Detailed information for compound 1318536

Basic information

Technical information
  • TDR Targets ID: 1318536
  • Name: SMR000292666
  • MW: 410.423 | Formula: C21H22N4O5
  • H donors: 2 H acceptors: 5 LogP: 1.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)NC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H22N4O5/c1-14(26)22-17-4-6-18(7-5-17)23-20(27)15-10-12-24(13-11-15)21(28)16-2-8-19(9-3-16)25(29)30/h2-9,15H,10-13H2,1H3,(H,22,26)(H,23,27)
  • InChiKey: BAXHYFZJRKMLIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01144321
  • MLS000663509
  • N-[4-(acetylamino)phenyl]-1-(4-nitrobenzoyl)-4-piperidinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0088 0.0198 0.0582
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0448 0.1305
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.002 0.0025 0.0075
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Onchocerca volvulus Cathepsin L homolog 0.0799 0.201 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0025 0.0146
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0448 0.2207
Trichomonas vaginalis bromodomain-containing protein, putative 0.002 0.0025 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) RNA binding protein 0.0062 0.0134 0.0394
Brugia malayi cathepsin F-like cysteine proteinase 0.0269 0.0659 0.1941
Treponema pallidum NADH oxidase 0.002 0.0025 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0012 0.0006 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0134 0.0394
Toxoplasma gondii cathepsin CPC2 0.0186 0.0448 0.2207
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Onchocerca volvulus 0.0053 0.011 0.0549
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Brugia malayi Serine protease Z688.6 precursor 0.0053 0.011 0.0325
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0799 0.201 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0465 0.1157 0.3397
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0448 0.1319
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0186 0.0448 0.2207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0264 0.0647 0.1905
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Loa Loa (eye worm) glutathione reductase 0.0035 0.0063 0.0187
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0025 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0049 0.01 0.0294
Schistosoma mansoni intermediate filament proteins 0.0033 0.0058 0.0058
Onchocerca volvulus 0.0044 0.0086 0.0426
Trypanosoma cruzi cysteine protease, putative 0.0455 0.1133 0.3324
Echinococcus multilocularis muscleblind protein 0.018 0.0434 0.1278
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0799 0.201 0.5918
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0544 0.136 0.6757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Brugia malayi Cathepsin L-like precursor 0.0531 0.1325 0.3902
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Echinococcus multilocularis musashi 0.0033 0.0058 0.0169
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0269 0.0659 0.1941
Echinococcus granulosus cathepsin L 0.0455 0.1133 0.3335
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.006
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0134 0.0394
Onchocerca volvulus Cathepsin L homolog 0.0799 0.201 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0025 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0799 0.201 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Brugia malayi acetyltransferase, GNAT family protein 0.0068 0.0147 0.0434
Plasmodium vivax vivapain-2 0.0799 0.201 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0019 0.0056
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0053 0.011 0.0523
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0186 0.0448 0.2207
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0088 0.0198 0.0582
Onchocerca volvulus 0.0036 0.0066 0.033
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.01 0.0229 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0448 0.2207
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.011 0.0523
Echinococcus granulosus carbonic anhydrase II 0.0465 0.1157 0.3408
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Echinococcus multilocularis cathepsin b 0.1344 0.3396 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0018 0.0021 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0025 0.0098
Plasmodium falciparum serine repeat antigen 9 0.0186 0.0448 0.2207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0455 0.1133 0.5623
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0544 0.136 0.3994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0186 0.0448 0.2207
Brugia malayi glutathione reductase 0.0035 0.0063 0.0187
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Brugia malayi Cathepsin L-like precursor 0.0531 0.1325 0.3902
Loa Loa (eye worm) hypothetical protein 0.0264 0.0647 0.1905
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0264 0.0647 0.1905
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0066 0.0196
Schistosoma mansoni cathepsin F (C01 family) 0.0799 0.201 0.201
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Onchocerca volvulus 0.0799 0.201 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0196
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0025 0.4096
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Plasmodium vivax vivapain-1 0.0455 0.1133 0.5623
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0086 0.0086
Giardia lamblia Encystation-specific protease 0.0186 0.0448 0.3267
Leishmania major trypanothione reductase 0.0035 0.0063 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.002 0.0025 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0703 0.3479
