Detailed information for compound 1166522

Basic information

Technical information
  • TDR Targets ID: 1166522
  • Name: 1-[[5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]e thyl]-1-methylpyrrol-2-yl]methyl]piperidin-2- one
  • MW: 410.552 | Formula: C24H34N4O2
  • H donors: 0 H acceptors: 1 LogP: 2.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCc1ccc(n1C)CN1CCCCC1=O
  • InChi: 1S/C24H34N4O2/c1-25-20(10-11-21(25)19-28-13-6-5-9-24(28)29)12-14-26-15-17-27(18-16-26)22-7-3-4-8-23(22)30-2/h3-4,7-8,10-11H,5-6,9,12-19H2,1-2H3
  • InChiKey: GWLNFZHDKJSSLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1-methyl-pyrrol-2-yl]methyl]piperidin-2-one
  • 1-[[5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1-methyl-2-pyrrolyl]methyl]-2-piperidinone
  • 1-[[5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1-methyl-pyrrol-2-yl]methyl]-2-piperidone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0041 0.0237 0.0254
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0259
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0313 0.3115 0.3521
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0322 0.0364
Echinococcus multilocularis pyruvate kinase 0.0028 0.0099 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.036 0.0409
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1715 0.2004
Leishmania major pyruvate kinase 0.0036 0.018 0.0199
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.1715 0.1943
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0041 0.023 0.6254
Brugia malayi hypothetical protein 0.0034 0.0161 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Schistosoma mansoni hypothetical protein 0.0039 0.021 0.0197
Echinococcus granulosus pyruvate kinase 0.0036 0.018 0.0197
Mycobacterium ulcerans acetyl-CoA synthetase 0.0041 0.023 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.1868 0.2213
Leishmania major pyruvate kinase 0.0036 0.018 0.0199
Echinococcus multilocularis pyruvate kinase 0.0036 0.018 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0223 0.0252
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0013 0.5
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0041 0.023 0.0259
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0313 0.3115 0.3575
Schistosoma mansoni pyruvate kinase 0.0036 0.018 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0851 0.8825 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.036 0.1635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0322 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Echinococcus granulosus pyruvate kinase 0.0036 0.018 0.0197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0124 0.0141
Loa Loa (eye worm) pyruvate kinase 0.0036 0.018 0.0204
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.018 0.0254
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.023 0.033
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.036 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.018 0.481
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0041 0.023 0.0261
Toxoplasma gondii MAPEG family protein 0.0221 0.2135 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0041 0.023 0.0246
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.018 0.0715
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0313 0.3115 0.3703
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.7918 0.9308
Schistosoma mansoni hypothetical protein 0.0024 0.005 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.023 0.0259
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0223 0.0319
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0034 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0401 0.0441
Plasmodium vivax acetyl-CoA synthetase, putative 0.0041 0.023 0.6254
Brugia malayi intermediate filament protein 0.0031 0.0124 0.0126
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0041 0.023 0.0259
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.005 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0322 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.021 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0261
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0124 0.0126
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.021 0.0224
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0041 0.023 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0259
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0221 0.2135 0.2499
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0261
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0041 0.023 0.0259
Trichomonas vaginalis antibiotic synthetase, putative 0.0041 0.023 0.033
Echinococcus multilocularis pyruvate kinase 0.0036 0.018 0.0197
Schistosoma mansoni alpha-glucosidase 0.0156 0.1448 0.1436
Onchocerca volvulus 0.0041 0.023 0.1356
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0261
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0223 0.0319
Echinococcus granulosus intermediate filament protein 0.0031 0.0124 0.0131
Leishmania major acetyl-CoA synthetase, putative 0.0041 0.023 0.0259
Mycobacterium ulcerans hypothetical protein 0.0041 0.023 0.0246
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0482 0.0552
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0041 0.023 0.0256
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0204
Loa Loa (eye worm) pyruvate kinase 0.0036 0.018 0.0204
Echinococcus multilocularis lamin 0.0031 0.0124 0.0131
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0821 0.8506 1
Treponema pallidum fructose-bisphosphate aldolase 0.0641 0.659 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.1868 0.2184
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.018 0.0715
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0041 0.023 0.0259
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0041 0.023 0.0256
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1715 0.2004
Entamoeba histolytica acyl-coA synthetase, putative 0.0041 0.023 0.033
Echinococcus granulosus long chain fatty acid transport protein 4 0.0821 0.8506 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.018 0.0189
Loa Loa (eye worm) hypothetical protein 0.0053 0.036 0.0408
Leishmania major fatty acid transporter protein-like protein 0.0811 0.8392 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0041 0.023 0.0256
Brugia malayi PHD-finger family protein 0.0027 0.0083 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0322 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0269
Brugia malayi Bromodomain containing protein 0.0081 0.0658 0.0732
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Schistosoma mansoni lamin 0.0031 0.0124 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0223 0.0247
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0056 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.036 1
Echinococcus granulosus lamin dm0 0.0031 0.0124 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0322 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Echinococcus multilocularis lamin dm0 0.0031 0.0124 0.0131
Leishmania major hypothetical protein, conserved 0.0053 0.036 0.0414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1868 0.2105
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.018 0.0189
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.023 0.0246
Onchocerca volvulus 0.0041 0.023 0.1356
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0223 0.0319
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.018 0.481
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0061
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0223 0.0319
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0821 0.8506 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0041 0.023 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0322 0.0309
Trichomonas vaginalis antibiotic synthetase, putative 0.0041 0.023 0.033
Loa Loa (eye worm) hypothetical protein 0.0044 0.0265 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0041 0.023 0.0259
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0064 0.0078
Echinococcus granulosus neuropeptide receptor A26 0.05 0.5102 0.5992
Onchocerca volvulus 0.0041 0.023 0.1356
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.018 0.0197
