Detailed information for compound 1152550

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 247.319 | Formula: C11H13N5S
  • H donors: 2 H acceptors: 2 LogP: 1.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)cc(c1)c1nnc(s1)N=C(N)N
  • InChi: 1S/C11H13N5S/c1-6-3-7(2)5-8(4-6)9-15-16-11(17-9)14-10(12)13/h3-5H,1-2H3,(H4,12,13,14,16)
  • InChiKey: PIZOBDVUQPTLPR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0527
Giardia lamblia PHD finger protein 15 0.0029 0.0139 0.0382
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0192 0.0192
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0568 0.0568
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0041
Echinococcus granulosus acetylcholinesterase 0.0132 0.1224 0.1224
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0192 0.0192
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0079 0.0079
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0192 0.3387
Brugia malayi hypothetical protein 0.0025 0.0098 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.021 0.021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Onchocerca volvulus 0.0022 0.007 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0461 0.0461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1305 0.1305
Echinococcus granulosus tm gpcr rhodopsin 0.0521 0.5314 0.5314
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0778 0.0778
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.003
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0335 0.3365 0.3345
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.021 0.0624
Brugia malayi Carboxylesterase family protein 0.0132 0.1224 0.1224
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0568 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0237 0.0237
Onchocerca volvulus 0.0022 0.007 0.0041
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0079 0.0079
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0966 1 1
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0192 0.0192
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0168 0.0168
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.4716 0.4716
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0018 0.0018
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.132 0.3922
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0335 0.3365 0.3345
Mycobacterium tuberculosis Conserved protein 0.0036 0.021 0.0624
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.021 0.021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0079 0.0049
Schistosoma mansoni loxhd1 0.0019 0.0041 0.0041
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0335 0.3365 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.007 0.007
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.007 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0168 0.0168
Onchocerca volvulus 0.0082 0.07 0.0918
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0139 0.0139
Loa Loa (eye worm) carboxylesterase 0.0132 0.1224 0.1224
Onchocerca volvulus 0.0022 0.007 0.0041
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.003 0.053
Echinococcus granulosus carboxylesterase 5A 0.0132 0.1224 0.1224
Loa Loa (eye worm) hypothetical protein 0.009 0.0778 0.0778
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0132 0.1224 0.1224
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.021 0.0624
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0449 0.242
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1305 0.1305
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0966 1 1
Echinococcus granulosus X box binding protein 1 0.0285 0.283 0.283
Plasmodium vivax SET domain protein, putative 0.009 0.0778 0.0778
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0731 0.0731
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.021 0.0539
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.007 0.0209
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0029 0.0139 0.0139
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.6965 0.6965
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.021 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Echinococcus multilocularis protein phosphatase 5 0.0021 0.0058 0.0058
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0034 0.0192 0.3387
Echinococcus granulosus cpg binding protein 0.006 0.0467 0.0467
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.003
Brugia malayi Phospholipase A2 family protein 0.0091 0.0792 0.0792
Loa Loa (eye worm) serine/threonine protein phosphatase 5 0.0021 0.0058 0.0058
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2873 1
Brugia malayi Carboxylesterase family protein 0.0022 0.007 0.007
Plasmodium vivax serine/threonine protein phosphatase 5, putative 0.0021 0.0058 0.0058
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Mycobacterium ulcerans beta-lactamase 0.0036 0.021 0.0539
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.07 0.07
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.007 0.007
Schistosoma mansoni rab6-interacting 0.0019 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0025 0.0098 0.1722
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.003 0.003
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0449 0.7902
Entamoeba histolytica peptidase, C54 family 0.0023 0.0075 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0778 0.0778
Entamoeba histolytica hypothetical protein 0.0335 0.3365 0.3345
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0449 0.042
Brugia malayi Bromodomain containing protein 0.0029 0.0139 0.0139
Schistosoma mansoni cpg binding protein 0.0057 0.0433 0.0433
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.003 0.0162
Echinococcus multilocularis cpg binding protein 0.006 0.0467 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1629 0.1604
Mycobacterium leprae conserved hypothetical protein 0.0036 0.021 0.0399
Schistosoma mansoni hypothetical protein 0.0032 0.0168 0.0168
