Detailed information for compound 1275755

Basic information

Technical information
  • TDR Targets ID: 1275755
  • Name: N-(5-chloro-2-methoxyphenyl)-2-[(2-morpholin- 4-ylphenyl)amino]acetamide
  • MW: 375.849 | Formula: C19H22ClN3O3
  • H donors: 2 H acceptors: 1 LogP: 3.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CNc1ccccc1N1CCOCC1)Cl
  • InChi: 1S/C19H22ClN3O3/c1-25-18-7-6-14(20)12-16(18)22-19(24)13-21-15-4-2-3-5-17(15)23-8-10-26-11-9-23/h2-7,12,21H,8-11,13H2,1H3,(H,22,24)
  • InChiKey: IOYPUNFVJGPEHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-2-[(2-morpholinophenyl)amino]acetamide
  • N-(5-chloro-2-methoxyphenyl)-2-[(2-morpholinophenyl)amino]acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-[(2-morpholin-4-ylphenyl)amino]ethanamide
  • ZINC03325232
  • T5214943
  • MLS001033180
  • SMR000363674

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1087 0.2832
Loa Loa (eye worm) hypothetical protein 0.0352 0.4292 0.6225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Onchocerca volvulus 0.0057 0.0435 0.1348
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0118 0.0184
Toxoplasma gondii ABC1 family protein 0.0107 0.1087 0.5969
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0435 0.0631
Echinococcus multilocularis lamin dm0 0.0033 0.0118 0.0118
Echinococcus multilocularis serotonin receptor 0.0551 0.6896 0.6896
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0037 0.0171 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.084 0.2189
Loa Loa (eye worm) hypothetical protein 0.0163 0.1821 0.2641
Onchocerca volvulus 0.0057 0.0435 0.1348
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.3838 0.5
Brugia malayi neuropeptide F receptor 0.0057 0.0435 0.0676
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0298 0.3585 0.5199
Giardia lamblia Cathepsin B precursor 0.0037 0.0171 0.0446
Mycobacterium ulcerans lipase LipD 0.0107 0.1087 0.2245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0435 0.0494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1087 0.1235
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Giardia lamblia Cysteine protease 0.0037 0.0171 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi G protein-coupled receptor 0.0057 0.0435 0.0676
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Schistosoma mansoni cathepsin B (C01 family) 0.0037 0.0171 0.0248
Echinococcus granulosus cathepsin b 0.0298 0.3585 0.4072
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Echinococcus granulosus g protein coupled receptor 0.0057 0.0435 0.0494
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0057 0.0435 0.0631
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0435 0.0676
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0117 0.1227 0.3423
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.1152 0.3002
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0435 0.0494
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0076 0.0087
Onchocerca volvulus Cathepsin L homolog 0.0163 0.1821 0.6554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1087 0.0755
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0435 0.0494
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0883 0.0883
Echinococcus granulosus snurportin 1 0.0299 0.3605 0.4095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Loa Loa (eye worm) cathepsin B 0.0117 0.1227 0.1779
Mycobacterium tuberculosis Conserved protein 0.0107 0.1087 0.0755
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.1821 0.5079
Schistosoma mansoni biogenic amine receptor 0.0057 0.0435 0.0631
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0095 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0171 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Schistosoma mansoni hypothetical protein 0.0205 0.2369 0.3436
Mycobacterium ulcerans hypothetical protein 0.0107 0.1087 0.2245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0095 0.0095
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0037 0.0171 0.094
Schistosoma mansoni opsin-like receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Brugia malayi cathepsin L-like cysteine proteinase 0.0037 0.0171 0.0266
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0435 0.0494
Onchocerca volvulus 0.0057 0.0435 0.1348
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis snurportin 1 0.0299 0.3605 0.3605
Echinococcus multilocularis GPCR, family 2 0.0031 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0059 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0435 0.0676
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0171 0.0446
Schistosoma mansoni hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi Dopamine receptor protein 2 0.0057 0.0435 0.0676
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni hypothetical protein 0.0205 0.2369 0.3436
Echinococcus granulosus cysteine protease 0.0088 0.084 0.0954
Schistosoma mansoni amine GPCR 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0435 0.0435
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0435 0.0631
Giardia lamblia Cysteine protease 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus multilocularis serotonin receptor 0.0551 0.6896 0.6896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Echinococcus multilocularis sex peptide receptor 0.0057 0.0435 0.0435
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0435 0.0676
Echinococcus multilocularis cathepsin b 0.0298 0.3585 0.3585
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0163 0.1821 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Brugia malayi putative neuropeptide receptor 0.0057 0.0435 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0435 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0037 0.0171 0.0446
Echinococcus granulosus cathepsin l1 0.0163 0.1821 0.2068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0057 0.0435 0.1348
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Leishmania major hypothetical protein, conserved 0.0107 0.1087 0.5969
