Detailed information for compound 1286137

Basic information

Technical information
  • TDR Targets ID: 1286137
  • Name: N-(2,4-dimethoxyphenyl)-3-[3-(4-fluorophenyl) -4-oxo-[1,2]oxazolo[5,4-d]pyrimidin-5-yl]-N-m ethylpropanamide
  • MW: 452.435 | Formula: C23H21FN4O5
  • H donors: 0 H acceptors: 3 LogP: 2.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1N(C(=O)CCn1cnc2c(c1=O)c(no2)c1ccc(cc1)F)C
  • InChi: 1S/C23H21FN4O5/c1-27(17-9-8-16(31-2)12-18(17)32-3)19(29)10-11-28-13-25-22-20(23(28)30)21(26-33-22)14-4-6-15(24)7-5-14/h4-9,12-13H,10-11H2,1-3H3
  • InChiKey: ROXJAGAHKZAMPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-3-[3-(4-fluorophenyl)-4-oxo-isoxazolo[5,4-d]pyrimidin-5-yl]-N-methyl-propanamide
  • N-(2,4-dimethoxyphenyl)-3-[3-(4-fluorophenyl)-4-oxo-5-isoxazolo[5,4-d]pyrimidinyl]-N-methylpropanamide
  • N-(2,4-dimethoxyphenyl)-3-[3-(4-fluorophenyl)-4-keto-isoxazolo[5,4-d]pyrimidin-5-yl]-N-methyl-propionamide
  • N-(2,4-dimethoxyphenyl)-3-[3-(4-fluorophenyl)-4-oxo-[1,2]oxazolo[5,4-d]pyrimidin-5-yl]-N-methyl-propanamide
  • E910-0114
  • NCGC00126583-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0686 0.0686
Schistosoma mansoni hypothetical protein 0.0041 0.0455 0.0606
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0144 0.3143 0.4187
Schistosoma mansoni hypothetical protein 0.0082 0.1505 0.2005
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0686 0.0914
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.095 0.1509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1875 0.1875
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0411 0.0411
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0411 0.7978
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0515 1
Echinococcus granulosus CREB binding protein 0.0097 0.1917 0.1917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1875 0.1875
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0686 0.0686
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0515 0.4197
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.3124 0.4961
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0866 0.0866
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0686 0.1633
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0515 0.5
Mycobacterium tuberculosis Conserved protein 0.0043 0.0515 0.0168
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0411 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0515 1
Onchocerca volvulus 0.0043 0.0515 0.1226
Trichomonas vaginalis bromodomain-containing protein, putative 0.0266 0.6298 1
Trichomonas vaginalis bromodomain containing protein, putative 0.0122 0.2557 0.4061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0612 0.2392
Loa Loa (eye worm) CBP-B 0.0107 0.2166 0.3439
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Echinococcus multilocularis geminin 0.0175 0.3935 0.3935
Brugia malayi hypothetical protein 0.0098 0.1941 0.3083
Onchocerca volvulus 0.0122 0.2557 0.6084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.4203 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Entamoeba histolytica bromodomain-containing protein 0.0122 0.2557 1
Echinococcus multilocularis CREB binding protein 0.0106 0.2138 0.2138
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Echinococcus granulosus geminin 0.0175 0.3935 0.3935
Schistosoma mansoni hypothetical protein 0.0175 0.3935 0.5242
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0515 0.0168
Echinococcus multilocularis Bromodomain containing protein 0.0122 0.2557 0.2557
Mycobacterium leprae Probable lipase LipE 0.0043 0.0515 0.5
Schistosoma mansoni hypothetical protein 0.0312 0.7507 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Entamoeba histolytica hypothetical protein 0.0082 0.1505 0.5885
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0515 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0515 0.0818
Echinococcus granulosus histone acetyltransferase KAT2B 0.0071 0.1228 0.1228
Schistosoma mansoni hypothetical protein 0.0175 0.3935 0.5242
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0515 0.0515
Brugia malayi N-terminal motif family protein 0.0185 0.4203 0.6674
Mycobacterium ulcerans lipase LipD 0.0043 0.0515 1
Trichomonas vaginalis bromodomain containing protein, putative 0.0167 0.374 0.5939
Echinococcus granulosus bromodomain containing 2 0.0266 0.6298 0.6298
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0938 0.1249
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0411 0.3348
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0515 0.0686
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0515 0.0818
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.374 0.5939
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0411 0.7978
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0686 0.0914
Trichomonas vaginalis esterase, putative 0.0043 0.0515 0.0818
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0612 0.2392
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0411 0.0411
Loa Loa (eye worm) beta-lactamase 0.0043 0.0515 0.0818
Onchocerca volvulus 0.005 0.0686 0.1633
Loa Loa (eye worm) hypothetical protein 0.0266 0.6298 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6611 1
Brugia malayi Bromodomain containing protein 0.0266 0.6298 1
Loa Loa (eye worm) bromodomain containing protein 0.0122 0.2557 0.4061
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0515 0.0818
Loa Loa (eye worm) acetyltransferase 0.0194 0.4442 0.7054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0515 0.0818
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0686 0.0686
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0515 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0866 0.1154
Brugia malayi Bromodomain containing protein 0.0266 0.6298 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0411 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0886 0.1407
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Entamoeba histolytica bromodomain-containing protein 0.0122 0.2557 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0266 0.6298 0.8389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.1505 0.1505
Echinococcus multilocularis bromodomain containing 2 0.0266 0.6298 0.6298
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.2557 0.4061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.1228 0.1949
