Detailed information for compound 1313518

Basic information

Technical information
  • TDR Targets ID: 1313518
  • Name: 3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-5 -fluoro-3-hydroxy-1H-indol-2-one
  • MW: 353.347 | Formula: C19H16FN3O3
  • H donors: 2 H acceptors: 3 LogP: 1.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)C(O)(C(=O)N2)c1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C19H16FN3O3/c1-11-16(17(24)23(22(11)2)13-6-4-3-5-7-13)19(26)14-10-12(20)8-9-15(14)21-18(19)25/h3-10,26H,1-2H3,(H,21,25)
  • InChiKey: NCPPLSMWMMYJBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-5-fluoro-3-hydroxy-indolin-2-one
  • 3-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-5-fluoro-3-hydroxy-2-indolinone
  • 5-fluoro-3-hydroxy-3-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)oxindole
  • 3-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-5-fluoro-3-hydroxy-1H-indol-2-one
  • 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-fluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one
  • MLS000064269
  • SMR000076329

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0982 0.097
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1221 0.4287
Echinococcus granulosus peregrin 0.0033 0.033 0.0317
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0151 0.0138
Schistosoma mansoni hypothetical protein 0.0021 0.0151 0.0138
Loa Loa (eye worm) glutaminase 0.0295 0.4306 0.7018
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0151 0.0138
Brugia malayi Pre-SET motif family protein 0.0059 0.0732 0.1066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Schistosoma mansoni carbonic anhydrase 0.0083 0.1096 0.1083
Echinococcus multilocularis carbonic anhydrase 0.0083 0.1096 0.1083
Echinococcus granulosus tar DNA binding protein 0.0061 0.0762 0.075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Echinococcus granulosus carbonic anhydrase 0.0083 0.1096 0.1083
Schistosoma mansoni hypothetical protein 0.0083 0.1096 0.1083
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0747 0.5919
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0732 0.5744
Schistosoma mansoni polycystin 1-related 0.0021 0.0151 0.0138
Brugia malayi hypothetical protein 0.0286 0.4169 0.6817
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0732 0.0719
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.2202 0.2192
Echinococcus granulosus geminin 0.0164 0.2326 0.2316
Schistosoma mansoni rab6-interacting 0.0021 0.0151 0.0138
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1221 0.2081
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0177 0.2526 0.4068
Trichomonas vaginalis glutaminase, putative 0.0295 0.4306 0.5906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1933 0.29
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0241 0.0519
Onchocerca volvulus 0.0029 0.0265 0.0168
Loa Loa (eye worm) hypothetical protein 0.0083 0.1096 0.1595
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0733 0.072
Schistosoma mansoni hypothetical protein 0.0164 0.2326 0.2316
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0762 0.1032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0823 0.081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1221 0.1884
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0527 0.0514
Schistosoma mansoni loxhd1 0.0021 0.0151 0.0138
Onchocerca volvulus Huntingtin homolog 0.0148 0.2077 0.284
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0272 0.0585
Echinococcus granulosus carbonic anhydrase 0.0083 0.1096 0.1083
Brugia malayi Doublecortin family protein 0.0021 0.0151 0.0094
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0823 0.081
Echinococcus multilocularis carbonic anhydrase 0.0083 0.1096 0.1083
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0317 0.465 0.5
Schistosoma mansoni lipoxygenase 0.0059 0.0733 0.072
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0272 0.0259
Loa Loa (eye worm) hypothetical protein 0.0059 0.0732 0.0981
Brugia malayi Bromodomain containing protein 0.0033 0.033 0.0393
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0151 0.0138
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0823 0.2546
Plasmodium vivax SET domain protein, putative 0.0059 0.0732 0.1574
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.1096 0.1083
Toxoplasma gondii hypothetical protein 0.0083 0.1096 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0762 0.075
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0317 0.465 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.014 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0732 0.0719
Schistosoma mansoni glutaminase 0.0295 0.4306 0.4298
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.2136 0.2125
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0714 0.1035
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0317 0.465 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0151 0.0326
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.1096 0.1674
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0272 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0732 0.0719
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.1096 0.1083
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0265 0.0192
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0272 0.0259
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0762 0.075
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0177 0.2526 0.4012
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4169 0.4161
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0272 0.0203
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1281 0.1269
Loa Loa (eye worm) carbonic anhydrase 3 0.0177 0.2526 0.4012
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0762 0.075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0527 0.3339
Schistosoma mansoni cpg binding protein 0.003 0.029 0.0277
Brugia malayi TAR-binding protein 0.0061 0.0762 0.1116
Loa Loa (eye worm) RNA binding protein 0.0061 0.0762 0.1032
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0468 0.0509
Leishmania major carbonic anhydrase-like protein 0.0177 0.2526 1
Schistosoma mansoni cpg binding protein 0.003 0.029 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0732 0.0719
Schistosoma mansoni lipoxygenase 0.0021 0.0151 0.0138
Echinococcus multilocularis RUN 0.0021 0.0151 0.0138
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.4136 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1221 0.1209
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0788 0.0775
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.3253
Echinococcus multilocularis cpg binding protein 0.003 0.029 0.0277
Schistosoma mansoni kinase 0.0047 0.0536 0.0523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.039 0.0377
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1933 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0115 0.0101
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4136 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0468 0.1007
Schistosoma mansoni hypothetical protein 0.0029 0.0272 0.0259
