Detailed information for compound 1329014

Basic information

Technical information
  • TDR Targets ID: 1329014
  • Name: N-(4-nitro-1,2,5-oxadiazol-3-yl)-2-pyridin-2- ylsulfanylacetamide
  • MW: 281.248 | Formula: C9H7N5O4S
  • H donors: 1 H acceptors: 6 LogP: 1.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nonc1[N+](=O)[O-])CSc1ccccn1
  • InChi: 1S/C9H7N5O4S/c15-6(5-19-7-3-1-2-4-10-7)11-8-9(14(16)17)13-18-12-8/h1-4H,5H2,(H,11,12,15)
  • InChiKey: CMBQZZZKKJLRIR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-nitro-1,2,5-oxadiazol-3-yl)-2-(2-pyridylsulfanyl)acetamide
  • N-(4-nitro-1,2,5-oxadiazol-3-yl)-2-(2-pyridylthio)acetamide
  • N-(4-nitrofurazan-3-yl)-2-(2-pyridylthio)acetamide
  • N-(4-nitro-1,2,5-oxadiazol-3-yl)-2-pyridin-2-ylsulfanyl-ethanamide
  • ZINC04689377
  • A3497/0148313

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Infectious bronchitis virus 3C-like protease Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Cryptosporidium parvum preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis preprocathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Dipeptidyl-peptidase I precursor Get druggable targets OG5_130494 All targets in OG5_130494
Toxoplasma gondii preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii cathepsin CPC1 Get druggable targets OG5_130494 All targets in OG5_130494
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum dipeptidyl aminopeptidase 1 Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Get druggable targets OG5_130494 All targets in OG5_130494
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii Homo sapiens P3ECSL-related Get druggable targets OG5_130494 All targets in OG5_130494
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_130494 All targets in OG5_130494
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii cathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2197 0.8837
Schistosoma mansoni hypothetical protein 0.0043 0.0841 0.0841
Brugia malayi CXXC zinc finger family protein 0.0062 0.1254 0.2362
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0814 0.2619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0144 0.0271
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0891 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0551 0.1706
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.3059 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0144 0.0144
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2456 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.3943 0.743
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1579 0.1579
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0551 0.115
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0144 0.0144
Brugia malayi N-terminal motif family protein 0.0061 0.1239 0.2334
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.1254 0.2362
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0814 0.2078
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0144 0.0144
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0037 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1579 0.1579
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0144 0.0365
Toxoplasma gondii thioredoxin reductase 0.0046 0.0891 0.235
Schistosoma mansoni smad1 5 8 and 0.0017 0.0242 0.0242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0905 0.0905
Schistosoma mansoni Smad4 0.0007 0.0037 0.0037
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0891 0.235
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1579 0.2974
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.004 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0144 0.0144
Brugia malayi MH1 domain containing protein 0.0009 0.0076 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0814 0.2619
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0015 0.0015
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0037 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0144 0.0271
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0131 0.0247
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0225 0.238
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0225 0.5
Schistosoma mansoni myst-related protein 0.0007 0.0035 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0225 0.238
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0144 0.0365
Leishmania major trypanothione reductase 0.0046 0.0891 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Echinococcus multilocularis transcription factor btf3 0.0042 0.0814 0.0814
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0144 0.0144
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0185 0.0552
Brugia malayi nuclear receptor RXR 0.0006 0.0015 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0225 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0144 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0215 0.0215
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0814 0.9117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Brugia malayi hypothetical protein 0.0006 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0551 0.1038
Schistosoma mansoni myst-related protein 0.0007 0.0035 0.0035
Brugia malayi Thioredoxin reductase 0.0046 0.0891 0.1679
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.5307 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0144 0.0144
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0144 0.0144
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0814 0.2078
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0225 0.238
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0225 0.0684
Plasmodium falciparum thioredoxin reductase 0.0016 0.0225 0.0629
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.249 0.7992
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0242 0.0242
Brugia malayi MH2 domain containing protein 0.0007 0.0037 0.007
Onchocerca volvulus 0.0182 0.3943 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.1405 0.2648
Entamoeba histolytica hypothetical protein 0.0043 0.0841 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.1405 0.1405
Echinococcus granulosus smad 0.0017 0.0242 0.0242
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0015 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0225 0.0225
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0143 0.3059 1
Brugia malayi MH1 domain containing protein 0.0009 0.0076 0.0144
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0242 0.0456
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0225 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0225 0.238
Brugia malayi hypothetical protein 0.003 0.0551 0.1038
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Entamoeba histolytica hypothetical protein 0.0043 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.5307 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0144 0.0271
