TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 557.627 | Formula: C29H30F3N3O3S
H donors: 2 H acceptors: 4 LogP: 5.79 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CC([C@@H](C(=O)N[C@@H](Cc1ccccc1)C#N)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)S(=O)(=O)C)C
InChi: 1S/C29H30F3N3O3S/c1-19(2)26(28(36)34-24(18-33)17-20-7-5-4-6-8-20)35-27(29(30,31)32)23-11-9-21(10-12-23)22-13-15-25(16-14-22)39(3,37)38/h4-16,19,24,26-27,35H,17H2,1-3H3,(H,34,36)/t24-,26-,27-/m0/s1
InChiKey: UPCGYFVYJJCJTE-URORMMCBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References
Homo sapiens	cathepsin F	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.1903	0.271
Echinococcus granulosus	carbonic anhydrase II	0.0155	0.4364	0.4323
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0547	0.0478
Brugia malayi	amine oxidase, flavin-containing family protein	0.0023	0.0072	0.0085
Schistosoma mansoni	pyruvate kinase	0.0051	0.0987	0.1797
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0027	0.0196	0.3767
Giardia lamblia	Pyruvate kinase	0.0051	0.0987	0.2101
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0155	0.4364	0.8432
Loa Loa (eye worm)	inositol-1	0.0036	0.0519	0.0726
Mycobacterium ulcerans	monoamine oxidase	0.0023	0.0072	0.0284
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Toxoplasma gondii	cathepsin CPL	0.0079	0.1903	0.7375
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0519	0.1372
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0683	0.2459
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1429	0.203
Echinococcus granulosus	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0519	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2394
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1429	0.203
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0023	0.0072	0.0284
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.1903	0.7375
Schistosoma mansoni	alpha glucosidase	0.0036	0.0505	0.085
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0896	0.1617
Trypanosoma brucei	pyruvate kinase 1	0.0099	0.2555	0.5311
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0155	0.4364	0.6239
Trichomonas vaginalis	pyruvate kinase, putative	0.0099	0.2555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.0736	0.2291
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0505	0.1312
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.013	0.0114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Schistosoma mansoni	hypothetical protein	0.007	0.1614	0.3029
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0736	0.1304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.013	0.0168
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Loa Loa (eye worm)	hypothetical protein	0.018	0.5163	0.7383
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Leishmania major	carbonic anhydrase-like protein	0.0155	0.4364	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1429	0.1366
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1107	0.3865
Echinococcus granulosus	cathepsin b	0.018	0.5163	0.5127
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0505	0.085
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Loa Loa (eye worm)	transcription factor SMAD2	0.0236	0.6988	1
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1903	0.7375
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0878
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0162	0.4609	0.659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0736	0.1037
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0155	0.4364	0.8432
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Schistosoma mansoni	alpha-glucosidase	0.014	0.3875	0.747
Leishmania major	pyruvate kinase	0.0099	0.2555	0.5784
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0068	0.1555	0.3455
Loa Loa (eye worm)	cathepsin B	0.0068	0.1555	0.2211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0505	0.1312
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1903	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0505	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	Inositol-1	0.0036	0.0519	0.0726
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.1903	0.271
Echinococcus granulosus	pyruvate kinase	0.0099	0.2555	0.25
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0781	0.1102
Echinococcus multilocularis	pyruvate kinase	0.0099	0.2555	0.25
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus granulosus	cathepsin l1	0.0079	0.1903	0.1844
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0547	0.0478
Plasmodium vivax	unspecified product	0.0025	0.013	0.0233
Schistosoma mansoni	alpha-glucosidase	0.014	0.3875	0.747
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Trypanosoma cruzi	major cysteine proteinase, putative	0.0075	0.1785	0.3364
Plasmodium vivax	vivapain-2	0.0079	0.1903	0.7375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0505	0.0706
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.1614	0.1553
Onchocerca volvulus		0.0079	0.1903	0.7375
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1429	0.6609
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0068	0.1555	0.2722
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0505	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0069	0.158	0.2247
Brugia malayi	cathepsin L-like precursor	0.0055	0.1107	0.1569
Onchocerca volvulus		0.0079	0.1903	0.7375
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0099	0.2555	0.4876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0395	0.1547
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1903	0.7375
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1903	0.1844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.0736	0.2291
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0155	0.4364	0.6239
Plasmodium falciparum	pyruvate kinase 2	0.0051	0.0987	0.3686
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0023	0.0072	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2555	0.3644
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.018	0.5163	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0736	0.0598
Brugia malayi	Cathepsin L-like precursor	0.0025	0.013	0.0168
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0155	0.4364	0.8432
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0505	0.1008
Brugia malayi	hypothetical protein	0.0023	0.0072	0.0085
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0505	0.0436
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0072	0.0284
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1903	0.1844