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0361 0.0561
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0171 0.0446
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0435 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Mycobacterium ulcerans beta-lactamase 0.0107 0.1087 0.2245
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0435 0.0494
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0112 0.1152 0.1671
Echinococcus granulosus hypothetical protein 0.0057 0.0435 0.0494
Brugia malayi sulfakinin receptor protein 0.0057 0.0435 0.0676
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Onchocerca volvulus 0.0037 0.0171 0.0357
Schistosoma mansoni neuropeptide receptor 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0352 0.4292 0.6225
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica hypothetical protein 0.0037 0.0171 0.0446
Onchocerca volvulus 0.0233 0.2738 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0435 0.0435
Schistosoma mansoni amine GPCR 0.0057 0.0435 0.0631
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0076 0.0418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.084 0.2189
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0435 0.0435
Echinococcus multilocularis musashi 0.0033 0.0118 0.0118
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.1717 0.153
Brugia malayi AKH receptor 0.0057 0.0435 0.0676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0435 0.0631
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0435 0.0435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0062 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0037 0.0171 0.0446
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0435 0.0435
Brugia malayi fibroinase precursor 0.0037 0.0171 0.0266
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Loa Loa (eye worm) hypothetical protein 0.0051 0.0361 0.0524
Onchocerca volvulus 0.0107 0.1087 0.3797
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0435 0.0435
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0435 0.0494
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0112 0.1152 0.3214
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0171 0.0266
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0435 0.0435
Toxoplasma gondii preprocathepsin c precursor, putative 0.0037 0.0171 0.094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0171 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Onchocerca volvulus 0.0057 0.0435 0.1348
Schistosoma mansoni hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.084 0.2189
Giardia lamblia Cathepsin B precursor 0.0117 0.1227 0.3197
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0435 0.0631
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Echinococcus granulosus cathepsin L cysteine proteinase 0.0163 0.1821 0.2068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Brugia malayi RE15519p 0.0057 0.0435 0.0676
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0037 0.0171 0.094
Entamoeba histolytica cysteine proteinase 2 0.0088 0.084 0.2189
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0171 0.094
Onchocerca volvulus 0.0163 0.1821 0.6554
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1087 0.2245
Schistosoma mansoni myosin xvIII 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0163 0.1821 0.4745
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0435 0.0435
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0435 0.0435
Brugia malayi G-protein coupled receptor 0.0057 0.0435 0.0676
Echinococcus granulosus geminin 0.0205 0.2369 0.2691
Mycobacterium tuberculosis Conserved protein 0.0107 0.1087 0.0755
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Giardia lamblia Cathepsin B precursor 0.0037 0.0171 0.0446
Echinococcus granulosus sex peptide receptor 0.0057 0.0435 0.0494
Trypanosoma cruzi cysteine proteinase, putative 0.0088 0.084 0.2343
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0435 0.0494
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0435 0.0631
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3605 0.5228
Onchocerca volvulus 0.0112 0.1152 0.4041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0473 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0171 0.094
Onchocerca volvulus 0.0057 0.0435 0.1348
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1087 0.3032
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0435 0.0676
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0435 0.0435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0883 0.0883
Onchocerca volvulus 0.0163 0.1821 0.6554
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0966 0.1501
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0095 0.0148
Schistosoma mansoni importin beta-1 0.0028 0.0059 0.0085
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Brugia malayi beta-lactamase family protein 0.0107 0.1087 0.1689
Echinococcus granulosus intermediate filament protein 0.0033 0.0118 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Plasmodium vivax vivapain-2 0.0163 0.1821 1
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1087 0.0755
Echinococcus multilocularis cathepsin b 0.0298 0.3585 0.3585
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0361 0.1007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2369 0.3435
Plasmodium falciparum serine repeat antigen 2 0.0037 0.0171 0.094
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0435 0.0494
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0171 0.0478
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.1152 0.3002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Echinococcus granulosus serotonin receptor 0.0057 0.0435 0.0494
Echinococcus granulosus lamin 0.0033 0.0118 0.0134
Echinococcus multilocularis geminin 0.0205 0.2369 0.2369
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0435 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1087 0.2832
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0435 0.0435
