Detailed information for compound 1256550

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.466 | Formula: C23H27NO2
  • H donors: 2 H acceptors: 2 LogP: 5.94 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C1(C2CCCCCC2)C(=O)Nc2c1cc(C)cc2C
  • InChi: 1S/C23H27NO2/c1-15-13-16(2)21-20(14-15)23(22(26)24-21,17-7-5-3-4-6-8-17)18-9-11-19(25)12-10-18/h9-14,17,25H,3-8H2,1-2H3,(H,24,26)
  • InChiKey: SWKCKBXWFUZBAD-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0274 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Onchocerca volvulus Putative sulfate transporter 0.0613 0.1921 1
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0001 0.0001
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Trypanosoma brucei carbonic anhydrase-like protein 0.1091 0.3433 1
Toxoplasma gondii hypothetical protein 0.0009 0.0009 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0007
Schistosoma mansoni neurotransmitter gated ion channel 0.003 0.0076 0.022
Schistosoma mansoni hypothetical protein 0.0526 0.1643 0.4787
Brugia malayi 6-phosphofructokinase 0.0114 0.0343 0.0997
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0056 0.0157 0.0454
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0058 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0056 0.0056
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0009 0.0024
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0371 0.1154 0.336
Schistosoma mansoni hypothetical protein 0.0321 0.0996 0.2901
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0056 0.024
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0009 0.0023
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0003 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0079 0.0475
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0343 0.0996
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0526 0.1643 0.4786
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Entamoeba histolytica carbonic anhydrase, putative 0.0375 0.1166 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Echinococcus multilocularis cpg binding protein 0.003 0.0077 0.022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus multilocularis carbonic anhydrase II 0.1091 0.3433 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.004 0.0115
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0157 0.0454
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0181 0.0525
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0003 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Onchocerca volvulus 0.0056 0.0157 0.0811
Toxoplasma gondii exonuclease III APE 0.0019 0.004 0.024
Onchocerca volvulus 0.0026 0.0062 0.0318
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0003 0.001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0051 0.0306
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1091 0.3433 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0009 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.004 0.0115
Echinococcus multilocularis nAChR subunit 0.003 0.0076 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Leishmania major DNA polymerase eta, putative 0.002 0.0045 0.0128
Trypanosoma cruzi hypothetical protein 0.0006 0.0001 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0056 0.0157 0.0454
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1091 0.3433 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0009 0.0023
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0003 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0071 0.0206
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0003 0.0003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0003 0.0002
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0056 0.0056
Leishmania major carbonic anhydrase-like protein 0.1091 0.3433 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0003 0.0002
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0526 0.1643 0.4786
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0343 0.0372
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Leishmania major importin beta-1 subunit, putative 0.0024 0.0058 0.0167
Echinococcus multilocularis glycine receptor subunit beta 0.0056 0.0157 0.0454
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1091 0.3433 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0009 0.0026
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0003 0.0002
Schistosoma mansoni cpg binding protein 0.003 0.0077 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0003 0.0003
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0003 0.0014
Onchocerca volvulus 0.0009 0.0009 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.0026 0.0062 0.0181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0056 0.0056
Trypanosoma brucei unspecified product 0.0014 0.0025 0.007
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0026 0.0062 0.0178
Brugia malayi hypothetical protein 0.0009 0.0009 0.0024
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0098 0.029 0.1761
Trichomonas vaginalis helicase, putative 0.0006 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0045 0.0044
Schistosoma mansoni acetylcholine receptor subunit beta 0.0026 0.0062 0.0181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0274 0.0795
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0003 0.0002
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0009 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0001
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0098 0.029 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.0475
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1091 0.3433 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0056 0.0157 0.0454
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0003 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0526 0.1643 0.4786
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0076 0.0219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Mycobacterium leprae Probable transmembrane transport protein 0.0708 0.2222 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0056 0.0157 0.0454
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0045 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Schistosoma mansoni dishevelled 0.0009 0.0009 0.0026
Trypanosoma brucei unspecified product 0.0014 0.0025 0.007
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.018 0.0549 0.1597
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0009 0.0026
Brugia malayi excitatory GABA receptor EXP-1A 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0062 0.0178
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0079 0.1642
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0076 0.0218
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0343 0.0999
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0079 0.0475
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0026 0.0062 0.0178
Brugia malayi hypothetical protein 0.0009 0.0009 0.0024
Echinococcus multilocularis GPCR, family 2 0.0034 0.009 0.0258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0057
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0079 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus multilocularis snurportin 1 0.0321 0.0996 0.2899
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0009 0.0023
Schistosoma mansoni nAChR subunit 0.0026 0.0062 0.0181
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0343 0.0999
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1091 0.3433 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0371 0.1154 0.336
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0003 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0181 0.0528
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0343 0.0996
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0076 0.0219
Toxoplasma gondii hypothetical protein 0.0526 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0001 0.0003
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Onchocerca volvulus 0.0007 0.0003 0.0011
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0056 0.0157 0.0454
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0003 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0056 0.0056
