Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.005 | 0.0561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.3575 | 0.3575 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0187 | 0.0368 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.3605 | 0.3605 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0217 | 0.3681 | 0.3681 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.014 | 0.014 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0038 | 0.0321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0321 | 0.0321 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0281 | 0.0281 |
Echinococcus multilocularis | musashi | 0.006 | 0.0747 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0561 | 0.0561 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0501 | 0.0985 |
Onchocerca volvulus | 0.0047 | 0.0501 | 0.0779 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0321 | 0.0321 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.4156 | 0.4143 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0561 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0191 | 0.3188 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.005 | 0.0561 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0022 | 0.0042 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0187 | 0.0586 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0281 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0034 | 0.0252 | 0.0789 |
Brugia malayi | intermediate filament protein | 0.006 | 0.0747 | 0.0747 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0623 | 0.1955 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0561 | 0.2801 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.2198 | 0.2198 |
Onchocerca volvulus | 0.006 | 0.0747 | 0.1161 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0161 | 0.0161 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0187 | 0.5514 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0321 | 0.0321 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0029 | 0.0161 | 0.0505 |
Echinococcus granulosus | intermediate filament protein | 0.006 | 0.0747 | 0.2342 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0155 | 0.2522 | 0.7912 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0038 | 0.0321 | 0.5563 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0187 | 0.0586 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0383 | 0.6796 | 0.6789 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0501 | 0.0501 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0561 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0029 | 0.0161 | 0.0505 |
Schistosoma mansoni | lamin | 0.006 | 0.0747 | 0.1469 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.059 | 0.059 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0561 | 0.0561 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0034 | 0.0252 | 0.0495 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0022 | 0.0068 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0038 | 0.0321 | 1 |
Echinococcus granulosus | lamin dm0 | 0.006 | 0.0747 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0561 | 0.0561 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0036 | 0.0283 | 0.4847 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0383 | 0.6796 | 0.6789 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.2198 | 0.2198 |
Echinococcus multilocularis | lamin | 0.006 | 0.0747 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.059 | 0.059 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0501 | 0.0501 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.005 | 0.0561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0321 | 0.0321 |
Mycobacterium ulcerans | hypothetical protein | 0.005 | 0.0561 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.2198 | 0.2198 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.059 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.014 | 0.014 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0032 | 0.0221 | 0.0221 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0036 | 0.0283 | 0.4847 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0623 | 0.1955 |
Echinococcus multilocularis | lamin dm0 | 0.006 | 0.0747 | 0.2342 |
Schistosoma mansoni | lamin | 0.006 | 0.0747 | 0.1469 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0034 | 0.0252 | 0.0789 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0022 | 0.5 |
Brugia malayi | cation channel family protein | 0.0332 | 0.5831 | 0.5831 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.35 | 0.35 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0747 | 0.0747 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0281 | 0.0553 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0561 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0561 | 0.0561 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0501 | 0.157 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.005 | 0.0561 | 1 |
Onchocerca volvulus | 0.0031 | 0.0187 | 0.0291 | |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0155 | 0.2522 | 0.7912 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2522 | 0.2522 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0038 | 0.0321 | 0.5563 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.006 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0022 | 0.0022 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0501 | 0.0985 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0187 | 0.0586 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0561 | 0.2801 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0561 | 0.0561 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0187 | 1 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0034 | 0.0252 | 0.0252 |
Onchocerca volvulus | 0.0034 | 0.0252 | 0.0391 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0022 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0561 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0036 | 0.0283 | 0.4847 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0022 | 0.0022 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0038 | 0.0321 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0363 | 0.6429 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0183 | 0.3044 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0561 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.006 | 0.0747 | 0.0747 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0501 | 0.157 |
Brugia malayi | MIR domain containing protein | 0.0034 | 0.0252 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0187 | 0.0187 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0034 | 0.0252 | 0.0231 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0187 | 0.0368 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0623 | 0.1955 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0183 | 0.3044 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Schistosoma mansoni | intermediate filament proteins | 0.006 | 0.0747 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0623 | 0.0623 |
Echinococcus granulosus | ryanodine receptor 44f | 0.012 | 0.1871 | 0.5869 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0036 | 0.0283 | 0.4847 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0561 | 0.0561 |
Onchocerca volvulus | 0.006 | 0.0747 | 0.1161 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0623 | 0.1955 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0623 | 0.1226 |
Loa Loa (eye worm) | ryanodine receptor | 0.0059 | 0.0712 | 0.0712 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.059 | 0.059 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0501 | 0.0985 |
Onchocerca volvulus | 0.0242 | 0.4156 | 0.6465 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0561 | 1 |
Entamoeba histolytica | MIR domain protein | 0.0034 | 0.0252 | 0.4268 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0321 | 0.0321 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0561 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0191 | 0.3188 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0501 | 0.157 |
Leishmania major | hypothetical protein, conserved | 0.0124 | 0.1946 | 1 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0501 | 0.0501 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0176 | 0.2923 | 0.5751 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.005 | 0.0561 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0032 | 0.0221 | 0.0221 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0022 | 0.0042 |
Schistosoma mansoni | ryanodine receptor related | 0.0217 | 0.3681 | 0.7242 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0561 | 0.2801 |
Onchocerca volvulus | 0.005 | 0.0561 | 0.0872 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.005 | 0.0561 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0187 | 0.0368 |
Loa Loa (eye worm) | intermediate filament protein | 0.006 | 0.0747 | 0.0747 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0501 | 0.157 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0187 | 0.0187 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.0501 | 0.0779 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0363 | 0.6429 | 0.6421 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.5083 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.3605 | 0.3605 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0166 | 0.052 |
Echinococcus granulosus | lamin | 0.006 | 0.0747 | 0.2342 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0059 | 0.0712 | 0.1402 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0022 | 0.0068 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.012 | 0.1871 | 0.5869 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.027 | 0.4672 | 0.9193 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0623 | 0.0623 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0187 | 0.0368 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 50 % | Inhibition of electric eel AChE at 500 uM by Ellman's method | ChEMBL. | 20580236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.