Detailed information for compound 1256550

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.466 | Formula: C23H27NO2
  • H donors: 2 H acceptors: 2 LogP: 5.94 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C1(C2CCCCCC2)C(=O)Nc2c1cc(C)cc2C
  • InChi: 1S/C23H27NO2/c1-15-13-16(2)21-20(14-15)23(22(26)24-21,17-7-5-3-4-6-8-17)18-9-11-19(25)12-10-18/h9-14,17,25H,3-8H2,1-2H3,(H,24,26)
  • InChiKey: SWKCKBXWFUZBAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0056 0.0061
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0526 0.1643 0.4786
Onchocerca volvulus 0.0007 0.0003 0.0011
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0009 0.0023
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0343 0.0372
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0009 0.0023
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0079 1
Onchocerca volvulus 0.0007 0.0003 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Trichomonas vaginalis helicase, putative 0.0006 0.0002 0.0001
Onchocerca volvulus Putative sulfate transporter 0.0613 0.1921 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0009 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0003 0.0002
Echinococcus granulosus nAChR subunit 0.0056 0.0157 0.0454
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Entamoeba histolytica carbonic anhydrase, putative 0.0375 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0324 0.0942
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.009 0.0258
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1091 0.3433 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0003 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0056 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0115
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0037 0.1262
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Brugia malayi Cation transporter family protein 0.0056 0.0157 0.0454
Echinococcus granulosus importin subunit beta 1 0.003 0.0076 0.0219
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1091 0.3433 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0274 0.0794
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0003 0.0014
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0076 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0045 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.004 0.0115
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1091 0.3433 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0157 0.0454
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0181 0.0528
Schistosoma mansoni hypothetical protein 0.0526 0.1643 0.4787
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.0475
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1091 0.3433 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0056 0.0056
Plasmodium falciparum importin beta, putative 0.003 0.0076 0.0458
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0079 0.0475
Toxoplasma gondii exonuclease III APE 0.0019 0.004 0.024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0181 0.0526
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.004 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0056 0.0157 0.0454
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.003 0.0076 0.022
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0037 0.0222
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0003 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Trypanosoma brucei unspecified product 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) hypothetical protein 0.018 0.0549 0.1597
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0343 0.0997
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0146
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Echinococcus multilocularis cpg binding protein 0.003 0.0077 0.022
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0173 0.0503
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0079 0.2696
Echinococcus granulosus nAChR subunit 0.003 0.0076 0.0218
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0098 0.029 0.0289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.009 0.0259
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0023
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0009 0.0023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0003 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0079 0.0475
Loa Loa (eye worm) carbonic anhydrase 3 0.1091 0.3433 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0181 0.0525
Brugia malayi RNA, U transporter 1 0.0085 0.0251 0.073
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0056 0.0157 0.0454
Entamoeba histolytica hypothetical protein 0.003 0.0076 0.0641
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0343 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0003 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Onchocerca volvulus 0.0371 0.1154 0.6003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0045 0.0044
Entamoeba histolytica Ran family GTPase 0.0022 0.0051 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Echinococcus granulosus cpg binding protein 0.003 0.0077 0.022
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0157 0.0454
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0079 0.0475
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0026 0.0062 0.0178
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0062 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0056 0.0157 0.0454
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0024
Loa Loa (eye worm) acetylcholine receptor protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) LGC-31 protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0343 0.0997
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0079 0.0475
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.6437
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Echinococcus multilocularis nAChR subunit 0.0056 0.0157 0.0454
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0079 0.2696
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0343 0.0999
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0079 0.0475
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Echinococcus granulosus glycine receptor subunit beta 0.0056 0.0157 0.0454
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.004 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Schistosoma mansoni cpg binding protein 0.0029 0.0071 0.0208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.004 0.5053
