Detailed information for compound 1203299

Basic information

Technical information
  • TDR Targets ID: 1203299
  • Name: N-(2-phenylethyl)-3,4-dihydro-1H-isoquinoline -2-carbothioamide
  • MW: 296.43 | Formula: C18H20N2S
  • H donors: 1 H acceptors: 0 LogP: 3.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCc2c(C1)cccc2)NCCc1ccccc1
  • InChi: 1S/C18H20N2S/c21-18(19-12-10-15-6-2-1-3-7-15)20-13-11-16-8-4-5-9-17(16)14-20/h1-9H,10-14H2,(H,19,21)
  • InChiKey: UALKWIIVDGFZKO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • MLS000662572
  • N-(2-phenylethyl)-3,4-dihydro-2(1H)-isoquinolinecarbothioamide
  • SMR000292465
  • Oprea1_044288
  • ZINC00467434
  • STK143556

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0022 0.0192 0.0192
Echinococcus multilocularis protein dispatched 1 0.0058 0.0886 0.1693
Brugia malayi nuclear hormone receptor 0.0012 0.0006 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0006 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0006 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0137 0.0262
Entamoeba histolytica hypothetical protein 0.0022 0.0198 0.0969
Schistosoma mansoni hypothetical protein 0.0019 0.0137 0.0658
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1235 0.1235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2529 0.2529
Brugia malayi ecdysteroid receptor 0.0012 0.0006 0.0006
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.5233 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1235 0.5936
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0924 0.0924
Trichomonas vaginalis Periplasmic beta-glucosidase precursor, putative 0.0022 0.0198 0.0664
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0066 0.1038 0.1984
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0207 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0012
Trichomonas vaginalis beta-hexosaminidase, putative 0.0066 0.1038 0.3476
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0748 0.143
Schistosoma mansoni hypothetical protein 0.0049 0.0713 0.3426
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.3022 0.5774
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.2046 0.391
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.2987 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0748 0.0748
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0012
Brugia malayi Cytochrome P450 family protein 0.003 0.0343 0.0343
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0207 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0535 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.5233 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0343 0.0343
Schistosoma mansoni hypothetical protein 0.0058 0.0886 0.4259
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.2046 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqI 0.0168 0.2987 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0207 0.0395
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1235 0.1235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0012
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.2081 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0886 0.0886
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0118 0.5717
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0022 0.0192 0.0366
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0006 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0029
Toxoplasma gondii exonuclease III APE 0.0023 0.0207 1
Schistosoma mansoni patched 1 0.0051 0.0748 0.3595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0207 0.0693
Schistosoma mansoni coup transcription factor 0.0012 0.0006 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Schistosoma mansoni lozenge 0.0067 0.1056 0.5072
Schistosoma mansoni hypothetical protein 0.0049 0.0713 0.3426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0207 0.0395
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0118 0.0396
Schistosoma mansoni ap endonuclease 0.0023 0.0207 0.0994
Echinococcus granulosus tar DNA binding protein 0.0076 0.1235 0.2361
Mycobacterium ulcerans beta-glucosidase BglS 0.0022 0.0198 0.0664
Loa Loa (eye worm) hypothetical protein 0.0119 0.2046 0.2046
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0207 1
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0118 0.5717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0006
Echinococcus granulosus beta hexosaminidase subunit beta 0.0022 0.0192 0.0366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0207 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0118
Brugia malayi CHE-14 protein 0.0051 0.0748 0.0748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0049 0.0713 0.3426
Trichomonas vaginalis beta-hexosaminidase, putative 0.0168 0.2987 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0006 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0006 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0924 0.0924
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0207 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQI 0.0168 0.2987 1
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0022 0.0192 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0137 0.0262
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2529 0.2529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0207 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1235 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0118 0.5717
Echinococcus granulosus beta D xylosidase 2 0.0022 0.0198 0.0379
Schistosoma mansoni hypothetical protein 0.0019 0.0137 0.0658
Brugia malayi MH2 domain containing protein 0.0144 0.2529 0.2529
Onchocerca volvulus 0.0535 1 1
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0022 0.0192 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0006 0.0006
Chlamydia trachomatis DNA ligase 0.0012 0 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.0012
Schistosoma mansoni beta-hexosaminidase B 0.0022 0.0192 0.0921
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.0012
Trichomonas vaginalis beta-hexosaminidase, putative 0.0168 0.2987 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0012
Trichomonas vaginalis beta-hexosaminidase, putative 0.0066 0.1038 0.3476
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.2046 0.391
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0207 0.1011
Loa Loa (eye worm) runx1 0.0067 0.1056 0.1056
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0006 0.0006
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0748 0.143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0207 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1235 0.5936
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.2689
Echinococcus multilocularis protein patched 0.0051 0.0748 0.143
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0066 0.1038 0.3476
Onchocerca volvulus 0.0012 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0006
Brugia malayi hypothetical protein 0.0044 0.0619 0.0619
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.2046 0.2046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0207 1
Schistosoma mansoni ap endonuclease 0.0023 0.0207 0.0994
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0207 0.0207
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.0012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0006 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1235 0.5936
Loa Loa (eye worm) hypothetical protein 0.0062 0.0968 0.0968
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0012
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0022 0.0192 0.0192
Echinococcus granulosus GPCR family 2 0.0019 0.0137 0.0262
Echinococcus multilocularis Protein lozenge 0.0067 0.1056 0.2017
Echinococcus multilocularis expressed conserved protein 0.0112 0.1908 0.3646
Schistosoma mansoni beta-hexosaminidase B 0.0022 0.0192 0.0921
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.0012
Loa Loa (eye worm) RNA binding protein 0.0076 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0286 0.5233 0.5233
Trichomonas vaginalis beta-hexosaminidase, putative 0.0066 0.1038 0.3476
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0006 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0207 1
Schistosoma mansoni hypothetical protein 0.0022 0.0198 0.0952
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0118 0.0118
Echinococcus multilocularis beta D xylosidase 2 0.0022 0.0198 0.0379
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.3022 0.5774
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0006 0.0029
Brugia malayi hypothetical protein 0.0286 0.5233 0.5233
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0118 0.0118
Brugia malayi nuclear receptor NHR-88 0.0012 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.0012 0.0006 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.056 0.056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0137 0.0262
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0137 0.0658
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0924 0.0924
Onchocerca volvulus 0.0058 0.0886 0.0886
Schistosoma mansoni hypothetical protein 0.0049 0.0713 0.3426
Schistosoma mansoni survival motor neuron protein 0.0058 0.0886 0.4259
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.056 0.056
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1235 0.5936
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0207 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0207 0.0693
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0748 0.143
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0006 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0006 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0137 0.0658
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0066 0.1038 0.1984
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0924 0.0924
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0137
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1235 0.2361
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1235 0.5936
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0207 0.0693
Echinococcus multilocularis GPCR, family 2 0.0019 0.0137 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0748 0.2505
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0118
Echinococcus granulosus expressed conserved protein 0.0112 0.1908 0.3646
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0006 0.0029
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0022 0.0192 0.0937
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0535 1 1
Mycobacterium ulcerans lipoprotein LpqI 0.0168 0.2987 1
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0022 0.0192 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0006
Brugia malayi RNA binding protein 0.0076 0.1235 0.1235
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0137 0.0262
Brugia malayi TAR-binding protein 0.0076 0.1235 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0051 0.0748 0.0748

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 26.281 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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