Detailed information for compound 1324264

Basic information

Technical information
  • TDR Targets ID: 1324264
  • Name: 2-[5-[(4-fluorophenyl)methylsulfanyl]-3-oxo-2 H-imidazo[1,2-c]quinazolin-2-yl]-N-(thiophen- 2-ylmethyl)acetamide
  • MW: 478.562 | Formula: C24H19FN4O2S2
  • H donors: 1 H acceptors: 2 LogP: 3.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1N=c2n(C1=O)c(SCc1ccc(cc1)F)nc1c2cccc1)NCc1cccs1
  • InChi: 1S/C24H19FN4O2S2/c25-16-9-7-15(8-10-16)14-33-24-28-19-6-2-1-5-18(19)22-27-20(23(31)29(22)24)12-21(30)26-13-17-4-3-11-32-17/h1-11,20H,12-14H2,(H,26,30)
  • InChiKey: QARLOIMJZNSWEU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[5-[(4-fluorophenyl)methylsulfanyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-(2-thienylmethyl)acetamide
  • 2-[5-[(4-fluorophenyl)methylthio]-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-(2-thienylmethyl)acetamide
  • 2-[5-[(4-fluorobenzyl)thio]-3-keto-2H-imidazo[1,2-c]quinazolin-2-yl]-N-(2-thienylmethyl)acetamide
  • 2-[5-[(4-fluorophenyl)methylsulfanyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-(thiophen-2-ylmethyl)ethanamide
  • EU-0094248
  • K279-1060
  • NCGC00138406-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0189 0.0171
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.0158 0.0334
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0178 0.0021
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.4739 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0178 0.0334
Onchocerca volvulus Alhambra homolog 0.0029 0.0426 0.0582
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.003
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0426 0.0409
Echinococcus granulosus peregrin 0.0029 0.0426 0.0409
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0426 0.0899
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0178 0.0161
Schistosoma mansoni polycystin 1-related 0.0019 0.0189 0.0032
Onchocerca volvulus Glutaminyl cyclase homolog 0.0113 0.2566 0.5254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0938 0.1979
Schistosoma mansoni nicalin (M28 family) 0.0018 0.016 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0938 0.0813
Brugia malayi jmjC domain containing protein 0.0094 0.2068 0.434
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0426 0.1202
Giardia lamblia PHD finger protein 15 0.0029 0.0426 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.2068 0.2054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0938 0.0813
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0178 0.0161
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.2377 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0426 0.1202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0938 0.0922
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0178 1
Schistosoma mansoni hypothetical protein 0.0029 0.0426 0.0279
Echinococcus multilocularis musashi 0.0026 0.0372 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Echinococcus granulosus cpg binding protein 0.0059 0.1195 0.118
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.0158 0.0334
Onchocerca volvulus 0.0019 0.0189 0.0063
Brugia malayi leucyl aminopeptidase 0.0018 0.016 0.0295
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0158 0.0291
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0371 0.0743
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0189 0.0398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0938 0.0922
Onchocerca volvulus 0.0019 0.0189 0.0063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0141 0.0123
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0158 0.0141
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0178 1
Brugia malayi PHD-finger family protein 0.0029 0.0426 0.0859
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0372 0.0745
Echinococcus multilocularis cpg binding protein 0.0059 0.1195 0.118
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0178 0.0161
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0178 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0178 1
Schistosoma mansoni rab6-interacting 0.0019 0.0189 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0027 0.0009
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0018 0.016 0.0142
Echinococcus granulosus dnaJ subfamily B 0.0398 0.9749 0.9749
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0426 1
Schistosoma mansoni hypothetical protein 0.0398 0.9749 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2726 0.5753
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0018 0.016 0.0002
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0113 0.2566 0.2552
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2726 0.5753
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0178 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0189 0.0171
Schistosoma mansoni hypothetical protein 0.0019 0.0189 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0426 0.0899
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi nicalin 0.0018 0.016 0.0295
Schistosoma mansoni intermediate filament proteins 0.0026 0.0372 0.0223
Schistosoma mansoni cpg binding protein 0.0056 0.1115 0.0998
Loa Loa (eye worm) hypothetical protein 0.0049 0.0942 0.1987
Brugia malayi N-terminal motif family protein 0.02 0.4739 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0938 0.1943
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.2068 0.2054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.1115 0.2353
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0372 0.0785
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.9749 0.9749
Schistosoma mansoni lamin 0.0026 0.0372 0.0223
Schistosoma mansoni cpg binding protein 0.0059 0.1195 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.016 0.8793
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0426 0.0409
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0158 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0372 0.0785
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0709 0.0692
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0113 0.2566 0.2552
Schistosoma mansoni loxhd1 0.0019 0.0189 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.036 0.0759
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0113 0.2566 0.251
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0018 0.016 0.0142
Brugia malayi MH2 domain containing protein 0.012 0.2726 0.5735
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1211 0.1098
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0055 0.0037
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0189 0.0171
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0141 0.0297