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0035 0.0063 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Onchocerca volvulus 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0186 0.0448 0.0448
Mycobacterium ulcerans hypothetical protein 0.0023 0.0034 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Schistosoma mansoni hypothetical protein 0.0264 0.0647 0.0647
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Loa Loa (eye worm) hypothetical protein 0.0053 0.011 0.0325
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0063 0.0171
Plasmodium falciparum carbonic anhydrase 0.0264 0.0647 0.3201
Loa Loa (eye worm) hypothetical protein 0.0799 0.201 0.5918
Echinococcus granulosus cathepsin l1 0.0531 0.1325 0.3902
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Loa Loa (eye worm) cysteine protease 0.0799 0.201 0.5918
Entamoeba histolytica hypothetical protein 0.0186 0.0448 0.2146
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0053 0.011 0.0523
Loa Loa (eye worm) hypothetical protein 0.0044 0.0086 0.0252
Onchocerca volvulus Cathepsin F homolog 0.0799 0.201 1
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Trypanosoma cruzi cruzipain precursor, putative 0.0799 0.201 0.5911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0186 0.0448 0.2207
Plasmodium vivax thioredoxin reductase, putative 0.0035 0.0063 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.011 0.0523
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Onchocerca volvulus 0.0531 0.1325 0.6594
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0615 0.1809
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Giardia lamblia Cathepsin L-like protease 0.0186 0.0448 0.3267
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Brugia malayi Muscleblind-like protein 0.018 0.0434 0.1278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0169
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0012 0.0006 0.0016
Plasmodium vivax glutathione reductase, putative 0.0035 0.0063 0.0289
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.0189 0.0558
Leishmania major carbonic anhydrase-like protein 0.0465 0.1157 0.5747
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Schistosoma mansoni cathepsin B (C01 family) 0.0186 0.0448 0.0448
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Toxoplasma gondii cathepsin CPL 0.0799 0.201 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0025 0.0074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.002 0.0025 0.1836
Loa Loa (eye worm) acetyltransferase 0.0068 0.0147 0.0434
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0025 0.0098
Echinococcus granulosus cathepsin b 0.1344 0.3396 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0448 0.2146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0098
Echinococcus granulosus cathepsin L cysteine proteinase 0.0799 0.201 0.5918
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0042
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.002 0.0025 0.0099
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Trypanosoma cruzi cysteine proteinase, putative 0.0455 0.1133 0.3324
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0799 0.201 1
Plasmodium falciparum serine repeat antigen 4 0.0186 0.0448 0.2207
Giardia lamblia Histone acetyltransferase GCN5 0.0018 0.0021 0.0116
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0025 0.0098
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0018 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Loa Loa (eye worm) ctsf protein 0.0799 0.201 0.5918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Toxoplasma gondii thioredoxin reductase 0.0035 0.0063 0.0289
Loa Loa (eye worm) thioredoxin reductase 0.0035 0.0063 0.0187
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0186 0.0448 0.2207
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0465 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Trypanosoma cruzi cysteine peptidase, putative 0.0269 0.0659 0.1928
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.01 0.0294
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0264 0.0647 0.1905
Echinococcus multilocularis cysteine protease 0.0799 0.201 0.5918
Echinococcus multilocularis cysteine protease 0.0799 0.201 0.5918
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0012 0.0006 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0098
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0025 0.0098
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0012 0.0006 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Onchocerca volvulus 0.0799 0.201 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0244 0.0596 0.1756
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0448 0.2146
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0186 0.0448 0.2207
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0465 0.1157 0.3397
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0065 0.0191
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0043
Plasmodium vivax vivapain-2 0.0799 0.201 1
Plasmodium falciparum thioredoxin reductase 0.002 0.0025 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0848 0.2133 0.6279
Echinococcus granulosus cathepsin l1 0.0799 0.201 0.5918
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0799 0.201 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium vivax SET domain protein, putative 0.0036 0.0066 0.0304
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1344 0.3396 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0455 0.1133 0.3324
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Onchocerca volvulus 0.0038 0.007 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Brugia malayi Papain family cysteine protease containing protein 0.0799 0.201 0.5918
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0034 1
