Detailed information for compound 1334017

Basic information

Technical information
  • TDR Targets ID: 1334017
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-[[5-(4 -methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]sul fanyl]acetamide
  • MW: 473.544 | Formula: C26H23N3O4S
  • H donors: 2 H acceptors: 2 LogP: 4.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1[nH]c(nc1SCC(=O)Nc1ccc2c(c1)OCCO2)c1ccccc1
  • InChi: 1S/C26H23N3O4S/c1-31-20-10-7-17(8-11-20)24-26(29-25(28-24)18-5-3-2-4-6-18)34-16-23(30)27-19-9-12-21-22(15-19)33-14-13-32-21/h2-12,15H,13-14,16H2,1H3,(H,27,30)(H,28,29)
  • InChiKey: JQYVWEYKDHHMNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-[[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]thio]acetamide
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-[[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]sulfanyl]ethanamide
  • C331-1949
  • NCGC00107726-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0038 0.0162 0.0637
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0066 0.0138
Schistosoma mansoni cathepsin s 0.0029 0.0108 0.0225
Echinococcus multilocularis cathepsin b 0.0446 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0425
Loa Loa (eye worm) hypothetical protein 0.0321 0.1815 0.7121
Entamoeba histolytica cysteine protease, putative 0.01 0.0523 0.258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0277 0.1235
Echinococcus granulosus high affinity choline transporter 1 0.0344 0.1949 0.4053
Schistosoma mansoni cathepsin C 0.0029 0.011 0.0228
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0052 0.0203
Schistosoma mansoni hypothetical protein 0.0405 0.2304 0.4791
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0277 0.1087
Leishmania major cathepsin L-like protease 0.01 0.0523 0.4035
Loa Loa (eye worm) hypothetical protein 0.0344 0.1949 0.7648
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0052 0.0107
Trypanosoma cruzi cysteine proteinase, putative 0.0058 0.0277 0.0692
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0066 0.0138
Echinococcus multilocularis solute carrier family 5 0.0038 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Onchocerca volvulus Cathepsin F homolog 0.01 0.0523 0.2879
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0066 0.0138
Brugia malayi cathepsin L-like precursor 0.0071 0.0355 0.1394
Onchocerca volvulus 0.0321 0.1815 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0052 0.0052
Brugia malayi cathepsin L-like cysteine proteinase 0.0029 0.011 0.0431
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0052 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Plasmodium vivax vivapain-3 0.0058 0.0277 0.4075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Schistosoma mansoni cathepsin B (C01 family) 0.0029 0.011 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0052 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.011 0.0318
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Plasmodium falciparum cysteine proteinase falcipain 3 0.01 0.0523 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.0384 0.113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0066 0.0066
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0052 0.0052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.0523 0.0523
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0066 0.026
Brugia malayi steroid hormone receptor 0.0021 0.0066 0.026
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.0699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0066 0.0138
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.1878 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0425
Loa Loa (eye worm) hypothetical protein 0.0155 0.0847 0.3324
Brugia malayi nuclear hormone receptor 0.0021 0.0066 0.026
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0052 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0228 0.0473
Giardia lamblia Cathepsin B precursor 0.0158 0.0864 0.4268
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Brugia malayi ecdysteroid receptor 0.0021 0.0066 0.026
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0029 0.011 0.0036
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0162 0.0637
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0016 0.0033
Echinococcus granulosus intermediate filament protein 0.0027 0.0097 0.0201
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0052 0.0052
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0052 0.0203
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2549 0.53
Schistosoma mansoni intermediate filament proteins 0.0027 0.0097 0.0201
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0066 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Schistosoma mansoni cathepsin S (C01 family) 0.0029 0.011 0.0228
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0162 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0066 0.026
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0277 0.1235
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0016 0.0016
Plasmodium falciparum cysteine proteinase falcipain 1 0.0058 0.0277 0.4054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0066 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Schistosoma mansoni coup transcription factor 0.0021 0.0066 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Plasmodium vivax unspecified product 0.0029 0.011 0.0036
Onchocerca volvulus Cathepsin L homolog 0.0029 0.011 0.0605
Echinococcus multilocularis geminin 0.0192 0.1064 0.1064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.0523 0.0523
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.011 0.0228
Brugia malayi hypothetical protein 0.0019 0.0052 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0029 0.011 0.0318
Echinococcus multilocularis cathepsin L 0.0058 0.0277 0.0277
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0066 0.0138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0066 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0066 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0293 0.0609
Loa Loa (eye worm) hypothetical protein 0.0446 0.2549 1
Onchocerca volvulus 0.0028 0.0107 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.063 0.2136
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.011 0.0318
