Detailed information for compound 1307015

Basic information

Technical information
  • TDR Targets ID: 1307015
  • Name: N-[1-[(4-chlorophenyl)methyl]-5-methylpyrazol -3-yl]-7-methoxy-4,5-dihydrobenzo[g][1,2]benz oxazole-3-carboxamide
  • MW: 448.902 | Formula: C24H21ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 4.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)CCc1c2onc1C(=O)Nc1nn(c(c1)C)Cc1ccc(cc1)Cl
  • InChi: 1S/C24H21ClN4O3/c1-14-11-21(27-29(14)13-15-3-6-17(25)7-4-15)26-24(30)22-20-9-5-16-12-18(31-2)8-10-19(16)23(20)32-28-22/h3-4,6-8,10-12H,5,9,13H2,1-2H3,(H,26,27,30)
  • InChiKey: RPMGRWSWGYXZOA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[1-[(4-chlorophenyl)methyl]-5-methyl-pyrazol-3-yl]-7-methoxy-4,5-dihydrobenzo[g][1,2]benzoxazole-3-carboxamide
  • N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-7-methoxy-4,5-dihydrobenzo[g][1,2]benzoxazole-3-carboxamide
  • N-[1-(4-chlorobenzyl)-5-methyl-pyrazol-3-yl]-7-methoxy-4,5-dihydrobenzo[g]indoxazene-3-carboxamide
  • N-[1-(4-chlorobenzyl)-5-methyl-1H-pyrazol-3-yl]-7-methoxy-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide
  • SMR000023681
  • MLS000087458