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0563 0.0875
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0435 0.0435
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0435 0.0631
Loa Loa (eye worm) beta-lactamase 0.0107 0.1087 0.1576
Plasmodium falciparum importin beta, putative 0.0028 0.0059 0.0323
Leishmania major cysteine peptidase A (CPA) 0.0163 0.1821 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0298 0.3585 0.5571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.084 0.4613
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0037 0.0171 0.094
Schistosoma mansoni biogenic amine receptor 0.0057 0.0435 0.0631
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.3838 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0966 0.1501
Brugia malayi Cathepsin L-like cysteine proteinase 0.0112 0.1152 0.179
Schistosoma mansoni neuropeptide receptor 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0171 0.0446
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0435 0.0494
Plasmodium falciparum serine repeat antigen 6 0.0037 0.0171 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Entamoeba histolytica cysteine protease, putative 0.0163 0.1821 0.4745
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.1821 0.4745
Onchocerca volvulus 0.0163 0.1821 0.6554
Echinococcus granulosus g protein coupled receptor 0.0057 0.0435 0.0494
Schistosoma mansoni opsin-like receptor 0.0057 0.0435 0.0631
Schistosoma mansoni amine GPCR 0.0548 0.6862 0.9951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0883 0.128
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0057 0.0435 0.0631
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0171 0.0446
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1087 0.5969
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.3838 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1087 0.2245
Onchocerca volvulus 0.0057 0.0435 0.1348
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.1026 0.1488
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0163 0.1821 0.2641
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0051 0.0361 0.0524
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0171 0.0357
Toxoplasma gondii cathepsin B 0.0117 0.1227 0.6739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1087 0.0755
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0171 0.0248
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0163 0.1821 0.4745
Giardia lamblia Cathepsin B precursor 0.0037 0.0171 0.0446
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0435 0.0494
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Brugia malayi Pre-SET motif family protein 0.0205 0.2369 0.3681
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Loa Loa (eye worm) glutaminase 0.0269 0.3208 0.4651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.1821 0.2829
Loa Loa (eye worm) hypothetical protein 0.0352 0.4292 0.6225
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0435 0.0631
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0118 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0883 0.1003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1087 0.1087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0435 0.0435
Giardia lamblia Cysteine protease 0.0037 0.0171 0.0446
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0037 0.0171 0.094
Onchocerca volvulus 0.0163 0.1821 0.6554
Schistosoma mansoni lamin 0.0033 0.0118 0.0172
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0138
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0435 0.0631
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0059 0.0323
Onchocerca volvulus 0.0163 0.1821 0.6554
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0435 0.0631
Brugia malayi hypothetical protein 0.0147 0.1613 0.2507
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1087 0.0755
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Schistosoma mansoni cathepsin F (C01 family) 0.0163 0.1821 0.2641
Trypanosoma cruzi cruzipain precursor, putative 0.0163 0.1821 0.5079
Onchocerca volvulus 0.0057 0.0435 0.1348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0551 0.6896 1
Brugia malayi GnHR receptor homolog 0.0057 0.0435 0.0676
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0298 0.3585 1
Schistosoma mansoni hypothetical protein 0.0067 0.0563 0.0816
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0435 0.0494
Mycobacterium tuberculosis Conserved protein 0.0107 0.1087 0.0755
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi Dopamine receptor 0.0057 0.0435 0.0676
Schistosoma mansoni glutaminase 0.0269 0.3208 0.4651
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0163 0.1821 0.1821
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Echinococcus granulosus cathepsin l1 0.0112 0.1152 0.1309
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0088 0.084 0.2343
Onchocerca volvulus 0.0057 0.0435 0.1348
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0435 0.0631
Giardia lamblia Encystation-specific protease 0.0037 0.0171 0.0446
Giardia lamblia Cysteine protease 0.0037 0.0171 0.0446
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0361 0.1007
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0037 0.0171 0.094
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0171 0.0266
Loa Loa (eye worm) hypothetical protein 0.0102 0.1026 0.1488
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.1821 0.4745
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1087 0.2832
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Onchocerca volvulus 0.0057 0.0435 0.1348
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0681 0.8603 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis cathepsin L cysteine protease 0.0163 0.1821 0.1821
Giardia lamblia Cathepsin B precursor 0.0037 0.0171 0.0446
Toxoplasma gondii cathepsin CPL 0.0163 0.1821 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.3208 0.8358
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1087 0.1576