Entamoeba histolytica cysteine proteinase, putative 0.01 0.0523 0.258
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0052 0.0203
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0066 0.026
Loa Loa (eye worm) hypothetical protein 0.01 0.0523 0.2051
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.0523 0.258
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0277 0.1087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0066 0.0138
Onchocerca volvulus 0.0021 0.0066 0.0365
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0066 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Giardia lamblia Cathepsin B precursor 0.0158 0.0864 0.4268
Echinococcus multilocularis musashi 0.0027 0.0097 0.0097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.011 0.0228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0066 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0066 0.026
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0097 0.0379
Echinococcus multilocularis cpg binding protein 0.003 0.0116 0.0116
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0066 0.0138
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0063
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Onchocerca volvulus 0.01 0.0523 0.2879
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0355 0.1663
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0052 0.0107
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0797 0.2822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0066 0.026
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0561 0.2199
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0066 0.0138
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0158 0.0864 0.3097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0066 0.026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.011 0.0228
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0052 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0066 0.0138
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.01 0.0523 0.2051
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Echinococcus granulosus cathepsin L cysteine protease 0.0058 0.0277 0.0576
Trypanosoma cruzi cruzipain precursor, putative 0.0147 0.0797 0.2822
Schistosoma mansoni hypothetical protein 0.0192 0.1064 0.2211
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0158 0.0864 1
Toxoplasma gondii cathepsin CPL 0.01 0.0523 0.5474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0277 0.1235
Brugia malayi PXA domain containing protein 0.0019 0.0052 0.0203
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.011 0.0431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.1878 1
Trypanosoma cruzi cysteine proteinase, putative 0.0058 0.0277 0.0692
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0162 0.0162
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0179 0.0373
Schistosoma mansoni lamin 0.0027 0.0097 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Schistosoma mansoni hypothetical protein 0.0041 0.0179 0.0373
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0797 0.2822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.011 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0066 0.026
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0097 0.0379
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0158 0.0864 0.445
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0028
Leishmania major cathepsin L-like protease 0.0147 0.0797 0.8826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Brugia malayi nuclear receptor NHR-88 0.0021 0.0066 0.026
Entamoeba histolytica cysteine proteinase 1, putative 0.0058 0.0277 0.1235
Schistosoma mansoni hypothetical protein 0.0192 0.1064 0.2211
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Echinococcus granulosus cysteine protease 0.0058 0.0277 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0052 0.0107
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0379
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0052 0.0203
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.011 0.0431
Brugia malayi Cathepsin L-like precursor 0.0071 0.0355 0.1394
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0029 0.011 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Leishmania major cathepsin L-like protease 0.01 0.0523 0.4035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0847 0.3324
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0024 0.0095
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0446 0.2549 0.53
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0162 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0066 0.026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0228 0.0893
Schistosoma mansoni sodium/solute symporter 0.0038 0.0162 0.0338
Schistosoma mansoni high-affinity choline transporter 0.0344 0.1949 0.4053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0847 0.3324
Onchocerca volvulus 0.01 0.0523 0.2879
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0292 0.0292
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0028
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Brugia malayi fibroinase precursor 0.0029 0.011 0.0431
Entamoeba histolytica cysteine proteinase, putative 0.01 0.0523 0.258
Trypanosoma brucei cysteine peptidase C (CPC) 0.0158 0.0864 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.011 0.0036
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0052 0.0107
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0052 0.0107
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Loa Loa (eye worm) ctsf protein 0.01 0.0523 0.2051
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.011 0.0228
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.2304 0.2304
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0277 0.1235
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0473
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.2199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Loa Loa (eye worm) hypothetical protein 0.0071 0.0355 0.1394
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0228 0.0893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.011 0.0036
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.011 0.0431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0179 0.0179
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0066 0.0066
