TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 217.267 | Formula: C12H15N3O
H donors: 2 H acceptors: 3 LogP: 2.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1[nH]cnc2c1ncc2CC1CCCC1
InChi: 1S/C12H15N3O/c16-12-11-10(14-7-15-12)9(6-13-11)5-8-3-1-2-4-8/h6-8,16H,1-5H2,(H,14,15)
InChiKey: DSCXEPCBJOUADF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Purine-nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania donovani	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	270 aa	22.6 %
Leishmania braziliensis	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	255 aa	23.5 %
Leishmania major	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	258 aa	22.9 %
Leishmania mexicana	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	259 aa	23.9 %
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	243 aa	24.3 %
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	276 aa	23.2 %
Trypanosoma brucei gambiense	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	276 aa	23.2 %
Echinococcus multilocularis	methylthioadenosine phosphorylase	Purine-nucleoside phosphorylase	289 aa	234 aa	26.5 %
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	243 aa	23.9 %
Onchocerca volvulus		Purine-nucleoside phosphorylase	289 aa	275 aa	22.2 %
Trypanosoma congolense	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	238 aa	27.3 %
Leishmania infantum	methylthioadenosine phosphorylase, putative	Purine-nucleoside phosphorylase	289 aa	270 aa	22.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	hypothetical protein	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Loa Loa (eye worm)	tubulin alpha chain	0.0419	0.6459	0.553
Toxoplasma gondii	alpha tubulin TUBA1	0.0419	0.6459	0.6434
Loa Loa (eye worm)	BEN-1 protein	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0555	1	1
Schistosoma mansoni	alpha tubulin	0.0419	0.6459	0.3619
Echinococcus multilocularis	tubulin subunit TubB	0.0419	0.6459	0.437
Leishmania major	beta tubulin	0.0555	1	1
Trypanosoma brucei	epsilon tubulin	0.0341	0.445	0.445
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Trypanosoma brucei	tubulin delta chain	0.0322	0.3968	0.3968
Leishmania major	beta tubulin	0.0555	1	1
Giardia lamblia	Alpha-tubulin	0.0419	0.6459	0.6434
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0249	0.2078	0.2078
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0419	0.6459	0.6459
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Trypanosoma brucei	beta tubulin	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0555	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0341	0.4461	0.3008
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Echinococcus granulosus	expressed protein	0.0401	0.5997	0.3636
Echinococcus multilocularis	Tubulin beta 2C chain	0.0555	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0419	0.6459	0.3619
Loa Loa (eye worm)	tubulin alpha 2	0.0275	0.2749	0.0847
Echinococcus granulosus	peroxisome assembly protein 26	0.0419	0.6459	0.437
Entamoeba histolytica	tubulin family protein	0.0555	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.6459	0.3619
Echinococcus multilocularis	tubulin alpha 3 chain	0.0419	0.6459	0.437
Trypanosoma cruzi	zeta tubulin, putative	0.0443	0.7085	0.5167
Brugia malayi	Tubulin gamma chain	0.0341	0.4461	0.4461
Leishmania major	beta tubulin	0.0555	1	1
Plasmodium falciparum	tubulin beta chain	0.0555	1	1
Echinococcus granulosus	tubulin epsilon chain	0.0341	0.445	0.1177
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Echinococcus multilocularis	tubulin subunit beta	0.0555	1	1
Plasmodium falciparum	tubulin gamma chain	0.0341	0.4461	0.002
Echinococcus multilocularis	beta tubulin	0.0555	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0419	0.6459	0.553
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.6459	0.3619
Onchocerca volvulus		0.0169	0	0.5
Echinococcus granulosus	tubulin subunit TubB	0.0419	0.6459	0.437
Echinococcus granulosus	tubulin alpha chain	0.0419	0.6459	0.437
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0322	0.3968	0.3926
Trypanosoma brucei	alpha tubulin	0.0419	0.6459	0.6459
Leishmania major	beta tubulin	0.0555	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0555	1	1