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0034 0.3735
Echinococcus granulosus tar DNA binding protein 0.0062 0.0134 0.0394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0186 0.0448 0.2207
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0053 0.011 0.011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0019 0.0519
Brugia malayi Cathepsin L-like cysteine proteinase 0.0531 0.1325 0.3902
Plasmodium vivax vivapain-3 0.0455 0.1133 0.5623
Echinococcus granulosus lamin dm0 0.0033 0.0058 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Echinococcus granulosus cysteine protease 0.0455 0.1133 0.3335
Plasmodium falciparum glutathione reductase 0.0035 0.0063 0.0289
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0018
Echinococcus granulosus cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0018 0.006
Schistosoma mansoni cathepsin F (C01 family) 0.0799 0.201 0.201
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0053 0.011 0.0523
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0012 0.0006 0.0016
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0012 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0086 0.0086
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0025 0.0098
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0025 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Plasmodium falciparum serine repeat antigen 1 0.0186 0.0448 0.2207
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Giardia lamblia Thymus-specific serine protease precursor 0.0053 0.011 0.0774
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0063 0.0186
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0269 0.0659 0.1941
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0014 0.0042
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0025 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0264 0.0647 0.1905
Onchocerca volvulus 0.0799 0.201 1
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.1133 0.3335
Schistosoma mansoni cathepsin S (C01 family) 0.0186 0.0448 0.0448
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0063 0.0187
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0186 0.0448 0.2207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0025 0.0098
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Echinococcus multilocularis cathepsin L cysteine protease 0.0799 0.201 0.5918
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0088 0.0198 0.0582
Brugia malayi Pre-SET motif family protein 0.0251 0.0615 0.1809
Brugia malayi Serine protease Z688.6 precursor 0.0053 0.011 0.0325
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.1325 0.6584
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0034 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0019 0.0056
Brugia malayi Thioredoxin reductase 0.0035 0.0063 0.0187
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Trypanosoma brucei cysteine peptidase C (CPC) 0.0544 0.136 0.6757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Toxoplasma gondii hypothetical protein 0.0264 0.0647 0.3201
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0025 0.0098
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.1133 0.3335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0042
Schistosoma mansoni hypothetical protein 0.0035 0.0065 0.0065
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Plasmodium vivax unspecified product 0.0455 0.1133 0.5623
Plasmodium falciparum serine repeat antigen 5 0.0186 0.0448 0.2207
Echinococcus granulosus intermediate filament protein 0.0033 0.0058 0.0169
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0025 0.4096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0014 0.0042
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Echinococcus granulosus muscleblind protein 0.018 0.0434 0.1278
Plasmodium falciparum serine repeat antigen 7 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0044 0.0086 0.0252
Entamoeba histolytica cysteine proteinase 1, putative 0.0455 0.1133 0.5588
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0012 0.0006 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0448 0.1319
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0448 0.2207
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0186 0.0448 0.1319
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium falciparum thioredoxin reductase 0.0035 0.0063 0.0289
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.0189 0.0558
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0012 0.0006 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0544 0.136 0.136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0053 0.011 0.0523
Giardia lamblia Hypothetical protein 0.0186 0.0448 0.3267
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0177
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0186 0.0448 0.0448
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0063 0.0187
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0465 0.1157 0.3408
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0465 0.1157 0.3408
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0244 0.0596 0.1756
Brugia malayi hypothetical protein 0.0035 0.0065 0.0191
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0448 0.2207
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.1133 0.5623
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0025 0.1836
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Plasmodium falciparum glutathione reductase 0.002 0.0025 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.1133 0.5623
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0058 0.0169
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0053 0.011 0.0309
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0068 0.0147 0.0147