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0041 0.023 0.0246
Schistosoma mansoni lamin 0.0031 0.0124 0.0111
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0041 0.023 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.036 0.0409
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0021
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0041 0.023 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.023 0.033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0401 0.0455
Echinococcus granulosus lamin 0.0031 0.0124 0.0131
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.1868 0.2184
Plasmodium vivax pyruvate kinase, putative 0.0036 0.018 0.481
Trypanosoma brucei glucosidase, putative 0.004 0.0223 0.6042
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.018 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0322 0.0309
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.5102 0.5992
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.018 0.0197
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0041 0.023 0.033
Giardia lamblia Fructose-bisphosphate aldolase 0.0641 0.659 1
Loa Loa (eye worm) oxidoreductase 0.0041 0.023 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.005 0.0043
Onchocerca volvulus 0.0041 0.023 0.1356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0322 0.0364
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0223 0.0319
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.1868 0.8739
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0041 0.023 0.0246
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1868 0.2105
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0259
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0116 0.0123
Loa Loa (eye worm) hypothetical protein 0.0077 0.0609 0.069
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0041 0.023 0.0259
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.018 0.0715
Brugia malayi hypothetical protein 0.0053 0.036 0.0394
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0041 0.023 0.0246
Echinococcus granulosus microtubule associated protein 2 0.0766 0.7918 0.9308
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0064 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0134
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0641 0.659 1
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0041 0.023 0.1023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0223 0.0319
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0641 0.659 1
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.7918 0.7916
Echinococcus granulosus neuropeptide s receptor 0.05 0.5102 0.5992
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.036 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0073
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0056 0.005
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.1715 0.2004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0322 0.0351
Schistosoma mansoni pyruvate kinase 0.0036 0.018 0.0167
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0041 0.023 0.0246
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.021 0.0231
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0041 0.023 0.0246
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0851 0.8825 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.1868 0.2213
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.036 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0287 0.0325
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0041 0.023 0.0259
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0821 0.8506 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0041 0.023 0.0246
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0041 0.023 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Onchocerca volvulus 0.0041 0.023 0.1356
Schistosoma mansoni zinc finger protein 0.0021 0.0022 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.1715 0.1931
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.018 0.0787
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0223 0.0319
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0041 0.023 0.0246
Echinococcus granulosus microsomal glutathione S transferase 3 0.0221 0.2135 0.2499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0401 0.0455
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0041 0.023 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.018 0.0254
Schistosoma mansoni alpha glucosidase 0.004 0.0223 0.021
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.023 0.1023
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0223 0.0319
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0811 0.8392 1
Echinococcus multilocularis neuropeptide s receptor 0.05 0.5102 0.5992
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0259
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0851 0.8825 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0223 0.0319
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0261
Echinococcus granulosus zinc finger protein 0.0021 0.0022 0.001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0041 0.023 0.0256
Giardia lamblia Pyruvate kinase 0.0036 0.018 0.0254
Leishmania major acetyl-CoA synthetase, putative 0.0041 0.023 0.0259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.023 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0401 0.0441
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0041 0.023 0.6254
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0223 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.1868 0.1857
Plasmodium falciparum pyruvate kinase 0.0036 0.018 0.481
Schistosoma mansoni intermediate filament proteins 0.0031 0.0124 0.0111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0811 0.8392 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.023 0.0246
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.023 0.0061
Schistosoma mansoni acetyl-CoA synthetase 0.0041 0.023 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0223 0.0247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.023 0.0061
Toxoplasma gondii propionate-CoA ligase 0.0041 0.023 0.1023
Onchocerca volvulus 0.0105 0.0906 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0223 0.0238
Schistosoma mansoni alpha-glucosidase 0.0156 0.1448 0.1436
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0223 0.0247
Brugia malayi AMP-binding enzyme family protein 0.0041 0.023 0.0246
Schistosoma mansoni FFA transport protein 0.0821 0.8506 0.8504
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.023 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1868 0.2105
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0261
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.1868 0.1857
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0223 0.0988
Mycobacterium ulcerans pyruvate kinase 0.0036 0.018 0.0189
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0041 0.023 0.6254
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0223 0.0247
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0223 0.025
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0124 0.0141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.021 0.0231
Echinococcus multilocularis zinc finger protein 0.0021 0.0022 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0013 0.0015
Schistosoma mansoni microsomal glutathione s-transferase 0.0221 0.2135 0.2125
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.023 0.0259
Schistosoma mansoni bromodomain containing protein 0.0068 0.0523 0.0511
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0223 0.0319
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.023 0.0259
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0482 0.0552
Chlamydia trachomatis pyruvate kinase 0.0036 0.018 0.5
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.023 0.0259
Echinococcus multilocularis musashi 0.0031 0.0124 0.0131
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.023 0.0246
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0041 0.023 0.0246
Loa Loa (eye worm) pyruvate kinase 0.0036 0.018 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.659 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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