Detailed information for compound 1238818

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.457 | Formula: C21H27N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(OC(=O)C1=NN(C(=O)CC1)c1ccccc1)C)NC1CCCCC1C
  • InChi: 1S/C21H27N3O4/c1-14-8-6-7-11-17(14)22-20(26)15(2)28-21(27)18-12-13-19(25)24(23-18)16-9-4-3-5-10-16/h3-5,9-10,14-15,17H,6-8,11-13H2,1-2H3,(H,22,26)
  • InChiKey: UKPQPLKFCIELAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0292 0.0551
Brugia malayi aspartic protease BmAsp-2, identical 0.0086 0.0574 0.1226
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0841 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.012 0.5
Brugia malayi Muscleblind-like protein 0.0151 0.1194 0.2556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.012 0.5
Echinococcus multilocularis muscleblind protein 0.0151 0.1194 0.2926
Echinococcus multilocularis lamin dm0 0.0054 0.0265 0.065
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.012 0.028
Schistosoma mansoni fatty acid binding protein 0.0034 0.0078 0.0074
Plasmodium vivax aspartyl protease, putative 0.0086 0.0574 0.1461
Plasmodium falciparum plasmepsin X 0.0086 0.0574 0.1461
Echinococcus granulosus Smad4 0.0026 0.0004 0.0009
Schistosoma mansoni ap endonuclease 0.0039 0.012 0.0117
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Loa Loa (eye worm) hypothetical protein 0.0086 0.0574 0.1233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0782 0.1671
Schistosoma mansoni ap endonuclease 0.0039 0.012 0.0117
Loa Loa (eye worm) aspartyl protease 6 0.0086 0.0574 0.1233
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0004 0.0009
Schistosoma mansoni hypothetical protein 0.0034 0.0078 0.0075
Brugia malayi hypothetical protein 0.0036 0.01 0.0207
Schistosoma mansoni hypothetical protein 0.0034 0.0078 0.0075
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.4079 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0841 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0364 0.3228 0.7914
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0364 0.3228 0.7914
Trypanosoma brucei polo-like protein kinase 0.0114 0.0841 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0078 0.0168
Onchocerca volvulus 0.0086 0.0574 0.5367
Schistosoma mansoni cathepsin D (A01 family) 0.1074 1 1
Echinococcus multilocularis Smad4 0.0026 0.0004 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Plasmodium falciparum plasmepsin IV 0.0364 0.3228 1
Plasmodium vivax aspartyl proteinase, putative 0.0086 0.0574 0.1461
Toxoplasma gondii aspartyl protease ASP1 0.0364 0.3228 1
Loa Loa (eye worm) Smad1 0.0026 0.0004 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Loa Loa (eye worm) hypothetical protein 0.0086 0.0574 0.1233
Plasmodium falciparum plasmepsin I 0.0364 0.3228 1
Echinococcus multilocularis fatty acid binding protein FABP2 0.0034 0.0078 0.019
Brugia malayi MH2 domain containing protein 0.0386 0.3435 0.737
Echinococcus multilocularis geminin 0.0166 0.1338 0.328
Schistosoma mansoni hypothetical protein 0.0034 0.0078 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0841 0.1806
Plasmodium falciparum plasmepsin VI 0.0364 0.3228 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0004 0.0008
Plasmodium falciparum plasmepsin IX 0.0086 0.0574 0.1461
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.01 0.0096
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.012 0.0251
Loa Loa (eye worm) hypothetical protein 0.0074 0.0456 0.0979
Echinococcus granulosus smad 0.0026 0.0004 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0004 0.0009
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0841 0.2063
Schistosoma mansoni hypothetical protein 0.0166 0.1338 0.1335
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0364 0.3228 1
Schistosoma mansoni fatty acid binding protein 0.0034 0.0078 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.012 0.5
Schistosoma mansoni lamin 0.0054 0.0265 0.0262
Loa Loa (eye worm) MH2 domain-containing protein 0.0386 0.3435 0.7372
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0004 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.012 0.0259
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0514 0.4659 1
Loa Loa (eye worm) transcription factor SMAD2 0.0386 0.3435 0.7372
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.4079 1
Onchocerca volvulus 0.0086 0.0574 0.5367
Giardia lamblia Kinase, PLK 0.0114 0.0841 1
Plasmodium falciparum plasmepsin II 0.0364 0.3228 1
Toxoplasma gondii aspartyl protease 0.0086 0.0574 0.1461
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0514 0.4659 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0004 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Brugia malayi aspartic protease BmAsp-1, identical 0.0086 0.0574 0.1226
Echinococcus granulosus muscleblind protein 0.0151 0.1194 0.2926
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0086 0.0574 0.1233
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0265 0.0569
Echinococcus granulosus neuropeptide s receptor 0.0453 0.4079 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0841 1