Plasmodium vivax unspecified product 0.0269 0.0659 0.3261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Brugia malayi Trypsin family protein 0.0044 0.0086 0.0252
Brugia malayi RNA binding protein 0.0062 0.0134 0.0394
Brugia malayi TAR-binding protein 0.0062 0.0134 0.0394
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.002 0.0025 0.1836
Echinococcus multilocularis carbonic anhydrase II 0.0465 0.1157 0.3408
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0448 0.1319
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0088 0.0198 0.0582
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0053 0.011 0.0325
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.002 0.0025 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Onchocerca volvulus 0.0799 0.201 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0019 0.0068
Plasmodium falciparum serine repeat antigen 8 0.0186 0.0448 0.2207
Entamoeba histolytica cysteine proteinase, putative 0.0531 0.1325 0.6557
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0186 0.0448 0.3267
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0066 0.0196
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1344 0.3396 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Toxoplasma gondii cathepsin B 0.0544 0.136 0.6757
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0018 0.006
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0186 0.0448 0.1319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.1344 0.3396 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0066 0.0304
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0186 0.0448 0.2207
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0018 0.0052
Plasmodium falciparum cysteine proteinase falcipain 3 0.0799 0.201 1
Entamoeba histolytica cysteine protease, putative 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0053 0.011 0.0325
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.01 0.0229 0.0673
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0065 0.0191
Brugia malayi Cathepsin L-like precursor 0.0269 0.0659 0.1941
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Onchocerca volvulus Cathepsin L homolog 0.0186 0.0448 0.2229
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0012 0.0006 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0025 0.0058
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Echinococcus multilocularis lamin dm0 0.0033 0.0058 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Schistosoma mansoni cathepsin C 0.0186 0.0448 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0018 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.01 0.0229 0.1648
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0025 0.0098
Loa Loa (eye worm) hypothetical protein 0.0032 0.0056 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0799 0.201 1
Giardia lamblia Hypothetical protein 0.0186 0.0448 0.3267
Plasmodium falciparum serine repeat antigen 6 0.0186 0.0448 0.2207
Echinococcus granulosus lamin 0.0033 0.0058 0.0169
Onchocerca volvulus 0.0286 0.0703 0.3497
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Brugia malayi cathepsin L-like precursor 0.0531 0.1325 0.3902
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0012 0.0006 0.0016
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.0189 0.0558
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0025 0.1836
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0066 0.0196
Plasmodium falciparum serine repeat antigen 3 0.0186 0.0448 0.2207
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Onchocerca volvulus 0.0033 0.0058 0.0286
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.01 0.0294
Brugia malayi cathepsin L-like cysteine proteinase 0.0186 0.0448 0.1319
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.0189 0.0558
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0014 0.0042
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0034 1
Brugia malayi intermediate filament protein 0.0033 0.0058 0.0169
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0186 0.0448 0.2207
Brugia malayi Protein kinase domain containing protein 0.0017 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.018 0.0434 0.1278
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Brugia malayi Kringle domain containing protein 0.0017 0.0018 0.0052
Brugia malayi fibroinase precursor 0.0186 0.0448 0.1319
Plasmodium vivax histone acetyltransferase GCN5, putative 0.002 0.0025 0.0099
Schistosoma mansoni hypothetical protein 0.0034 0.006 0.006
Trypanosoma cruzi cysteine proteinase, putative 0.0455 0.1133 0.3324
Echinococcus multilocularis cathepsin L 0.0186 0.0448 0.1319
Loa Loa (eye worm) hypothetical protein 0.018 0.0434 0.1278
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0025 0.0098
Echinococcus multilocularis GPCR, family 2 0.0016 0.0014 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0799 0.201 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0448 0.0448
Echinococcus granulosus GPCR family 2 0.0016 0.0014 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0019 0.0068
Schistosoma mansoni cathepsin s 0.0269 0.0659 0.0659
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0012 0.0006 0.0016
Echinococcus granulosus cathepsin b 0.1344 0.3396 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0025 0.4096
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0018 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Plasmodium falciparum serine repeat antigen 2 0.0186 0.0448 0.2207
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0269 0.0659 0.1928
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Toxoplasma gondii preprocathepsin c precursor, putative 0.0186 0.0448 0.2207
Echinococcus multilocularis cathepsin L 0.0455 0.1133 0.3335
