Detailed information for compound 1173493

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.516 | Formula: C25H29N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1N(C(=O)NC2CCCCC2)[C@@H]([C@@H]1c1ccccc1c1ccc(cc1)OC)C#N
  • InChi: 1S/C25H29N3O3/c1-31-19-13-11-17(12-14-19)20-9-5-6-10-21(20)24-22(15-26)28(23(24)16-29)25(30)27-18-7-3-2-4-8-18/h5-6,9-14,18,22-24,29H,2-4,7-8,16H2,1H3,(H,27,30)/t22-,23+,24+/m1/s1
  • InChiKey: GNZKTJGPQVQFBU-SGNDLWITSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0253 0.2375 0.5709
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.1113 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0793 0.1872
Mycobacterium leprae Conserved hypothetical protein 0.0429 0.416 1
Echinococcus multilocularis snurportin 1 0.0332 0.3175 0.7623
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0054 0.0087
Mycobacterium ulcerans hypothetical protein 0.0074 0.0567 0.1325
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0233 0.0519
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.2842 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0097 0.1446
Onchocerca volvulus 0.0052 0.0343 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0429 0.416 0.9087
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0116
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0116
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0162 0.1313
Schistosoma mansoni hypothetical protein 0.0052 0.0343 0.0786
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0567 0.1204
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0793 0.1872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0793 0.1872
Onchocerca volvulus 0.0074 0.0567 0.0441
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0567 0.1325
Brugia malayi Thioredoxin family protein 0.0429 0.416 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.039 0.1177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1113 0.2644
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0024 0.0014
Mycobacterium tuberculosis Long conserved protein 0.0429 0.416 0.9087
Schistosoma mansoni DNA polymerase eta 0.002 0.0024 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0567 0.1325
Onchocerca volvulus Alhambra homolog 0.0034 0.0162 0.0031
Mycobacterium ulcerans lipase LipD 0.0074 0.0567 0.1325
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0377
Trichomonas vaginalis peptide N-glycanase, putative 0.0429 0.416 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0567 1
Echinococcus multilocularis musashi 0.0056 0.039 0.0897
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0131 0.0274
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0656
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0024 0.0058
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0126 0.0344
Mycobacterium ulcerans hypothetical protein 0.0429 0.416 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.1113 0.2644
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0294 0.0668
Loa Loa (eye worm) hypothetical protein 0.0173 0.1575 0.4933
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0096 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0793 0.1872
Echinococcus multilocularis geminin 0.0173 0.1575 0.3759
Brugia malayi beta-lactamase family protein 0.0074 0.0567 0.1363
Echinococcus granulosus importin subunit beta 1 0.0031 0.0137 0.0287
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0567 0.1325
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0567 0.1325
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0137 0.2166
Schistosoma mansoni hypothetical protein 0.0173 0.1575 0.3759
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0015
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0567 0.1204
Schistosoma mansoni hypothetical protein 0.0332 0.3175 0.7623
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0656
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0131 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0793 0.1872
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0018 0.0043
Brugia malayi jmjC domain containing protein 0.0041 0.0233 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1527 0.3645
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.1113 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0162 0.0347
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0096 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0567 1
Echinococcus granulosus tumor protein p63 0.0342 0.3277 0.787
Schistosoma mansoni hypothetical protein 0.0429 0.416 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.2503
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0567 0.1363
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0567 0.1325
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1113 0.2644
Loa Loa (eye worm) hypothetical protein 0.0253 0.2375 0.7465
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0024 0.0015
Echinococcus multilocularis tumor protein p63 0.0342 0.3277 0.787
Brugia malayi beta-lactamase 0.0074 0.0567 0.1363
Brugia malayi Bromodomain containing protein 0.0034 0.0162 0.0389
Schistosoma mansoni ran 0.0023 0.0054 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0793 0.1872
Loa Loa (eye worm) hypothetical protein 0.0056 0.039 0.1177
Echinococcus granulosus dna polymerase kappa 0.002 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Mycobacterium tuberculosis Hypothetical protein 0.0429 0.416 0.9087
Giardia lamblia Hypothetical protein 0.0429 0.416 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1298 0.2035