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0158 0.0141
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0178 0.0376
Schistosoma mansoni lipoxygenase 0.008 0.1729 0.1638
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0337
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0158 0.0141
Schistosoma mansoni Fxna peptidase (M28 family) 0.0018 0.016 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0658 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.016 0.8793
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0158 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0141 0.0123
Onchocerca volvulus 0.0026 0.0372 0.0464
Echinococcus multilocularis RUN 0.0019 0.0189 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0938 0.0922
Trypanosoma brucei unspecified product 0.0019 0.0178 1
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0018 0.016 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.016 0.8793
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Schistosoma mansoni lipoxygenase 0.0115 0.2601 0.2547
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0158 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0189 0.4059
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi hypothetical protein 0.0019 0.0189 0.0356
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.2696 0.2646
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0337
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.0158 0.8692
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1211 0.2556
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0372 0.0785
Loa Loa (eye worm) hypothetical protein 0.0018 0.0158 0.0334
Schistosoma mansoni rab6-interacting 0.0019 0.0189 0.0032
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0658 0.0642
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.003
Schistosoma mansoni lamin 0.0026 0.0372 0.0223
Brugia malayi CXXC zinc finger family protein 0.0056 0.1115 0.2319
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0189 0.0171
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0189 0.0171
Echinococcus multilocularis dna polymerase eta 0.0019 0.0178 0.0161
Schistosoma mansoni DNA polymerase eta 0.0019 0.0178 0.0021
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0158 0.8692
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0018 0.016 0.8793
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0055 0.0037
Brugia malayi hypothetical protein 0.0019 0.0189 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0578 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0062 0.0088
Brugia malayi FXNA 0.0018 0.016 0.0295
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.0158 0.8692
Echinococcus multilocularis lamin 0.0026 0.0372 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0178 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0178 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1582 0.1485
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2601 0.2588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0178 1
Schistosoma mansoni cpg binding protein 0.0059 0.1195 0.1081
Echinococcus multilocularis peregrin 0.0029 0.0426 0.0409
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2601 0.2588
Leishmania major DNA polymerase eta, putative 0.0019 0.0178 1
Onchocerca volvulus 0.0026 0.0372 0.0464
Echinococcus granulosus intermediate filament protein 0.0026 0.0372 0.0355
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.0158 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0158 0.0334
Plasmodium falciparum phd finger protein, putative 0.0029 0.0426 1
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0018 0.016 0.0002
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0189 0.4059
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0658 0.0522
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.0158 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0055 0.0037
Onchocerca volvulus 0.006 0.1211 0.2297
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0158 0.0334
Loa Loa (eye worm) hypothetical protein 0.0113 0.2566 0.5414
Echinococcus granulosus dna polymerase eta 0.0019 0.0178 0.0161
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0178 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0709 0.0692
Onchocerca volvulus 0.0056 0.1115 0.2086
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0018 0.016 0.0142
Trypanosoma brucei glutaminyl cyclase, putative 0.0018 0.016 0.8734
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0291 0.0138
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0158 0.8692
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0178 1
Echinococcus granulosus RUN 0.0019 0.0189 0.0171
Echinococcus multilocularis lamin dm0 0.0026 0.0372 0.0355
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0189 0.0171
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0178 0.0334
Brugia malayi Bromodomain containing protein 0.0029 0.0426 0.0859
Echinococcus granulosus dna polymerase kappa 0.0019 0.0178 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0938 0.0922
Loa Loa (eye worm) leucyl aminopeptidase 0.0018 0.016 0.0337
Echinococcus granulosus lamin 0.0026 0.0372 0.0355
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0178 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0376
Leishmania major DNA polymerase kappa, putative 0.0019 0.0178 1
Brugia malayi intermediate filament protein 0.0026 0.0372 0.0745
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0337
Brugia malayi jmjC domain containing protein 0.0038 0.0658 0.1352
Loa Loa (eye worm) hypothetical protein 0.02 0.4739 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0398
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0027 0.0009
Brugia malayi Doublecortin family protein 0.0019 0.0189 0.0356
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0055 0.0037
Brugia malayi Peptidase family M28 containing protein 0.0113 0.2566 0.5394
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0062 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0938 0.0813
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0018 0.016 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0658 0.139
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0426 0.0279
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0178 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0178 1
Echinococcus granulosus lamin dm0 0.0026 0.0372 0.0355
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0178 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1195 0.2521

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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