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.381 0.381
Giardia lamblia Kinase, putative 0.0122 0.2557 1
Toxoplasma gondii bromodomain-containing protein 0.0122 0.2557 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0515 0.0686
Echinococcus granulosus CREB binding protein 0.0144 0.3143 0.3143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.1505 0.1505
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0411 0.672
Loa Loa (eye worm) hypothetical protein 0.005 0.0686 0.109
Leishmania major hypothetical protein, conserved 0.0043 0.0515 1
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0411 0.0653
Schistosoma mansoni ap endonuclease 0.0039 0.0411 0.0548
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0411 0.0653
Mycobacterium ulcerans beta-lactamase 0.0043 0.0515 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1875 0.2977
Onchocerca volvulus 0.006 0.0938 0.2232
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0194 0.4442 0.5917
Trichomonas vaginalis bromodomain-containing protein, putative 0.0167 0.374 0.5939
Loa Loa (eye worm) hypothetical protein 0.006 0.095 0.1509
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0515 1
Brugia malayi TAZ zinc finger family protein 0.0144 0.3143 0.4991
Brugia malayi mbt repeat family protein 0.005 0.0686 0.109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0455 0.0722
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0411 0.7978
Entamoeba histolytica hypothetical protein 0.0082 0.1505 0.5885
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0071 0.1228 0.1949
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.4722 0.4722
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0071 0.1228 0.48
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0686 0.0686
Entamoeba histolytica hypothetical protein 0.0082 0.1505 0.5885
Brugia malayi beta-lactamase 0.0043 0.0515 0.0818
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.095 0.1509
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0411 0.0653
Brugia malayi acetyltransferase, GNAT family protein 0.0194 0.4442 0.7054
Onchocerca volvulus 0.0043 0.0515 0.1226
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0411 0.7978
Onchocerca volvulus 0.0043 0.0515 0.1226
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.4722 0.4722
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0866 0.1376
Brugia malayi beta-lactamase family protein 0.0043 0.0515 0.0818
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0686 0.0914
Brugia malayi mbt repeat family protein 0.005 0.0686 0.109
Schistosoma mansoni ap endonuclease 0.0039 0.0411 0.0548
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0016 0.0026
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0122 0.2557 0.4061
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.1505 0.2005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0167 0.374 0.5939
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0515 0.0818
Mycobacterium ulcerans hypothetical protein 0.0043 0.0515 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1875 0.2498
Mycobacterium tuberculosis Conserved protein 0.0043 0.0515 0.0168
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0612 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0515 0.0168
Entamoeba histolytica bromodomain-containing protein 0.0122 0.2557 1
Loa Loa (eye worm) MBCTL1 0.0057 0.0866 0.1376
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0515 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1875 0.1875
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0411 0.1607
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Entamoeba histolytica hypothetical protein 0.0082 0.1505 0.5885
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0866 0.0866
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0071 0.1228 0.48
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0515 0.0818
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0515 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0411 0.1607
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0122 0.2557 0.4061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818
Loa Loa (eye worm) hypothetical protein 0.0185 0.4203 0.6674
Loa Loa (eye worm) hypothetical protein 0.006 0.0938 0.1489
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.095 0.1509
Trichomonas vaginalis bromodomain-containing protein, putative 0.0266 0.6298 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1875 0.2977
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0016 0.0026
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0515 0.0168
Schistosoma mansoni CREB-binding protein 2 0.0144 0.3143 0.4187
Brugia malayi hypothetical protein 0.0082 0.1505 0.239
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0515 0.0168
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0866 0.0866
Brugia malayi beta-lactamase family protein 0.0043 0.0515 0.0818
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1875 0.1875
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Mycobacterium tuberculosis Conserved protein 0.0043 0.0515 0.0168
Toxoplasma gondii exonuclease III APE 0.0039 0.0411 0.1607
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818
Trichomonas vaginalis bromodomain-containing protein, putative 0.0167 0.374 0.5939
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0686 0.109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0194 0.4442 0.4442
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0515 0.0168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0455 0.0722
Toxoplasma gondii ABC1 family protein 0.0043 0.0515 0.2015
Trichomonas vaginalis bromodomain-containing protein, putative 0.0122 0.2557 0.4061
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0071 0.1228 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1875 0.2498
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0515 0.0168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0411 0.0653
Loa Loa (eye worm) hypothetical protein 0.0057 0.0866 0.1376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1875 0.2498
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0043 0.0515 0.0818

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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