Detailed information for compound 1209078

Basic information

Technical information
  • TDR Targets ID: 1209078
  • Name: 3-(3-methoxy-1,2-oxazol-5-yl)propanoic acid
  • MW: 171.151 | Formula: C7H9NO4
  • H donors: 1 H acceptors: 3 LogP: 0.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(on1)CCC(=O)O
  • InChi: 1S/C7H9NO4/c1-11-6-4-5(12-8-6)2-3-7(9)10/h4H,2-3H2,1H3,(H,9,10)
  • InChiKey: XWBIAAGRBWFOCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-methoxyisoxazol-5-yl)propanoic acid
  • 3-(3-methoxy-5-isoxazolyl)propanoic acid
  • 3-(3-methoxyisoxazol-5-yl)propionic acid
  • 52898-06-3
  • MLS000757057
  • SMR000528899
  • 3-(3-Methoxy-isoxazol-5-yl)-propionic acid
  • BAS 07566608
  • ZERO/005433
  • 3-Methoxy-5-isoxazolepropanoic acid
  • EC-000.1934
  • NSC303800

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.1928
Loa Loa (eye worm) hypothetical protein 0.005 0.0285 0.0285
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0235 0.0938
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.1316 0.1316
Loa Loa (eye worm) hypothetical protein 0.1058 1 1
Brugia malayi hypothetical protein 0.0072 0.05 0.05
Schistosoma mansoni tsg101-related 0.0049 0.0279 0.1331
Echinococcus multilocularis GPCR, family 2 0.005 0.0285 0.0285
Echinococcus granulosus carboxylesterase 5A 0.0136 0.1118 0.1118
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0196 0.0761
Schistosoma mansoni hypothetical protein 0.005 0.0285 0.1361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.1128 0.1128
Onchocerca volvulus 0.0153 0.128 0.5766
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0761
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0279 0.2499
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0358 0.1709
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0761
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0197 0.0389
Schistosoma mansoni tsg101-related 0.006 0.0384 0.1836
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0112 0.0112
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0358 0.0762
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0113 0.0893 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Trypanosoma brucei calpain-like protein, putative 0.0113 0.0893 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0342
Schistosoma mansoni acetylcholinesterase 0.0023 0.0029 0.0139
Loa Loa (eye worm) hypothetical protein 0.0136 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0235 0.1121
Toxoplasma gondii thioredoxin reductase 0.0039 0.0184 0.2136
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0029 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0112 0.0533
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0029 0.0029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0761
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.05
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0761
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0452 0.5337
Loa Loa (eye worm) hypothetical protein 0.0135 0.1108 0.1108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.1316 0.1316
Echinococcus granulosus hypothetical protein 0.0027 0.0072 0.0072
Trichomonas vaginalis set domain proteins, putative 0.025 0.222 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0235 0.2379
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0235 0.2379
Loa Loa (eye worm) RNA binding protein 0.0137 0.1128 0.1128
Echinococcus granulosus protein quaking 0.0027 0.0072 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0893 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0528 0.2276
Trypanosoma brucei hypothetical protein 0.0113 0.0893 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0667 0.856
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0647 1
Brugia malayi hypothetical protein 0.0027 0.0072 0.0072
Trypanosoma brucei metacaspase MCA3 0.0046 0.0248 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0517 0.1132
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0358 0.3919
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0197 0.2715
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0517 0.1132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2094 0.2094
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0358 0.1709
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.4342 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0196 0.0196
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0235 0.0235
Toxoplasma gondii hypothetical protein 0.003 0.0097 0.0649
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0893 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0358 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0112 0.0533
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0121 0.0972 0.0972
Onchocerca volvulus 0.0074 0.0517 0.2331
Schistosoma mansoni hypothetical protein 0.0027 0.0072 0.0342
Brugia malayi beta-lactamase family protein 0.0074 0.0517 0.0517
Brugia malayi RNA binding protein 0.0137 0.1128 0.1128
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0197 0.0197
Echinococcus granulosus muscleblind protein 0.1058 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0305 0.1258
Schistosoma mansoni caspase-3 (C14 family) 0.0121 0.0972 0.4644
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0285 0.0285
Trichomonas vaginalis esterase, putative 0.0074 0.0517 0.2229
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0235 0.0235
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Echinococcus multilocularis acetylcholinesterase 0.0136 0.1118 0.1118
