Detailed information for compound 1175590

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.515 | Formula: C23H35Cl2N3OS
  • H donors: 0 H acceptors: 1 LogP: 8.39 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCCC)CCCOc1ccc(cc1)c1nc2n(c1C)ccs2.Cl.Cl
  • InChi: 1S/C23H33N3OS.2ClH/c1-4-6-13-25(14-7-5-2)15-8-17-27-21-11-9-20(10-12-21)22-19(3)26-16-18-28-23(26)24-22;;/h9-12,16,18H,4-8,13-15,17H2,1-3H3;2*1H
  • InChiKey: OAKZSXWOYAAVLG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0429 0.6181
Brugia malayi hypothetical protein 0.0031 0.0291 0.0906
Echinococcus granulosus FTZ F1 alpha 0.002 0.0139 0.0139
Schistosoma mansoni ferritin light chain 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0977
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0097 0.1194 0.1194
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0139 0.0139
Schistosoma mansoni nardilysin (M16 family) 0.0026 0.0222 0.0222
Schistosoma mansoni ferritin light chain 0.001 0.0005 0.0005
Schistosoma mansoni ferritin 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0097 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0179 0.0179
Echinococcus granulosus 5'partial|nardilysin 0.0011 0.0026 0.0026
Schistosoma mansoni apoferritin-2 0.001 0.0005 0.0005
Echinococcus multilocularis heat shock protein 0.0038 0.039 0.039
Onchocerca volvulus Protein cycle homolog 0.0022 0.0164 0.0227
Echinococcus granulosus expressed protein 0.001 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0179 0.171
Echinococcus granulosus insulin degrading enzyme 0.0026 0.0222 0.0222
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0643 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0841 0.0841
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0841 1
Plasmodium falciparum heat shock protein 90 0.0038 0.039 0.0705
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0179 0.171
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.039 0.8863
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Echinococcus granulosus neuropeptide receptor A26 0.054 0.7265 0.7265
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0179 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0435
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0643 0.1288
Loa Loa (eye worm) calcium channel 0.0093 0.1143 0.3563
Trypanosoma cruzi peptidase, putative 0.0026 0.0222 0.2476
Echinococcus granulosus heat shock protein 0.0038 0.039 0.039
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1779 0.5545
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.0512
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0841 0.0841
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0244 0.3208 1
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0026 0.0222 0.0222
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.039 0.5477
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0179 0.1707
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.1143 0.1143
Schistosoma mansoni cpg binding protein 0.0035 0.0355 0.0355
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0643 0.1288
Echinococcus multilocularis cpg binding protein 0.0035 0.0355 0.0355
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0179 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0435
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0139 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Loa Loa (eye worm) apoptosis regulator protein 0.0097 0.1194 0.3722
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0541 0.0541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0357 0.0357
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0429 1
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.039 0.5478
Schistosoma mansoni endoplasmin 0.0038 0.039 0.039
Onchocerca volvulus 0.0034 0.0329 0.0687
Brugia malayi steroid hormone receptor 0.002 0.0139 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0435
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0026 0.0222 0.0222
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0139
Plasmodium falciparum endoplasmin, putative 0.0023 0.0189 0.0243
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0177 0.1675
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0179 0.0557
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0179 0.0472
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0179 0.0179
Treponema pallidum heat shock protein 90 0.003 0.0284 0.0629
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0179 0.1707
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Giardia lamblia Grp94/Hsp90 0.003 0.0284 0.4987
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0139 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0357 0.0357
Trichomonas vaginalis set domain proteins, putative 0.0277 0.3668 1
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.039 0.5477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0435
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0189 0.05
Echinococcus granulosus dnaJ subfamily B 0.0478 0.6411 0.6411
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0179 0.0557
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.026 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0435
Echinococcus multilocularis microtubule associated protein 2 0.074 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Schistosoma mansoni hypothetical protein 0.0478 0.6411 0.6411
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0758 0.8998
Echinococcus multilocularis neuropeptide s receptor 0.054 0.7265 0.7265
Leishmania major DNA polymerase kappa, putative 0.0023 0.0179 0.1262
Loa Loa (eye worm) hypothetical protein 0.0097 0.1194 0.3722
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.1143 0.1143
Schistosoma mansoni insulysin (M16 family) 0.0014 0.0065 0.0065
Echinococcus multilocularis neuropeptide receptor A26 0.054 0.7265 0.7265
