Detailed information for compound 1323755

Basic information

Technical information
  • TDR Targets ID: 1323755
  • Name: morpholin-4-yl-(2-morpholin-4-yl-5-nitropheny l)methanone
  • MW: 321.328 | Formula: C15H19N3O5
  • H donors: 0 H acceptors: 3 LogP: 0.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1N1CCOCC1)[N+](=O)[O-])N1CCOCC1
  • InChi: 1S/C15H19N3O5/c19-15(17-5-9-23-10-6-17)13-11-12(18(20)21)1-2-14(13)16-3-7-22-8-4-16/h1-2,11H,3-10H2
  • InChiKey: DHWMHBVFMVLDNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • morpholino-(2-morpholino-5-nitro-phenyl)methanone
  • morpholino-(2-morpholino-5-nitrophenyl)methanone
  • morpholin-4-yl-(2-morpholin-4-yl-5-nitro-phenyl)methanone
  • STK150247
  • ZINC04187955
  • 4-[2-(4-morpholinylcarbonyl)-4-nitrophenyl]morpholine
  • MLS000677134
  • SMR000270960
  • Oprea1_617603

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0748 0.0748
Brugia malayi MH2 domain containing protein 0.0501 0.1414 0.1414
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0281 0.0734 0.186
Onchocerca volvulus 0.0058 0.0046 0.0046
Plasmodium falciparum peptidase, putative 0.0281 0.0734 0.0899
Echinococcus multilocularis geminin 0.0712 0.2064 0.2064
Echinococcus multilocularis chromobox protein 1 0.0155 0.0344 0.0344
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0046 0.0046
Trypanosoma cruzi prolyl endopeptidase 0.0281 0.0734 0.186
Brugia malayi Heterochromatin protein 1 0.0155 0.0344 0.0344
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0281 0.0734 0.2068
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.0734 0.0734
Trypanosoma brucei oligopeptidase b 0.0281 0.0734 0.186
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.3282 1 1
Loa Loa (eye worm) hypothetical protein 0.0466 0.1304 0.1304
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0748 0.0748
Echinococcus granulosus tar DNA binding protein 0.0071 0.0085 0.0085
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0281 0.0734 0.0734
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0056 0.007
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0016 0.0016
Loa Loa (eye worm) prolyl oligopeptidase 0.0281 0.0734 0.0734
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.2634 0.8 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0016 0.0041
Schistosoma mansoni hypothetical protein 0.0058 0.0046 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0085 0.0085
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0215 0.0529 0.0529
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0106 0.0112
Brugia malayi TAR-binding protein 0.0071 0.0085 0.0085
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.2634 0.8 0.5
Schistosoma mansoni hypothetical protein 0.0712 0.2064 0.2064
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.1321 0.3946 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0202 0.049 0.049
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0016 0.0045
Loa Loa (eye worm) hypothetical protein 0.0064 0.0064 0.0064
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0281 0.0734 0.0734
Onchocerca volvulus Alhambra homolog 0.0062 0.0056 0.0056
Giardia lamblia Alanyl dipeptidyl peptidase 0.0281 0.0734 1
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.2634 0.8 1
Loa Loa (eye worm) heterochromatin protein 1 0.0155 0.0344 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0138 0.0293 0.0293
Plasmodium falciparum phd finger protein, putative 0.0062 0.0056 0.005
Brugia malayi RNA binding protein 0.0071 0.0085 0.0085
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0281 0.0734 0.186
Brugia malayi hypothetical protein 0.0911 0.2681 0.2681
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0602 0.0602
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0093 0.0154 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0085 0.0085
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.0131 0.0131
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0016 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0064 0.0064
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0106 0.0297
Loa Loa (eye worm) prolyl oligopeptidase 0.3282 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0096 0.0096
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0016 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0501 0.1414 0.1414
Loa Loa (eye worm) RNA binding protein 0.0071 0.0085 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0281 0.0734 0.186
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0064 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0016 0.0016
Echinococcus granulosus Dipeptidyl peptidase 9 0.1321 0.3946 0.3946
Brugia malayi hypothetical protein 0.005 0.0021 0.0021
Trypanosoma brucei prolyl oligopeptidase, putative 0.0281 0.0734 0.186
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.0734 1
Loa Loa (eye worm) transcription factor SMAD2 0.0501 0.1414 0.1414
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.2634 0.8 1
Schistosoma mansoni hypothetical protein 0.0064 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0286 0.0748 0.0748
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.0491 0.0491
Entamoeba histolytica fatty acid elongase, putative 0.0342 0.0922 1
Loa Loa (eye worm) hypothetical protein 0.041 0.1131 0.1131
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0281 0.0734 0.186
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0096 0.0096
Toxoplasma gondii hypothetical protein 0.0281 0.0734 0.2068
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0056 0.0056
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.1321 0.3946 1
Brugia malayi chromobox protein homolog 3 0.0087 0.0134 0.0134
Echinococcus granulosus chromobox protein 1 0.0155 0.0344 0.0344
Onchocerca volvulus 0.0068 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0199 0.0481 0.0481
Chlamydia trachomatis oxoacyl-ACP synthase III 0.2634 0.8 0.5
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.3282 1 1
Mycobacterium tuberculosis Probable peptidase 0.0281 0.0734 0.0918
Loa Loa (eye worm) hypothetical protein 0.0068 0.0076 0.0076
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.3282 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.0481 0.0481
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0106 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0281 0.0734 0.0918
Onchocerca volvulus Prolyl endopeptidase homolog 0.0281 0.0734 0.0734
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.3282 1 1
Trypanosoma cruzi oligopeptidase b 0.0281 0.0734 0.186
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0281 0.0734 0.0918
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.0734 0.0734
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0353 0.0956 0.0956
Entamoeba histolytica fatty acid elongase, putative 0.0342 0.0922 1
Echinococcus multilocularis prolyl endopeptidase 0.0281 0.0734 0.0734
Echinococcus multilocularis peregrin 0.0062 0.0056 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0106 0.0112
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0064 0.0064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0056 0.0757
Echinococcus granulosus peregrin 0.0062 0.0056 0.0056
Echinococcus granulosus chromobox protein 1 0.0155 0.0344 0.0344
