Detailed information for compound 1271965

Basic information

Technical information
  • TDR Targets ID: 1271965
  • Name: 3-(acridin-9-ylamino)propan-1-ol
  • MW: 252.311 | Formula: C16H16N2O
  • H donors: 2 H acceptors: 2 LogP: 3.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C16H16N2O/c19-11-5-10-17-16-12-6-1-3-8-14(12)18-15-9-4-2-7-13(15)16/h1-4,6-9,19H,5,10-11H2,(H,17,18)
  • InChiKey: NBKULGKZTNSHLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(9-acridinylamino)propan-1-ol
  • 55468-74-1
  • BAS 02138984
  • 1-Propanol, 3-(9-acridinylamino)-
  • 3-(9-Acridinylamino)-1-propanol
  • STOCK2S-81162
  • 3-(Acridin-9-ylamino)-propan-1-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Starlite/ChEMBL No references
Homo sapiens RAD54-like (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Neospora caninum SNF2 family N-terminal domain-containing protein (EC 2.7.11.1), related Get druggable targets OG5_127595 All targets in OG5_127595
Candida albicans transcriptional regulator Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium berghei DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium berghei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans DNA helicase Get druggable targets OG5_127595 All targets in OG5_127595
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni helicase Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum DNA repair and recombination protein RAD54B, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01529 SMARCA2, SNF2L2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [EC Get druggable targets OG5_127595 All targets in OG5_127595
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania mexicana DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus DNA repair and recombination protein RAD54B Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans transcriptional regulator Get druggable targets OG5_127595 All targets in OG5_127595
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trichomonas vaginalis lymphoid specific helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Loa Loa (eye worm) type III restriction enzyme Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Schistosoma japonicum ATP-dependent RNA helicase DDX1, putative Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Type III restriction enzyme, res subunit family protein Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii SWI2/SNF2 Brahma-like putative Get druggable targets OG5_127595 All targets in OG5_127595
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax DNA repair protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis global transcription activator snf2l2 Get druggable targets OG5_127595 All targets in OG5_127595
Candida albicans DNA helicase Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium yoelii DNA repair protein RAD54-like-related Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi recombination factor GdRad54 Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum Homeotic gene regulator, putative Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium parvum RAD54 like SWI/SNF2 ATpase Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania braziliensis DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum IPR000299,Band 4.1,domain-containing Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium parvum SWI/SNF related putative transcriptional regulator ATpase Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium falciparum DEAD/DEAH box helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Babesia bovis DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Theileria parva DNA repair protein rad54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium yoelii Arabidopsis thaliana BRAHMA ortholog-related Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii SWI2/SNF2 Brahma-like putative Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Cryptosporidium hominis DNA repair protein RAD54-like Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma congolense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium knowlesi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Neospora caninum hypothetical protein Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Cryptosporidium parvum brahma like protein with a HSA domain, SNF2 like helicase and a bromo domain Get druggable targets OG5_127595 All targets in OG5_127595
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus global transcription activator snf2l2 Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania major hypothetical protein, conserved RAD54-like (S. cerevisiae) 747 aa 633 aa 24.2 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0196 0.5
Schistosoma mansoni transient receptor potential channel 0.0078 0.1549 0.3151
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.1903 0.2022
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0447 0.1106
Onchocerca volvulus 0.0033 0.0447 0.128
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3897 0.4383
Toxoplasma gondii hypothetical protein 0.0033 0.0447 0.0622
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0136 0.0067
Loa Loa (eye worm) Notch2 0.002 0.0136 0.0099
Giardia lamblia DNA repair protein RAD52 0.042 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0196 0.0293
Brugia malayi Cadherin domain containing protein 0.002 0.0136 0.0099