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0244 0.0596 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.1325 0.6584
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0186 0.0448 0.2207
Plasmodium vivax unspecified product 0.0186 0.0448 0.2207
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0012 0.0006 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0012 0.0035
Trypanosoma brucei carbonic anhydrase-like protein 0.0465 0.1157 0.5747
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0134 0.0394
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0465 0.1157 0.3408
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0025 1
Giardia lamblia Serine peptidase, putative 0.0053 0.011 0.0774
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0012 0.0006 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0025 0.0025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0066 0.0066
Loa Loa (eye worm) PDE1B protein 0.0012 0.0006 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Toxoplasma gondii cathepsin CPC1 0.0186 0.0448 0.2207
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0039
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.01 0.0229 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0189 0.0189
Onchocerca volvulus 0.0186 0.0448 0.2229
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0034 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0039
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0134 0.0394
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0455 0.1133 0.5623
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0066 0.0143 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0186 0.0448 0.2207
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Loa Loa (eye worm) cathepsin B 0.0544 0.136 0.4004
Schistosoma mansoni carbonic anhydrase 0.0264 0.0647 0.0647
Brugia malayi Pre-SET motif family protein 0.0036 0.0066 0.0196
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0034 0.0065
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0068 0.0147 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0455 0.1133 0.5623
Echinococcus granulosus cathepsin L cysteine protease 0.0455 0.1133 0.3335
Trypanosoma brucei trypanothione reductase 0.0035 0.0063 0.0289
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0025 0.0074
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Echinococcus granulosus cathepsin L 0.0186 0.0448 0.1319
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0025 0.0074
Schistosoma mansoni lamin 0.0033 0.0058 0.0058
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0544 0.136 0.6757
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0058 0.0169
Giardia lamblia Cathepsin L-like protease 0.0186 0.0448 0.3267
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Schistosoma mansoni lamin 0.0033 0.0058 0.0058
Brugia malayi cathepsin L precursor 0.0186 0.0448 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0465 0.1157 0.1157
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0053 0.011 0.0309
Onchocerca volvulus 0.0033 0.0058 0.0286
Entamoeba histolytica cysteine proteinase 2 0.0455 0.1133 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0186 0.0448 0.2207
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0025 0.0098
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0455 0.1133 0.3324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.01 0.0294
Brugia malayi cathepsin B-like cysteine proteinase 0.1344 0.3396 1
Brugia malayi Serine carboxypeptidase S28 family protein 0.0244 0.0596 0.1756
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0043
Echinococcus multilocularis cathepsin b 0.1344 0.3396 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0448 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0052
Onchocerca volvulus 0.0023 0.0034 0.017
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0799 0.201 0.5918
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0448 0.0448
Echinococcus multilocularis lamin 0.0033 0.0058 0.0169
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0531 0.1325 0.3892
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0018 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Leishmania major cysteine peptidase A (CPA) 0.0799 0.201 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0799 0.201 0.5918
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Onchocerca volvulus 0.0799 0.201 1
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Loa Loa (eye worm) fibroinase 0.0799 0.201 0.5918
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0025 0.5
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0025 0.0098
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0448 0.2207
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Onchocerca volvulus 0.0799 0.201 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.0434 0.1278
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.006 0.0177
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0025 0.0058
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0053 0.011 0.0309
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0058 0.0169
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0716 0.1797 0.1797
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0034 0.3735
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0189 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) carbonic anhydrase 3 0.0465 0.1157 0.3408
Schistosoma mansoni cathepsin F (C01 family) 0.0531 0.1325 0.1325
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Onchocerca volvulus 0.0017 0.0018 0.0088
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Leishmania major cathepsin L-like protease 0.0799 0.201 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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