Schistosoma mansoni Smad4 0.0007 0.0037 0.0037
Brugia malayi MH2 domain containing protein 0.0244 0.5307 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0551 0.611
Loa Loa (eye worm) hypothetical protein 0.0217 0.4719 0.8892
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0294 0.0553
Brugia malayi MH1 domain containing protein 0.0017 0.0242 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0144 0.0271
Schistosoma mansoni hypothetical protein 0.0069 0.1405 0.1405
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0814 0.9117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2456 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0242 0.0456
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0225 0.5
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0143 0.3059 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.1405 0.2648
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0814 0.9117
Leishmania major basic transcription factor 3a, putative 0.0042 0.0814 0.8841
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.3059 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.3185 0.6002
Trichomonas vaginalis hypothetical protein 0.0008 0.004 0.0075
Entamoeba histolytica hypothetical protein 0.0043 0.0841 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0144 0.0271
Schistosoma mansoni hypothetical protein 0.0069 0.1405 0.1405
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0037 0.007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2197 0.8837
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0037 0.0037
Schistosoma mansoni smad 0.0007 0.0037 0.0037
Brugia malayi MH1 domain containing protein 0.0017 0.0242 0.0456
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0225 0.238
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0144 0.0144
Loa Loa (eye worm) Smad1 0.0017 0.0242 0.0456
Schistosoma mansoni hypothetical protein 0.0168 0.3628 0.3628
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0144 0.0144
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0176 0.0176
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0061 0.1239 0.3142
Echinococcus multilocularis smad 0.0017 0.0242 0.0242
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0069 0.1405 0.2648
Toxoplasma gondii cathepsin CPC1 0.0143 0.3059 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0144 0.0271
Brugia malayi steroid hormone receptor 0.0012 0.0144 0.0271
Echinococcus multilocularis cpg binding protein 0.0065 0.1332 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0144 0.0271
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0144 0.0144
Toxoplasma gondii preprocathepsin c precursor, putative 0.0143 0.3059 1
Brugia malayi MH2 domain containing protein 0.0017 0.0242 0.0456
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0144 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1579 0.1579
Brugia malayi Latrophilin receptor protein 2 0.0069 0.1405 0.2648
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0144 0.0271
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0015 0.0015
Brugia malayi RNA binding protein 0.0076 0.1579 0.2974
Brugia malayi MH2 domain containing protein 0.0017 0.0242 0.0456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.2803 0.2803
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0176 0.0176
Plasmodium falciparum glutathione reductase 0.0016 0.0225 0.0629
Schistosoma mansoni Smad4 0.0017 0.0242 0.0242
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0891 0.1679
Schistosoma mansoni smad1 5 8 and 0.0017 0.0242 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0144 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0144 0.0144
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0144 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Echinococcus multilocularis GPCR, family 2 0.0069 0.1405 0.1405
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0144 0.0144
Onchocerca volvulus 0.0062 0.1254 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0215 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1579 0.1579
Schistosoma mansoni hypothetical protein 0.0454 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0144 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.007 0.007
Schistosoma mansoni cpg binding protein 0.0065 0.1332 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0144 0.0271
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.004 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0144 0.0271
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0225 0.0225
Brugia malayi ecdysteroid receptor 0.0012 0.0144 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Echinococcus multilocularis geminin 0.0168 0.3628 0.3628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0144 0.0271
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0217 0.4719 0.8892
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0029
Trypanosoma brucei trypanothione reductase 0.0046 0.0891 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Schistosoma mansoni hypothetical protein 0.0168 0.3628 0.3628
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0037 0.0037
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0242 0.0242
Entamoeba histolytica hypothetical protein 0.0043 0.0841 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1579 0.1579
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0144 0.0144
Schistosoma mansoni transcription factor btf3 0.0042 0.0814 0.0814
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0814 0.1533
Schistosoma mansoni hypothetical protein 0.0148 0.3185 0.3185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0144 0.0144
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0215 0.0215
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.1405 0.1405
Brugia malayi TAR-binding protein 0.0076 0.1579 0.2974
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0225 0.0225
Loa Loa (eye worm) nuclear factor I 0.0009 0.0076 0.0144
Echinococcus granulosus GPCR family 2 0.0069 0.1405 0.1405
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0299 0.0299
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0551 0.611
Brugia malayi hypothetical protein 0.0043 0.0841 0.1585
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0144 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0144 0.0271
Plasmodium falciparum thioredoxin reductase 0.0046 0.0891 0.2831
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0841 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0144 0.0271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2456 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0275 0.6013 0.6013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0144 0.0271