Onchocerca volvulus 0.0033 0.0447 0.128
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1549 0.3151
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0136 0.0067
Schistosoma mansoni slit 0.002 0.0136 0.0067
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0447 0.1106
Echinococcus granulosus protein jagged 2 0.002 0.0136 0.0067
Brugia malayi BRM protein 0.0081 0.1638 0.496
Echinococcus multilocularis enteropeptidase 0.007 0.137 0.276
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.2584 0.2436
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Echinococcus granulosus neurogenic locus protein delta 0.002 0.0136 0.0067
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0447 0.1106
Brugia malayi Muscle positioning protein 4 0.002 0.0136 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0651 0.1767
Toxoplasma gondii calcium binding egf domain-containing protein 0.0053 0.0948 0.1318
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Echinococcus multilocularis laminin 0.0053 0.0948 0.1839
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0447 0.0622
Loa Loa (eye worm) hypothetical protein 0.0119 0.2567 0.7967
Onchocerca volvulus 0.0033 0.0447 0.128
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Onchocerca volvulus 0.0119 0.2567 1
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Toxoplasma gondii microneme protein, putative 0.0033 0.0447 0.0622
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0196 0.0293
Schistosoma mansoni septate junction protein 0.002 0.0136 0.0067
Onchocerca volvulus 0.0086 0.1761 0.6684
Mycobacterium ulcerans hypothetical protein 0.0033 0.0441 0.0587
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.2567 0.5372
Toxoplasma gondii EGF family domain-containing protein 0.002 0.0136 0.0189
Onchocerca volvulus 0.0033 0.0441 0.1256
Schistosoma mansoni notch 0.002 0.0136 0.0067
Echinococcus granulosus neural cadherin 0.002 0.0136 0.0067
Echinococcus granulosus neurogenic locus notch protein 4 0.002 0.0136 0.0067
Loa Loa (eye worm) hypothetical protein 0.0074 0.1453 0.4361
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0053 0.0948 0.2727
Echinococcus granulosus tissue type plasminogen activator 0.0092 0.1903 0.3923
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0441 0.0733
Schistosoma mansoni egf-like domain protein 0.0053 0.0948 0.1839
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Onchocerca volvulus 0.0033 0.0441 0.1256
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.864 1
Schistosoma mansoni hypothetical protein 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Plasmodium falciparum cysteine repeat modular protein 1 0.0092 0.1903 1
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0441 0.0733
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0197
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.007 0.137 0.276
Echinococcus granulosus slit 2 protein 0.002 0.0136 0.0067
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1087
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.864 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1549 0.3151
Onchocerca volvulus 0.0033 0.0447 0.128
Brugia malayi notch-like transmembrane receptor 0.002 0.0136 0.0099
Echinococcus granulosus protein jagged 2 0.002 0.0136 0.0067
Toxoplasma gondii PAN domain-containing protein 0.0306 0.7191 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.004 0.0615 0.1649
Loa Loa (eye worm) BRM protein 0.0052 0.0914 0.2618
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1121 0.3289
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Schistosoma mansoni notch 0.002 0.0136 0.0067
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.002 0.0136 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0053 0.0948 0.2727
Loa Loa (eye worm) hypothetical protein 0.0117 0.2529 0.7845
Entamoeba histolytica hypothetical protein 0.0043 0.0708 0.0522
Loa Loa (eye worm) trypsin family protein 0.0033 0.0441 0.1087
Echinococcus granulosus Tolloid protein 1 0.0053 0.0948 0.1839
Echinococcus multilocularis protein jagged 1 0.002 0.0136 0.0067
Onchocerca volvulus 0.0033 0.0447 0.128
Brugia malayi Cadherin domain containing protein 0.002 0.0136 0.0099
Onchocerca volvulus 0.0033 0.0447 0.128
Brugia malayi Kringle domain containing protein 0.0092 0.1903 0.5818
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Onchocerca volvulus 0.0092 0.1903 0.7269
Brugia malayi Trypsin family protein 0.0033 0.0441 0.1087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.2567 0.5372
Echinococcus multilocularis protein jagged 2 0.002 0.0136 0.0067
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1549 0.3151
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.2727
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0136 0.0099
Echinococcus multilocularis geminin 0.0205 0.4687 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1121 0.3289
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0053 0.0948 0.2727
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0447 0.0622
Brugia malayi Trypsin family protein 0.0033 0.0441 0.1087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0708 0.1315
Toxoplasma gondii subtilisin SUB12 0.0033 0.0447 0.0622
Toxoplasma gondii hypothetical protein 0.0059 0.1087 0.1512
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.2727
