Detailed information for compound 1315255

Basic information

Technical information
  • TDR Targets ID: 1315255
  • Name: methyl N-[[2-hydroxy-2,2-di(phenyl)acetyl]ami no]-N-phenylcarbamate
  • MW: 376.405 | Formula: C22H20N2O4
  • H donors: 2 H acceptors: 3 LogP: 3.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)N(c1ccccc1)NC(=O)C(c1ccccc1)(c1ccccc1)O
  • InChi: 1S/C22H20N2O4/c1-28-21(26)24(19-15-9-4-10-16-19)23-20(25)22(27,17-11-5-2-6-12-17)18-13-7-3-8-14-18/h2-16,27H,1H3,(H,23,25)
  • InChiKey: ORJJNMBGUZYIKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl N-[[2-hydroxy-2,2-di(phenyl)acetyl]amino]-N-phenyl-carbamate
  • N-[[2-hydroxy-1-oxo-2,2-di(phenyl)ethyl]amino]-N-phenylcarbamic acid methyl ester
  • N-[[2-hydroxy-2,2-di(phenyl)acetyl]amino]-N-phenyl-carbamic acid methyl ester
  • methyl N-[[2-hydroxy-2,2-di(phenyl)ethanoyl]amino]-N-phenyl-carbamate
  • MLS000589436
  • N'-(2-Hydroxy-2,2-diphenyl-acetyl)-N-phenyl-hydrazinecarboxylic acid methyl ester
  • SMR000212904
  • A2027/0085113
  • ZINC01800341

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii target of rapamycin (TOR), putative 0.0923 0.7254 1
Echinococcus granulosus protein kinase shaggy 0.0101 0.0133 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0177 0.0791 0.0735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.5071 0.5041
Echinococcus multilocularis snurportin 1 0.0372 0.2481 0.2435
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0101 0.0133 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.5062 0.5032
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0588 0.4352 0.4318
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0418 0.2878 0.2835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0418 0.2878 0.2878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0806 0.6241 0.6218
Schistosoma mansoni fkbp-rapamycin associated protein 0.0237 0.1312 0.1258
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0112 0.0233 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.0596 0.0538
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.1312 0.1312
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0127 0.0357 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Entamoeba histolytica protein kinase, putative 0.0101 0.0133 0.0073
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0101 0.0133 0.0073
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0112 0.0233 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.1312 0.1258
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.7808 0.7794
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0177 0.0791 0.0735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2878 0.2835
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0517 0.3736 0.3697
Loa Loa (eye worm) hypothetical protein 0.0181 0.0827 0.0771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.6472 0.6451
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0177 0.0791 0.0735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.5071 0.5041
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0143 0.0496 0.0437
Brugia malayi RNA, U transporter 1 0.0099 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.5062 0.5032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0177 0.0791 0.0791
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0133 0.0073
Echinococcus multilocularis protein kinase shaggy 0.0101 0.0133 0.0073
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0143 0.0496 0.0437
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0596 0.0538
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0418 0.2878 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.5624 0.5597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.7808 0.7794
Loa Loa (eye worm) phosphatidylinositol 3 0.0418 0.2878 0.2835
Loa Loa (eye worm) hypothetical protein 0.0237 0.1312 0.1258
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0827 0.0771
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0262 0.1531 0.1479
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0237 0.1312 0.1258
Trypanosoma cruzi target of rapamycin kinase 3 0.0988 0.7816 0.7803
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0101 0.0133 0.0073
Loa Loa (eye worm) phosphatidylinositol 3 0.0242 0.136 0.1306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.1312 0.1312
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0177 0.0791 0.0735
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0112 0.0233 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2878 0.2835
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0101 0.0133 0.0073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0154 0.0596 0.0538
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0262 0.1531 0.1479
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0112 0.0233 0.0173
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0418 0.2878 0.2835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0496 0.0496
Toxoplasma gondii FATC domain-containing protein 0.0237 0.1312 0.1739
Loa Loa (eye worm) hypothetical protein 0.0154 0.0596 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2878 0.2835
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0988 0.7816 0.7803
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0133 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.7808 0.7794
Echinococcus granulosus serine protein kinase ATM 0.0237 0.1312 0.1258
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.1543 0.1491
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0133 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0112 0.0233 0.0173
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0102 0.0148 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2878 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.5624 0.5597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Onchocerca volvulus 0.0101 0.0133 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.7808 0.7794
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0263 0.1543 0.2061
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0133 0.0073
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0177 0.0791 0.0735
Plasmodium falciparum glycogen synthase kinase 3 0.0101 0.0133 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0418 0.2878 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0742 0.5688 0.5661
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0262 0.1531 0.1479
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0237 0.1312 0.1258
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0146 0.0528 0.047
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0418 0.2878 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.5071 0.5041
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0094 0.0075 0.0014
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0101 0.0133 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.7808 0.7794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.1312 0.1258
Echinococcus multilocularis serine protein kinase ATM 0.0237 0.1312 0.1258
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0092 0.0061 0.0061
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0112 0.0233 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.5062 0.5032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Schistosoma mansoni hypothetical protein 0.0181 0.0827 0.0771
Loa Loa (eye worm) hypothetical protein 0.0143 0.0496 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0418 0.2878 0.2835
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0181 0.0827 0.0771
Brugia malayi intracellular kinase 0.0101 0.0133 0.0133
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0324 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0742 0.5688 0.5661
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0181 0.0827 0.0771
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0112 0.0233 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0742 0.5688 0.5661
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0418 0.2878 0.2835
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0177 0.0791 0.0735
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0157 0.062 0.0562
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0418 0.2878 0.2835
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0146 0.0528 0.047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0112 0.0233 0.0173
Plasmodium vivax glycogen synthase kinase 3, putative 0.0101 0.0133 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0418 0.2878 0.2835
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0101 0.0133 0.0073
Entamoeba histolytica hypothetical protein 0.0237 0.1312 0.1258
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0101 0.0133 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0923 0.7254 0.7237
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2481 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2878 0.2835
Loa Loa (eye worm) hypothetical protein 0.0252 0.1444 0.1391
Loa Loa (eye worm) hypothetical protein 0.0263 0.1543 0.1491
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.1059 0.8433 0.8424
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0112 0.0233 0.0233
Trypanosoma brucei protein kinase, putative 0.0101 0.0133 0.0073
Entamoeba histolytica hypothetical protein 0.0157 0.062 0.0562
Echinococcus granulosus snurportin 1 0.0372 0.2481 0.2435
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0101 0.0133 0.0073
Schistosoma mansoni hypothetical protein 0.0372 0.2481 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.216 0.2112
Brugia malayi FAT domain containing protein 0.0181 0.0827 0.0827
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0988 0.7816 0.7803
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0237 0.1312 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.5071 0.5041
Entamoeba histolytica protein kinase rad3, putative 0.0237 0.1312 0.1258

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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