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0435
Loa Loa (eye worm) hypothetical protein 0.0093 0.1143 0.3563
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.0083 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0357 0.0357
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0097 0.1194 0.1194
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0139 0.0435
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0179 0.1707
Echinococcus granulosus neuropeptide s receptor 0.054 0.7265 0.7265
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.1143 0.1143
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.1143 0.1143
Schistosoma mansoni transcription factor btf3 0.0041 0.0429 0.0429
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0083 0.0891
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0541 0.1688
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0139 0.0158
Echinococcus granulosus aryl hydrocarbon receptor 0.0031 0.0291 0.0291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0179 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Trichomonas vaginalis heat shock protein, putative 0.0038 0.039 0.1049
Toxoplasma gondii hypothetical protein 0.0028 0.026 0.3018
Toxoplasma gondii toxolysin TLN4 0.0011 0.0026 0.0208
Schistosoma mansoni thyroid hormone receptor 0.002 0.0139 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0541 0.1688
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0139
Echinococcus multilocularis transcription factor btf3 0.0041 0.0429 0.0429
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0002
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0429 0.0796
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0557
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0038
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0026 0.0222 0.183
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0139 0.0139
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0429 0.618
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0139 0.0139
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0179 0.2763
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0028 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0429 0.1156
Echinococcus granulosus 3'partial|nardilysin 0.0026 0.0222 0.0222
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0841 1
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0429 0.505
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0541 0.0541
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0097 0.1194 0.1194
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus heat shock protein 90 0.0038 0.039 0.039
Toxoplasma gondii heat shock protein 90, putative 0.0038 0.039 0.4577
Schistosoma mansoni coup transcription factor 0.002 0.0139 0.0139
Schistosoma mansoni ferritin 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Schistosoma mansoni heat shock protein 0.0038 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0284 0.0629
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0541 0.0541
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0435
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus transcription factor btf3 0.0041 0.0429 0.0429
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0083 0.0891
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0022 0.0164 0.0512
Leishmania major DNA polymerase eta, putative 0.0023 0.0179 0.1262
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0038
Schistosoma mansoni voltage-gated cation channel 0.0093 0.1143 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0435
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0841 0.1887
Brugia malayi hypothetical protein 0.0056 0.0643 0.2004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0179 0.0391
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Schistosoma mansoni hypothetical protein 0.0097 0.1194 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus dna polymerase kappa 0.0023 0.0179 0.0179
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.039 0.8863
Trypanosoma cruzi peptidase, putative 0.0026 0.0222 0.2476
Brugia malayi hypothetical protein 0.001 0.0012 0.0038
Schistosoma mansoni nardilysin (M16 family) 0.0026 0.0222 0.0222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0841 0.1887
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.0313 0.3661
Trichomonas vaginalis heat shock protein, putative 0.003 0.0284 0.076
Onchocerca volvulus 0.0277 0.3668 1
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.6411 0.6411
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0083 0.0083
Echinococcus granulosus nardilysin 0.0026 0.0222 0.0222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0139
Trichomonas vaginalis heat shock protein, putative 0.003 0.0284 0.076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.0512
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0333 0.4433 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.039 1
Brugia malayi Hsp90 protein 0.0016 0.0083 0.0258
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0139 0.0139
Toxoplasma gondii heat shock protein HSP90 0.0038 0.039 0.4577
Brugia malayi nuclear receptor RXR 0.001 0.0012 0.0038
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0189 0.05
Brugia malayi nuclear receptor NHR-88 0.002 0.0139 0.0435
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.039 0.5477
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0031 0.0291 0.0906
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0056 0.0643 0.7389
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0435
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.1143 0.1143
Entamoeba histolytica hypothetical protein 0.0041 0.0429 1
Schistosoma mansoni ferritin 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0284 0.3587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0541 0.0541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.1143 0.1143
