Detailed information for compound 1248360

Basic information

Technical information
  • TDR Targets ID: 1248360
  • Name: (E)-4-[[6-(7-chloroquinazolin-4-yl)oxypyridin -3-yl]amino]-4-oxobut-2-enoic acid
  • MW: 370.747 | Formula: C17H11ClN4O4
  • H donors: 2 H acceptors: 6 LogP: 2.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(nc1)Oc1ncnc2c1ccc(c2)Cl)/C=C/C(=O)O
  • InChi: 1S/C17H11ClN4O4/c18-10-1-3-12-13(7-10)20-9-21-17(12)26-15-5-2-11(8-19-15)22-14(23)4-6-16(24)25/h1-9H,(H,22,23)(H,24,25)/b6-4+
  • InChiKey: LWVDNUDCNQDWIX-GQCTYLIASA-N  


Substructure search Similarity search

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Synonyms

  • (E)-4-[[6-(7-chloroquinazolin-4-yl)oxy-3-pyridyl]amino]-4-oxo-but-2-enoic acid
  • (E)-4-[[6-[(7-chloro-4-quinazolinyl)oxy]-3-pyridyl]amino]-4-oxobut-2-enoic acid
  • (E)-4-[[6-(7-chloroquinazolin-4-yl)oxy-3-pyridyl]amino]-4-keto-but-2-enoic acid
  • (E)-4-[[6-(7-chloroquinazolin-4-yl)oxypyridin-3-yl]amino]-4-oxo-but-2-enoic acid
  • 4-({6-[(7-chloro-4-quinazolinyl)oxy]-3-pyridinyl}amino)-4-oxo-2-butenoic acid
  • MLS000850376
  • SMR000456394

