Detailed information for compound 1326541

Basic information

Technical information
  • TDR Targets ID: 1326541
  • Name: 27994-11-2
  • MW: 616.782 | Formula: C35H52O9
  • H donors: 4 H acceptors: 4 LogP: 3.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1[C@H](O)CO[C@H]([C@@H]1O)OC1CC[C@]23[C@H](C1(C)C)CC=C1[C@@]3(C2)CC[C@]2([C@@]1(C)CC1C2[C@H](C)CC2(O1)OC(C1(C2O1)C)O)C
  • InChi: 1S/C35H52O9/c1-17-13-35(27-32(6,43-27)28(39)44-35)42-19-14-31(5)21-8-7-20-29(2,3)22(41-26-25(38)24(37)18(36)15-40-26)9-10-33(20)16-34(21,33)12-11-30(31,4)23(17)19/h8,17-20,22-28,36-39H,7,9-16H2,1-6H3/t17-,18-,19?,20+,22?,23?,24+,25-,26+,27?,28?,30-,31+,32?,33-,34+,35?/m1/s1
  • InChiKey: GQLUAQZLAZUHEL-NKMZKCBCSA-N  


Substructure search Similarity search

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Synonyms

  • NCGC00091911-01
  • Cimicifugoside
  • (2S,3R,4S,5R)-2-{[(4aR,5aR,7aR,8R,12aR,14aR)-4'-hydroxy-1,1,5',7a,8,12a-hexamethyl-1,3,4,6,7,7a,7b,8,9,11a,12,12a,14,14a-tetradecahydro-2H-spiro[cyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]pyran-10,2'-[3,6]dioxabicyclo[3.1.0]hexan]-2-yl]oxy}tetrahydr

