TDR Targets

Basic information

Technical information

TDR Targets ID: 1239012
Name: 3-(4-fluorophenyl)sulfonyl-N-(5-thiophen-2-yl -1,3,4-oxadiazol-2-yl)propanamide
MW: 381.402 | Formula: C15H12FN3O4S2
H donors: 1 H acceptors: 5 LogP: 1.61 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1nnc(o1)c1cccs1)CCS(=O)(=O)c1ccc(cc1)F
InChi: 1S/C15H12FN3O4S2/c16-10-3-5-11(6-4-10)25(21,22)9-7-13(20)17-15-19-18-14(23-15)12-2-1-8-24-12/h1-6,8H,7,9H2,(H,17,19,20)
InChiKey: JZRNSNZKIAKZHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(4-fluorophenyl)sulfonyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]propanamide
3-(4-fluorophenyl)sulfonyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]propionamide
ZINC04496317

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0351	0.5
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.2255	0.3629
Schistosoma mansoni	hypothetical protein	0.0205	0.5581	0.6991
Giardia lamblia	Kinase, PLK	0.0093	0.2255	0.2517
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0177	0.4752	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0226	0.6214	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0026	0.0262	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Echinococcus granulosus	geminin	0.0205	0.5581	0.8981
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0551	0.0728
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0026	0.0262	0.0328
Mycobacterium leprae	Conserved hypothetical protein	0.0177	0.4752	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0161	0.0201
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0171	0.4582	0.7374
Brugia malayi	Bromodomain containing protein	0.0038	0.0621	0.055
Trypanosoma brucei	polo-like protein kinase	0.0093	0.2255	0.5
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1089	0.1365
Brugia malayi	glutaminase DH11.1	0.0264	0.7348	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0026	0.0262	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0896	0.1199
Loa Loa (eye worm)	MBCTL1	0.0053	0.1089	0.1462
Onchocerca volvulus		0.0029	0.036	0.0101
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0026	0.0262	0.0333
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1089	0.1753
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0552	0.0889
Onchocerca volvulus	Alhambra homolog	0.0029	0.0351	0.0091
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.7913	1
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.2255	0.2825
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.2255	1
Brugia malayi	jmjC domain containing protein	0.0094	0.2285	0.2887
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2255	0.5
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0161	0.0258
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0226	0.6214	0.8407
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1037	0.1134
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0226	0.6214	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0177	0.4752	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0026	0.0262	0.0422
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0046	0.0859	0.1383
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0958	0.1283
Mycobacterium ulcerans	hypothetical protein	0.0177	0.4752	0.5793
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.2285	0.3677
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0171	0.4582	0.6115
Echinococcus granulosus	Transglutaminase	0.0177	0.4752	0.7648
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Brugia malayi	Bromodomain containing protein	0.0031	0.042	0.0268
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.6319	0.7738
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0262	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1089	0.1462
Plasmodium vivax	SET domain protein, putative	0.0029	0.036	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0226	0.6214	0.7784
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0351	0.0455
Echinococcus multilocularis	glycine receptor subunit beta	0.0026	0.0262	0.0422
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.2255	0.2046
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1256	0.1689
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0226	0.6214	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0171	0.4582	0.7374
Mycobacterium ulcerans	transglutaminase family protein	0.0177	0.4752	0.5793
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.2285	0.3677
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0684	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.7913	1
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Loa Loa (eye worm)	glutaminase 2	0.0264	0.7348	1
Mycobacterium tuberculosis	Hypothetical protein	0.0177	0.4752	1
Brugia malayi	mbt repeat family protein	0.0047	0.0896	0.0936
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0896	0.1123
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0896	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Onchocerca volvulus		0.0229	0.6319	0.622
Mycobacterium leprae	Conserved hypothetical protein	0.0177	0.4752	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0171	0.4582	0.7374
Brugia malayi	Cation transporter family protein	0.0026	0.0262	0.0045
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0226	0.6214	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0026	0.0262	0.0422
Echinococcus granulosus	glycine receptor subunit beta	0.0026	0.0262	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0351	0.0455
Brugia malayi	Cation transporter family protein	0.0026	0.0262	0.0045
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0171	0.4582	0.7374
Echinococcus multilocularis	nAChR subunit	0.0026	0.0262	0.0422
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.4999	0.8045
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0171	0.4582	0.7374
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0026	0.0262	0.0422
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.036	0.0451
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0226	0.6214	0.8453
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0226	0.6214	0.7784
Loa Loa (eye worm)	hypothetical protein	0.007	0.157	0.2117
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.3611	0.6804
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.1066	0.143
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0262	0.0328
Schistosoma mansoni	glutaminase	0.0264	0.7348	0.9204
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0171	0.4582	0.6227
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Loa Loa (eye worm)	hypothetical protein	0.004	0.0693	0.0921
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Loa Loa (eye worm)	glutaminase	0.0264	0.7348	1
Schistosoma mansoni	hypothetical protein	0.002	0.0105	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0859	0.1148
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0026	0.0262	0.0328
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0026	0.0262	0.0045
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1713	0.2145
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1089	0.1208
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1089	0.1753
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0586	0.0734
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1089	0.1753
Brugia malayi	Bromodomain containing protein	0.0074	0.1695	0.2058
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0896	0.1443
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0262	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1037	0.1391