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0074 0.0216 0.0626
Brugia malayi N-terminal motif family protein 0.0006 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0077 0.0223
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0219
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0037 0.0036
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0045 0.0048
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0003 0.0009
Onchocerca volvulus 0.0056 0.0157 0.0811
Schistosoma mansoni nAChR subunit 0.0026 0.0062 0.0181
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0079 1
Brugia malayi N-terminal motif family protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0371 0.1154 0.3359
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0152 0.0922
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0076 0.0458
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0045 0.0048
Brugia malayi Cation transporter family protein 0.0056 0.0157 0.0454
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.004 0.5
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0037 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.3168 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Plasmodium vivax importin-beta 2, putative 0.003 0.0076 0.2603
Echinococcus multilocularis dna polymerase eta 0.002 0.0045 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Schistosoma mansoni ran 0.0022 0.0051 0.0149
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0056 0.0475
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0058 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Entamoeba histolytica hypothetical protein 0.003 0.0076 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0343 0.0997
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0003 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0045 0.0044
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0009 0.0024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0056 0.0157 0.0454
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Onchocerca volvulus Putative nachr subunit 0.0056 0.0157 0.0811
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0056 0.0157 0.0454
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.1362
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.009 0.0258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0023
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0056 0.0157 0.0454
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.004 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0037 0.004
Onchocerca volvulus 0.0029 0.0071 0.0367
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0007
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0009 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0996 0.2899
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Echinococcus multilocularis glycine receptor subunit beta 0.0056 0.0157 0.0454
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0343 0.0342
Schistosoma mansoni carbonic anhydrase 0.0526 0.1643 0.4787
Loa Loa (eye worm) oxidoreductase 0.0007 0.0003 0.0007
Onchocerca volvulus 0.0371 0.1154 0.6003
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0117
Loa Loa (eye worm) LGC-31 protein 0.0056 0.0157 0.0454
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0056 0.0157 0.0454
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0098 0.029 0.1761
Leishmania major DNA polymerase kappa, putative 0.002 0.0045 0.0128
Onchocerca volvulus 0.003 0.0076 0.0389
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.004 0.0115
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0003 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0115
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0026 0.0062 0.0178
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0056 0.0157 0.0454
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0955 0.3 0.3253
Onchocerca volvulus 0.0026 0.0062 0.0318
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Echinococcus granulosus importin subunit beta 1 0.003 0.0076 0.0219
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Onchocerca volvulus 0.0371 0.1154 0.6003
Loa Loa (eye worm) acetylcholine receptor protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0128
Onchocerca volvulus 0.0371 0.1154 0.6003
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Echinococcus granulosus nAChR subunit 0.003 0.0076 0.0218
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0003 0.0006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Onchocerca volvulus 0.0007 0.0003 0.0011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0051 0.0146
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0003 0.0002
Loa Loa (eye worm) ACC-1 protein 0.0056 0.0157 0.0454
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0045 0.0375
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0056 0.0157 0.0454
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0024 0.0058 0.049
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0157 0.0454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0029 0.0071 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.6437
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0079 0.1642
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0056 0.0157 0.0454
Schistosoma mansoni hypothetical protein 0.0074 0.0216 0.0628
Echinococcus granulosus snurportin 1 0.0321 0.0996 0.2899
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0306
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0259
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0001 0.0003
Entamoeba histolytica Ran family GTPase 0.0022 0.0051 0.0429
Echinococcus multilocularis nAChR subunit 0.0056 0.0157 0.0454
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0062 0.0178
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0079 0.0475
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0037 0.1262
Schistosoma mansoni neurotransmitter gated ion channel 0.0026 0.0062 0.0181
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0079 0.2696
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.009 0.0258
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni cpg binding protein 0.0029 0.0071 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0007
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0003 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0181 0.0525
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0009 0.0023
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0117
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0009 0.0023
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0079 0.0475
Schistosoma mansoni dep domain containing protein 0.0009 0.0009 0.0026
Brugia malayi N-terminal motif family protein 0.018 0.0549 0.1597
Mycobacterium ulcerans carbonic anhydrase 0.0375 0.1166 0.1166
Onchocerca volvulus 0.0024 0.0056 0.0288
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0371 0.1154 0.3359
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0343 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0003 0.0002
Brugia malayi RNA, U transporter 1 0.0085 0.0251 0.073
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0026 0.0062 0.0178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0324 0.0942
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0056 0.0157 0.0454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0274 0.0795
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Schistosoma mansoni ran 0.0022 0.0051 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Trypanosoma cruzi hypothetical protein 0.0006 0.0001 0.0001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0343 0.0997
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0324 0.0942
Trichomonas vaginalis conserved hypothetical protein 0.3168 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0039
Brugia malayi DIX domain containing protein 0.0009 0.0009 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Onchocerca volvulus 0.0026 0.0062 0.0318
Loa Loa (eye worm) hypothetical protein 0.0345 0.1073 0.3123
Plasmodium falciparum carbonic anhydrase 0.0526 0.1643 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.004 0.5053
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0051 0.1736
