TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.881 | Formula: C22H21ClN4O2
H donors: 0 H acceptors: 2 LogP: 4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1=NN(C(C1)c1c(C)nn(c1Cl)c1ccccc1)C(=O)C
InChi: 1S/C22H21ClN4O2/c1-14-21(22(23)27(24-14)17-7-5-4-6-8-17)20-13-19(25-26(20)15(2)28)16-9-11-18(29-3)12-10-16/h4-12,20H,13H2,1-3H3
InChiKey: RSLVKZLMAHKMHO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0125	0.0238
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.017	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0241	0.034
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0079	0.0111
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0214	0.0302
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0379	0.0521
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0241	0.0848
Brugia malayi	hypothetical protein	0.0025	0.0125	0.0176
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0301	0.0243
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0079	0.0899
Toxoplasma gondii	exonuclease III APE	0.0038	0.0271	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0138	0.0194
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0143	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0241	0.034
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0214	0.0155
Schistosoma mansoni	hypothetical protein	0.0033	0.0214	0.02
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0257	0.0245
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0379	0.0534
Leishmania major	hypothetical protein, conserved	0.0025	0.0125	0.0334
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0219	0.4987
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0104	0.0055
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0271	0.1001
Brugia malayi	Pre-SET motif family protein	0.0091	0.0876	0.1234
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0271	0.6607
Brugia malayi	PHD-finger family protein	0.0029	0.017	0.024
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.0933	0.1132
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0379	0.0521
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0379	0.1649
Schistosoma mansoni	lamin	0.0027	0.0143	0.0108
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0271	0.0212
Leishmania major	glyoxalase I,trypanothione-dependent glyoxalase I	0.0189	0.1993	1
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0379	0.0521
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0379	0.0521
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	0.0044	0.0334	0.0471
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1034	0.1457
Brugia malayi	intermediate filament protein	0.0027	0.0143	0.0202
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0271	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0379	0.1649
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0085
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0271	0.5
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.006	0.0085
Schistosoma mansoni	alpha-glucosidase	0.0144	0.1473	0.1832
Brugia malayi	glutaminase DH11.1	0.0556	0.6173	0.8705
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0091	0.0876	0.082
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.024	0.0234
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0241	0.0848
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0257	0.0362
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0167	0.1738	0.2451
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0167	0.0458
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	0.0044	0.0334	0.0471
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0271	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0241	0.034
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0088	0.0837	0.1008
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0257	0.0245
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0334	0.8598
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0527	0.0743
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.024	0.0234
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0257	0.1019
Mycobacterium ulcerans	glutaminase	0.0556	0.6173	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.017	0.0143
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0125	0.0238
Schistosoma mansoni	hypothetical protein	0.0029	0.017	0.0143
Echinococcus granulosus	microtubule associated protein 2	0.0696	0.7773	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0379	1
Echinococcus granulosus	GPCR family 2	0.0033	0.0214	0.02
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0079	0.0111
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0079	0.0899
Schistosoma mansoni	ap endonuclease	0.0038	0.0271	0.0273
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	0.1738	0.1688
Echinococcus granulosus	lamin	0.0027	0.0143	0.0108
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0241	0.5
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0241	0.0296
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1034	0.1457
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0214	0.0155
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0257	0.093
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0104	0.0227
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0379	1
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0167	0.0138
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Mycobacterium ulcerans	biphenyl-2,3-diol 1,2-dioxygenase	0.0044	0.0334	0.0448
Plasmodium falciparum	glyoxalase I	0.0189	0.1993	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0167	0.5061
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1993	0.2811
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0257	0.6179
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0219	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0125	0.0176