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0215
Mycobacterium tuberculosis Conserved protein 0.0429 0.416 0.9087
Trichomonas vaginalis ran, putative 0.0023 0.0054 0.0087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1111 0.3463
Brugia malayi Importin beta-1 subunit 0.0031 0.0137 0.0329
Echinococcus granulosus peregrin 0.0034 0.0162 0.0347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0233 0.0519
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0162 0.0455
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0656
Giardia lamblia PHD finger protein 15 0.0034 0.0162 0.0347
Leishmania major GTP-binding protein, putative 0.0023 0.0054 0.0329
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1113 0.2644
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0024 0.0015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.3175 1
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0705 0.1658
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.012 0.0246
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0054 0.0656
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.0087
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1113 0.2644
Brugia malayi hypothetical protein 0.0027 0.0097 0.0234
Echinococcus granulosus intermediate filament protein 0.0056 0.039 0.0897
Echinococcus multilocularis Transglutaminase 0.0429 0.416 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0116
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0097 0.0725
Schistosoma mansoni intermediate filament proteins 0.0056 0.039 0.0897
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.013
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.0933 0.2209
Echinococcus granulosus snurportin 1 0.0332 0.3175 0.7623
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0251
Mycobacterium ulcerans hypothetical protein 0.0429 0.416 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0097 0.5521
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0567 0.1204
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Leishmania major hypothetical protein, conserved 0.0074 0.0567 0.5012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0567 0.1325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.039 0.0936
Schistosoma mansoni hypothetical protein 0.0034 0.0162 0.0347
Leishmania major hypothetical protein, conserved 0.0027 0.0097 0.0725
Plasmodium vivax SET domain protein, putative 0.0031 0.0131 0.2064
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0567 0.1325
Mycobacterium leprae Conserved hypothetical protein 0.0429 0.416 1
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0126 0.0304
Mycobacterium tuberculosis Conserved protein 0.0074 0.0567 0.1204
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0097 0.5521
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0131 0.0274
Onchocerca volvulus 0.0074 0.0567 0.0441
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.0211
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.2842 0.682
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0116
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0567 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1973 0.6193
Loa Loa (eye worm) hypothetical protein 0.0034 0.0162 0.0455
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0131 0.0274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0096 0.0248
Plasmodium falciparum phd finger protein, putative 0.0034 0.0162 1
Schistosoma mansoni lamin 0.0056 0.039 0.0897
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0162 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0567 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0137 0.1086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0131 0.0274
Schistosoma mansoni survival motor neuron protein 0.0052 0.0343 0.0786
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0162 0.0347
Onchocerca volvulus 0.0056 0.039 0.0262
Brugia malayi Pre-SET motif family protein 0.0031 0.0131 0.0315
Trichomonas vaginalis set domain proteins, putative 0.0242 0.227 0.5438
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.2375 0.569
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0144
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.0933 0.2209
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0054 0.0087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1298 0.2808
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0567 0.1204
Mycobacterium tuberculosis Conserved hypothetical protein 0.0429 0.416 0.9087
Echinococcus multilocularis peregrin 0.0034 0.0162 0.0347
Echinococcus granulosus Transglutaminase 0.0429 0.416 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0024 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0144
Loa Loa (eye worm) hypothetical protein 0.0055 0.0379 0.1144
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.1113 0.2402
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0328 0.075
Trichomonas vaginalis esterase, putative 0.0074 0.0567 0.1325
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0024 0.002
Schistosoma mansoni hypothetical protein 0.0173 0.1575 0.3759
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0097 0.1446
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0058
Schistosoma mansoni importin beta-1 0.0031 0.0137 0.0287
Giardia lamblia DINP protein human, muc B family 0.002 0.0024 0.0015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2842 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.4576 1
Brugia malayi jmjC domain containing protein 0.011 0.0933 0.2243
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0015