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Trypanosoma brucei	beta tubulin	0.0555	1	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2749	0.0847
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Leishmania major	gamma-tubulin	0.0341	0.4461	0.0817
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0555	1	1
Echinococcus granulosus	tubulin alpha chain	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin, putative	0.0555	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0419	0.6459	0.437
Echinococcus granulosus	beta tubulin	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Trypanosoma brucei	beta tubulin	0.0555	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0555	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0312	0.371	0.3666
Leishmania major	beta tubulin	0.0555	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0312	0.371	0.371
Leishmania major	beta tubulin	0.0555	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0555	1	1
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0419	0.6459	0.3619
Trypanosoma brucei	zeta tubulin	0.0443	0.7085	0.7085
Giardia lamblia	Gamma tubulin	0.0341	0.4461	0.4422
Echinococcus granulosus	tubulin alpha chain	0.0419	0.6459	0.437
Leishmania major	zeta tubulin, putative	0.0443	0.7085	0.5167
Giardia lamblia	Alpha-tubulin	0.0419	0.6459	0.6434
Leishmania major	beta tubulin	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0555	1	1
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Trichomonas vaginalis	tubulin, putative	0.0172	0.008	0.008
Brugia malayi	beta-tubulin, identical	0.0555	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.6459	0.437
Schistosoma mansoni	alpha tubulin	0.0419	0.6459	0.3619
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Loa Loa (eye worm)	alpha-tubulin	0.0419	0.6459	0.553
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin gamma chain, putative	0.0341	0.445	0.445
Entamoeba histolytica	tubulin family protein	0.0555	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0275	0.2749	0.0847
Echinococcus granulosus	tubulin beta 4A class IVa	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0555	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0419	0.6459	0.6459
Trypanosoma cruzi	epsilon tubulin, putative	0.0341	0.445	0.0798
Echinococcus multilocularis	Tubulin beta 2C chain	0.0555	1	1
Toxoplasma gondii	beta tubulin	0.0555	1	1
Giardia lamblia	Beta tubulin	0.0555	1	1
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Schistosoma mansoni	alpha tubulin	0.0419	0.6459	0.3619
Trypanosoma brucei	alpha tubulin	0.0419	0.6459	0.6459
Echinococcus granulosus	tubulin alpha 3 chain	0.0419	0.6459	0.437
Plasmodium vivax	tubulin beta chain, putative	0.0555	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0555	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0275	0.2749	0.2749
Echinococcus granulosus	tubulin alpha 1C chain	0.0419	0.6459	0.437
Brugia malayi	Tubulin alpha chain	0.0419	0.6459	0.6459
Echinococcus granulosus	Tubulin beta 2C chain	0.0555	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0555	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0419	0.6459	0.6459
Trypanosoma brucei	beta tubulin	0.0555	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0419	0.6459	0.437
Leishmania major	beta tubulin	0.0555	1	1
Echinococcus granulosus	tubulin alpha chain	0.0419	0.6459	0.437
Loa Loa (eye worm)	hypothetical protein	0.0419	0.6459	0.553
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Echinococcus multilocularis	tubulin alpha 1C chain	0.0419	0.6459	0.437
Trypanosoma cruzi	zeta tubulin, putative	0.0443	0.7085	0.5167
Brugia malayi	tubulin alpha chain - mouse	0.0419	0.6459	0.6459
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Echinococcus multilocularis	Tubulin beta 2C chain	0.0555	1	1
Toxoplasma gondii	beta-tubulin, putative	0.0555	1	1
Trypanosoma brucei	alpha tubulin	0.0419	0.6459	0.6459
Echinococcus multilocularis	tubulin epsilon chain	0.0341	0.445	0.1177
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0555	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0555	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0419	0.6459	0.6459