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0218 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0197 0.1941
Brugia malayi Probable ClpP-like protease 0.0087 0.0647 0.0647
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0647 1
Brugia malayi hypothetical protein 0.0026 0.0059 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0763 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0029 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2094 0.2094
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0248 0.3835
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0528 0.7972
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0763 0.1701
Echinococcus multilocularis tar DNA binding protein 0.0137 0.1128 0.1128
Trypanosoma brucei protein kinase, putative 0.0052 0.0305 0.319
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0658 0.2966
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0667 0.1479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2094 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0305 0.319
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0197 0.0766
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0517 0.0517
Echinococcus multilocularis carboxylesterase 5A 0.0136 0.1118 0.1118
Echinococcus multilocularis acetylcholinesterase 0.0136 0.1118 0.1118
Loa Loa (eye worm) carboxylesterase 0.0136 0.1118 0.1118
Leishmania major hypothetical protein, conserved 0.0074 0.0517 0.5652
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1927 0.1927
Schistosoma mansoni alpha glucosidase 0.004 0.0196 0.0935
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0305 0.319
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Conserved protein 0.0074 0.0517 0.1132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0486 0.0486
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0305 0.0305
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.007 0.0486 0.2319
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0235 0.0938
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0248 0.3221
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0893 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0528 0.5772
Mycobacterium ulcerans putative regulatory protein 0.0053 0.0314 0.4615
Echinococcus granulosus caspase 0.0121 0.0972 0.0972
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1128 0.5388
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0528 0.2276
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0121 0.0972 0.0972
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0112 0.0112
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0358 0.0358
Echinococcus granulosus neuroligin 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0088 0.0658 0.0658
Brugia malayi beta-lactamase 0.0074 0.0517 0.0517
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Loa Loa (eye worm) carboxylesterase 0.0023 0.0029 0.0029
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0517 0.0517
Onchocerca volvulus 0.0053 0.032 0.1442
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0112 0.0533
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0235 0.2379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2094 0.2094
Mycobacterium tuberculosis Probable reductase 0.0089 0.0667 0.1479
Echinococcus multilocularis aryl hydrocarbon receptor 0.0153 0.1286 0.1286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Schistosoma mansoni inositol monophosphatase 0.0075 0.0528 0.2521
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0197 0.0033
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0196 0.0196
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0761
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1128 0.5388
Loa Loa (eye worm) hypothetical protein 0.0046 0.0248 0.0248
Entamoeba histolytica hypothetical protein 0.007 0.0486 0.8731
Schistosoma mansoni lipoxygenase 0.0056 0.0346 0.1653
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0517 0.0517
Trypanosoma brucei Metacaspase-4 0.0046 0.0248 0.2535
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0235 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0517 0.5652
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0647 1
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0517 0.7996
Plasmodium falciparum glutathione reductase 0.0039 0.0184 0.2849
Mycobacterium tuberculosis Conserved protein 0.0074 0.0517 0.1132
Onchocerca volvulus Huntingtin homolog 0.0119 0.0954 0.4296
Plasmodium vivax glutathione reductase, putative 0.0039 0.0184 0.2849
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Brugia malayi tumor suppressor. 0.0324 0.2927 0.2927
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2094 0.2094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Brugia malayi Carboxylesterase family protein 0.0023 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0517 0.5652
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0029 0.0139
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0839 0.0839
Loa Loa (eye worm) beta-lactamase 0.0074 0.0517 0.0517
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.05 0.05
Plasmodium vivax metacaspase 1, putative 0.0046 0.0248 0.3835
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0761
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0346 0.0346
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0528 0.5772
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0528 0.5772
