Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vasopressin V2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vasopressin V1a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0567 | 0.6798 | 0.566 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0454 | 0.5376 | 0.8358 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.2258 | 0.2258 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0 | 0.5 |
Brugia malayi | Phospholipase A2 family protein | 0.0096 | 0.0833 | 0.0833 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.082 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0567 | 0.6798 | 0.566 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0096 | 0.0833 | 0.1295 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0538 | 0.6431 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0373 | 0.435 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.2258 | 0.2258 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0373 | 0.435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.5376 | 0.5376 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Onchocerca volvulus | 0.0237 | 0.2622 | 0.4078 | |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0538 | 0.6431 | 0.5163 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0833 | 0.0833 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.015 uM | Inhibition of [3H]-AVP binding to Dawley rat kidney medullary vasopressin V2 receptor. | ChEMBL. | 12798333 |
IC50 (binding) | = 0.015 uM | Inhibition of [3H]-AVP binding to Dawley rat kidney medullary vasopressin V2 receptor. | ChEMBL. | 12798333 |
IC50 (binding) | = 0.094 uM | Inhibition of [3H]-AVP binding to Dawley rat hepatic vasopressin V1a receptor. | ChEMBL. | 12798333 |
IC50 (binding) | = 0.094 uM | Inhibition of [3H]-AVP binding to Dawley rat hepatic vasopressin V1a receptor. | ChEMBL. | 12798333 |
Urine volume (functional) | = 11.3 ml 4hr-1 | Aquaretic effect of the compound was measured by the amount of urine collected after 4 hr at a dose of 10 mg/kg ip in 2 Dawley rats | ChEMBL. | 12798333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.