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0139 0.0139
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0429 0.1337
Schistosoma mansoni endoplasmin 0.0038 0.039 0.039
Echinococcus multilocularis ferritin 0.001 0.0005 0.0005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0217 0.0217
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0022 0.0164 0.0512
Trypanosoma brucei Heat shock protein 83, putative 0.0038 0.039 0.5478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0435
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Schistosoma mansoni apoferritin-2 0.001 0.0005 0.0005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0217 0.0217
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0284 0.3587
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0179 0.0391
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0643 0.1288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0541 0.0541
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0179 0.0557
Brugia malayi Pre-SET motif family protein 0.0036 0.0357 0.1114
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Echinococcus multilocularis insulin degrading enzyme 0.0026 0.0222 0.0222
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0643 1
Brugia malayi ecdysteroid receptor 0.002 0.0139 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0357 0.0357
Schistosoma mansoni ferritin 0.001 0.0005 0.0005
Brugia malayi hypothetical protein 0.0022 0.0164 0.0512
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0032 0.0313 0.4116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.0512
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Loa Loa (eye worm) endoplasmin 0.0038 0.039 0.1215
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Echinococcus multilocularis nardilysin 0.0026 0.0222 0.0222
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0139 0.0139
Brugia malayi MH2 domain containing protein 0.0139 0.1779 0.5545
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Schistosoma mansoni microtubule-associated protein tau 0.074 1 1
Brugia malayi hypothetical protein 0.0036 0.0369 0.115
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.1143 0.1143
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0643 0.7622
Brugia malayi nuclear hormone receptor 0.002 0.0139 0.0435
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0097 0.1194 0.1194
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0025 0.0217 0.0217
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0022 0.0164 0.0512
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.3208 1
Trichomonas vaginalis heat shock protein, putative 0.003 0.0284 0.076
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.039 0.5477
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0333 0.4433 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0179 0.0179
Brugia malayi hypothetical protein 0.001 0.0012 0.0038
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.039 0.5477
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0139 0.0139
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.1143 0.1143
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1779 0.5545
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0179 0.0179
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0291 0.0906
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0026 0.0222 0.2557
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0284 1
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0429 0.618
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0179 0.1707
Schistosoma mansoni thyroid hormone receptor 0.002 0.0139 0.0139
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0357 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0357 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0862 0.0862
Trypanosoma brucei peptidase, putative 0.0026 0.0222 0.2478
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0002 0.0002
Schistosoma mansoni apoptosis regulator bax 0.0097 0.1194 0.1194
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0139 0.0139
Mycobacterium ulcerans heat shock protein 90 0.003 0.0284 0.0629
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0179 0.0179
Schistosoma mansoni nuclear hormone receptor 0.002 0.0139 0.0139
Schistosoma mansoni heat shock protein 0.0016 0.0083 0.0083
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0179 0.171
Loa Loa (eye worm) insulin-degrading enzyme 0.0026 0.0222 0.0691
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0022 0.0164 0.0164
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.039 0.5478
Onchocerca volvulus 0.0036 0.0357 0.0765
Schistosoma mansoni heat shock protein 0.0038 0.039 0.039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0139 0.0139
Toxoplasma gondii sporozoite developmental protein 0.0026 0.0222 0.2557
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0139 0.0158
Schistosoma mansoni cpg binding protein 0.0035 0.0355 0.0355
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0139 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0429 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0139 0.0139
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0841 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0429 0.1156
Echinococcus multilocularis nardilysin 0.0016 0.0083 0.0083
Schistosoma mansoni cpg binding protein 0.0034 0.0329 0.0329
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0284 0.0629
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0643 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0083 0.0211
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0083 0.0083
Echinococcus multilocularis aryl hydrocarbon receptor 0.0031 0.0291 0.0291
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0313 0.0313
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0284 0.0284