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens jun proto-oncogene Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus multilocularis jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Basic leucine zipper bZIP transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi bZIP transcription factor family protein Get druggable targets OG5_131442 All targets in OG5_131442
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.4 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Schistosoma mansoni retinoic acid receptor RXR Nuclear receptor subfamily 1 group I member 2   431 aa 412 aa 25.5 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 390 aa 24.6 %
Brugia malayi nuclear hormone receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.4 %
Onchocerca volvulus C-mannosyltransferase dpy-19 homolog Nuclear receptor subfamily 1 group I member 2   431 aa 397 aa 29.2 %
Brugia malayi ecdysteroid receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.9 %
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 Nuclear receptor subfamily 1 group I member 2   431 aa 440 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 400 aa 29.8 %
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 379 aa 24.5 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 417 aa 24.0 %
Echinococcus multilocularis ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 381 aa 26.2 %
Brugia malayi Nuclear hormone receptor E75 Nuclear receptor subfamily 1 group I member 2   431 aa 359 aa 22.0 %
Echinococcus granulosus ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 424 aa 24.1 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Brugia malayi photoreceptor-specific nuclear receptor Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.1 %
Schistosoma japonicum Probable nuclear hormone receptor HR3, putative Nuclear receptor subfamily 1 group I member 2   431 aa 487 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Leishmania major cathepsin L-like protease 0.002 0.0251 0.0863
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0519 0.2089
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0519 0.0519
Brugia malayi hypothetical protein 0.0031 0.0642 0.0642
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2135 0.8925
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0519 0.0703
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0146 0.4992 0.6698
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2386 1
Loa Loa (eye worm) ctsf protein 0.002 0.0251 0.0251
Brugia malayi nuclear receptor NHR-67 0.0027 0.0519 0.0519
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0251 0.0251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Loa Loa (eye worm) DR-78 0.0027 0.0519 0.0519
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0519 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.167 0.167
Schistosoma mansoni retinoic acid receptor RXR 0.0177 0.6142 0.8321
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.167 0.6723
Echinococcus multilocularis jun protein 0.0101 0.3302 0.4363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0519 0.0845
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0251 0.5
Leishmania major cysteine peptidase A (CPA) 0.002 0.0251 0.0863
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.005 0.005
Schistosoma mansoni thyroid hormone receptor 0.021 0.7381 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.167 0.2108
Echinococcus multilocularis cysteine protease 0.002 0.0251 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0058 0.167 0.2262
Plasmodium vivax vivapain-2 0.002 0.0251 0.5
Brugia malayi nuclear receptor NHR-88 0.0027 0.0519 0.0519
Onchocerca volvulus 0.002 0.0251 0.1011
Loa Loa (eye worm) hypothetical protein 0.0099 0.3197 0.3197
Brugia malayi conserved hypotetical protein 0.0027 0.0519 0.0519
Schistosoma mansoni jun-related protein 0.0082 0.2588 0.3506
Brugia malayi hypothetical protein 0.0027 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0251 0.034
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.167 0.167
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0251 0.0148
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0251 0.0409
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Brugia malayi steroid hormone receptor 0.0058 0.167 0.167
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.167 0.167
Onchocerca volvulus 0.002 0.0251 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Onchocerca volvulus Cathepsin L homolog 0.002 0.0251 0.1011
Schistosoma mansoni nuclear receptor 0.0027 0.0519 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Brugia malayi ecdysone receptor 0.0027 0.0519 0.0519
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.167 0.2262
Brugia malayi hypothetical protein 0.0027 0.0519 0.0519
Leishmania major cathepsin L-like protease 0.0077 0.2386 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0519 0.0703
Echinococcus granulosus jun protein 0.0101 0.3302 0.5375
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0251 0.0251
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0519 0.0518
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0519 0.0703
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0149 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.167 0.6723
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.167 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.167 0.167
Brugia malayi hypothetical protein 0.0031 0.0642 0.0642
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0251 0.034
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0251 0.0863
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0251 0.0148
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2386 1
Onchocerca volvulus 0.002 0.0251 0.1011
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0144 0.0195
Loa Loa (eye worm) CYP4Cod1 0.0015 0.005 0.005
Echinococcus multilocularis Ankyrin 0.0018 0.0149 0.0008
Schistosoma mansoni coup transcription factor 0.0058 0.167 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.167 0.167
Schistosoma mansoni zinc finger protein 0.0027 0.0519 0.0703
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0144 0.0579
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0251 1
Brugia malayi tailless protein 0.0027 0.0519 0.0519
Echinococcus multilocularis cysteine protease 0.002 0.0251 0.0148
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0519 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.167 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Leishmania major cathepsin L-like protease 0.0077 0.2386 1
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0519 0.0519
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0251 1
Plasmodium vivax vivapain-2 0.002 0.0251 0.5
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0519 0.0703
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.5203 0.6991
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Echinococcus multilocularis thyroid hormone receptor alpha 0.021 0.7381 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0251 0.1011
Schistosoma mansoni hypothetical protein 0.0152 0.5203 0.7049
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.167 0.2718
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0519 0.0518
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.167 0.2108
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0251 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.3302 0.5375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0519 0.0845
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.167 0.2718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1766 0.7348
Brugia malayi Uncoordinated protein 44 0.0017 0.0144 0.0144
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.2833 0.3715
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0519 0.2089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.167 0.2262