Onchocerca volvulus 0.0007 0.0003 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Giardia lamblia DINP protein human, muc B family 0.002 0.0045 0.5624
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0343 0.0997
Loa Loa (eye worm) ACC-1 protein 0.0056 0.0157 0.0454
Echinococcus granulosus dna polymerase kappa 0.002 0.0045 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Echinococcus granulosus dna polymerase eta 0.002 0.0045 0.0127
Onchocerca volvulus 0.0026 0.0062 0.0318
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0003 0.0002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0003 0.0014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0375 0.1166 0.5242
Leishmania major DNA polymerase eta, putative 0.002 0.0045 0.0128
Leishmania major GTP-binding protein, putative 0.0022 0.0051 0.0146
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0129 0.0388 0.0421
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Brugia malayi Cation transporter family protein 0.0371 0.1154 0.3359
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Trypanosoma brucei unspecified product 0.0014 0.0025 0.007
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0056 0.0157 0.0454
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni dishevelled 0.0009 0.0009 0.0026
Schistosoma mansoni cpg binding protein 0.003 0.0077 0.0223
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0009 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0274 0.0794
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0324 0.0942
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Onchocerca volvulus Putative nachr subunit 0.0056 0.0157 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0003 0.001
Schistosoma mansoni neurotransmitter gated ion channel 0.0026 0.0062 0.0181
Schistosoma mansoni hypothetical protein 0.0321 0.0996 0.2901
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Schistosoma mansoni cpg binding protein 0.003 0.0077 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0076 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0074 0.0216 0.0626
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Echinococcus multilocularis glycine receptor subunit beta 0.0056 0.0157 0.0454
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Schistosoma mansoni acetylcholine receptor subunit beta 0.0026 0.0062 0.0181
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0343 0.1531
Schistosoma mansoni carbonic anhydrase 0.0375 0.1166 0.3398
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.004 0.0114
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0009 0.0023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Onchocerca volvulus 0.0029 0.0071 0.0367
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0324 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0056 0.024
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0274 0.0794
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0009 0.0023
Brugia malayi Importin beta-1 subunit 0.003 0.0076 0.0219
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0062 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0216 0.0626
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0009 0.0023
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.004 0.0115
Echinococcus multilocularis snurportin 1 0.0321 0.0996 0.2899
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0003 0.0007
Brugia malayi hypothetical protein 0.0009 0.0009 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0051 0.0146
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0071 0.0206
Mycobacterium leprae Probable transmembrane transport protein 0.0708 0.2222 1
Onchocerca volvulus 0.003 0.0076 0.0389
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1091 0.3433 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0079 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0526 0.1643 0.4786
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.1362
Loa Loa (eye worm) oxidoreductase 0.0007 0.0003 0.0007
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0026 0.0062 0.0178
Echinococcus granulosus carbonic anhydrase II 0.1091 0.3433 1
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0219
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0051 0.0306
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0009 0.0024
Onchocerca volvulus 0.0007 0.0003 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.004 0.0115
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0127
Toxoplasma gondii hypothetical protein 0.0009 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.009 0.0258
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0056 0.0056
Schistosoma mansoni acetylcholine receptor-related 0.0026 0.0062 0.0181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0045 0.0044
Echinococcus granulosus snurportin 1 0.0321 0.0996 0.2899
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0526 0.1643 0.4786
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0009 0.0024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0056 0.0157 0.0454
Schistosoma mansoni neurotransmitter gated ion channel 0.003 0.0076 0.022
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0117
Plasmodium vivax sulfate transporter, putative 0.0098 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0007
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0056 0.0157 0.0454
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.009 0.0258
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Schistosoma mansoni ran 0.0022 0.0051 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0058 0.0057
Schistosoma mansoni nAChR subunit 0.0026 0.0062 0.0181
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0056 0.0157 0.0454
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Echinococcus multilocularis carbonic anhydrase II 0.1091 0.3433 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0001 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.0371 0.1154 0.3359
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Leishmania major carbonic anhydrase family protein, putative 0.0375 0.1166 0.3396
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0009 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.009 0.0258
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0045 0.0128
Schistosoma mansoni nAChR subunit 0.0026 0.0062 0.0181
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Trypanosoma cruzi hypothetical protein 0.0006 0.0001 0.0001
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0955 0.3 0.3253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0056 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0056 0.0157 0.0454
