Detailed information for compound 1173222

Basic information

Technical information
  • TDR Targets ID: 1173222
  • Name: 6-amino-2-phenylchromen-4-one
  • MW: 237.253 | Formula: C15H11NO2
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)c(=O)cc(o2)c1ccccc1
  • InChi: 1S/C15H11NO2/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9H,16H2
  • InChiKey: YWHKBWPNCFDUPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-amino-2-phenyl-chromen-4-one
  • 6-amino-2-phenyl-4-chromenone
  • 6-amino-2-phenyl-chromone
  • 576263_ALDRICH
  • 6-Aminoflavone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.0081
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0169 0.0194
Schistosoma mansoni protein phosphatase 2C 0.0017 0.005 0.005
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0026 0.0173 0.0199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1105 0.4116
Brugia malayi Endoplasmin precursor 0.0032 0.0261 0.0972
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0173 0.2494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1105 0.1105
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0203 0.2684 1
Plasmodium falciparum small ubiquitin-related modifier 0.0033 0.0281 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0173 0.0173
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.005 0.0724
Schistosoma mansoni eyes absent homolog 0.0096 0.1164 0.1164
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.005 0.0188
Echinococcus multilocularis caspase 8 0.0029 0.0217 0.0217
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0261 0.3753
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0173 0.0173
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0341 0.0341
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Echinococcus granulosus phd:f box containing protein 0.0017 0.005 0.005
Plasmodium falciparum endoplasmin, putative 0.002 0.0086 0.3076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Schistosoma mansoni endoplasmin 0.0032 0.0261 0.0261
Plasmodium falciparum metacaspase-like protein 0.0029 0.0217 0.7736
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi metacaspase, putative 0.0029 0.0217 0.3123
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0261 0.7654
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0695 0.0798
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0026 0.0173 0.0646
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0026 0.0173 0.0173
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3871 1
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0261 0.3753
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0217 0.637
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0217 0.3123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.2339
Brugia malayi jmjC domain containing protein 0.0017 0.005 0.0188
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0169 0.0376
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Echinococcus multilocularis Small ubiquitin modifier 2 0.0033 0.0281 0.0281
Plasmodium vivax JmjC domain containing protein 0.0017 0.005 0.1476
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0695 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0026 0.0173 0.0646
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2684 0.3079
Trypanosoma brucei Metacaspase-4 0.0029 0.0217 0.3123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0203 0.2684 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0695 0.0798
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0261 0.0674
Echinococcus granulosus Small ubiquitin modifier 2 0.0033 0.0281 0.0281
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2684 0.3079
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.005 0.005
Echinococcus granulosus caspase 0.0029 0.0217 0.0217
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0341 0.0341
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0203 0.2684 0.6934
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0217 0.3123
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.005 0.0188
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2684 0.3079
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0026 0.0173 0.0646
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0713 0.0713
Trypanosoma brucei metacaspase MCA2 0.0029 0.0217 0.3123
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0173 0.0173
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1793 0.5494
Brugia malayi jmjC domain containing protein 0.0017 0.005 0.0188
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0026 0.0173 0.0173
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0026 0.0173 0.0173
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0026 0.0173 0.0173
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0026 0.0173 0.0173
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0629 0.8718 1
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.005 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0071 0.1016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3871 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Plasmodium vivax small ubiquitin-related modifier, putative 0.0033 0.0281 0.8234
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0188
Leishmania major hypothetical protein, conserved 0.0038 0.0341 0.4903
Treponema pallidum heat shock protein 90 0.0025 0.0169 0.0259
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0071 0.0263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0713 0.0713
Brugia malayi jmjC domain containing protein 0.0017 0.005 0.0188
Trichomonas vaginalis endoplasmin, putative 0.002 0.0086 0.0099
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0071 0.1016
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.1899 0.1899
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0341 0.0341
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0713 0.2657
Trypanosoma cruzi small ubiquitin protein, putative 0.0033 0.0281 0.4037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0713 0.0713
Toxoplasma gondii exonuclease III APE 0.0018 0.0071 0.1036
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0026 0.0173 0.0173
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0026 0.0173 0.0173
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.005 0.005
Brugia malayi heat shock protein 90 0.0032 0.0261 0.0972
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0169 0.0314
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.2684 0.3079
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0026 0.0173 0.0173
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.005 0.1793
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.2072
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Brugia malayi beta-lactamase 0.0038 0.0341 0.1271
Giardia lamblia Grp94/Hsp90 0.0025 0.0169 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Onchocerca volvulus 0.0038 0.0341 0.0667
Echinococcus multilocularis heat shock protein 0.0032 0.0261 0.0261
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0341 0.0862
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0169 0.243
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Echinococcus granulosus heat shock protein 0.0032 0.0261 0.0261
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.2339
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0071 0.0183
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0629 0.8718 1
Schistosoma mansoni heat shock protein 0.0032 0.0261 0.0261
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0261 0.3753
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0169 0.243
Onchocerca volvulus 0.0203 0.2684 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0071 0.0071
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.005 0.0724
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0281 0.0322
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0217 0.0217