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0028
Leishmania major cysteine peptidase A (CPA) 0.01 0.0523 0.4035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0158 0.0864 0.1797
Echinococcus granulosus cathepsin b 0.0446 0.2549 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0277 0.1235
Schistosoma mansoni hypothetical protein 0.0106 0.0561 0.1165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2549 0.53
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0066 0.026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0066 0.026
Plasmodium falciparum cysteine proteinase falcipain 2b 0.01 0.0523 1
Loa Loa (eye worm) cathepsin B 0.0158 0.0864 0.339
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0066 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0029 0.011 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0355 0.1663
Loa Loa (eye worm) cysteine protease 0.01 0.0523 0.2051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0847 0.3324
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0052 0.0203
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.0523 0.1087
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0028
Onchocerca volvulus 0.01 0.0523 0.2879
Brugia malayi hypothetical protein 0.0011 0.0007 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0405 0.2304 0.4791
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0797 0.2822
Plasmodium falciparum cysteine proteinase falcipain 2a 0.01 0.0523 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0066 0.026
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0066 0.0138
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.481 0.481
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0066 0.0138
Giardia lamblia Fructose-bisphosphate aldolase 0.0331 0.1878 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.0887 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0523 0.2051
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0029 0.011 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0066 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0052 0.0107
Echinococcus multilocularis lamin dm0 0.0027 0.0097 0.0097
Echinococcus multilocularis GPCR, family 2 0.0049 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0277 0.0576
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0052 0.0107
Echinococcus granulosus cathepsin l1 0.01 0.0523 0.1087
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.011 0.0318
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0052 0.0107
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0052 0.0203
Echinococcus granulosus lamin dm0 0.0027 0.0097 0.0201
Echinococcus granulosus cathepsin l1 0.0071 0.0355 0.0739
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Plasmodium vivax vivapain-2 0.01 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0052
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.0887 0.5
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0058 0.0277 0.0692
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0052 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.0523 0.1698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0052 0.0107
Plasmodium vivax vivapain-2 0.01 0.0523 1
Echinococcus multilocularis lamin 0.0027 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0066 0.0138
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0052 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.011 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0052 0.0107
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0029 0.011 0.0036
Brugia malayi Cathepsin L-like precursor 0.0029 0.0108 0.0425
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0097 0.0379
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0052 0.0203
Brugia malayi hypothetical protein 0.0019 0.0052 0.0203
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0162 0.0338
Onchocerca volvulus 0.0029 0.011 0.0605
Schistosoma mansoni cpg binding protein 0.0028 0.0107 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0066 0.026
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0029 0.011 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0029 0.011 0.0318
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0052 0.0203
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0893
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0292 0.0607
Brugia malayi CXXC zinc finger family protein 0.0028 0.0107 0.0419
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.011 0.0431
Echinococcus multilocularis expressed protein 0.0369 0.2098 0.2098
Loa Loa (eye worm) hypothetical protein 0.0071 0.0355 0.1394
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0277 0.0576
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0066 0.0138
Brugia malayi cathepsin L precursor 0.0029 0.011 0.0431
Onchocerca volvulus Cathepsin L homolog 0.01 0.0523 0.2879
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0066 0.0138
Entamoeba histolytica hypothetical protein 0.0029 0.011 0.0318
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0108 0.0425
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0015
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0007 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0066 0.026
Schistosoma mansoni cpg binding protein 0.003 0.0116 0.0242
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0029 0.011 0.0228
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0066 0.0138
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0277 0.1235
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0052 0.0107
Onchocerca volvulus 0.0038 0.0162 0.0895
Schistosoma mansoni lamin 0.0027 0.0097 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0162 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.011 0.0318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Toxoplasma gondii cathepsin B 0.0158 0.0864 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0052 0.0203
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0052 0.0107
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0052 0.0052
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0029 0.011 0.0431
Leishmania major cathepsin L-like protease 0.01 0.0523 0.4035
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0052 0.0107