Brugia malayi Pepsin A precursor 0.0086 0.0574 0.1226
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0078 0.016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0782 0.1678
Plasmodium vivax aspartyl protease, putative 0.0086 0.0574 0.1461
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0078 0.016
Echinococcus granulosus lamin dm0 0.0054 0.0265 0.065
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0456 0.0972
Loa Loa (eye worm) hypothetical protein 0.0364 0.3228 0.6929
Brugia malayi Eukaryotic aspartyl protease family protein 0.0086 0.0574 0.1226
Schistosoma mansoni hypothetical protein 0.0166 0.1338 0.1335
Schistosoma mansoni kinase 0.0058 0.0306 0.0303
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0364 0.3228 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0292 0.0551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.01 0.0245
Loa Loa (eye worm) hypothetical protein 0.0151 0.1194 0.2562
Brugia malayi intermediate filament protein 0.0054 0.0265 0.0562
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0841 0.2063
Schistosoma mansoni hypothetical protein 0.0074 0.0456 0.0453
Schistosoma mansoni hypothetical protein 0.0036 0.01 0.0096
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0364 0.3228 0.6929
Echinococcus multilocularis musashi 0.0054 0.0265 0.065
Plasmodium falciparum plasmepsin V 0.0086 0.0574 0.1461
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0841 0.18
Plasmodium falciparum plasmepsin III 0.0086 0.0574 0.1461
Echinococcus granulosus geminin 0.0166 0.1338 0.328
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0086 0.0574 0.0571
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0078 0.0192
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0027 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0078 0.0192
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0841 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0265 0.0262
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.012 0.5
Echinococcus granulosus lamin 0.0054 0.0265 0.065
Plasmodium vivax aspartyl proteinase, putative 0.0364 0.3228 1
Echinococcus granulosus fatty acid binding protein FABP2 0.0034 0.0078 0.019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.012 0.0295
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0004 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.012 0.0295
Brugia malayi hypothetical protein 0.0086 0.0574 0.1226
Schistosoma mansoni lamin 0.0054 0.0265 0.0262
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0168
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0086 0.0574 0.1461
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0078 0.0192
Toxoplasma gondii aspartyl protease ASP3 0.0086 0.0574 0.1461
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0841 0.0838
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0782 0.1671
Schistosoma mansoni memapsin-2 (A01 family) 0.0086 0.0574 0.0571
Plasmodium falciparum plasmepsin VII 0.0086 0.0574 0.1461
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1194 0.2926
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0027 0.0058
Loa Loa (eye worm) hypothetical protein 0.0054 0.0265 0.0569
Echinococcus multilocularis fatty acid binding protein FABP2 0.0034 0.0078 0.019
Echinococcus granulosus GPCR family 2 0.0034 0.0078 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Echinococcus granulosus intermediate filament protein 0.0054 0.0265 0.065
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0364 0.3228 0.3226
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.4079 1
Echinococcus multilocularis lamin 0.0054 0.0265 0.065
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0265 0.0562
Loa Loa (eye worm) hypothetical protein 0.0151 0.1194 0.2562
Echinococcus multilocularis GPCR, family 2 0.0034 0.0078 0.0192
Plasmodium vivax plasmepsin IV, putative 0.0364 0.3228 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0256 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0841 0.232
Plasmodium vivax aspartyl protease, putative 0.0086 0.0574 0.1461
Echinococcus granulosus fatty acid binding protein FABP2 0.0034 0.0078 0.019
Loa Loa (eye worm) hypothetical protein 0.0108 0.0782 0.1678
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0078 0.0192
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0265 0.0569
Brugia malayi hypothetical protein 0.0086 0.0574 0.1226
Plasmodium vivax plasmepsin V, putative 0.0086 0.0574 0.1461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.01 0.0245
Schistosoma mansoni hypothetical protein 0.0034 0.0078 0.0075
Echinococcus multilocularis smad 0.0026 0.0004 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0841 1
Plasmodium falciparum plasmepsin VIII, putative 0.0086 0.0574 0.1461

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4744 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5193 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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