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0654	0.0922
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0311	0.3379	0.4765
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0334	0.8598
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0707	0.0839
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0271	0.1089
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0257	0.0245
Schistosoma mansoni	alpha-glucosidase	0.0144	0.1473	0.1832
Echinococcus granulosus	protein quaking	0.0028	0.0152	0.012
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0636	0.7092	1
Schistosoma mansoni	microtubule-associated protein tau	0.0696	0.7773	1
Brugia malayi	Temporarily assigned gene name protein 44	0.0028	0.0153	0.0215
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0271	0.6607
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0271	1
Schistosoma mansoni	glutaminase	0.0556	0.6173	0.7926
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0257	0.0245
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0379	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0241	0.034
Onchocerca volvulus	Alhambra homolog	0.0029	0.017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0379	0.0534
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0167	0.0107
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.017	0.0475
Leishmania major	GTP-binding protein, putative	0.0021	0.0079	0.0098
Echinococcus granulosus	hypothetical protein	0.0028	0.0152	0.012
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0079	0.0098
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0257	0.0245
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0091	0.0876	0.4161
Trichomonas vaginalis	ran, putative	0.0021	0.0079	0.0024
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0257	0.0245
Echinococcus granulosus	lysosomal alpha glucosidase	0.0167	0.1738	0.2176
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0876	0.1234
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0257	0.0362
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0079	0.0019
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0091	0.0876	0.082
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0379	0.0521
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0257	0.0245
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0257	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0379	0.0534
Toxoplasma gondii	glyoxalase I, putative	0.0189	0.1993	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.006	0.0085
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0125	0.0334
Brugia malayi	lactoylglutathione lyase	0.0189	0.1993	0.2811
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0125	0.0238
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0167	0.5061
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0257	0.1019
Echinococcus multilocularis	snurportin 1	0.0311	0.3379	0.334
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0379	0.1649
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.024	0.0182
Schistosoma mansoni	hypothetical protein	0.0072	0.0654	0.077
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Schistosoma mansoni	ap endonuclease	0.0038	0.0271	0.0273
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0271	0.1089
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0104	0.0055
Onchocerca volvulus		0.0091	0.0876	0.0921
Mycobacterium ulcerans	glyoxalase GloA	0.0044	0.0334	0.0448
Brugia malayi	tumor suppressor.	0.0329	0.3592	0.5065
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0257	0.0198
Schistosoma mansoni	ran	0.0021	0.0079	0.0025
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0876	0.1057
Brugia malayi	RNA, U transporter 1	0.0083	0.0779	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0214	0.0302
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0271	0.0262
Schistosoma mansoni	hypothetical protein	0.0311	0.3379	0.4304
Plasmodium vivax	glyoxalase I, putative	0.0044	0.0334	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0153	0.0215
Schistosoma mansoni	hypothetical protein	0.0033	0.0214	0.02
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.024	0.0234
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0143	0.0202
Loa Loa (eye worm)	tumor suppressor	0.0329	0.3592	0.5065
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0334	0.0341
Echinococcus multilocularis	musashi	0.0027	0.0143	0.0084
Brugia malayi	Pre-SET motif family protein	0.0636	0.7092	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0876	0.1057
Onchocerca volvulus		0.0724	0.8095	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0379	0.0521
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0214	0.02
Plasmodium falciparum	importin beta, putative	0.0029	0.0167	0.0458
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0379	0.0534
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0104	0.0227
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0379	1
Schistosoma mansoni	gynecophoral canal protein	0.0044	0.0334	0.0355
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.017	0.024
Trichomonas vaginalis	glutaminase, putative	0.0556	0.6173	0.7609
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	0.1738	0.1688
Plasmodium vivax	SET domain protein, putative	0.0091	0.0876	0.4161
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0379	1
Brugia malayi	Importin beta-1 subunit	0.0029	0.0167	0.0235
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0271	0.5
Trypanosoma brucei	glucosidase, putative	0.0037	0.0257	0.9351
Mycobacterium tuberculosis	Cadmium inducible protein CadI	0.0044	0.0334	0.8598
Mycobacterium ulcerans	glyoxalase GloA	0.0044	0.0334	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0334	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0654	0.0922