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Trypanosoma brucei	pyruvate kinase 1, putative	0.0099	0.2555	0.5311
Mycobacterium ulcerans	dehydrogenase	0.0023	0.0072	0.0284
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.013	0.0114
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0099	0.2555	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.3919	0.7557
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.0714
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0878
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0395	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Loa Loa (eye worm)	MH2 domain-containing protein	0.0236	0.6988	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0505	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1903	0.271
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Onchocerca volvulus		0.0079	0.1903	0.7375
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0519	0.2033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0683	0.2065
Mycobacterium tuberculosis	Possible oxidoreductase	0.0023	0.0072	0.0284
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus granulosus	pyruvate kinase	0.0099	0.2555	0.25
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1429	0.3161
Echinococcus granulosus	cathepsin L	0.0043	0.0736	0.0668
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0043	0.0736	0.2673
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0683	0.2459
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0781	0.1102
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.057	0.2006
Plasmodium vivax	vivapain-1	0.0043	0.0736	0.2673
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.0714
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1429	0.1366
Onchocerca volvulus		0.0048	0.0896	0.3317
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0023	0.0072	0.0284
Echinococcus multilocularis	carbonic anhydrase	0.0058	0.1202	0.1138
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0896	0.1266
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.003	0.0309	0.0424
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0683	0.2065
Entamoeba histolytica	cysteine proteinase 1, putative	0.0043	0.0736	0.1652
Trypanosoma brucei	carbonic anhydrase-like protein	0.0155	0.4364	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0068	0.1555	0.5764
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Plasmodium vivax	vivapain-3	0.0043	0.0736	0.2673
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.013	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Schistosoma mansoni	carbonic anhydrase	0.0058	0.1202	0.2219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1903	0.3596
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0736	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Schistosoma mansoni	cathepsin s	0.0025	0.013	0.0114
Toxoplasma gondii	pyruvate kinase PyKII	0.0051	0.0987	0.3686
Trypanosoma cruzi	cruzipain precursor, putative	0.0136	0.3748	0.722
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0099	0.2555	0.4876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1903	0.7238
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0099	0.2555	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0099	0.2555	1
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0058	0.1202	0.1705
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1903	1
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0736	0.0598
Toxoplasma gondii	cathepsin B	0.0068	0.1555	0.5975
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.3791	0.3745
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Echinococcus multilocularis	cathepsin L	0.0043	0.0736	0.0668
Plasmodium falciparum	carbonic anhydrase	0.0058	0.1202	0.4551
Onchocerca volvulus		0.0055	0.1107	0.4169
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1903	0.271
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1903	0.3596
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0519	0.045
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.013	0.0168
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0099	0.2555	0.3644
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Loa Loa (eye worm)	acetyltransferase	0.0141	0.3919	0.5601
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.018	0.5163	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Plasmodium vivax	unspecified product	0.0043	0.0736	0.2673
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.1903	0.7375
Onchocerca volvulus		0.0079	0.1903	0.7375
Schistosoma mansoni	carbonic anhydrase-related	0.0058	0.1202	0.2219
Giardia lamblia	Cathepsin B precursor	0.0068	0.1555	0.4964
Mycobacterium ulcerans	oxidoreductase	0.0023	0.0072	0.0284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.3748	0.722
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0736	0.1037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1429	0.2665
Entamoeba histolytica	pyruvate kinase, putative	0.0069	0.158	0.7692
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.1614	0.1553
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Brugia malayi	MH2 domain containing protein	0.0236	0.6988	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0519	0.1372
Leishmania major	pyruvate kinase	0.0099	0.2555	0.5784
Schistosoma mansoni	pyruvate kinase	0.0099	0.2555	0.4876
Echinococcus multilocularis	tumor protein p63	0.0329	1	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0058	0.1202	0.1705
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Leishmania major	cysteine peptidase A (CPA)	0.0079	0.1903	0.4265
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0505	0.1312
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.1903	0.7375
Loa Loa (eye worm)	ctsf protein	0.0079	0.1903	0.271
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Echinococcus granulosus	cathepsin L cysteine protease	0.0043	0.0736	0.0668
Entamoeba histolytica	cysteine proteinase 2	0.0043	0.0736	0.1652
Onchocerca volvulus		0.0079	0.1903	0.7375
Echinococcus multilocularis	cysteine protease	0.0079	0.1903	0.1844
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0162	0.4609	0.659
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1429	0.2665
Onchocerca volvulus		0.0079	0.1903	0.7375
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.1903	0.1844
Echinococcus granulosus	cathepsin l1	0.0055	0.1107	0.1042
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0505	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1202	0.1705
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0519	0.045
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0155	0.4364	0.6239