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0188 0.5264 0.9323
Schistosoma mansoni ap endonuclease 0.0037 0.0823 0.1854
Trypanosoma brucei trypanothione reductase 0.0046 0.1087 0.573
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1222 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1022 0.2359
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3143 0.7578
Brugia malayi Cell death protein 3 precursor 0.0027 0.0554 0.0836
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0823 0.4218
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0213 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1222 0.6693
Echinococcus granulosus nibrin 0.0012 0.0097 0.0032
Leishmania major hypothetical protein, conserved 0.005 0.1222 0.6693
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0213 0.1334
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0215 0.1352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0823 0.1578
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1825 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.8613 0.86
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3143 0.7578
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0097 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0588 0.0894
Brugia malayi Thioredoxin reductase 0.0046 0.1087 0.1798
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0376 0.0539
Onchocerca volvulus 0.0028 0.0567 0.0739
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0215 0.071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0376 0.0512
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0823 0.6576
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1825 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0214 0.0224
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0823 0.1321
Echinococcus granulosus GPCR family 2 0.0016 0.0214 0.0706
Loa Loa (eye worm) hypothetical protein 0.0027 0.0552 0.0829
Echinococcus multilocularis nibrin 0.0012 0.0097 0.0032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.2802 0.6793
Plasmodium falciparum glutathione reductase 0.0046 0.1087 0.8848
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0213 0.0222
Plasmodium vivax glutathione reductase, putative 0.0046 0.1087 0.8848
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Echinococcus granulosus caspase 0.0027 0.0554 0.2666
Trypanosoma brucei metacaspase 0.0027 0.0554 0.2643
Schistosoma mansoni topbp1 0.0012 0.0097 0.0014
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0554 0.2666
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0668
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0588 0.0949
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0567 0.0856
Brugia malayi intermediate filament protein 0.0028 0.0567 0.086
Brugia malayi isocitrate dehydrogenase 0.0016 0.0215 0.0225
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0588 0.3221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0213 0.1591
Schistosoma mansoni hypothetical protein 0.0023 0.0409 0.0806
Brugia malayi hypothetical protein 0.0043 0.1022 0.168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0567 0.0856
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.1222 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0588 0.0898
Loa Loa (eye worm) hypothetical protein 0.0021 0.0376 0.0512
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0213 0.0223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0823 0.4509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0213 0.1334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0823 0.4509
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0144 0.03
Brugia malayi hypothetical protein 0.005 0.1222 0.2039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0144 0.0094
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0563 0.2718
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0342 0.0333
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0215 0.0222
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0823 0.6576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.4079 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0554 0.4265
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0588 0.0949
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0594 0.4609
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0588 0.0495
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.8613 1
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0215 0.0312
Echinococcus multilocularis caspase 0.0027 0.0554 0.2666
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0554 0.2643
Onchocerca volvulus 0.0029 0.0594 0.0781
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.1825 0.3124
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1449 0.794
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1022 0.5366
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0588 0.3221
Treponema pallidum NADH oxidase 0.0016 0.0213 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0588 0.0898
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0588 0.1232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0588 0.0949
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0097 0.0014
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0188 0.5264 0.6068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1022 0.5366
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0213 0.1334
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0823 0.0852
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0588 0.0495
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0187 0.0172
Trypanosoma cruzi metacaspase, putative 0.0027 0.0554 0.3035
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0097 0.0533
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0554 0.4265
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0823 0.0733
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0144 0.03
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Brugia malayi hypothetical protein 0.0032 0.07 0.1099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Echinococcus granulosus global transcription activator snf2l2 0.0068 0.1729 0.9448
Echinococcus multilocularis Chromo domain 0.0012 0.0092 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0215 0.1352
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0823 0.0852
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0213 0.0668
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0588 0.0949
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.013 0.3564 0.8668
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1449 0.1587
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0188 0.5264 0.6068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0823 0.4218
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0213 0.0136
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0951 0.4956
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Onchocerca volvulus 0.0188 0.5264 0.8128
Echinococcus granulosus lamin 0.0028 0.0567 0.2741
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0594 0.2897
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0376 0.2734
Brugia malayi topoisomerase 0.0012 0.0097 0.0014
Brugia malayi BRM protein 0.0068 0.1729 0.2954
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0188 0.5264 0.6068
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0213 0.1166
Entamoeba histolytica hypothetical protein 0.0043 0.1022 0.0934
Schistosoma mansoni DNA ligase IV 0.0012 0.0097 0.0014
Mycobacterium tuberculosis Probable reductase 0.0104 0.2802 0.6697
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0213 0.4147
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.031
Echinococcus multilocularis musashi 0.0028 0.0567 0.2741
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0588 0.0949
Brugia malayi hypothetical protein 0.0012 0.0097 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0342 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0097 0.0533
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0215 0.0225
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0097 0.0342
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0376 0.0422
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0554 0.0718
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0588 0.0949
Brugia malayi Pre-SET motif family protein 0.0201 0.564 1
Loa Loa (eye worm) hypothetical protein 0.005 0.1222 0.2036
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1449 0.794
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0594 0.1274
Loa Loa (eye worm) hypothetical protein 0.0029 0.0588 0.0894
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1219 0.2034
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0188 0.5264 0.5218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0213 0.1166
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0409 0.1833
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0188 0.5264 0.5218
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0215 0.068
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0215 0.071
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0215 0.1352
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2802 0.6697
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0342 0.0333
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0188 0.5264 0.6068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0594 0.1274
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.1825 0.4396
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0213 0.1166
Loa Loa (eye worm) hypothetical protein 0.0029 0.0594 0.0905
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.1825 1
Brugia malayi DKFZp564C0469 protein 0.0012 0.0097 0.0014
Onchocerca volvulus 0.0029 0.0588 0.0772
Toxoplasma gondii thioredoxin reductase 0.0046 0.1087 0.8848
Echinococcus granulosus Chromo domain 0.0012 0.0092 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0588 0.0898
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Plasmodium falciparum glutathione reductase 0.0016 0.0213 0.1334
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0097 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1222 0.6693
Plasmodium vivax metacaspase 1, putative 0.0027 0.0554 0.4265
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0215 0.1177
Plasmodium vivax SET domain protein, putative 0.0029 0.0594 0.4609
Trypanosoma cruzi metacaspase, putative 0.0027 0.0554 0.3035
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0213 0.1166
Brugia malayi hypothetical protein 0.0012 0.0097 0.0014
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.1825 0.3127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.1222 0.6507