Brugia malayi	hypothetical protein	0.0016	0.0022	0.0031
Plasmodium falciparum	phd finger protein, putative	0.0029	0.017	0.0475
Echinococcus multilocularis	microtubule associated protein 2	0.0696	0.7773	0.776
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0167	0.1738	0.2451
Echinococcus multilocularis	lamin	0.0027	0.0143	0.0084
Schistosoma mansoni	ran	0.0021	0.0079	0.0025
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1034	0.1457
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0876	0.1057
Schistosoma mansoni	hypothetical protein	0.0028	0.0152	0.012
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0334	0.8598
Brugia malayi	hypothetical protein	0.0028	0.0153	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0167	0.0235
Plasmodium falciparum	glyoxalase I	0.0044	0.0334	0.1333
Onchocerca volvulus	Lactoylglutathione lyase homolog	0.0189	0.1993	0.2327
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0257	0.0245
Loa Loa (eye worm)	glutaminase 2	0.0556	0.6173	0.8705
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.0933	0.0878
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0379	0.0534
Echinococcus multilocularis	protein quaking	0.0028	0.0152	0.0093
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0079	0.0098
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0079	0.0025
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.006	0.0085
Echinococcus granulosus	intermediate filament protein	0.0027	0.0143	0.0108
Schistosoma mansoni	importin beta-1	0.0029	0.0167	0.0138
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.017	0.0475
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0271	0.1001
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.017	0.0111
Schistosoma mansoni	alpha glucosidase	0.0037	0.0257	0.0255
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0143	0.0202
Echinococcus multilocularis	lamin dm0	0.0027	0.0143	0.0084
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0104	0.0055
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0257	0.0245
Brugia malayi	Bromodomain containing protein	0.0029	0.017	0.024
Entamoeba histolytica	hypothetical protein	0.0024	0.0104	0.1374
Mycobacterium tuberculosis	Conserved protein TB27.3	0.0044	0.0334	0.8598
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Plasmodium vivax	glyoxalase I, putative	0.0189	0.1993	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0271	0.0382
Entamoeba histolytica	Ran family GTPase	0.0021	0.0079	0.0594
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0091	0.0876	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0029	0.017	0.024
Echinococcus granulosus	histone lysine methyltransferase setb	0.0091	0.0876	0.1057
Trichomonas vaginalis	set domain proteins, putative	0.0724	0.8095	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0241	0.034
Schistosoma mansoni	hypothetical protein	0.0028	0.0152	0.012
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0379	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0271	0.0345
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0271	0.1089
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0214	0.0302
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.017	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1034	0.1457
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0189	0.1993	1
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0334	0.0448
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0271	0.0382
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0271	0.0262
Schistosoma mansoni	hypothetical protein	0.0033	0.0214	0.02
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0214	0.0302
Schistosoma mansoni	lamin	0.0027	0.0143	0.0108
Onchocerca volvulus		0.0097	0.0936	0.0996
Echinococcus multilocularis	peregrin	0.0029	0.017	0.0111
Schistosoma mansoni	hypothetical protein	0.0033	0.0214	0.02
Onchocerca volvulus		0.0048	0.0379	0.0296
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0241	0.5684
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0219	0.4987
Schistosoma mansoni	4-hydroxyphenylpyruvate dioxygenase	0.0044	0.0334	0.0355
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0167	0.0458
Toxoplasma gondii	glyoxalase family protein	0.0044	0.0334	0.1333
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0379	0.0521
Echinococcus granulosus	snurportin 1	0.0311	0.3379	0.4304
Loa Loa (eye worm)	glutaminase	0.0556	0.6173	0.8705
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0143	0.0108
Echinococcus granulosus	peregrin	0.0029	0.017	0.0143
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0125	0.0238
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0257	0.1019
Onchocerca volvulus	Putative protein	0.0044	0.0334	0.024
Loa Loa (eye worm)	hypothetical protein	0.005	0.041	0.0577
Brugia malayi	jmjC domain containing protein	0.0036	0.024	0.0339
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0189	0.1993	1
Giardia lamblia	PHD finger protein 15	0.0029	0.017	0.5218
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0125	0.3062
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0214	0.02
Brugia malayi	jmjC domain containing protein	0.0096	0.0933	0.1316
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0257	0.6179
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0379	0.0534
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0125	0.0334
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0301	0.0313
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0214	0.0155
Echinococcus granulosus	lamin dm0	0.0027	0.0143	0.0108
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.024	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0143	0.0202
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0219	0.4987

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1254807

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1181850