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0139 0.0139
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0022 0.0164 0.0512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0841 0.1887
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0179 0.0472
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0012 0.0038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0435
Loa Loa (eye worm) histone methyltransferase 0.0012 0.003 0.0092
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus heat shock protein 90 0.003 0.0284 0.0284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0841 0.1887
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0179 0.171
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0284 0.4987
Loa Loa (eye worm) voltage-dependent calcium channel 0.0032 0.0313 0.0977
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0333 0.4433 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0097 0.1194 0.1194
Schistosoma mansoni family M16 unassigned peptidase (M16 family) 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0333 0.4433 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Leishmania major basic transcription factor 3a, putative 0.0041 0.0429 0.4566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0435
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0429 0.0796
Schistosoma mansoni hypothetical protein 0.0097 0.1194 0.1194
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0038
Echinococcus granulosus cpg binding protein 0.0035 0.0355 0.0355
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.1143 0.1143
Echinococcus multilocularis endoplasmin 0.003 0.0284 0.0284
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0032 0.0313 0.4118
Onchocerca volvulus 0.002 0.0139 0.0158
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0333 0.4433 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0435
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0139 0.0435
Brugia malayi hypothetical protein 0.0022 0.0164 0.0512
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0083 0.0258
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0357 0.4188
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0139 0.0435
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.1143 0.3563
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus multilocularis expressed protein 0.001 0.0005 0.0005
Echinococcus granulosus dna polymerase eta 0.0023 0.0179 0.0179
Treponema pallidum hypothetical protein 0.0333 0.4433 1
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0357 0.0357
Trypanosoma brucei unspecified product 0.0023 0.0179 0.171
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Onchocerca volvulus 0.0031 0.0291 0.058
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0139 0.0435
Plasmodium vivax SET domain protein, putative 0.0036 0.0357 0.0631
Brugia malayi Endoplasmin precursor 0.0038 0.039 0.1215
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0016 0.0083 0.0889
Echinococcus granulosus endoplasmin 0.003 0.0284 0.0284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0541 0.0541
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.1143 0.1143
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0284 0.2651
Loa Loa (eye worm) hypothetical protein 0.0028 0.026 0.081
Chlamydia trachomatis insulinase family protease III 0.0026 0.0222 1
Echinococcus multilocularis nardilysin 0.0026 0.0222 0.0222
Brugia malayi beta-NAC-like protein 0.0041 0.0429 0.1337
Echinococcus multilocularis heat shock protein 90 0.0038 0.039 0.039
Loa Loa (eye worm) heat shock protein 90 0.0038 0.039 0.1215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0435
Toxoplasma gondii insulysin, putative 0.0024 0.0204 0.235
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus multilocularis dna polymerase eta 0.0023 0.0179 0.0179
Trypanosoma brucei heat shock protein, putative 0.0038 0.039 0.5478
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0139 0.0139
Plasmodium vivax endoplasmin, putative 0.0038 0.039 0.0705
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0329 0.1026
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0139 0.0139
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0097 0.1194 0.3722
Echinococcus multilocularis heat shock protein 90 0.003 0.0284 0.0284
Leishmania major heat shock protein 83-1 0.0038 0.039 0.4047
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.1143 0.1143
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0179 0.171
Brugia malayi CXXC zinc finger family protein 0.0034 0.0329 0.1026
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0139 0.0435
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.2004
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0841 0.0841
Brugia malayi insulin-degrading enzyme 0.0026 0.0222 0.0691
Plasmodium vivax heat shock protein 86, putative 0.0038 0.039 0.0705
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0541 0.0541
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0179 0.1707
Echinococcus granulosus ferritin 0.001 0.0005 0.0005
Brugia malayi heat shock protein 90 0.0038 0.039 0.1215
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0179 0.1262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0357 0.1114
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.033 0.033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0139 0.0139
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0139 0.0139

Activities

Activity type Activity value Assay description Source Reference
Concentration (functional) = 0.1 % Concentration causing local anesthetic activity in mice ChEMBL. 3184128
IC50 (binding) = 1.3 uM Inhibition of [3H]-nitrendipine binding to calcium channels in Rabbit cardiac muscle. ChEMBL. 3184128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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