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0237 0.0237
Echinococcus granulosus tumor protein p63 0.0342 0.3432 0.3432
Echinococcus multilocularis transcription factor Dp 1 0.004 0.026 0.026
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1062 0.1062
Echinococcus granulosus jumonji domain containing protein 0.004 0.0257 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.021 0.021
Brugia malayi hypothetical protein 0.0019 0.0041 0.0041
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0568 0.0539
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0041 0.0041
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0075 0.0404
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.07 0.07
Brugia malayi Cytochrome P450 family protein 0.0029 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0032 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0082 0.07 0.07
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0778 0.0778
Schistosoma mansoni cpg binding protein 0.006 0.0467 0.0467
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.007 0.007
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.0449 0.0449
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0778 0.0778
Entamoeba histolytica peptidase, C54 family 0.0023 0.0075 0.0045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0828 0.0828
Echinococcus multilocularis dUTP pyrophosphatase 0.0966 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0139 0.0139
Brugia malayi PHD-finger family protein 0.0029 0.0139 0.0139
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0237 0.0237
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0041 0.0041
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0192 0.0192
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0075 0.1318
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0098 0.0098
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0192 0.1037
Mycobacterium tuberculosis Conserved protein 0.0036 0.021 0.0624
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0449 0.042
Schistosoma mansoni cpg binding protein 0.006 0.0467 0.0467
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.1224 0.1224
Onchocerca volvulus 0.0022 0.007 0.0041
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0192 0.0192
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0335 0.3365 0.3312
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.021 0.018
Toxoplasma gondii exonuclease III APE 0.0018 0.003 0.003
Echinococcus multilocularis peregrin 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0355
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0098 0.0098
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0192 0.0192
Echinococcus granulosus neuropeptide s receptor 0.0464 0.4716 0.4716
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0966 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0075 0.0404
Loa Loa (eye worm) hypothetical protein 0.0175 0.1679 0.1679
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.003 0.0089
Plasmodium falciparum phd finger protein, putative 0.0029 0.0139 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1305 0.1305
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0041 0.0041
Entamoeba histolytica peptidase, C54 family 0.0023 0.0075 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0168 0.0168
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0041 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.132 0.3867
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1136 0.1136
Onchocerca volvulus 0.005 0.0362 0.0448
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0055 0.0055
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0162
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.021 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0553 0.0553
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0449 0.0449
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0079 0.1388
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0362 0.0362
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.07 0.07
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0335 0.3365 1
Loa Loa (eye worm) hypothetical protein 0.0432 0.4378 0.4378
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1854 1
Onchocerca volvulus 0.0036 0.021 0.0236
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1001 0.1001
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0966 1 1
Echinococcus granulosus cysteine protease atg4b 0.0058 0.0449 0.0449
Echinococcus granulosus protein phosphatase 5 0.0021 0.0058 0.0058
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.007 0.004
Entamoeba histolytica hypothetical protein 0.0966 1 1
Schistosoma mansoni acetylcholinesterase 0.0022 0.007 0.007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0168 0.0168
Brugia malayi serine/threonine protein phosphatase 5 0.0021 0.0058 0.0058
Toxoplasma gondii ABC1 family protein 0.0036 0.021 0.021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0568 0.3063
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1854 1
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.4716 0.4716
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0168 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0168 0.0168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.1224 0.1224
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0335 0.3365 0.3345
Echinococcus multilocularis GPCR, family 2 0.0032 0.0168 0.0168
Echinococcus granulosus neuroligin 0.0022 0.007 0.007
Entamoeba histolytica peptidase, C54 family 0.0058 0.0449 0.042
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Brugia malayi Carboxylesterase family protein 0.0022 0.007 0.007
Loa Loa (eye worm) beta-lactamase 0.0036 0.021 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0433 0.0433
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0568 0.0568
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.0449 0.0449