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0441 0.0733
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.2432 0.5079
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.2432 0.5079
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0196 0.5
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0447 0.0622
Schistosoma mansoni notch 0.002 0.0136 0.0067
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1087
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0447 0.1106
Schistosoma mansoni hypothetical protein 0.0033 0.0441 0.0733
Entamoeba histolytica hypothetical protein 0.0119 0.2584 0.2436
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.2529 0.529
Echinococcus granulosus notch 0.002 0.0136 0.0067
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0447 0.0622
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0447 0.0622
Schistosoma mansoni transient receptor potential channel 0.0117 0.2529 0.529
Echinococcus multilocularis protein jagged 1 0.002 0.0136 0.0067
Echinococcus granulosus geminin 0.0205 0.4687 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1178 0.1163
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0447 0.0622
Schistosoma mansoni laminin gamma-3 chain 0.002 0.0136 0.0067
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0708 0.1315
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Entamoeba histolytica hypothetical protein 0.0043 0.0708 0.0522
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Toxoplasma gondii exonuclease III APE 0.0023 0.0196 0.0272
Schistosoma mansoni helicase 0.0081 0.1638 0.3344
Echinococcus multilocularis neurogenic locus notch protein 4 0.002 0.0136 0.0067
Echinococcus granulosus Mastin 0.007 0.137 0.276
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.2727
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Echinococcus granulosus fibropellin Ia 0.002 0.0136 0.0067
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0136 0.0067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0441 0.0733
Onchocerca volvulus 0.0033 0.0441 0.1256
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0196 0.0061
Echinococcus granulosus protein jagged 1 0.002 0.0136 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1121 0.3289
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0901 0.0835
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.002 0.0136 0.0067
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.864 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.2727
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0441 0.1087
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1549 0.3151
Echinococcus granulosus laminin 0.0053 0.0948 0.1839
Echinococcus multilocularis fibrillin 1 0.0053 0.0948 0.1839
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0708 0.1315
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0092 0.1903 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3897 0.4383
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0197
Echinococcus multilocularis fat cadherin tumor suppressor 0.002 0.0136 0.0067
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.2529 0.529
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Entamoeba histolytica hypothetical protein 0.0043 0.0708 0.0522
Onchocerca volvulus 0.0033 0.0447 0.128
Toxoplasma gondii hypothetical protein 0.0033 0.0447 0.0622
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0136 0.0067
Echinococcus granulosus delta-like protein 1 0.002 0.0136 0.0067
Toxoplasma gondii kringle domain-containing protein 0.0092 0.1903 0.2646
Onchocerca volvulus Arrow homolog 0.0053 0.0948 0.334
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0901 0.0835
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Entamoeba histolytica hypothetical protein 0.0043 0.0708 0.0522
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Brugia malayi GCC2 and GCC3 family protein 0.002 0.0136 0.0099
Loa Loa (eye worm) TK/ROR protein kinase 0.0092 0.1903 0.5818
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0196 1
Schistosoma mansoni hypothetical protein 0.0092 0.1903 0.3923
Brugia malayi Delta serrate ligand family protein 0.002 0.0136 0.0099
Schistosoma mansoni hypothetical protein 0.0041 0.0651 0.1191
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0711 0.1323
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0447 0.0622
Loa Loa (eye worm) BRM protein 0.0042 0.0671 0.183
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Toxoplasma gondii PAN domain-containing protein 0.0306 0.7191 1
Onchocerca volvulus 0.0033 0.0441 0.1256
Schistosoma mansoni transient receptor potential channel 0.0078 0.1549 0.3151
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3195 1
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0441 0.0733
Onchocerca volvulus 0.0033 0.0447 0.128
Echinococcus multilocularis slit 2 protein 0.002 0.0136 0.0067
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Toxoplasma gondii microneme protein MIC4 0.0033 0.0447 0.0622
Onchocerca volvulus 0.0033 0.0447 0.128
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.0948 0.2727
Loa Loa (eye worm) hypothetical protein 0.0119 0.2567 0.7967
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0053 0.0948 0.1839
Leishmania major hypothetical protein, conserved 0.0092 0.1903 0.2022
Brugia malayi Trypsin family protein 0.0119 0.2567 0.7967