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine proteinase 1, putative 0.0088 0.084 0.2189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Brugia malayi glutaminase DH11.1 0.0269 0.3208 0.4984
Schistosoma mansoni opsin-like receptor 0.0057 0.0435 0.0631
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0435 0.0494
Echinococcus granulosus neuropeptide receptor 0.0057 0.0435 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Giardia lamblia Hypothetical protein 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0147 0.1613 0.2339
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0473 0.0686
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0435 0.0494
Brugia malayi larval opioid receptor 0.0057 0.0435 0.0676
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0095 0.0108
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Echinococcus granulosus cathepsin l cysteine peptidase 0.0163 0.1821 0.2068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0435 0.0435
Trypanosoma brucei cysteine peptidase C (CPC) 0.0117 0.1227 0.6739
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0171 0.0478
Plasmodium vivax importin-beta 2, putative 0.0028 0.0059 0.0323
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0171 0.094
Echinococcus granulosus somatostatin receptor 0.0057 0.0435 0.0494
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0435 0.0494
Echinococcus granulosus lamin dm0 0.0033 0.0118 0.0134
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0435 0.0435
Plasmodium falciparum serine repeat antigen 9 0.0037 0.0171 0.094
Echinococcus granulosus cathepsin L 0.0037 0.0171 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0037 0.0171 0.0266
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0435 0.0435
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0883 0.128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0171 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0163 0.1821 0.6554
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0171 0.0446
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0435 0.0676
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0435 0.0494
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0435 0.0676
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Plasmodium vivax unspecified product 0.0051 0.0361 0.1983
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Plasmodium falciparum serine repeat antigen 7 0.0037 0.0171 0.094
Onchocerca volvulus 0.0107 0.1087 0.3797
Plasmodium vivax unspecified product 0.0037 0.0171 0.094
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0037 0.0171 0.094
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1087 0.2832
Echinococcus multilocularis cathepsin L 0.0037 0.0171 0.0171
Giardia lamblia Cathepsin B precursor 0.0117 0.1227 0.3197
Plasmodium falciparum serine repeat antigen 1 0.0037 0.0171 0.094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0435 0.0494
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0435 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.084 0.1305
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0361 0.0524
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0033 0.0118 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0966 0.1401
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0138
Brugia malayi Cathepsin L-like precursor 0.0112 0.1152 0.179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0095 0.0095
Brugia malayi cathepsin L precursor 0.0037 0.0171 0.0266
Brugia malayi Melatonin receptor type 1A 0.0057 0.0435 0.0676
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.3585 0.5199
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0037 0.0171 0.094
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0435 0.0435
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.011
Onchocerca volvulus 0.0057 0.0435 0.1348
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0171 0.0266
Schistosoma mansoni histamine h1 receptor 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni cathepsin C 0.0037 0.0171 0.0248
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0037 0.0171 0.0446
Onchocerca volvulus 0.0147 0.1613 0.5773
Brugia malayi ORL1-like opioid receptor 0.0057 0.0435 0.0676
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0435 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.011
Schistosoma mansoni cathepsin S (C01 family) 0.0037 0.0171 0.0248
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.1821 0.5079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0138
Giardia lamblia Cathepsin L-like protease 0.0037 0.0171 0.0446
Echinococcus granulosus fmrfamide receptor 0.0057 0.0435 0.0494
Echinococcus granulosus cathepsin L cysteine protease 0.0088 0.084 0.0954
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0473 0.2598
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0435 0.0631
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Plasmodium vivax vivapain-3 0.0088 0.084 0.4613
Mycobacterium ulcerans glutaminase 0.0269 0.3208 1
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.084 0.2189
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0033 0.0118 0.0158
Trypanosoma cruzi cysteine protease, putative 0.0088 0.084 0.2343
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0435 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.084 0.4613
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0435 0.0631
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0037 0.0171 0.0446
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0059 0.0323
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1087 0.0755
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0117 0.1227 0.6739
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0112 0.1152 0.1671
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.1717 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi follicle stimulating hormone receptor 0.0057 0.0435 0.0676
Echinococcus granulosus cathepsin L 0.0088 0.084 0.0954