Onchocerca volvulus 0.0026 0.0062 0.0318
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Echinococcus multilocularis glycine receptor subunit beta 0.0056 0.0157 0.0454
Entamoeba histolytica hypothetical protein 0.0024 0.0058 0.049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0343 0.0996
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.0549 0.2854
Echinococcus multilocularis nAChR subunit 0.003 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0045 0.0375
Brugia malayi Latrophilin receptor protein 2 0.0034 0.009 0.0259
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0045 0.0048
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0026 0.0062 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0056 0.0157 0.0454
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0127
Trypanosoma brucei unspecified product 0.0014 0.0025 0.007
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0056 0.0157 0.0454
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Plasmodium falciparum carbonic anhydrase 0.0526 0.1643 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0045 0.0127
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0526 0.1643 0.4786
Brugia malayi hypothetical protein 0.0009 0.0009 0.0024
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0003 0.0003
Echinococcus multilocularis importin subunit beta 1 0.003 0.0076 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Onchocerca volvulus 0.003 0.0076 0.0389
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0098 0.029 0.0289
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0045 0.0044
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trypanosoma brucei carbonic anhydrase-like protein 0.1091 0.3433 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Schistosoma mansoni neurotransmitter gated ion channel 0.0026 0.0062 0.0181
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.004 0.0114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0045 0.013
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0343 0.0997
Leishmania major DNA polymerase kappa, putative 0.002 0.0045 0.0128
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0056 0.0157 0.0454
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0076 0.0218
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0045 0.013
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787
Brugia malayi N-terminal motif family protein 0.0006 0.0001 0.0001
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0009 0.0026
Onchocerca volvulus 0.0056 0.0157 0.0811
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0003 0.0014
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0098 0.029 0.1761
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0007
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0051 0.1736
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0003 0.0002
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0026 0.0062 0.0178
Schistosoma mansoni hypothetical protein 0.0074 0.0216 0.0628
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0007
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0324 0.0942
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0026 0.0062 0.0178
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0009 0.0024
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0343 0.0996
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0056 0.0157 0.0454
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0003 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0003 0.0002
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0003 0.0007
Plasmodium vivax importin-beta 2, putative 0.003 0.0076 0.2603
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0009 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.3168 1 1
Trichomonas vaginalis ran, putative 0.0022 0.0051 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0009 0.0026
Loa Loa (eye worm) ACC-1 protein 0.0056 0.0157 0.0454
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0003 0.0007
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0056 0.0157 0.0454
Onchocerca volvulus 0.0056 0.0157 0.0811
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.004 0.0115
Loa Loa (eye worm) hypothetical protein 0.0345 0.1073 0.3123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0274 0.0795
Onchocerca volvulus 0.0009 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0343 0.2934
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Brugia malayi 6-phosphofructokinase 0.0114 0.0343 0.0997
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0003 0.0002
Brugia malayi Cation transporter family protein 0.0056 0.0157 0.0454
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0343 0.0997
Schistosoma mansoni carbonic anhydrase 0.0526 0.1643 0.4787
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0037
Echinococcus multilocularis carbonic anhydrase 0.0526 0.1643 0.4786
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0157 0.0454
Brugia malayi DIX domain containing protein 0.0009 0.0009 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1091 0.3433 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0071 0.0206
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0259
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0037 0.0036
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1091 0.3433 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0056 0.0157 0.0454
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Onchocerca volvulus 0.0024 0.0056 0.0288
Leishmania major carbonic anhydrase-like protein 0.1091 0.3433 1
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0343 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0026 0.0062 0.0178
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0343 0.0999
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0001 0.0001
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0056 0.0157 0.0454
Brugia malayi hypothetical protein 0.0026 0.0062 0.0178
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0001 0.0002
Onchocerca volvulus 0.0613 0.1921 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0162
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0009 0.0042
Echinococcus granulosus carbonic anhydrase 0.0526 0.1643 0.4786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0056 0.0157 0.0454
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0274 0.0797
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0076 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0076 0.0219