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0079 0.1388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0132 0.1224 0.1224
Loa Loa (eye worm) hypothetical protein 0.01 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0884 0.0884
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.003
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0568 1
Loa Loa (eye worm) carboxylesterase 0.0022 0.007 0.007
Brugia malayi Peptidase family C54 containing protein 0.0058 0.0449 0.0449
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.021 0.018
Brugia malayi Doublecortin family protein 0.0019 0.0041 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0237 0.0237
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.0792 0.1047
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0041 0.0041
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0966 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.021 0.018
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1224 0.1224
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0075 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.021 0.018
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0041 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0527
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0257 0.0257
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0285 0.283 0.283
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0036 0.021 0.3698
Brugia malayi Carboxylesterase family protein 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0041
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.07 0.07
Entamoeba histolytica hypothetical protein 0.0023 0.0079 0.0049
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0966 1 1
Echinococcus granulosus GPCR family 2 0.0032 0.0168 0.0168
Echinococcus multilocularis neuroligin 0.0022 0.007 0.007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.021 0.0539
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0568 0.0568
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0203 0.0203
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0041 0.0041
Brugia malayi Carboxylesterase family protein 0.0132 0.1224 0.1224
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.1679 0.1679
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.053
Trichomonas vaginalis set domain proteins, putative 0.0702 0.722 0.7211
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0631 0.6471 0.646
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0079 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.021 0.1133
Loa Loa (eye worm) dUTP diphosphatase 0.0966 1 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.021 0.0539
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0075 0.1318
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.021 0.021
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.4716 0.4716
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.021 0.1133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Loa Loa (eye worm) hypothetical protein 0.005 0.0362 0.0362
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0449 0.042
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0449 0.0449
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Brugia malayi CXXC zinc finger family protein 0.0057 0.0433 0.0433
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.021 0.0624
Entamoeba histolytica hypothetical protein 0.0192 0.1854 0.183
Loa Loa (eye worm) carboxylesterase 0.0022 0.007 0.007
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0075 0.0075
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0139 0.0139
Onchocerca volvulus 0.0702 0.722 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1305 0.1305
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0022 0.007 0.1237
Mycobacterium tuberculosis Conserved protein 0.0036 0.021 0.0624
Echinococcus granulosus RUN 0.0019 0.0041 0.0041
Brugia malayi beta-lactamase family protein 0.0036 0.021 0.021
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.007 0.007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Mycobacterium ulcerans lipase LipD 0.0036 0.021 0.0539
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0022 0.007 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0778 0.0778
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0778 0.0778
Schistosoma mansoni rab6-interacting 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2226 0.6617
Echinococcus multilocularis tumor protein p63 0.0342 0.3432 0.3432
Echinococcus granulosus dnaJ subfamily B 0.0808 0.8338 0.8338
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0139 0.0139
Onchocerca volvulus 0.0057 0.0433 0.0546
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0778 0.0778
Mycobacterium leprae Probable lipase LipE 0.0036 0.021 0.0399
Echinococcus granulosus geminin 0.0171 0.1639 0.1639
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0568 0.0568
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0139 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1305 0.1305
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0966 1 1
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0966 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0139 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0966 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0144 0.0144
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.1224 0.1224
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.6965 0.6965
Echinococcus granulosus transcription factor Dp 1 0.004 0.026 0.026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.021 0.0624
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1305 0.1305
Onchocerca volvulus Alhambra homolog 0.0029 0.0139 0.0137
Echinococcus granulosus Peptidase C54 0.0058 0.0449 0.0449
Schistosoma mansoni polycystin 1-related 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Schistosoma mansoni gliotactin 0.0022 0.007 0.007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0022 0.007 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Echinococcus multilocularis Peptidase C54 0.0058 0.0449 0.0449