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Leishmania major	epsilon tubulin, putative	0.0341	0.445	0.0798
Trypanosoma cruzi	alpha tubulin, putative	0.0419	0.6459	0.4129
Trypanosoma brucei	epsilon tubulin	0.0341	0.445	0.445
Trichomonas vaginalis	tubulin gamma chain, putative	0.0341	0.4461	0.4461
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0275	0.2749	0.0847
Echinococcus multilocularis	tubulin gamma 1 chain	0.0341	0.4461	0.1194
Entamoeba histolytica	tubulin alpha chain, putative	0.0419	0.6459	0.3607
Toxoplasma gondii	beta-1 tubulin, putative	0.0555	1	1
Giardia lamblia	Beta tubulin	0.0555	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0419	0.6459	0.6459
Brugia malayi	tubulin alpha-2 chain	0.0419	0.6459	0.6459
Leishmania major	beta tubulin	0.0555	1	1
Leishmania major	beta tubulin	0.0555	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0419	0.6459	0.437
Trypanosoma brucei	epsilon tubulin	0.0312	0.371	0.371
Schistosoma mansoni	tubulin subunit gamma	0.0341	0.4461	0.002
Trypanosoma cruzi	epsilon tubulin, putative	0.0341	0.445	0.0798
Toxoplasma gondii	alpha-tubulin I, putative	0.0419	0.6459	0.6434
Brugia malayi	alpha-tubulin	0.0419	0.6459	0.6459
Echinococcus granulosus	tubulin alpha chain	0.0419	0.6459	0.437
Echinococcus multilocularis	beta tubulin	0.0555	1	1
Echinococcus granulosus	beta tubulin	0.0555	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0419	0.6459	0.553
Loa Loa (eye worm)	tubulin beta-4 chain	0.0555	1	1
Trypanosoma brucei	zeta tubulin, putative	0.0443	0.7085	0.7085
Loa Loa (eye worm)	beta-tubulin	0.0555	1	1
Trypanosoma brucei	alpha tubulin	0.0419	0.6459	0.6459
Leishmania major	beta tubulin	0.0555	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0341	0.4461	0.0817
Plasmodium falciparum	alpha tubulin 2	0.0419	0.6459	0.3619
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Echinococcus granulosus	tubulin gamma 1 chain	0.0341	0.4461	0.1194
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.6459	0.437
Entamoeba histolytica	tubulin alpha-1 chain	0.0419	0.6459	0.3607
Plasmodium vivax	tubulin gamma chain, putative	0.0341	0.4461	0.002
Echinococcus multilocularis	expressed protein	0.0401	0.5997	0.3636
Trypanosoma brucei	beta tubulin	0.0312	0.371	0.371
Echinococcus granulosus	tubulin subunit beta	0.0555	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0555	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.6459	0.3619
Trichomonas vaginalis	tubulin gamma chain, putative	0.0555	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0555	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0419	0.6459	0.553
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0555	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.6459	0.437
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.6459	0.437
Schistosoma mansoni	tubulin subunit beta	0.0555	1	1
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Echinococcus granulosus	alpha tubulin	0.0419	0.6459	0.437
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.6459	0.6459
Echinococcus multilocularis	tubulin beta 1 chain	0.0555	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.6459	0.437
Leishmania major	alpha tubulin	0.0419	0.6459	0.4129
Echinococcus granulosus	tubulin alpha 1C chain	0.0419	0.6459	0.437
Trypanosoma brucei	tubulin gamma chain	0.0341	0.4461	0.4461
Trichomonas vaginalis	tubulin beta chain, putative	0.0555	1	1
Giardia lamblia	Beta tubulin	0.0555	1	1
Plasmodium falciparum	alpha tubulin 1	0.0419	0.6459	0.3619
Echinococcus granulosus	Tubulin beta 2C chain	0.0555	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 29 nM	Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)	ChEMBL.	8057293
IC50 (binding)	= 29 nM	Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)	ChEMBL.	8057293
Ratio (binding)	= 1	Ratio of IC50 values for guanine and related hypoxanthines in PNP inhibition assay	ChEMBL.	8057293
Ratio (binding)	= 1	Ratio of IC50 values for guanine and related hypoxanthines in PNP inhibition assay	ChEMBL.	8057293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL310458

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 132200