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0062 0.0178
Brugia malayi N-terminal motif family protein 0.018 0.0549 0.1597
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0343 0.0997
Brugia malayi RasGEF domain containing protein 0.0006 0.0001 0.0001
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.009 0.0259
Loa Loa (eye worm) GABA receptor subunit 0.003 0.0076 0.0218
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.0475
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0157 0.0454
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0098 0.029 0.1761
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0056 0.0157 0.0454
Schistosoma mansoni ran 0.0022 0.0051 0.0149
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Mycobacterium ulcerans carbonic anhydrase 0.0375 0.1166 0.1166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0274 0.0794
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0079 0.1275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Schistosoma mansoni dep domain containing protein 0.0009 0.0009 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0039
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0003 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0003 0.0019
Echinococcus granulosus GPCR family 2 0.0034 0.009 0.0258
Schistosoma mansoni dishevelled 0.0009 0.0009 0.0026
Trypanosoma cruzi hypothetical protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0996 0.2899
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0181 0.018
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0001 0.0003
Echinococcus multilocularis GPCR, family 2 0.0034 0.009 0.0258
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0045 0.0044
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0371 0.1154 0.3359
Schistosoma mansoni carbonic anhydrase-related 0.0526 0.1643 0.4787
Mycobacterium ulcerans hypothetical protein 0.0024 0.0056 0.0056
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0079 0.0668
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0079 0.1642
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.003 0.0076 0.0218
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0076 0.0458
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0157 0.0454
Brugia malayi 6-phosphofructokinase 0.0114 0.0343 0.0997
Schistosoma mansoni DNA polymerase eta 0.002 0.0045 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0098 0.029 0.0843
Brugia malayi phosphofructokinase 0.0114 0.0343 0.0997
Mycobacterium ulcerans integral membrane transporter 0.0098 0.029 0.0289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0003 0.0002
Onchocerca volvulus 0.0371 0.1154 0.6003
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0181 0.1098
Onchocerca volvulus 0.0056 0.0157 0.0811
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0003 0.0003
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0371 0.1154 0.336
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0056 0.0157 0.0456
Onchocerca volvulus 0.0026 0.0062 0.0318
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0157 0.0456
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0056 0.0475
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.004 0.0039
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2922 0.9222 1
Toxoplasma gondii hypothetical protein 0.0526 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0162
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0056 0.0157 0.0454
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0056 0.024
Onchocerca volvulus 0.0371 0.1154 0.6003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.004 0.0337
Chlamydia trachomatis sulfate transporter 0.0098 0.029 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0181 0.0528
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0274 0.0795
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0181 0.0196
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0003 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0079 0.0078
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0003 0.0081
Echinococcus granulosus glycine receptor subunit beta 0.0056 0.0157 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0056
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0181 0.0525
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0062 0.0178
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0058 0.0167
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0152 0.0922
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0371 0.1154 0.336
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0343 0.0342
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0178
Brugia malayi N-terminal motif family protein 0.0006 0.0001 0.0001
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0009 0.0026
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0056 0.0157 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0128
Schistosoma mansoni importin beta-1 0.003 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0003 0.0014
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.0056 0.0157 0.0456
Loa Loa (eye worm) hypothetical protein 0.0526 0.1643 0.4786
Brugia malayi excitatory GABA receptor EXP-1A 0.0056 0.0157 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0218
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0051 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0162
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0056 0.0157 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0128
Echinococcus granulosus glycine receptor subunit alpha 1 0.0056 0.0157 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.3168 1 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0708 0.2222 0.2409
Echinococcus multilocularis dna polymerase eta 0.002 0.0045 0.0127
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0454
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0106
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0003 0.0002
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0003 0.0002
Leishmania major importin beta-1 subunit, putative 0.0024 0.0058 0.0167
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0079 0.1642

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1000 nM Cytotoxicity against human MCF7 cells after 72 hrs by WST-1 assay ChEMBL. 20845961
IC50 (functional) > 1000 nM Cytotoxicity against human PC3 cells after 72 hrs by WST-1 assay ChEMBL. 20845961

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20845961

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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