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Brugia malayi Serotonin receptor 0.0057 0.0435 0.0676
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0435 0.1348
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0435 0.0435
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1087 0.1576
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus granulosus neuropeptide receptor 0.0057 0.0435 0.0494
Plasmodium vivax SET domain protein, putative 0.0029 0.0076 0.0418
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0435 0.0494
Echinococcus granulosus orexin receptor type 2 0.0057 0.0435 0.0494
Loa Loa (eye worm) hypothetical protein 0.0107 0.1087 0.1576
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Brugia malayi Pre-SET motif family protein 0.0029 0.0076 0.0118
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0163 0.1821 0.1821
Entamoeba histolytica cysteine protease, putative 0.0037 0.0171 0.0446
Giardia lamblia Hypothetical protein 0.0037 0.0171 0.0446
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.3585 0.5199
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.1821 0.5079
Plasmodium vivax vivapain-2 0.0163 0.1821 1
Brugia malayi Serotonin receptor 0.0515 0.6435 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0435 0.1348
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.084 0.1218
Echinococcus multilocularis cysteine protease 0.0163 0.1821 0.1821
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.084 0.1218
Brugia malayi beta-lactamase family protein 0.0107 0.1087 0.1689
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0435 0.0631
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0163 0.1821 1
Echinococcus granulosus g protein coupled receptor 0.0057 0.0435 0.0494
Onchocerca volvulus 0.0057 0.0435 0.1348
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0037 0.0171 0.094
Echinococcus multilocularis lamin 0.0033 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0051 0.0361 0.0524
Brugia malayi neuropeptide F receptor 0.0057 0.0435 0.0676
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0435 0.0435
Schistosoma mansoni amine GPCR 0.0057 0.0435 0.0631
Brugia malayi G-protein coupled receptor 0.0057 0.0435 0.0676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0171 0.0446
Brugia malayi cathepsin L-like precursor 0.0112 0.1152 0.179
Schistosoma mansoni lamin 0.0033 0.0118 0.0172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0883 0.128
Giardia lamblia Cathepsin L-like protease 0.0037 0.0171 0.0446
Schistosoma mansoni adenoreceptor 0.0057 0.0435 0.0631
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0473 0.0686
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0037 0.0171 0.094
Echinococcus multilocularis tumor protein p63 0.0696 0.8804 0.8804
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0435 0.0435
Plasmodium falciparum serine repeat antigen 5 0.0037 0.0171 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1087 0.3032
Echinococcus granulosus tumor protein p63 0.0696 0.8804 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0163 0.1821 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0059 0.0091
Plasmodium falciparum cysteine proteinase falcipain 1 0.0088 0.084 0.4613
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0435 0.0631
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.084 0.2343
Onchocerca volvulus Cathepsin F homolog 0.0163 0.1821 0.6554
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0037 0.0171 0.0248
Schistosoma mansoni amine GPCR 0.0057 0.0435 0.0631
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Plasmodium falciparum serine repeat antigen 3 0.0037 0.0171 0.094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0111 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0118 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.1821 0.5079
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0171 0.0446
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1087 0.5969
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0435 0.0435
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0315 0.381 0.5525
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.1821 0.4745
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0435 0.0631
Echinococcus multilocularis somatostatin receptor 0.0057 0.0435 0.0435
Brugia malayi beta-lactamase 0.0107 0.1087 0.1689
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.084 0.1218
Schistosoma mansoni cathepsin s 0.0051 0.0361 0.0524
Loa Loa (eye worm) hypothetical protein 0.0037 0.0171 0.0248
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.084 0.2189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0435 0.0435
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0171 0.0248
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0435 0.0435
Echinococcus granulosus importin subunit beta 1 0.0028 0.0059 0.0067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0118 0.0172
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Loa Loa (eye worm) fibroinase 0.0163 0.1821 0.2641
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0171 0.0446
Loa Loa (eye worm) glutaminase 2 0.0269 0.3208 0.4651
Schistosoma mansoni cathepsin F (C01 family) 0.0163 0.1821 0.2641
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0095 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1087 0.1576
Plasmodium vivax unspecified product 0.0088 0.084 0.4613
Echinococcus granulosus cathepsin b 0.0298 0.3585 0.4072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0171 0.0248
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.084 0.1305
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1087 0.0755
Trichomonas vaginalis esterase, putative 0.0107 0.1087 0.2832
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0171 0.0446
Echinococcus multilocularis cathepsin L cysteine protease 0.0163 0.1821 0.1821
Giardia lamblia Cathepsin B precursor 0.0117 0.1227 0.3197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Onchocerca volvulus Cathepsin L homolog 0.0163 0.1821 0.6554