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0761
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0305 0.1258
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0358 0.0358
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0763 0.1701
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0305 0.0305
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.1556 0.1556
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 1
Schistosoma mansoni hypothetical protein 0.005 0.0285 0.1361
Echinococcus multilocularis caspase 2 0.0088 0.0658 0.0658
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0305 1
Brugia malayi hypothetical protein 0.007 0.0486 0.0486
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0197 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1128 0.5388
Plasmodium vivax SET domain protein, putative 0.0032 0.0112 0.1726
Brugia malayi hypothetical protein 0.0119 0.0954 0.0954
Brugia malayi beta-lactamase family protein 0.0074 0.0517 0.0517
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 1
Mycobacterium leprae Probable lipase LipE 0.0074 0.0517 0.6315
Brugia malayi glutathione reductase 0.0039 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0032 0.0112 0.0112
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0647 0.309
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0184 0.0184
Brugia malayi TAR-binding protein 0.0137 0.1128 0.1128
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0452 0.0981
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0517 0.2229
Echinococcus multilocularis muscleblind protein 1 0.1058 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1556 0.1556
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0528 0.8069
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0248 0.2535
Schistosoma mansoni hypothetical protein 0.005 0.0285 0.1361
Onchocerca volvulus 0.0023 0.0029 0.0131
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0285 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1128 0.5388
Loa Loa (eye worm) tumor suppressor 0.0324 0.2927 0.2927
Schistosoma mansoni tsg101-related 0.006 0.0384 0.1836
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0235 0.0235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0893 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0517 0.1132
Trypanosoma brucei metacaspase MCA2 0.0046 0.0248 0.2535
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0667 0.1479
Echinococcus granulosus GPCR family 2 0.005 0.0285 0.0285
Mycobacterium ulcerans hypothetical protein 0.0074 0.0517 0.7902
Echinococcus multilocularis transfer RNA-Lys 0.0053 0.0314 0.0314
Trypanosoma cruzi metacaspase, putative 0.0046 0.0248 0.2535
Entamoeba histolytica hypothetical protein 0.007 0.0486 0.8731
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0196 0.0196
Echinococcus multilocularis neuroligin 0.0023 0.0029 0.0029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 1
Echinococcus granulosus caspase 3 0.0075 0.0532 0.0532
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0248 0.3221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.2094 0.2094
Echinococcus granulosus single minded 2 0.0053 0.0314 0.0314
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0235 0.2379
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.007 0.0486 0.8731
Brugia malayi Carboxylesterase family protein 0.0023 0.0029 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0235 0.1171
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Loa Loa (eye worm) hypothetical protein 0.1058 1 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0112 0.0112
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0305 0.319
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0305 0.0305
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0235 0.3504
Mycobacterium ulcerans beta-lactamase 0.0074 0.0517 0.7902
Onchocerca volvulus 0.0074 0.0517 0.2331
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0358 0.0358
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0184 0.1797
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0517 0.7902
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0517 0.2229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0197 0.0197
Schistosoma mansoni alpha-glucosidase 0.0156 0.1313 0.6271
Schistosoma mansoni hypothetical protein 0.0027 0.0072 0.0342
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0029 0.0029
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0197 0.0197
Schistosoma mansoni alpha-glucosidase 0.0156 0.1313 0.6271
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0112 0.0112
Mycobacterium ulcerans lipase LipD 0.0074 0.0517 0.7902
Plasmodium falciparum metacaspase 1 0.0046 0.0248 0.3835
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0197 0.1941
Onchocerca volvulus 0.0023 0.0029 0.0131
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0517 0.5652
Loa Loa (eye worm) hypothetical protein 0.0087 0.0647 0.0647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0112 0.0533
Loa Loa (eye worm) hypothetical protein 0.0044 0.0235 0.0235
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Trypanosoma cruzi metacaspase, putative 0.0046 0.0248 0.2535
Schistosoma mansoni hypothetical protein 0.0107 0.0839 0.4005
Onchocerca volvulus 0.0074 0.0517 0.2331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0839 0.0839
Echinococcus granulosus acetylcholinesterase 0.0136 0.1118 0.1118
Echinococcus multilocularis protein quaking 0.0027 0.0072 0.0072