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.3253
Schistosoma mansoni cpg binding protein 0.0029 0.0265 0.0252
Brugia malayi hypothetical protein 0.0027 0.0241 0.0245
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0177 0.2526 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0762 0.1116
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1281 0.1269
Brugia malayi glutaminase DH11.1 0.0295 0.4306 0.7046
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0744 0.1001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0177 0.2526 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0241 0.0519
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1221 0.4287
Echinococcus multilocularis carbonic anhydrase 0.0083 0.1096 0.1083
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4136 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0762 0.1032
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.2202 0.3526
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0762 0.075
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1221 0.4287
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0241 0.0519
Trichomonas vaginalis set domain proteins, putative 0.0467 0.6932 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1221 0.1209
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0177 0.2526 0.2516
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1933 0.29
Brugia malayi PHD-finger family protein 0.0029 0.0272 0.0296
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0151 0.0138
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0527 0.3339
Echinococcus multilocularis geminin 0.0164 0.2326 0.2316
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0317 0.465 0.5
Schistosoma mansoni hypothetical protein 0.0164 0.2326 0.2316
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0151 0.0138
Brugia malayi hypothetical protein 0.0021 0.0151 0.0094
Plasmodium falciparum carbonic anhydrase 0.0083 0.1096 0.2356
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0527 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0732 0.0719
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.0152
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0468 0.0037
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0317 0.465 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4169 0.4161
Brugia malayi hypothetical protein 0.0021 0.0151 0.0094
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0083 0.1096 0.1674
Echinococcus multilocularis peregrin 0.0033 0.033 0.0317
Brugia malayi hypothetical protein 0.0148 0.2077 0.3317
Loa Loa (eye worm) acetyltransferase 0.0156 0.2202 0.3465
Loa Loa (eye worm) hypothetical protein 0.0029 0.0272 0.0203
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0317 0.465 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0823 0.081
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0527 0.1132
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1221 0.1577
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0527 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0272 0.0358
Brugia malayi RNA binding protein 0.0061 0.0762 0.1116
Loa Loa (eye worm) hypothetical protein 0.0083 0.1096 0.1595
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.4136 1
Onchocerca volvulus 0.0059 0.0732 0.0856
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0762 0.075
Loa Loa (eye worm) hypothetical protein 0.005 0.0589 0.0739
Echinococcus granulosus RUN 0.0021 0.0151 0.0138
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0733 0.072
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0317 0.465 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0365 0.0352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Schistosoma mansoni survival motor neuron protein 0.0058 0.0714 0.0701
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0151 0.0138
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0445 0.0432
Schistosoma mansoni rab6-interacting 0.0021 0.0151 0.0138
Echinococcus granulosus cpg binding protein 0.003 0.029 0.0277
Trypanosoma brucei polo-like protein kinase 0.0092 0.1221 0.4287
Loa Loa (eye worm) glutaminase 2 0.0295 0.4306 0.7018
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1221 0.1807
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0151 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4136 0.5642
Onchocerca volvulus Huntingtin homolog 0.0148 0.2077 0.284
Loa Loa (eye worm) hypothetical protein 0.0286 0.4169 0.6787
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.039 0.0403
Trypanosoma brucei carbonic anhydrase-like protein 0.0177 0.2526 1
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.1096 0.1083
Echinococcus granulosus carbonic anhydrase II 0.0177 0.2526 0.2516
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0177 0.2526 0.4068
Onchocerca volvulus 0.0058 0.0714 0.0829
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0083 0.1096 0.1595
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0823 0.6808
Onchocerca volvulus Alhambra homolog 0.0029 0.0272 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0762 0.075
Mycobacterium ulcerans glutaminase 0.0295 0.4306 0.9099
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.1096 0.1674
Brugia malayi jmjC domain containing protein 0.0037 0.039 0.0494
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0317 0.465 1
Brugia malayi jmjC domain containing protein 0.0096 0.1281 0.1984
Brugia malayi Pre-SET motif family protein 0.0411 0.6071 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.6071 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0445 0.0432
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.2202 0.2192
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0732 0.0719
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.1096 0.1674
Onchocerca volvulus 0.0467 0.6932 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1221 0.1096
Loa Loa (eye worm) hypothetical protein 0.0083 0.1096 0.1595
Echinococcus granulosus carbonic anhydrase 0.0083 0.1096 0.1083
Giardia lamblia Kinase, PLK 0.0092 0.1221 0.2455
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0272 0.0358
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1221 0.1209
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0732 0.0719
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0177 0.2526 0.2516
Echinococcus multilocularis carbonic anhydrase II 0.0177 0.2526 0.2516
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.069 0.0677
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.039 0.0377
Brugia malayi CXXC zinc finger family protein 0.0029 0.0265 0.0285
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0823 0.081
Plasmodium falciparum phd finger protein, putative 0.0029 0.0272 0.0585
Schistosoma mansoni hypothetical protein 0.0058 0.0714 0.0701
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0083 0.1096 0.1674
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.039 0.0377

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0224 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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