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0144 0.0271
Schistosoma mansoni hypothetical protein 0.0069 0.1405 0.1405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0144 0.0144
Loa Loa (eye worm) RNA binding protein 0.0076 0.1579 0.2974
Mycobacterium tuberculosis Probable reductase 0.0104 0.2197 0.8837
Schistosoma mansoni coup transcription factor 0.0012 0.0144 0.0144
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0131 0.0247
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.1405 0.1405
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2456 1
Brugia malayi hypothetical protein 0.0182 0.3943 0.743
Brugia malayi hypothetical protein 0.0006 0.0015 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1579 0.1579
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0891 0.2985
Schistosoma mansoni smad1 5 8 and 0.0017 0.0242 0.0242
Brugia malayi glutathione reductase 0.0046 0.0891 0.1679
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0814 0.2619
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0551 0.1706
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.1405 0.1405
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0841 0.0841
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Echinococcus granulosus tar DNA binding protein 0.0076 0.1579 0.1579
Schistosoma mansoni cpg binding protein 0.0062 0.1254 0.1254
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0215 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0551 0.115
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0225 0.0424
Brugia malayi hypothetical protein 0.002 0.031 0.0584
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1579 0.2974
Treponema pallidum NADH oxidase 0.0016 0.0225 0.5
Brugia malayi nuclear receptor NHR-88 0.0012 0.0144 0.0271
Echinococcus multilocularis dnaJ subfamily B 0.0454 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0015 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0144 0.0144
Echinococcus multilocularis Smad4 0.0017 0.0242 0.0242
Schistosoma mansoni smad 0.0017 0.0242 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0144 0.0271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0144 0.0144
Echinococcus granulosus transcription factor btf3 0.0042 0.0814 0.0814
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0144 0.0271
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0299 0.0564
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0143 0.3059 0.3059
Brugia malayi beta-NAC-like protein 0.0042 0.0814 0.1533
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0271
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0014 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0042 0.0814 0.9661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0144 0.0271
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0144 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0015 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0144 0.0271
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0551 0.611
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0143 0.3059 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0242 0.0242
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0144 0.0144
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0144 0.0144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1579 0.2974
Brugia malayi Calcitonin receptor-like protein seb-1 0.0217 0.4719 0.8892
Brugia malayi nuclear hormone receptor 0.0012 0.0144 0.0271
Loa Loa (eye worm) glutathione reductase 0.0046 0.0891 0.1679
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0144 0.0144
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0814 0.2576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0225 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0144 0.0144
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0225 0.238
Schistosoma mansoni hypothetical protein 0.0069 0.1405 0.1405
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0143 0.3059 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0144 0.0271
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0225 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0185 0.0552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0144 0.0144
Trichomonas vaginalis helicase, putative 0.0014 0.0185 0.0552
Onchocerca volvulus 0.0012 0.0144 0.0365
Plasmodium vivax glutathione reductase, putative 0.0046 0.0891 0.235
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0037 0.0037
Brugia malayi Smad1 0.0017 0.0242 0.0456
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0144 0.0144
Echinococcus granulosus cpg binding protein 0.0065 0.1332 0.1332
Schistosoma mansoni cpg binding protein 0.0065 0.1332 0.1332
Echinococcus granulosus Smad4 0.0017 0.0242 0.0242
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2197 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0225 0.238
Loa Loa (eye worm) hypothetical protein 0.0061 0.1239 0.2334
Plasmodium falciparum glutathione reductase 0.0046 0.0891 0.2831
Echinococcus granulosus geminin 0.0168 0.3628 0.3628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0217 0.4719 0.8892
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0905 0.0905
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0185 0.0552
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0841 0.0841
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0225 0.238
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0814 0.9661
Loa Loa (eye worm) hypothetical protein 0.0148 0.3185 0.6002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2197 0.8837
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0299 0.0299
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2197 0.8837
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0185 0.0552
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0144
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0225 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0144 0.0271
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0015 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0225 0.0629
Leishmania major hypothetical protein, conserved 0.003 0.0551 0.4894
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0225 0.0684

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7.31 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 7.068 um PUBCHEM_BIOASSAY: QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro). (Class of assay: confirmatory) [Related pubchem assays: 1706 (Primary screening assay.), 1879 (Single concentration confirmatory assay.), 1859 (Summary AID.)] ChEMBL. No reference
Potency (functional) 0.1651 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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