccc1)C
  • InChi: 1S/C20H23N3O2/c1-23(13-15-8-5-4-6-9-15)14-16-12-21-20(22-16)17-10-7-11-18(24-2)19(17)25-3/h4-12H,13-14H2,1-3H3,(H,21,22)
  • InChiKey: SPRWFPWRLMRUIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0028 0.0076
Brugia malayi hypothetical protein 0.0127 0.0786 0.3047
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0606
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0052 0.0587
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0146 0.0783
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0146 0.0916
Giardia lamblia Kinase, PLK 0.0096 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.0359
Schistosoma mansoni intermediate filament proteins 0.0086 0.0492 0.0481
Schistosoma mansoni hypothetical protein 0.0165 0.1056 0.1044
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0167 0.0646
Schistosoma mansoni survival motor neuron protein 0.005 0.0237 0.0224
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0028 0.0015
Echinococcus multilocularis lamin dm0 0.0086 0.0492 0.0481
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0052 0.0587
Echinococcus granulosus intermediate filament protein 0.0086 0.0492 0.0481
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0028 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.03 0.1161
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0566 0.2193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0545 0.0533
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0028 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0146 0.0916
Onchocerca volvulus Huntingtin homolog 0.0127 0.0786 0.4726
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0219 0.1237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.01 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0146 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0028 0.0108
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0146 0.0134
Echinococcus multilocularis lamin 0.0086 0.0492 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0378 0.258 0.2571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0028 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536
Echinococcus multilocularis dna polymerase eta 0.002 0.002 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0012 0.0048
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0028 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0052 0.316
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0492 0.1883
Loa Loa (eye worm) beta-lactamase 0.0037 0.0146 0.0536
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0146 0.0916
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.0007
Mycobacterium tuberculosis Conserved protein 0.0037 0.0146 0.0916
Echinococcus multilocularis musashi 0.0086 0.0492 0.0481
Mycobacterium tuberculosis Conserved protein 0.0037 0.0146 0.0916
Echinococcus multilocularis dna polymerase kappa 0.002 0.002 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0028 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0028 0.0015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0208 0.0776
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.01 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0169
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0028 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0028 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0146 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0391 0.0379
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0175 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.03 0.1161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0028 0.0015
Echinococcus granulosus dna polymerase eta 0.002 0.002 0.0007
Schistosoma mansoni hypothetical protein 0.0072 0.0391 0.0379
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0028 0.0015
Loa Loa (eye worm) TAR-binding protein 0.0378 0.258 1
Brugia malayi Pre-SET motif family protein 0.0216 0.142 0.5503
Brugia malayi nuclear hormone receptor 0.0021 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0045
Schistosoma mansoni cellular tumor antigen P53 0.0149 0.094 0.0929
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0028 0.0015
Trichomonas vaginalis esterase, putative 0.0037 0.0146 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0028 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0028 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.01 0.4302
Schistosoma mansoni lamin 0.0086 0.0492 0.0481
Toxoplasma gondii ABC1 family protein 0.0037 0.0146 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0566 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0146 0.0783
Loa Loa (eye worm) hypothetical protein 0.0245 0.163 0.6304
Loa Loa (eye worm) hypothetical protein 0.0127 0.0786 0.3025
Loa Loa (eye worm) RNA binding protein 0.0378 0.258 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0566 1
Schistosoma mansoni hypothetical protein 0.005 0.0237 0.0224
Echinococcus multilocularis microtubule associated protein 2 0.1417 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0146 0.2313
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536
Leishmania major hypothetical protein, conserved 0.0026 0.0066 0.0849
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0052 0.0201
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0146 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0028 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0146 0.0916
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0028 0.0015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0052 0.316
Echinococcus granulosus lamin 0.0086 0.0492 0.0481
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0146 1
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0492 0.1909
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0052 0.032
Loa Loa (eye worm) hypothetical protein 0.0084 0.0481 0.1839
Brugia malayi hypothetical protein 0.0245 0.163 0.6316
Mycobacterium ulcerans lipase LipD 0.0037 0.0146 1
Onchocerca volvulus 0.005 0.0237 0.1301
Entamoeba histolytica hypothetical protein 0.0072 0.0391 0.6792
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0012 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0028 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.002 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0028 0.0015
Onchocerca volvulus 0.0037 0.0146 0.0737
Mycobacterium tuberculosis Conserved protein 0.0037 0.0146 0.0916
Schistosoma mansoni tar DNA-binding protein 0.0378 0.258 0.2571
Echinococcus granulosus tumor protein p63 0.1015 0.7127 0.7124
Mycobacterium ulcerans hypothetical protein 0.0024 0.0052 0.316
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.163 0.1619
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0028 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0028 0.0108
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0566 1
Brugia malayi RNA binding protein 0.0378 0.258 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.1831 0.7086
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.01 0.0088
Brugia malayi beta-lactamase family protein 0.0037 0.0146 0.0566
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0146 0.0134
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0028 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0028 0.0108
Onchocerca volvulus Huntingtin homolog 0.0127 0.0786 0.4726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0028 0.0108
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0028 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0028 0.0015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0237 0.0917
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0566 0.0554
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0378 0.258 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0146 0.0134
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0566 0.3352
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0028 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0146 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0616
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0052 0.316
Echinococcus multilocularis geminin 0.0165 0.1056 0.1044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0545 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0378 0.258 0.2571
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0028 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0052 0.0201