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0026	0.0262	0.0422
Brugia malayi	Pre-SET motif family protein	0.0029	0.036	0.0183
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0026	0.0262	0.0045
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0262	0.0328
Brugia malayi	Cation transporter family protein	0.0026	0.0262	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0623	0.0826
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.036	1
Brugia malayi	Thioredoxin family protein	0.0177	0.4752	0.6354
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0105	0.0118
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.1179	0.1477
Echinococcus granulosus	zinc finger protein	0.0019	0.0074	0.0119
Brugia malayi	Pre-SET motif family protein	0.0202	0.5491	0.7392
Echinococcus multilocularis	zinc finger protein	0.0019	0.0074	0.0119
Brugia malayi	PHD-finger family protein	0.0029	0.0351	0.017
Schistosoma mansoni	zinc finger protein	0.0019	0.0074	0.0092
Giardia lamblia	Fructose-bisphosphate aldolase	0.0283	0.7913	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0283	0.7913	0.5
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0351	0.0565
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0262	0.0328
Mycobacterium ulcerans	putative transglutaminase-like protein	0.0177	0.4752	0.5793
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1089	0.1753
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0171	0.4582	0.7374
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0586	0.0734
Echinococcus granulosus	glycine receptor subunit beta	0.0026	0.0262	0.0422
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0351	0.044
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0552	0.0889
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0026	0.0262	0.0045
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.1179	0.1898
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.4467	0.511
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0026	0.0262	0.0422
Echinococcus granulosus	histone lysine methyltransferase setb	0.0046	0.0859	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.4999	0.8045
Giardia lamblia	Hypothetical protein	0.0177	0.4752	0.582
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Schistosoma mansoni	hypothetical protein	0.0177	0.4752	0.5954
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.1247	0.2007
Echinococcus granulosus	peregrin	0.0031	0.042	0.0676
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.2255	0.2845
Schistosoma mansoni	hypothetical protein	0.0285	0.7983	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.3611	0.3942
Loa Loa (eye worm)	ACC-1 protein	0.0026	0.0262	0.0333
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.5491	0.7468
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0262	0.0422
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.036	0.0451
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0026	0.0262	0.0422
Loa Loa (eye worm)	ACC-1 protein	0.0026	0.0262	0.0333
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.036	0.058
Schistosoma mansoni	kinase	0.0047	0.0901	0.1128
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0859	0.1076
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0896	0.1443
Schistosoma mansoni	hypothetical protein	0.0035	0.0551	0.0691
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0026	0.0262	0.0045
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.7913	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1037	0.1134
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0026	0.0262	0.0422
Loa Loa (eye worm)	LGC-31 protein	0.0026	0.0262	0.0333
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.1179	0.1898
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0026	0.0262	0.0045
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0161	0.0258
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0859	0.1076
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0586	0.0943
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.053	0.0853
Brugia malayi	excitatory GABA receptor EXP-1A	0.0026	0.0262	0.0045
Trichomonas vaginalis	peptide N-glycanase, putative	0.0177	0.4752	0.5516
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2255	0.5
Schistosoma mansoni	nAChR subunit	0.0026	0.0262	0.0328
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0896	0.1443
Mycobacterium tuberculosis	Long conserved protein	0.0177	0.4752	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0351	0.044
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0329	0.0529
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0896	0.1123
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0226	0.6214	0.7784
Echinococcus multilocularis	glycine receptor subunit beta	0.0026	0.0262	0.0422
Brugia malayi	mbt repeat family protein	0.0047	0.0896	0.0936
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0896	0.0651
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0171	0.4582	0.6227
Trichomonas vaginalis	glutaminase, putative	0.0264	0.7348	0.9197
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1037	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0172	0.4606	0.626
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0551	0.0452
Onchocerca volvulus	Putative nachr subunit	0.0171	0.4582	0.4436
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0026	0.0262	0.0422
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0586	0.0775
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.1247	0.2007
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Onchocerca volvulus		0.0047	0.0896	0.0651
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.2255	0.3629
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0351	0.0565
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0262	0.0045
Echinococcus granulosus	nAChR subunit	0.0026	0.0262	0.0422
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0026	0.0262	0.0333
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.2255	0.3052
Giardia lamblia	Transglutaminase/protease, putative	0.0177	0.4752	0.582
Mycobacterium ulcerans	glutaminase	0.0264	0.7348	1
Schistosoma mansoni	hypothetical protein	0.0205	0.5581	0.6991
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0026	0.0262	0.0333
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0896	0.1199
Mycobacterium ulcerans	hypothetical protein	0.0177	0.4752	0.5793
Echinococcus multilocularis	Transglutaminase	0.0177	0.4752	0.7648
Echinococcus multilocularis	geminin	0.0205	0.5581	0.8981
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2255	0.1973
Echinococcus multilocularis	peregrin	0.0031	0.042	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0172	0.4606	0.6149
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0026	0.0262	0.0045
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.1179	0.1334
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0262	0.0045
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0684	0.1101
Mycobacterium tuberculosis	Conserved protein	0.0177	0.4752	1
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0896	0.1443
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0026	0.0262	0.0333
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0026	0.0262	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0262	0.0333
Schistosoma mansoni	bromodomain containing protein	0.0062	0.1352	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0749	0.0997
Brugia malayi	jmjC domain containing protein	0.0037	0.0586	0.05

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1318132

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1239012