Loa Loa (eye worm) inositol-1 0.0075 0.0528 0.0528
Loa Loa (eye worm) acetylcholinesterase 1 0.0136 0.1118 0.1118
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0248 0.1185
Plasmodium falciparum thioredoxin reductase 0.0039 0.0184 0.2849
Leishmania major trypanothione reductase 0.0039 0.0184 0.1797
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0196 0.2329
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0184 0.036
Onchocerca volvulus 0.0023 0.0029 0.0131
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0647 0.0647
Brugia malayi Carboxylesterase family protein 0.0023 0.0029 0.0029
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0235 0.0235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0305 0.319
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0248 0.0248
Brugia malayi Carboxylesterase family protein 0.0136 0.1118 0.1118
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0305 0.4182
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0893 1
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0528 0.0528
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0059 0.0907
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1128 0.5388
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0113 0.0893 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0358 0.1709
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0647 0.0647
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0517 0.1132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0197 0.1941
Trichomonas vaginalis hypothetical protein 0.0035 0.0145 0.0529
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0248 0.2535
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0184 0.2849
Loa Loa (eye worm) hypothetical protein 0.0153 0.128 0.128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0763 0.1701
Loa Loa (eye worm) hypothetical protein 0.0119 0.0954 0.0954
Trypanosoma cruzi metacaspase, putative 0.0046 0.0248 0.2535
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0658 0.3145
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0358 0.0358
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0647 0.8262
Schistosoma mansoni aryl hydrocarbon receptor 0.0206 0.1792 0.8561
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0285 0.0285
Onchocerca volvulus 0.0043 0.0218 0.0982
Echinococcus granulosus aryl hydrocarbon receptor 0.0153 0.1286 0.1286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2094 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0136 0.1118 0.5338
Brugia malayi Latrophilin receptor protein 2 0.005 0.0285 0.0285
Brugia malayi Thioredoxin reductase 0.0039 0.0184 0.0184
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 0.5
Schistosoma mansoni ap endonuclease 0.004 0.0197 0.094
Onchocerca volvulus Huntingtin homolog 0.0119 0.0954 0.4296
Loa Loa (eye worm) hypothetical protein 0.0119 0.0954 0.0954
Onchocerca volvulus 0.0023 0.0029 0.0131
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0305 0.1455
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0218 0.0218
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0059 0.0342
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0517 0.1132
Loa Loa (eye worm) glutathione reductase 0.0039 0.0184 0.0184
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0667 0.1479
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0342
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0305 0.0305
Brugia malayi bHLH-PAS transcription factor 0.0053 0.0314 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0517 0.2471
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0517 0.7902
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0235 0.1121
Toxoplasma gondii ABC1 family protein 0.0074 0.0517 0.7796
Loa Loa (eye worm) carboxylesterase 0.0023 0.0029 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0305 0.1258
Echinococcus granulosus caspase 8 0.0046 0.0248 0.0248
Brugia malayi Cell death protein 3 precursor 0.0088 0.0658 0.0658
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0097 0.1497
Trypanosoma brucei metacaspase 0.0046 0.0248 0.2535
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0358 0.0358
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0189 0.0189
Brugia malayi jmjC domain containing protein 0.0057 0.0358 0.0358
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0517 0.1132
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0517 0.2229
Echinococcus multilocularis caspase 8 0.0046 0.0248 0.0248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0517 0.1132
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0528 0.735
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0528 0.0528
Onchocerca volvulus 0.0023 0.0029 0.0131
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0112 0.0901
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0134 0.1102 0.1102
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1556 0.1556
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0248 0.2535
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Schistosoma mansoni caspase-7 (C14 family) 0.0121 0.0972 0.4644
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0305 0.319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0285 0.0285
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.1556 0.1556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.2094 0.2094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0517 0.2471
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0305 0.1258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0486 0.0486