Loa Loa (eye worm) hypothetical protein 0.0044 0.0711 0.1962
Loa Loa (eye worm) hypothetical protein 0.006 0.1121 0.3289
Schistosoma mansoni hypothetical protein 0.0043 0.0708 0.1315
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0136 0.0067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0901 0.0835
Loa Loa (eye worm) notch protein 0.002 0.0136 0.0099
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0196 0.0197
Loa Loa (eye worm) hypothetical protein 0.0041 0.0651 0.1767
Echinococcus multilocularis glycoprotein Antigen 5 0.007 0.137 0.276
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Echinococcus multilocularis tissue type plasminogen activator 0.0092 0.1903 0.3923
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0447 0.1106
Toxoplasma gondii calcium binding egf domain-containing protein 0.0053 0.0948 0.1318
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1087
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.864 1
Echinococcus granulosus protein jagged 1 0.002 0.0136 0.0067
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0441 0.0733
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106
Echinococcus granulosus global transcription activator snf2l2 0.0081 0.1638 0.3344
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1087
Echinococcus multilocularis Mastin 0.007 0.137 0.276
Schistosoma mansoni notch 0.002 0.0136 0.0067
Schistosoma mansoni notch 0.002 0.0136 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0136 0.0099
Brugia malayi hypothetical protein 0.0033 0.0441 0.1087
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0711 0.1962
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4378 1
Echinococcus multilocularis fibropellin Ia 0.002 0.0136 0.0067
Schistosoma mansoni notch 0.002 0.0136 0.0067
Echinococcus granulosus enteropeptidase 0.007 0.137 0.276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1087
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Onchocerca volvulus 0.0033 0.0447 0.128
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0136 0.0067
Brugia malayi hypothetical protein 0.0043 0.0708 0.195
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0196 0.0197
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0441 0.0733
Schistosoma mansoni hypothetical protein 0.0205 0.4687 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0711 0.1323
Echinococcus granulosus glycoprotein Antigen 5 0.007 0.137 0.276
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0441 0.0733
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0447 0.0622
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.2727
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0447 0.0622
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0441 0.0733
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Onchocerca volvulus 0.0033 0.0441 0.1256
Onchocerca volvulus 0.0033 0.0447 0.128
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0099
Mycobacterium ulcerans hypothetical protein 0.0192 0.4378 1
Schistosoma mansoni hypothetical protein 0.0205 0.4687 1
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0136 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3195 1
Brugia malayi EGF-like domain containing protein 0.002 0.0136 0.0099
Brugia malayi Trypsin family protein 0.0033 0.0441 0.1087
Echinococcus multilocularis Tolloid protein 1 0.0053 0.0948 0.1839
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0067
Schistosoma mansoni cell polarity protein 0.002 0.0136 0.0067
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.2529 0.529
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3897 0.4383
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0441 0.0733
Loa Loa (eye worm) hypothetical protein 0.0033 0.0447 0.1106
Echinococcus multilocularis global transcription activator snf2l2 0.0081 0.1638 0.3344
Brugia malayi Fibulin-1 precursor 0.0053 0.0948 0.2727
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0441 0.1087
Loa Loa (eye worm) hypothetical protein 0.0092 0.1903 0.5818
Brugia malayi Protein kinase domain containing protein 0.0092 0.1903 0.5818
Echinococcus multilocularis neural cadherin 0.002 0.0136 0.0067
Echinococcus multilocularis notch 0.002 0.0136 0.0067
Brugia malayi MH2 domain containing protein 0.0144 0.3195 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0053 0.0948 0.2727
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0901 0.0835
Brugia malayi PAN domain containing protein 0.0033 0.0447 0.1106

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.08 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 3.37 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 2.21 uM PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540364, AID588328, AID588350, AID588351] ChEMBL. No reference
EC50 (functional) > 3.376 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM). (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 6.6827 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] ChEMBL. No reference
EC50 (functional) > 59.66 uM PUBCHEM_BIOASSAY: Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput dose response assay to identify activators of the GAA30 frataxin promoter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540364, AID588328, AID588350, AID588351] ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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