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0217 0.3185
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0071
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0026 0.0173 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0261 0.3753
Schistosoma mansoni endoplasmin 0.0032 0.0261 0.0261
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0169 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0188
Trypanosoma brucei metacaspase MCA3 0.0029 0.0217 0.3123
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0026 0.0173 0.0173
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0261 0.0299
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0682 0.9806
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0071 0.0071
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0188
Loa Loa (eye worm) beta-lactamase 0.0038 0.0341 0.1271
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0173 0.0173
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.0081
Leishmania major metacaspase, putative 0.0029 0.0217 0.3123
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0261 0.3753
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Brugia malayi beta-lactamase family protein 0.0038 0.0341 0.1271
Trichomonas vaginalis heat shock protein, putative 0.002 0.0086 0.0099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Echinococcus multilocularis 0.0026 0.0173 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0341 0.0341
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0026 0.0173 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249
Onchocerca volvulus 0.0038 0.0341 0.0667
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.1899 0.1899
Mycobacterium ulcerans hypothetical protein 0.0038 0.0341 0.1034
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0682 0.0682
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0341 0.0391
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2684 0.3079
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0341 0.4903
Echinococcus granulosus protein tyrosine phosphatase n9 0.0026 0.0173 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1105 0.1105
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.1899 0.7076
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0341 0.4903
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0173 0.2494
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0682 0.0682
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0173 0.0173
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0682 0.0682
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0173 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1105 0.1105
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.005 0.005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0341 0.0862
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0261 0.3753
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.1016
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0217 0.0217
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0341 0.0862
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0261 0.0299
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Brugia malayi Cell death protein 3 precursor 0.0029 0.0217 0.0809
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0341 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Brugia malayi hypothetical protein 0.0096 0.1164 0.4335
Toxoplasma gondii ABC1 family protein 0.0038 0.0341 0.5
Plasmodium falciparum heat shock protein 90 0.0032 0.0261 0.9295
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0026 0.0173 0.0173
Echinococcus granulosus endoplasmin 0.0025 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0341 0.4903
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0261 0.0972
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0026 0.0173 0.0646
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0682 0.195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Brugia malayi beta-lactamase family protein 0.0038 0.0341 0.1271
Leishmania major hypothetical protein, conserved 0.0017 0.005 0.0724
Trypanosoma cruzi metacaspase, putative 0.0029 0.0217 0.3123
Schistosoma mansoni phd/f-box containing protein 0.0017 0.005 0.005
Mycobacterium ulcerans beta-lactamase 0.0038 0.0341 0.1034
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0173 0.0173
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0169 0.0194
Brugia malayi Ubiquitin-like protein SMT3 0.0033 0.0281 0.1046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Trichomonas vaginalis pten, drome, putative 0.0026 0.0173 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0026 0.0173 0.0173
Onchocerca volvulus 0.0038 0.0341 0.0667
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2684 0.3079
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0147 0.1899 0.1899
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0261 0.3753
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0217 0.3185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1793 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Echinococcus granulosus heat shock protein 90 0.0032 0.0261 0.0261
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0341 0.0862
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.005 0.0188
Echinococcus granulosus heat shock protein 90 0.0025 0.0169 0.0169
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Mycobacterium ulcerans lipase LipD 0.0038 0.0341 0.1034
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.005 0.0738
Loa Loa (eye worm) endoplasmin 0.0032 0.0261 0.0972
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0809
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0261 0.3753
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trypanosoma brucei metacaspase 0.0029 0.0217 0.3123
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.005 0.0724
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0217 0.3123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0713 0.0713
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2684 0.3079
Brugia malayi hypothetical protein 0.0026 0.0173 0.0646
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0261 0.0299
Trichomonas vaginalis esterase, putative 0.0038 0.0341 0.0391
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Echinococcus granulosus caspase 8 0.0029 0.0217 0.0217
Echinococcus granulosus caspase 2 0.0029 0.0217 0.0217
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0029 0.0217 0.0217
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0173 0.0173
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0029 0.0217 0.0217
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0682 0.0682
Leishmania major hypothetical protein, conserved 0.0063 0.0695 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.014 0.1798 0.5508
Giardia lamblia Sentrin 0.0033 0.0281 0.0725
Brugia malayi jmjC domain containing protein 0.0017 0.005 0.0188
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0261 0.3827
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0217 0.0217
Plasmodium vivax endoplasmin, putative 0.0032 0.0261 0.7654
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Schistosoma mansoni pcd6 interacting protein-related 0.0026 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249
Entamoeba histolytica ubiquitin like protein 0.0033 0.0281 0.0322
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.005 0.005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Leishmania major small ubiquitin protein, putative 0.0033 0.0281 0.4037
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.2684 0.3079
Trypanosoma brucei protein tyrosine phosphatase 1 0.0026 0.0173 0.2494
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0026 0.0173 0.2494
Echinococcus multilocularis hypothetical protein 0.0026 0.0173 0.0173
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.005 0.005
Plasmodium falciparum metacaspase 1 0.0029 0.0217 0.7736