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0893 1
Entamoeba histolytica hypothetical protein 0.007 0.0486 0.8731
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0517 0.2229
Trypanosoma brucei glucosidase, putative 0.004 0.0196 0.1928
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0029 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0528 0.5772
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0029 0.0029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.01 0.01
Trypanosoma brucei calpain, putative 0.0113 0.0893 1
Brugia malayi Inositol-1 0.0075 0.0528 0.0528
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0358 0.0762
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0305 0.0305
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0486 0.2319
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0517 0.6315
Schistosoma mansoni ap endonuclease 0.004 0.0197 0.094
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0235 0.0235
Echinococcus multilocularis caspase 0.0121 0.0972 0.0972
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0059
Schistosoma mansoni gliotactin 0.0023 0.0029 0.0139
Trypanosoma brucei trypanothione reductase 0.0039 0.0184 0.1797
Schistosoma mansoni hypothetical protein 0.005 0.0285 0.1361
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0528 1
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.1128 0.1128
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0196 0.0761
Brugia malayi Carboxylesterase family protein 0.0136 0.1118 0.1118
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) TAR-binding protein 0.0137 0.1128 0.1128
Brugia malayi MAP kinase sur-1 0.0052 0.0305 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.1316 0.1316
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0528 0.2276
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0285 0.0285
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0517 0.2229
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.0907
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0029 0.0029
Echinococcus granulosus acetylcholinesterase 0.0136 0.1118 0.1118
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0235 0.0235
Echinococcus granulosus caspase 2 0.0088 0.0658 0.0658
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0197 0.3042
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0097 0.1497
Loa Loa (eye worm) hypothetical protein 0.0156 0.1316 0.1316
Leishmania major hypothetical protein, conserved 0.0026 0.0059 0.0342
Brugia malayi jmjC domain containing protein 0.0057 0.0358 0.0358
Echinococcus multilocularis muscleblind protein 0.1058 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.0907
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0029 0.0139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0947 0.8934 0.8934
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0196 0.1928
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0358 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.1928
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0248 0.1
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0029 0.0029
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0647 0.5
Onchocerca volvulus 0.025 0.222 1
Echinococcus multilocularis caspase 3 0.0075 0.0532 0.0532
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0197 0.1941
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0235 0.0938
Onchocerca volvulus 0.0032 0.0112 0.0503
Leishmania major metacaspase, putative 0.0046 0.0248 0.2535
Echinococcus granulosus tar DNA binding protein 0.0137 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0043 0.0218 0.0218
Brugia malayi Carboxylesterase family protein 0.0023 0.0029 0.0029
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0248 0.3221
Schistosoma mansoni hypothetical protein 0.0043 0.0218 0.1041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0248 0.1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0197 0.0766
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0517 0.0517
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0517 0.1132
Toxoplasma gondii exonuclease III APE 0.004 0.0197 0.2348
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0305 0.319
Brugia malayi hypothetical protein 0.0043 0.0218 0.0218
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0029 0.0139
Brugia malayi PAS domain containing protein 0.0071 0.0492 0.0492
Schistosoma mansoni inositol monophosphatase 0.0075 0.0528 0.2521
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0517
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0134 0.1102 0.1102
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0667 0.1479
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0667 0.1479
Brugia malayi Pre-SET motif family protein 0.022 0.1927 0.1927
Plasmodium falciparum metacaspase-like protein 0.0046 0.0248 0.3835
Schistosoma mansoni single-minded 0.0071 0.0492 0.235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2094 1
Trypanosoma cruzi metacaspase, putative 0.0046 0.0248 0.2535
Onchocerca volvulus 0.0105 0.0819 0.369
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0197 0.1817
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0305 0.319
Loa Loa (eye worm) hypothetical protein 0.0136 0.1118 0.1118
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0197 0.3042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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