Plasmodium falciparum serine repeat antigen 4 0.0037 0.0171 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.3585 0.5199
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0352 0.4292 0.667
Onchocerca volvulus 0.0057 0.0435 0.1348
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0171 0.0446
Onchocerca volvulus 0.0107 0.1087 0.3797
Loa Loa (eye worm) cysteine protease 0.0163 0.1821 0.2641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0095 0.0108
Trypanosoma cruzi cysteine proteinase, putative 0.0088 0.084 0.2343
Schistosoma mansoni hypothetical protein 0.0031 0.0095 0.0138
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0057 0.0435 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Loa Loa (eye worm) ctsf protein 0.0163 0.1821 0.2641
Giardia lamblia Cathepsin L precursor 0.0037 0.0171 0.0446
Toxoplasma gondii cathepsin CPC2 0.0037 0.0171 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0037 0.0171 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.1821 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0102 0.1026 0.3568
Schistosoma mansoni biogenic amine (5HT) receptor 0.0551 0.6896 1
Echinococcus multilocularis cysteine protease 0.0163 0.1821 0.1821
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0117 0.1227 0.3197
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0171 0.0266
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0435 0.0435
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0171 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0435 0.0435
Schistosoma mansoni neuropeptide receptor 0.0057 0.0435 0.0631
Loa Loa (eye worm) hypothetical protein 0.0551 0.6896 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1087 0.0755
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0076 0.0076
Brugia malayi Cathepsin L-like precursor 0.0112 0.1152 0.179
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.1152 0.1671
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1087 0.2832
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0171 0.0266
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0883 0.1372
Toxoplasma gondii cathepsin CPC1 0.0037 0.0171 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0435 0.0494
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0883 0.1003
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0435 0.0435
Onchocerca volvulus 0.0163 0.1821 0.6554
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0172
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2738 0.7136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.011
Schistosoma mansoni hypothetical protein 0.0057 0.0435 0.0631
Onchocerca volvulus 0.0057 0.0435 0.1348
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0435 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0076 0.011
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.084 0.2189
Plasmodium falciparum serine repeat antigen 8 0.0037 0.0171 0.094
Onchocerca volvulus 0.0057 0.0435 0.1348
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni hypothetical protein 0.0299 0.3605 0.5228
Giardia lamblia Cathepsin B precursor 0.0037 0.0171 0.0446
Brugia malayi Cathepsin L-like precursor 0.0163 0.1821 0.2829
Brugia malayi hypothetical protein 0.0057 0.0435 0.0676
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0473 0.0473
Echinococcus granulosus biogenic amine 5HT receptor 0.0551 0.6896 0.7833
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0435 0.0435
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0037 0.0171 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0171 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1821 0.4745
Schistosoma mansoni biogenic amine receptor 0.0057 0.0435 0.0631
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0037 0.0171 0.094
Loa Loa (eye worm) hypothetical protein 0.0112 0.1152 0.1671
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3838 1
Brugia malayi Cathepsin L-like precursor 0.0051 0.0361 0.0561
Brugia malayi RNA, U transporter 1 0.008 0.0735 0.1141
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0435 0.0494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0117 0.1227 0.1779
Loa Loa (eye worm) hypothetical protein 0.0097 0.0966 0.1401
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Onchocerca volvulus 0.0057 0.0435 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.1152 0.3002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0435 0.0631
Schistosoma mansoni neuropeptide receptor 0.0057 0.0435 0.0631
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0473 0.2598
Brugia malayi Dopamine receptor protein 1 0.0057 0.0435 0.0676
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1087 0.1689
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0163 0.1821 0.2641
Plasmodium vivax vivapain-1 0.0088 0.084 0.4613
Loa Loa (eye worm) hypothetical protein 0.0067 0.0563 0.0816
Echinococcus multilocularis cathepsin L 0.0088 0.084 0.084
Echinococcus granulosus GPCR family 2 0.0031 0.0095 0.0108
Brugia malayi intermediate filament protein 0.0033 0.0118 0.0184
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0435 0.0494
Leishmania major cathepsin L-like protease 0.0163 0.1821 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0435 0.0494
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.1717 0.455
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0361 0.0561
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0435 0.0631
Entamoeba histolytica cysteine protease, putative 0.0088 0.084 0.2189
Loa Loa (eye worm) hypothetical protein 0.0298 0.3585 0.5199
Echinococcus granulosus allatostatin A receptor 0.0057 0.0435 0.0494
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0037 0.0171 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0435 0.0631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0883 0.128

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0184 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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