Brugia malayi hypothetical protein 0.0026 0.0173 0.0646
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0341 0.0391
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1793 0.6592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Plasmodium vivax metacaspase 1, putative 0.0029 0.0217 0.637
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0169 0.243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1105 0.4116
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0026 0.0173 0.0173
Mycobacterium tuberculosis Conserved protein 0.0038 0.0341 0.0862
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0261 0.3827
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0169 0.0437
Trypanosoma cruzi small ubiquitin protein, putative 0.0033 0.0281 0.4037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.2339
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Echinococcus multilocularis microtubule associated protein 2 0.0719 1 1
Brugia malayi Protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1105 0.1105
Echinococcus multilocularis caspase 2 0.0029 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0033 0.0281 0.0281
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Brugia malayi Protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Schistosoma mansoni caspase-3 (C14 family) 0.0029 0.0217 0.0217
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Trypanosoma brucei small ubiquitin-related modifier 0.0033 0.0281 0.4037
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0203 0.2684 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0341 0.1271
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0341 0.0391
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0217 0.0809
Brugia malayi jmjC domain containing protein 0.0064 0.0713 0.2657
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0096 0.1164 0.4335
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.2517
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0173 0.0173
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.1899 0.7076
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0071 0.0081
Mycobacterium leprae Probable lipase LipE 0.0038 0.0341 0.1059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0341 0.1271
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0341 0.0862
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0341 0.0862
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0169 0.0169
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.005 0.005
Echinococcus multilocularis phd:f box containing protein 0.0017 0.005 0.005
Brugia malayi jmjC domain containing protein 0.0064 0.0713 0.2657
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.005 0.0738
Brugia malayi hypothetical protein 0.0026 0.0173 0.0646
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.005 0.005
Brugia malayi hypothetical protein 0.0026 0.0173 0.0646
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0217 0.3185
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0341 0.1271
Giardia lamblia Protein tyrosine phosphatase 0.0026 0.0173 0.0448
Echinococcus multilocularis caspase 0.0029 0.0217 0.0217
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0026 0.0173 0.0173
Brugia malayi hypothetical protein 0.0026 0.0173 0.0646
Onchocerca volvulus Cell death protein 3 homolog 0.0029 0.0217 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Mycobacterium tuberculosis Conserved protein 0.0038 0.0341 0.0862
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0169 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0341 0.0862
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0071
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.005 0.005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.1899 0.1899
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0651 0.9039 0.9039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0809
Brugia malayi Protein-tyrosine phosphatase 1 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0026 0.0173 0.0199
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0713 0.0713
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1105 0.1105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0173 0.2494
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.1899 0.1899
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi metacaspase, putative 0.0029 0.0217 0.3123
Loa Loa (eye worm) SMO-1 protein 0.0033 0.0281 0.1046
Schistosoma mansoni jumonji domain containing protein 0.0017 0.005 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0026 0.0173 0.0173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0341 0.1034
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0096 0.1164 0.4335
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0341 0.0391
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.3206 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0341 0.0391
Echinococcus multilocularis heat shock protein 90 0.0032 0.0261 0.0261
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0713 0.0713
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1105 0.1105
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Leishmania major tyrosine specific protein phosphatase, putative 0.0026 0.0173 0.2494
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0713 0.0713
Trypanosoma brucei heat shock protein, putative 0.0032 0.0261 0.3753
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0173 0.0173
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0026 0.0173 0.0173
Mycobacterium tuberculosis Conserved protein 0.0038 0.0341 0.0862
Toxoplasma gondii small ubiquitin family modifier, putative 0.0033 0.0281 0.4117
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0341 0.1034
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0071 0.0263
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.1016
Schistosoma mansoni heat shock protein 0.0032 0.0261 0.0261
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0682 1
Schistosoma mansoni microtubule-associated protein tau 0.0719 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1105 0.1105
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0173 0.0646
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0695 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0173 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0646
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0076 0.1092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Trypanosoma cruzi metacaspase, putative 0.0029 0.0217 0.3123
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Loa Loa (eye worm) protein tyrosine phosphatase 0.0026 0.0173 0.0646
Leishmania major heat shock protein 83-1 0.0032 0.0261 0.3753
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0217 0.0249
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0173 0.0173
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0173 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3871 0.444
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0173 0.0173
Echinococcus multilocularis endoplasmin 0.0025 0.0169 0.0169
Echinococcus multilocularis heat shock protein 90 0.0025 0.0169 0.0169
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0341 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0249

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 209.1 uM Cytotoxicity against human MT4 cells after 4 days by MTT assay ChEMBL. 20638854
IC50 (functional) = 78.37 ug ml-1 Cytotoxicity against Homo sapiens (human) MDA-MB-435 cells assessed as inhibition of cell viability by SRB assay ChEMBL. No reference
IC50 (ADMET) = 36 uM Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry ChEMBL. 20638854
IC50 (functional) > 36 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of parasite proliferation after 48 hrs ChEMBL. 20638854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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