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0064 0.0064
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0096 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0202 0.049 0.049
Schistosoma mansoni jumonji domain containing protein 0.016 0.0361 0.0361
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.0734 0.0734
Echinococcus multilocularis GPCR, family 2 0.0064 0.0064 0.0064
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0016 0.002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0016 0.0016
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0016 0.0045
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.1321 0.3946 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0215 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0712 0.2064 0.2064
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0106 0.0268
Trichomonas vaginalis chromobox protein, putative 0.0093 0.0154 0.21
Toxoplasma gondii prolyl endopeptidase 0.0281 0.0734 0.2068
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.1193 0.3549 1
Trypanosoma brucei prolyl endopeptidase 0.0281 0.0734 0.186
Brugia malayi Stress-activated protein kinase jnk-1 0.0238 0.0602 0.0602
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0724 0.0905
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0106 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0134 0.1823
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0016 0.0016
Brugia malayi prolyl oligopeptidase family protein 0.1321 0.3946 0.3946
Echinococcus granulosus prolyl endopeptidase 0.0281 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0078 0.0106 0.0106
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0281 0.0734 1
Entamoeba histolytica fatty acid elongase, putative 0.0342 0.0922 1
Trypanosoma cruzi hypothetical protein, conserved 0.0281 0.0734 0.186
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0016 0.0016
Brugia malayi hypothetical protein 0.0466 0.1304 0.1304
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.1321 0.3946 0.3946
Giardia lamblia Alanyl dipeptidyl peptidase 0.0281 0.0734 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.0491 0.0491
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0106 0.0268
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0056 0.0056
Schistosoma mansoni survival motor neuron protein 0.0058 0.0046 0.0046
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0281 0.0734 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.0259 0.0259
Trichomonas vaginalis chromobox protein, putative 0.0155 0.0344 0.4686
Onchocerca volvulus 0.0466 0.1304 0.1304
Leishmania major oligopeptidase b 0.0281 0.0734 0.186
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0085 0.0085
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0056 0.0158
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0281 0.0734 0.0734
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0016 0.0016
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0238 0.0602 0.0602
Brugia malayi isocitrate dehydrogenase 0.0049 0.0016 0.0016
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.2634 0.8 1
Echinococcus multilocularis chromobox protein 1 0.0155 0.0344 0.0344
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0238 0.0602 0.0602
Brugia malayi PHD-finger family protein 0.0062 0.0056 0.0056
Brugia malayi hypothetical protein 0.0078 0.0106 0.0106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0016 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0064 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0096 0.0096
Brugia malayi jmjC domain containing protein 0.0075 0.0096 0.0096
Schistosoma mansoni chromobox protein 0.0155 0.0344 0.0344
Brugia malayi N-terminal motif family protein 0.0199 0.0481 0.0481
Echinococcus granulosus c-Jun N-terminal kinases 0.0238 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.0138 0.0293 0.0293
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2634 0.8 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0016 0.0041
Echinococcus granulosus jumonji domain containing protein 0.0086 0.0131 0.0131
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0281 0.0734 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.1321 0.3946 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0096 0.0096
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2634 0.8 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0016 0.0041
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0281 0.0734 0.186
Leishmania major hypothetical protein, conserved 0.0078 0.0106 0.0268
Schistosoma mansoni hypothetical protein 0.0062 0.0056 0.0056
Trypanosoma cruzi oligopeptidase b 0.0281 0.0734 0.186
Brugia malayi jmjC domain containing protein 0.0202 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0056 0.0056
Entamoeba histolytica fatty acid elongase, putative 0.0342 0.0922 1
Trichomonas vaginalis chromobox protein, putative 0.0093 0.0154 0.21
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0056 0.0056
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0056 0.0056
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.1321 0.3946 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0281 0.0734 0.186
Entamoeba histolytica fatty acid elongase, putative 0.0342 0.0922 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0281 0.0734 0.186
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0106 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0064 0.0064 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0155 0.0344 0.4686
Brugia malayi hypothetical protein 0.0286 0.0748 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0087 0.0134 0.0134
Echinococcus granulosus GPCR family 2 0.0064 0.0064 0.0064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0134 0.0134
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0016 0.0041
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0016 0.0016
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0281 0.0734 0.0918
Loa Loa (eye worm) hypothetical protein 0.0911 0.2681 0.2681
Echinococcus multilocularis acylamino acid releasing enzyme 0.0281 0.0734 0.0734
Schistosoma mansoni hypothetical protein 0.0064 0.0064 0.0064
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0281 0.0734 0.0734
Schistosoma mansoni chromobox protein 0.0155 0.0344 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0085 0.0085
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0281 0.0734 0.0734
Schistosoma mansoni hypothetical protein 0.0064 0.0064 0.0064
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0085 0.0085
Echinococcus granulosus geminin 0.0712 0.2064 0.2064
Brugia malayi Bromodomain containing protein 0.0062 0.0056 0.0056
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0056 0.0158
Loa Loa (eye worm) hypothetical protein 0.0281 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0353 0.0956 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0056 0.0757
Echinococcus multilocularis Dipeptidyl peptidase 9 0.1321 0.3946 0.3946
Echinococcus granulosus acylamino acid releasing enzyme 0.0281 0.0734 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0134 0.1823
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0293 0.0293

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.