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0554 0.2666
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0215 0.068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1219 0.2031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0376 0.0512
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0215 0.1177
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0554 0.1172
Echinococcus multilocularis lamin 0.0028 0.0567 0.2741
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0097 0.0342
Echinococcus granulosus lamin dm0 0.0028 0.0567 0.2741
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0214 0.0706
Trypanosoma brucei metacaspase MCA2 0.0027 0.0554 0.2643
Onchocerca volvulus 0.0229 0.6454 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0213 0.1166
Loa Loa (eye worm) glutathione reductase 0.0046 0.1087 0.1795
Trypanosoma cruzi metacaspase, putative 0.0027 0.0554 0.3035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0097 0.0342
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0214 0.0706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0342 0.0333
Entamoeba histolytica hypothetical protein 0.01 0.2666 0.2594
Entamoeba histolytica hypothetical protein 0.0043 0.1022 0.0934
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0213 0.1334
Trichomonas vaginalis set domain proteins, putative 0.0229 0.6454 0.7465
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0588 0.097
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0097 0.0533
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.1825 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.1825 0.1745
Echinococcus multilocularis caspase 8 0.0027 0.0554 0.2666
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0823 0.42
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0188 0.5264 0.6068
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0823 0.0733
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0097 0.0032
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0097 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0215 0.071
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0213 0.1591
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0588 0.0495
Echinococcus multilocularis global transcription activator snf2l2 0.0068 0.1729 0.9448
Schistosoma mansoni hypothetical protein 0.0043 0.1022 0.2359
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0754 0.1196
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0823 0.0852
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0554 0.4265
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1087 0.8848
Echinococcus multilocularis GPCR, family 2 0.0016 0.0214 0.0706
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0554 0.1172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1087 0.1795
Schistosoma mansoni helicase 0.0068 0.1729 0.4153
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0214 0.0706
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0213 0.0668
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0215 0.0005
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0097 0.0533
Echinococcus multilocularis caspase 2 0.0027 0.0554 0.2666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0129 0.0067
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.4079 1
Trypanosoma cruzi metacaspase, putative 0.0027 0.0554 0.3035
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3143 0.7578
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0215 0.071
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1825 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.8613 0.86
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.4079 0.7706
Plasmodium falciparum thioredoxin reductase 0.0016 0.0213 0.1334
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2802 0.6697
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0214 0.0706
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1449 0.7824
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0554 0.1172
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0823 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0594 0.2897
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1105 0.5847
Schistosoma mansoni ap endonuclease 0.0037 0.0823 0.1854
Brugia malayi glutathione reductase 0.0046 0.1087 0.1798
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1449 0.1587
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0307
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1087 0.5958
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0097 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.2666 0.2594
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0092 0.0004
Leishmania major metacaspase, putative 0.0027 0.0554 0.3035
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.1825 1
Giardia lamblia DNA repair protein RAD52 0.035 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0554 0.1172
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0588 0.0949
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1222 1
Schistosoma mansoni hypothetical protein 0.0034 0.0754 0.1679
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0823 0.1318
Schistosoma mansoni lamin 0.0028 0.0567 0.1205
Mycobacterium ulcerans hypothetical protein 0.0029 0.0588 0.0949
Echinococcus granulosus caspase 8 0.0027 0.0554 0.2666
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0554 0.0836
Loa Loa (eye worm) hypothetical protein 0.0021 0.0376 0.0512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0588 0.097
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0215 0.1352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0376 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0668
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0823 0.1404
Entamoeba histolytica hypothetical protein 0.0043 0.1022 0.0934
Loa Loa (eye worm) hypothetical protein 0.0034 0.0754 0.1193
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0188 0.5264 0.9323
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0213 0.1334
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0213 0.0223
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0214 0.0224
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0554 0.3035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0554 0.0833
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0215 0.071
Entamoeba histolytica hypothetical protein 0.0043 0.1022 0.0934
Loa Loa (eye worm) hypothetical protein 0.0027 0.0554 0.0833
Loa Loa (eye worm) BRM protein 0.0035 0.0773 0.1228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.001
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0554 0.4265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0213 0.1166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0594 0.1274
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0188 0.5264 0.5218
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0213 0.1334
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2802 0.6697
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.8613 0.86
Plasmodium falciparum thioredoxin reductase 0.0046 0.1087 0.8848
Loa Loa (eye worm) hypothetical protein 0.0013 0.0129 0.0067
Trypanosoma brucei metacaspase MCA3 0.0027 0.0554 0.2643
Loa Loa (eye worm) hypothetical protein 0.0016 0.0214 0.0221
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0215 0.1177
Toxoplasma gondii exonuclease III APE 0.0037 0.0823 0.6576
Echinococcus multilocularis lamin dm0 0.0028 0.0567 0.2741
Plasmodium falciparum metacaspase 1 0.0027 0.0554 0.4265
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0588 0.1232
Trypanosoma brucei Metacaspase-4 0.0027 0.0554 0.2643
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.011 0.0015
Echinococcus granulosus intermediate filament protein 0.0028 0.0567 0.2741
Plasmodium falciparum metacaspase-like protein 0.0027 0.0554 0.4265
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0554 0.0536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0376 0.0512
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0187 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0588 0.0894
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0223
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1087 0.2262
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0188 0.5264 1
Leishmania major hypothetical protein, conserved 0.0058 0.1449 0.794
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.011 0.045
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0588 0.3221
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0567 0.0856
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0376 0.2734
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0594 0.2897
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2802 0.6697
Loa Loa (eye worm) hypothetical protein 0.005 0.1219 0.2031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1219 0.2034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0409 0.1833
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.1222 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0594 0.0909
Onchocerca volvulus 0.0028 0.0567 0.0739
Loa Loa (eye worm) BRM protein 0.0043 0.1014 0.1662
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0554 0.0536
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1105 0.5847
Leishmania major trypanothione reductase 0.0046 0.1087 0.5958
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.564 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.8613 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3143 0.7649
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0951 0.4956
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0188 0.5264 0.6068
Schistosoma mansoni hypothetical protein 0.0012 0.0092 0.0001
Schistosoma mansoni topbp1 0.0012 0.0097 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0594 0.1274
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0213 0.0117
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0823 0.4509
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0567 0.086
Schistosoma mansoni lamin 0.0028 0.0567 0.1205
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2802 0.6697
Echinococcus granulosus caspase 2 0.0027 0.0554 0.2666
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0554 0.3035
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0213 0.0698
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0214 0.0221
Schistosoma mansoni intermediate filament proteins 0.0028 0.0567 0.1205
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0215 0.071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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