Onchocerca volvulus 0.0037 0.0146 0.0737
Brugia malayi ecdysteroid receptor 0.0021 0.0028 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0028 0.0108
Brugia malayi steroid hormone receptor 0.0021 0.0028 0.0108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0146 0.0134
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0028 0.0015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.01 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Echinococcus granulosus lamin dm0 0.0086 0.0492 0.0481
Brugia malayi TAR-binding protein 0.0378 0.258 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0052 0.0587
Onchocerca volvulus 0.0086 0.0492 0.2895
Schistosoma mansoni lamin 0.0086 0.0492 0.0481
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0146 0.0783
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0146 0.2313
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Brugia malayi hypothetical protein 0.0072 0.0391 0.1514
Entamoeba histolytica hypothetical protein 0.0072 0.0391 0.6792
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Brugia malayi beta-lactamase 0.0037 0.0146 0.0566
Loa Loa (eye worm) hypothetical protein 0.0149 0.094 0.3624
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.002 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1633 1
Schistosoma mansoni kinase 0.0049 0.0228 0.0216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0077
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0052 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0028 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0052 0.0201
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0566 0.0554
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0146 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0028 0.0108
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0835
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0028 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0028 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0028 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0378 0.258 0.2571
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.142 0.5488
Entamoeba histolytica hypothetical protein 0.0072 0.0391 0.6792
Onchocerca volvulus 0.0024 0.0052 0.015
Schistosoma mansoni hypothetical protein 0.0165 0.1056 0.1044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0391 0.0379
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0028 0.0108
Plasmodium vivax SET domain protein, putative 0.0031 0.01 0.6695
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0028 0.0108
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0028 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0849
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0052 0.032
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0028 0.0108
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0606
Schistosoma mansoni coup transcription factor 0.0021 0.0028 0.0015
Echinococcus granulosus dna polymerase kappa 0.002 0.002 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0012 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0146 0.2313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0028 0.0076
Brugia malayi beta-lactamase family protein 0.0037 0.0146 0.0566
Onchocerca volvulus 0.0149 0.094 0.5687
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Mycobacterium ulcerans beta-lactamase 0.0037 0.0146 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0146 0.0566
Loa Loa (eye worm) hypothetical protein 0.0041 0.0175 0.065
Loa Loa (eye worm) hypothetical protein 0.0127 0.0786 0.3025
Schistosoma mansoni microtubule-associated protein tau 0.1417 1 1
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0492 0.1883
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0028 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0028 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.01 0.0088
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0566 0.2168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0545 0.0533
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.03 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0028 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0052 0.0587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0028 0.0076
Schistosoma mansoni hypothetical protein 0.004 0.0167 0.0154
Echinococcus granulosus tar DNA binding protein 0.0378 0.258 0.2571
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0066 0.0849
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0052 0.0587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0545 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0028 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0849
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0117
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0146 0.0916
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536
Brugia malayi hypothetical protein 0.0026 0.0066 0.0256
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0028 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0378 0.258 0.2571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0545 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0028 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0378 0.258 0.2571
Loa Loa (eye worm) hypothetical protein 0.0086 0.0492 0.1883
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0175 0.0163
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.163 0.1619
Mycobacterium ulcerans hypothetical protein 0.0037 0.0146 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0146 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0391 0.0379
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.01 0.0088
Onchocerca volvulus 0.0037 0.0146 0.0737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0028 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0566 1
Brugia malayi RNA recognition motif domain containing protein 0.0378 0.258 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0146 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0545 0.0533
Trypanosoma brucei polo-like protein kinase 0.0096 0.0566 1
Brugia malayi follicle stimulating hormone receptor 0.0273 0.1831 0.7096
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0146 1
Onchocerca volvulus 0.0245 0.1633 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0117
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0545 0.2087
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0052 0.316
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0052 0.316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.03 0.1133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0545 0.0533
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0052 0.316
Leishmania major hypothetical protein, conserved 0.0037 0.0146 0.2313
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0146 0.0536
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0052 0.316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0028 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0545 0.2112
Brugia malayi nuclear receptor NHR-88 0.0021 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0076
Brugia malayi Pre-SET motif family protein 0.0031 0.01 0.0389
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0208 0.0806
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0566 0.3385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0225
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.01 0.0088
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0008 0.0044
Echinococcus granulosus geminin 0.0165 0.1056 0.1044
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0219 0.1237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0028 0.0015
Brugia malayi intermediate filament protein 0.0086 0.0492 0.1909
Echinococcus multilocularis tumor protein p63 0.1015 0.7127 0.7124
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0092 0.008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.1582 1
Onchocerca volvulus 0.0086 0.0492 0.2895
Onchocerca volvulus 0.0031 0.01 0.0453
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0066 0.42
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0566 0.0554
Entamoeba histolytica hypothetical protein 0.0072 0.0391 0.6792
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0536

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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