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2855 0.3358
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.1196 0.236
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 1
Trichomonas vaginalis helicase, putative 0.0008 0.018 0.018
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4086 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 0.5068
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0342 0.0403
Onchocerca volvulus 0.0014 0.0501 0.2955
Mycobacterium ulcerans L-lysine aminotransferase 0.0026 0.1196 0.1196
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.3155 0.7722
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0342 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0325 0.0641
Loa Loa (eye worm) cysteine protease 0.002 0.0878 0.1033
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0325 0.0382
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0026 0.1196 0.1196
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0325 0.0382
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0026 0.1196 0.1196
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0325 0.1499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.1573 0.3105
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0005 0 0.5
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.1196 0.236
Echinococcus multilocularis cysteine protease 0.002 0.0878 0.1033
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0026 0.1196 0.1196
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0878 0.4055
Leishmania major cathepsin L-like protease 0.002 0.0878 0.2149
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.5068 0.596
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.1196 0.1196
Loa Loa (eye worm) hypothetical protein 0.0014 0.0501 0.0589
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0325 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Onchocerca volvulus 0.0035 0.1695 1
Trypanosoma cruzi cysteine peptidase, putative 0.0007 0.0114 0.0279
Entamoeba histolytica hypothetical protein 0.0043 0.2166 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.8503 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.3647 0.429
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.5068 0.596
Plasmodium vivax unspecified product 0.0007 0.0114 0.0225
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0325 0.0641
Loa Loa (eye worm) hypothetical protein 0.0155 0.8503 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0878 0.0878
Leishmania major cathepsin L-like protease 0.0077 0.4086 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2855 0.3358
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.5068 0.5068
Schistosoma mansoni cathepsin s 0.0007 0.0114 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Entamoeba histolytica cysteine protease, putative 0.002 0.0878 0.4055
Trypanosoma cruzi cruzipain precursor, putative 0.0007 0.0114 0.0279
Echinococcus multilocularis cpg binding protein 0.0037 0.1806 0.2124
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.5068 1
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0501 0.2312
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0325 0.0795
Plasmodium vivax unspecified product 0.001 0.0325 0.0641
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0325 0.0641
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0325 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Leishmania major cathepsin L-like protease 0.002 0.0878 0.2149
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.3231 0.3231
Plasmodium vivax vivapain-2 0.002 0.0878 0.1733
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0878 0.1033
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Leishmania major cathepsin L-like protease 0.002 0.0878 0.2149
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2855 0.5634
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0325 0.1499
Echinococcus multilocularis Aminotransferase class III 0.0026 0.1196 0.1406
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0223 0.0262
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0325 0.0795
Brugia malayi CXXC zinc finger family protein 0.0035 0.1695 0.1993
Giardia lamblia Hypothetical protein 0.0005 0 0.5
Echinococcus granulosus cathepsin l1 0.0014 0.0501 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4086 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3889 0.7675
Loa Loa (eye worm) hypothetical protein 0.0014 0.0501 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0501 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Echinococcus multilocularis muscleblind protein 0.0155 0.8503 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0501 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.3708 0.9076
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.3231 0.3231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2855 0.3358
Brugia malayi cathepsin L-like precursor 0.0014 0.0501 0.0589
Plasmodium falciparum ornithine aminotransferase 0.0026 0.1196 0.236
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.3647 0.3647
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Echinococcus granulosus ornithine aminotransferase 0.0026 0.1196 0.1406
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0501 0.0988
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 1
Echinococcus granulosus muscleblind protein 0.0155 0.8503 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Trypanosoma cruzi cysteine protease, putative 0.001 0.0325 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.5068 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0026 0.1196 0.1196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0114 0.0134
Plasmodium vivax vivapain-1 0.001 0.0325 0.0641
Schistosoma mansoni hypothetical protein 0.0043 0.2166 0.4274
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0878 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.3647 0.429
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.3231 0.38
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.5068 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0325 0.0795
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2166 0.2547
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4086 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.5068 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3446 0.68
Schistosoma mansoni cpg binding protein 0.0037 0.1806 0.3564
Onchocerca volvulus 0.002 0.0878 0.5182
Loa Loa (eye worm) ctsf protein 0.002 0.0878 0.1033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0342 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Mycobacterium ulcerans hypothetical protein 0.0182 1 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Brugia malayi Cathepsin L-like precursor 0.0007 0.0114 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0878 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2855 0.3358
Echinococcus multilocularis muscleblind protein 1 0.0155 0.8503 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0223 0.044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0223 0.0262
Leishmania major cathepsin L-like protease 0.002 0.0878 0.2149
Echinococcus granulosus Aminotransferase class III 0.0026 0.1196 0.1406
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0878 0.1033
Brugia malayi Probable ClpP-like protease 0.0094 0.5068 0.596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0026 0.1196 0.1196
Schistosoma mansoni cpg binding protein 0.0035 0.1695 0.3344
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0878 0.1033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0114 0.0134
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0026 0.1196 0.1196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Entamoeba histolytica hypothetical protein 0.0043 0.2166 1
Entamoeba histolytica hypothetical protein 0.0043 0.2166 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.1573 0.3105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1695 0.1993
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0182 1 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.1573 0.1573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Toxoplasma gondii hypothetical protein 0.0033 0.1573 0.3105
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0026 0.1196 0.1196
Loa Loa (eye worm) hypothetical protein 0.002 0.0878 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0501 0.0501
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Echinococcus granulosus cpg binding protein 0.0037 0.1806 0.2124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Entamoeba histolytica cysteine proteinase 2 0.001 0.0325 0.1499
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Brugia malayi hypothetical protein 0.0043 0.2166 0.2547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0325 0.0795
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.3647 0.8927
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.3647 0.3647
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0007 0.0114 0.0134
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.3231 0.38
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0325 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Schistosoma mansoni cpg binding protein 0.0037 0.1806 0.3564
Leishmania major cathepsin L-like protease 0.0077 0.4086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.3647 0.3647
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0878 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Mycobacterium ulcerans acetylornithine aminotransferase 0.0026 0.1196 0.1196
Brugia malayi Cathepsin L-like precursor 0.0014 0.0501 0.0589
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0878 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.1196 0.1406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0325 0.0325
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Brugia malayi Cathepsin L-like precursor 0.002 0.0878 0.1033
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0026 0.1196 0.1196
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0878 0.1733
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Loa Loa (eye worm) fibroinase 0.002 0.0878 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0223 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0878 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Entamoeba histolytica hypothetical protein 0.0043 0.2166 1
Plasmodium vivax vivapain-2 0.002 0.0878 0.1733
Echinococcus granulosus cysteine protease 0.001 0.0325 0.0382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0335 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Giardia lamblia Short-chain dehydrogenase, putative 0.0005 0 0.5
Onchocerca volvulus 0.002 0.0878 0.5182
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.4086 1
Onchocerca volvulus 0.002 0.0878 0.5182
Onchocerca volvulus Cathepsin F homolog 0.002 0.0878 0.5182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2855 0.5634
Loa Loa (eye worm) hypothetical protein 0.0094 0.5068 0.596
Brugia malayi Cathepsin L-like precursor 0.0014 0.0501 0.0589
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.5068 0.5068
Giardia lamblia Reductase, putative 0.0005 0 0.5
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.3231 0.3231
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Echinococcus granulosus cathepsin L 0.001 0.0325 0.0382
Onchocerca volvulus 0.002 0.0878 0.5182
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.3384 0.398
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0026 0.1196 0.1196
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2166 0.4274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0878 0.0878
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.1196 0.1406
Echinococcus multilocularis cathepsin L 0.001 0.0325 0.0382
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.3647 0.429
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0007 0.0114 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0878 0.1033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0223 0.0262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2855 0.3358
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0182 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2166 0.2547
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0325 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0325 0.1499
Onchocerca volvulus Cathepsin L homolog 0.002 0.0878 0.5182
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0325 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0878 0.0878
Onchocerca volvulus 0.002 0.0878 0.5182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0878 0.0878
Onchocerca volvulus Cathepsin L homolog 0.002 0.0878 0.5182
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.1196 0.1196
Brugia malayi cathepsin F-like cysteine proteinase 0.0007 0.0114 0.0134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0114 0.0134
Brugia malayi Muscleblind-like protein 0.0155 0.8503 1
Toxoplasma gondii cathepsin CPL 0.002 0.0878 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0501 0.0501
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0878 0.2149
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0325 0.1499
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0878 0.1733
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0878 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0018 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.018 0.018
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.1196 0.236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.018 0.018
Leishmania major cathepsin L-like protease 0.002 0.0878 0.2149
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.1196 0.236
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.3647 0.7197
Plasmodium vivax vivapain-3 0.001 0.0325 0.0641
Echinococcus multilocularis cysteine protease 0.002 0.0878 0.1033
Mycobacterium tuberculosis Probable aminotransferase 0.0182 1 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0182 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.018 0.018
Entamoeba histolytica cysteine protease, putative 0.001 0.0325 0.1499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2855 0.5634
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0878 0.1033
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.1196 0.1406
Leishmania major cysteine peptidase A (CPA) 0.002 0.0878 0.2149
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0878 0.4055
Onchocerca volvulus 0.002 0.0878 0.5182
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0878 0.1733
Leishmania major cathepsin L-like protease 0.0077 0.4086 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4086 1
Onchocerca volvulus 0.002 0.0878 0.5182
Echinococcus granulosus cathepsin l1 0.002 0.0878 0.1033
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0325 0.1499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2855 0.3358

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 um PUBCHEM_BIOASSAY: Chemical Antagonists IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays: 1513, 1514, 1449 ] ChEMBL. No reference
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: Counter Screen using XIAP-Bir3 for Chemical Antagonists of Bir1/2 domains of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1514, AID1638, AID1749, AID1750, AID488957, AID488963] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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