Leishmania major	cathepsin L-like protease	0.0136	0.3748	0.8563
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1393
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Echinococcus granulosus	cysteine protease	0.0043	0.0736	0.0668
Plasmodium falciparum	pyruvate kinase	0.0099	0.2555	1
Toxoplasma gondii	hypothetical protein	0.0058	0.1202	0.4551
Echinococcus multilocularis	carbonic anhydrase II	0.0155	0.4364	0.4323
Onchocerca volvulus		0.0094	0.2385	0.9318
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Echinococcus multilocularis	pyruvate kinase	0.0078	0.1876	0.1817
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Brugia malayi	SWIRM domain containing protein	0.0023	0.0072	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.0037
Brugia malayi	hypothetical protein	0.007	0.1614	0.2296
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.1107	0.2033
Chlamydia trachomatis	pyruvate kinase	0.0099	0.2555	1
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.1107	0.4308
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0058	0.1202	0.1705
Plasmodium vivax	pyruvate kinase, putative	0.0099	0.2555	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Echinococcus multilocularis	cysteine protease	0.0079	0.1903	0.1844
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.0714
Plasmodium vivax	vivapain-2	0.0079	0.1903	0.7375
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0043	0.0736	0.1304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0058	0.1202	0.1705
Loa Loa (eye worm)	pyruvate kinase	0.0099	0.2555	0.3644
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0023	0.0072	0.0284
Loa Loa (eye worm)	cysteine protease	0.0079	0.1903	0.271
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Echinococcus multilocularis	cathepsin b	0.018	0.5163	0.5127
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.3919	0.5601
Trypanosoma cruzi	cysteine peptidase, putative	0.0043	0.0736	0.1304
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.3919	0.3875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1107	0.3865
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Trypanosoma cruzi	cysteine protease, putative	0.0043	0.0736	0.1304
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0519	0.0102
Toxoplasma gondii	pyruvate kinase PyK1	0.0099	0.2555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Echinococcus multilocularis	pyruvate kinase	0.0099	0.2555	0.25
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0155	0.4364	0.8432
Mycobacterium ulcerans	pyruvate kinase	0.0099	0.2555	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Echinococcus granulosus	pyruvate kinase	0.0051	0.0987	0.0922
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0519	0.0878
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0736	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1107	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1107	0.1569
Brugia malayi	cathepsin B-like cysteine proteinase	0.018	0.5163	0.7383
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.1614	0.3029
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1903	0.271
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Schistosoma mansoni	pyruvate kinase	0.0099	0.2555	0.4876
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0683	0.0615
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.1903	0.7375
Entamoeba histolytica	cysteine protease, putative	0.0043	0.0736	0.1652
Onchocerca volvulus		0.0079	0.1903	0.7375
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1903	0.1844
Echinococcus granulosus	cathepsin b	0.018	0.5163	0.5127
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.057	0.0468
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0519	0.0878
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0068	0.1555	0.2913
Entamoeba histolytica	hypothetical protein	0.007	0.1614	0.7935
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1107	0.1569
Loa Loa (eye worm)	pyruvate kinase-PB	0.0069	0.158	0.2247
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.5163	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0976	0.1775
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0111	0.2952	0.5657
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0505	0.1312
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.1555	0.2913
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0055	0.1107	0.1569
Echinococcus granulosus	carbonic anhydrase	0.0058	0.1202	0.1138
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.4609	0.457
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0099	0.2555	0.3644
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0683	0.2459
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0072	0.0085
Leishmania major	cathepsin L-like protease	0.0079	0.1903	0.4265
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.0714
Echinococcus multilocularis	pyruvate kinase	0.0051	0.0987	0.0922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Loa Loa (eye worm)	fibroinase	0.0079	0.1903	0.271
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0023	0.0072	0.0284
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Plasmodium vivax	pyruvate kinase 2, putative	0.0051	0.0987	0.3686
Onchocerca volvulus	Pyruvate kinase homolog	0.0099	0.2555	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0519	0.1372
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1903	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0519	0.18
Schistosoma mansoni	hypothetical protein	0.0058	0.1202	0.2219
Loa Loa (eye worm)	carbonic anhydrase 3	0.0155	0.4364	0.6239
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1903	0.3596
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0519	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1903	0.7238
Giardia lamblia	Pyruvate kinase	0.0099	0.2555	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.013	0.0168
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.0736	0.1652
Echinococcus multilocularis	cathepsin b	0.018	0.5163	0.5127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.3748	0.8402
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0505	0.1743

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 nM	Inhibition of Trypanosoma cruzi Cruzipain	ChEMBL.	21041084
IC50 (binding)	= 174 nM	Inhibition of human Cat F expressed in rabbit HIG82 cells	ChEMBL.	21041084
IC50 (binding)	= 433 nM	Inhibition of human Cat B in HepG2 cells	ChEMBL.	21041084
IC50 (binding)	= 631 nM	Inhibition of human Cat L	ChEMBL.	21041084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1290191

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1271007