Brugia malayi RNA, U transporter 1 0.0088 0.0716 0.1721
Trypanosoma brucei unspecified product 0.002 0.0024 0.0116
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0793 0.2456
Echinococcus granulosus lamin 0.0056 0.039 0.0897
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0343 0.0825
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0233 0.0681
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0567 0.1738
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0567 0.1325
Mycobacterium ulcerans putative transglutaminase-like protein 0.0429 0.416 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0024 0.0058
Leishmania major DNA polymerase eta, putative 0.002 0.0024 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0137 0.2166
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0024 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Leishmania major importin beta-1 subunit, putative 0.0025 0.0077 0.0543
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0233 0.0519
Echinococcus multilocularis dna polymerase eta 0.002 0.0024 0.0015
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0162 0.1313
Loa Loa (eye worm) hypothetical protein 0.005 0.0328 0.0984
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0793 0.1907
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0015
Schistosoma mansoni ran 0.0023 0.0054 0.0087
Plasmodium vivax importin-beta 2, putative 0.0031 0.0137 0.2166
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.2375 0.569
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0131 0.1035
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0567 0.1325
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0097 0.1446
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0131 0.0274
Echinococcus multilocularis lamin dm0 0.0056 0.039 0.0897
Echinococcus granulosus lamin dm0 0.0056 0.039 0.0897
Echinococcus multilocularis dna polymerase kappa 0.002 0.0024 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Giardia lamblia Transglutaminase/protease, putative 0.0429 0.416 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1113 0.2644
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0523 0.1599
Mycobacterium tuberculosis Conserved protein 0.0074 0.0567 0.1204
Plasmodium falciparum importin beta, putative 0.0031 0.0137 0.8269
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0018 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Brugia malayi MH2 domain containing protein 0.0128 0.1111 0.2671
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0077 0.1084
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Onchocerca volvulus 0.005 0.0328 0.02
Toxoplasma gondii ABC1 family protein 0.0074 0.0567 0.5012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.1113 0.2644
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0097 0.1446
Onchocerca volvulus 0.0056 0.039 0.0262
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0162 0.262
Onchocerca volvulus 0.0074 0.0567 0.0441
Brugia malayi Pre-SET motif family protein 0.0213 0.1973 0.4743
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0233 0.0519
Mycobacterium ulcerans transglutaminase family protein 0.0429 0.416 1
Echinococcus granulosus dna polymerase eta 0.002 0.0024 0.0015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2842 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Onchocerca volvulus 0.0242 0.227 0.2167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0793 0.1872
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0077 0.0144
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0054 0.0329
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1298 0.3091
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0173 0.1575 0.3787
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.0058 0.0404 0.1222
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0058
Mycobacterium ulcerans beta-lactamase 0.0074 0.0567 0.1325
Mycobacterium tuberculosis Conserved protein 0.0074 0.0567 0.1204
Brugia malayi beta-lactamase family protein 0.0074 0.0567 0.1363
Schistosoma mansoni lamin 0.0056 0.039 0.0897
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0567 0.1325
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0131 0.0274
Brugia malayi PHD-finger family protein 0.0034 0.0162 0.0389
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0567 0.1204
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0024 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0116
Loa Loa (eye worm) intermediate filament protein 0.0056 0.039 0.1177
Echinococcus multilocularis lamin 0.0056 0.039 0.0897
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0567 0.1325
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0015
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0024 0.0022
Entamoeba histolytica Ran family GTPase 0.0023 0.0054 0.0127
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1111 0.3463
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0294 0.0668
Loa Loa (eye worm) hypothetical protein 0.0074 0.0567 0.1738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2842 0.682
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0567 0.1204
Echinococcus granulosus geminin 0.0173 0.1575 0.3759
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0137 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0131 0.0359
Brugia malayi intermediate filament protein 0.0056 0.039 0.0936
Loa Loa (eye worm) beta-lactamase 0.0074 0.0567 0.1738

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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