Schistosoma mansoni nuclear receptor 0.0027 0.0519 0.0703
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.167 0.6723
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0144 0.0144
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0642 0.0642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Brugia malayi ecdysteroid receptor 0.0058 0.167 0.167
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.167 0.2108
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.0642 0.1045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 1 1
Onchocerca volvulus 0.002 0.0251 0.1011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0177 0.6142 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Onchocerca volvulus 0.0027 0.0519 0.2089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.167 0.2718
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.167 0.2262
Schistosoma mansoni netrin receptor unc5 0.0017 0.0144 0.0195
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.5203 0.8471
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0519 0.0845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.167 0.2262
Loa Loa (eye worm) cysteine protease 0.002 0.0251 0.0251
Brugia malayi Cytochrome P450 family protein 0.0015 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Onchocerca volvulus 0.002 0.0251 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0519 0.0518
Onchocerca volvulus 0.002 0.0251 0.1011
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0144 0.0234
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Onchocerca volvulus 0.0058 0.167 0.6723
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.167 0.2718
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0642 0.0642
Brugia malayi nuclear receptor NHR-88 0.0058 0.167 0.167
Leishmania major cathepsin L-like protease 0.002 0.0251 0.0863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.167 0.167
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.0642 0.0689
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0251 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.167 0.167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.167 0.167
Brugia malayi Cytochrome P450 family protein 0.0015 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Leishmania major cathepsin L-like protease 0.002 0.0251 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.0642 0.087
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.167 0.2262
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.167 0.2108
Echinococcus granulosus death domain containing protein 0.0017 0.0144 0.0234
Echinococcus granulosus FTZ F1 alpha 0.0058 0.167 0.2718
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.167 0.167
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.167 0.167
Toxoplasma gondii cathepsin CPL 0.002 0.0251 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0144 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.167 0.2718
Brugia malayi nuclear hormone receptor 0.0058 0.167 0.167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.167 0.167
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0519 0.0519
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0519 0.0519
Onchocerca volvulus 0.008 0.2483 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.167 0.167
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0251 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.167 0.2718
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.005 0.005
Brugia malayi hypothetical protein 0.008 0.2483 0.2483
Schistosoma mansoni hypothetical protein 0.0082 0.2588 0.3506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0642 0.087
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0519 0.0519
Brugia malayi Protein kinase domain containing protein 0.0017 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.0642 0.0642
Echinococcus granulosus Ankyrin 0.0018 0.0149 0.0243
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0251 0.0251
Leishmania major cathepsin L-like protease 0.0077 0.2386 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.167 0.2108
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.167 0.167
Leishmania major cathepsin L-like protease 0.002 0.0251 0.0863
Entamoeba histolytica cysteine protease, putative 0.002 0.0251 1
Schistosoma mansoni hypothetical protein 0.021 0.7373 0.9988
Brugia malayi bZIP transcription factor family protein 0.0101 0.3302 0.3302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.167 0.2718
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.167 0.2262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0519 0.0518
Loa Loa (eye worm) hypothetical protein 0.0058 0.167 0.167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.167 0.167
Brugia malayi nuclear hormone receptor 0.0027 0.0519 0.0519
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2386 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0251 1
Echinococcus granulosus cathepsin l1 0.002 0.0251 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.167 0.2262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Brugia malayi Death domain containing protein 0.0017 0.0144 0.0144
Schistosoma mansoni thyroid hormone receptor 0.021 0.7381 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.3302 0.4363
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0251 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0251 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.167 0.167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0519 0.0518
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0519 0.0845
Brugia malayi nuclear receptor RXR 0.0027 0.0519 0.0519
Onchocerca volvulus 0.0027 0.0519 0.2089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0251 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.167 0.2108
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2386 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.167 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.167 0.167
Leishmania major cathepsin L-like protease 0.002 0.0251 0.0863
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0519 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.167 0.167
Onchocerca volvulus Cathepsin L homolog 0.002 0.0251 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0251 1
Trypanosoma brucei RNA helicase, putative 0.021 0.7373 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0251 0.0251
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.005 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0144 0.0144
Onchocerca volvulus 0.002 0.0251 0.1011
Loa Loa (eye worm) fibroinase 0.002 0.0251 0.0251
Brugia malayi nuclear receptor RXR 0.0031 0.0642 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2386 0.319
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0519 0.0519
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0144 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0251 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0144 0.000000052255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.167 0.2108
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.2833 0.4612
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0519

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0007 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9252 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.7194 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 9.6489 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of vitamin D receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1317 uM PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of farnesoid X receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of farnesoid X receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of androgen receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 74.978 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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