Onchocerca volvulus 0.0036 0.021 0.0236
Schistosoma mansoni lipoxygenase 0.0117 0.1062 0.1062
Brugia malayi hypothetical protein 0.0019 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0808 0.8338 0.8338
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0966 1 1
Entamoeba histolytica hypothetical protein 0.0631 0.6471 0.646
Plasmodium vivax hypothetical protein, conserved 0.0036 0.021 0.021
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0079 0.0079
Schistosoma mansoni lipoxygenase 0.0081 0.0693 0.0693
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.021 0.0624
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.021 0.0624
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0168 0.0168
Onchocerca volvulus 0.0036 0.021 0.0236
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0966 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Loa Loa (eye worm) hypothetical protein 0.0058 0.0449 0.0449
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.007 0.0209
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0335 0.3365 1
Brugia malayi beta-lactamase 0.0036 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0171 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Brugia malayi Pre-SET motif family protein 0.009 0.0778 0.0778
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2873 0.2852
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0091 0.0792 0.0792
Echinococcus granulosus microtubule associated protein 2 0.0678 0.6965 0.6965
Brugia malayi hypothetical protein 0.0022 0.007 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0151 0.0151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0168 0.0168
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0192 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1305 0.1305
Echinococcus multilocularis RUN 0.0019 0.0041 0.0041
Loa Loa (eye worm) protein phosphatase 5 0.0021 0.0055 0.0055
Brugia malayi beta-lactamase family protein 0.0036 0.021 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.0098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0617 0.6325 0.6325
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0335 0.3365 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0068 0.0553 0.0553
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0449 0.7902
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0032 0.0168 0.0168
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0079 0.0079
Toxoplasma gondii serine/threonine protein phosphatase 0.0021 0.0058 0.0058
Echinococcus multilocularis geminin 0.0171 0.1639 0.1639
Schistosoma mansoni hypothetical protein 0.0171 0.1639 0.1639
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1305 0.1305
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1224 0.1224
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0041 0.0041
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.007 0.007
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0966 1 1
Brugia malayi Carboxylesterase family protein 0.0022 0.007 0.007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0568 0.3063
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0079 0.0146
Leishmania major serine/threonine protein phosphatase type 5, putative 0.0021 0.0058 0.1025
Echinococcus multilocularis X box binding protein 1 0.0285 0.283 0.283
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0032 0.0168 0.0168
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0966 1 1
Brugia malayi Augmenter of liver regeneration 0.0034 0.0192 0.0192
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1062 0.1062
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0449 0.042
Brugia malayi jmjC domain containing protein 0.0094 0.0828 0.0828
Entamoeba histolytica peptidase, C54 family 0.0023 0.0075 0.0045
Onchocerca volvulus 0.009 0.0778 0.1027
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0966 1 1
Brugia malayi jmjC domain containing protein 0.0038 0.0237 0.0237
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.003 0.003
Echinococcus granulosus acetylcholinesterase 0.0132 0.1224 0.1224
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0098 0.1722
Onchocerca volvulus Phospholipase A2 homolog 0.0432 0.4378 0.6042
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.007 0.007
Onchocerca volvulus 0.0022 0.007 0.0041
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0192 0.1037
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.007 0.007
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.007 0.004
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.003
Schistosoma mansoni protein phosphatase-5 0.0022 0.007 0.007
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0079 0.0234
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0079 0.0049
Brugia malayi Pre-SET motif family protein 0.0617 0.6325 0.6325
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.132 0.3776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2873 0.2852
Echinococcus granulosus dUTP pyrophosphatase 0.0966 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.021 0.021
Echinococcus multilocularis dnaJ subfamily B 0.0808 0.8338 0.8338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0449 0.042
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.007 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0521 0.5314 0.5314
Schistosoma mansoni hypothetical protein 0.0068 0.0553 0.0553
Trichomonas vaginalis esterase, putative 0.0036 0.021 0.018
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0966 1 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0192 0.1037
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.021 0.3698
Plasmodium falciparum serine/threonine protein phosphatase 5 0.0021 0.0058 0.0058
Echinococcus granulosus peregrin 0.0029 0.0139 0.0139

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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