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.004 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0009 0.0024
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0079 0.0668
Trypanosoma brucei unspecified product 0.002 0.0045 0.0128
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Brugia malayi Cation transporter family protein 0.0056 0.0157 0.0454
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0034 0.009 0.0259
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0274 0.0794
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0274 0.0794
Echinococcus granulosus dna polymerase eta 0.002 0.0045 0.0127
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0056 0.0157 0.0454
Loa Loa (eye worm) ACC-1 protein 0.0056 0.0157 0.0454
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0216 0.0626
Schistosoma mansoni DNA polymerase eta 0.002 0.0045 0.013
Onchocerca volvulus 0.0007 0.0003 0.0011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0127
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0098 0.029 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0274 0.0794
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.004 0.0115
Trichomonas vaginalis ran, putative 0.0022 0.0051 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.004 0.0337
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0056 0.0061
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0045 0.0128
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Onchocerca volvulus 0.0613 0.1921 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Mycobacterium ulcerans hypothetical protein 0.0024 0.0056 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0056 0.0157 0.0456
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Brugia malayi phosphofructokinase 0.0114 0.0343 0.0997
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.009 0.0258
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0003 0.0002
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0079 0.2696
Echinococcus granulosus glycine receptor subunit beta 0.0056 0.0157 0.0454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0076 0.0218
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0343 0.0997
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0003 0.0007
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0009 0.0026
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1091 0.3433 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0009 0.0042
Schistosoma mansoni importin beta-1 0.003 0.0076 0.0222
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.009 0.0259
Echinococcus granulosus carbonic anhydrase II 0.1091 0.3433 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0056 0.024
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0181 0.1098
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0181 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0079 0.1275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Echinococcus granulosus nAChR subunit 0.0056 0.0157 0.0454
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0181 0.0528
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0056 0.0157 0.0454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Loa Loa (eye worm) carbonic anhydrase 3 0.1091 0.3433 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0076 0.0218
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0056 0.0157 0.0454
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0045 0.013
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0343 0.1531
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.024
Mycobacterium ulcerans integral membrane transporter 0.0098 0.029 0.0289
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Echinococcus granulosus cpg binding protein 0.003 0.0077 0.022
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0026 0.0062 0.0178
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0343 1
Brugia malayi 6-phosphofructokinase 0.0114 0.0343 0.0997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.009 0.0259
Brugia malayi Cation transporter family protein 0.0371 0.1154 0.3359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2922 0.9222 1
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1091 0.3433 1
Leishmania major GTP-binding protein, putative 0.0022 0.0051 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Echinococcus granulosus glycine receptor subunit beta 0.0056 0.0157 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.0475
Giardia lamblia DINP protein human, muc B family 0.002 0.0045 0.5624
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0056 0.0157 0.0454
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Schistosoma mansoni dishevelled 0.0009 0.0009 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0375 0.1166 0.5242
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0003 0.0007
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0343 0.0997
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0056 0.0157 0.0454
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Plasmodium vivax sulfate transporter, putative 0.0098 0.029 1
Leishmania major carbonic anhydrase family protein, putative 0.0375 0.1166 0.3396
Loa Loa (eye worm) GABA receptor subunit 0.003 0.0076 0.0218
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0003 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.004 0.0114
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0009 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0181 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.003 0.0076 0.022
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0003 0.0006
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0009 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0115
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0045 0.013
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0056 0.0157 0.0454
Chlamydia trachomatis sulfate transporter 0.0098 0.029 1
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0108 0.0324 0.0942
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0324 0.0942
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0173 0.0503
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0056 0.0157 0.0454
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0343 0.0997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Plasmodium falciparum importin beta, putative 0.003 0.0076 0.0458
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0045 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.009 0.0258
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0003 0.0003
Schistosoma mansoni acetylcholine receptor-related 0.0026 0.0062 0.0181
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.003 0.0076 0.0218
Onchocerca volvulus 0.0007 0.0003 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0003 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Onchocerca volvulus 0.0056 0.0157 0.0811
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0045 0.0128
Schistosoma mansoni carbonic anhydrase 0.0375 0.1166 0.3398
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0708 0.2222 0.2409
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0129 0.0388 0.0421
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0157 0.0454
Echinococcus granulosus dna polymerase kappa 0.002 0.0045 0.0127
Echinococcus granulosus GPCR family 2 0.0034 0.009 0.0258
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.0549 0.2854
Echinococcus multilocularis dna polymerase kappa 0.002 0.0045 0.0127
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0076 0.022
Echinococcus multilocularis importin subunit beta 1 0.003 0.0076 0.0219
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0009 0.0023
Brugia malayi Importin beta-1 subunit 0.003 0.0076 0.0219
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.004 0.0044
Onchocerca volvulus 0.003 0.0076 0.0389
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1000 nM Cytotoxicity against human MCF7 cells after 72 hrs by WST-1 assay ChEMBL. 20845961
IC50 (functional) > 1000 nM Cytotoxicity against human PC3 cells after 72 hrs by WST-1 assay ChEMBL. 20845961

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20845961

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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