Echinococcus granulosus GPCR family 2 0.0049 0.0228 0.0473
Leishmania major cathepsin L-like protease 0.01 0.0523 0.4035
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0355 0.0739
Onchocerca volvulus 0.01 0.0523 0.2879
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.011 0.0228
Brugia malayi Cathepsin L-like cysteine proteinase 0.0071 0.0355 0.1394
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0066 0.026
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0052 0.0052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0277 0.0576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0066 0.026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.011 0.0431
Entamoeba histolytica cysteine protease, putative 0.0058 0.0277 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0066 0.026
Leishmania major cathepsin L-like protease 0.01 0.0523 0.4035
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0066 0.0365
Onchocerca volvulus 0.0027 0.0097 0.0533
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0066 0.0138
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.011 0.0036
Brugia malayi intermediate filament protein 0.0027 0.0097 0.0379
Leishmania major cathepsin L-like protease 0.0147 0.0797 0.8826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2549 0.53
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0052 0.0107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0425
Onchocerca volvulus 0.01 0.0523 0.2879
Schistosoma mansoni inositol transporter 0.0038 0.0162 0.0338
Echinococcus granulosus geminin 0.0192 0.1064 0.2211
Echinococcus granulosus cathepsin L cysteine proteinase 0.01 0.0523 0.1087
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0029 0.011 0.0036
Echinococcus multilocularis high affinity choline transporter 1 0.0344 0.1949 0.1949
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0029 0.011 0.0036
Echinococcus granulosus cathepsin L 0.0058 0.0277 0.0576
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.011 0.0431
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Schistosoma mansoni cpg binding protein 0.003 0.0116 0.0242
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0066 0.0066
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0052 0.0203
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0162 0.0338
Onchocerca volvulus 0.01 0.0523 0.2879
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.0699
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0066 0.0138
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0292 0.0607
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0228 0.0893
Echinococcus granulosus microtubule associated protein 2 0.0833 0.481 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0007
Echinococcus multilocularis cathepsin L 0.0029 0.011 0.011
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0029 0.011 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.481 1
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0052 0.0203
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0029 0.011 0.0036
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0007 0.0028
Loa Loa (eye worm) fibroinase 0.01 0.0523 0.2051
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0523 0.2051
Echinococcus granulosus expressed protein 0.0369 0.2098 0.4361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Echinococcus granulosus cathepsin l cysteine peptidase 0.01 0.0523 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.0887 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Echinococcus granulosus cpg binding protein 0.003 0.0116 0.0242
Plasmodium vivax unspecified product 0.0058 0.0277 0.4075
Brugia malayi hypothetical protein 0.0321 0.1815 0.7121
Trypanosoma cruzi cysteine protease, putative 0.0058 0.0277 0.0692
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0029 0.011 0.0431
Echinococcus granulosus lamin 0.0027 0.0097 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0431
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0107 0.0419
Leishmania major cathepsin L-like protease 0.0147 0.0797 0.8826
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.0028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.011 0.0228
Brugia malayi PXA domain containing protein 0.0019 0.0052 0.0203
Echinococcus multilocularis cysteine protease 0.01 0.0523 0.0523
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Echinococcus granulosus cathepsin b 0.0446 0.2549 0.53
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0028
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.0523 0.1087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0066 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0029 0.011 0.0318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0368
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0255 0.1929
Echinococcus multilocularis cysteine protease 0.01 0.0523 0.0523
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.0523 0.0523
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0473
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0108 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0523 0.258
Brugia malayi Cathepsin L-like precursor 0.0071 0.0355 0.1394
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0066 0.026
Echinococcus multilocularis cathepsin b 0.0446 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0071 0.0355 0.1394
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.011 0.0036
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.011 0.0431
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.0699
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0473
Plasmodium vivax vivapain-1 0.0058 0.0277 0.4075
Entamoeba histolytica cysteine protease, putative 0.0029 0.011 0.0318
Entamoeba histolytica cysteine proteinase 2 0.0058 0.0277 0.1235
Onchocerca volvulus 0.0071 0.0355 0.1957
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.011 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.011 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0066 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Onchocerca volvulus 0.01 0.0523 0.2879
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0228 0.0473
Brugia malayi cathepsin B-like cysteine proteinase 0.0446 0.2549 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.1878 1
Onchocerca volvulus Cathepsin L homolog 0.01 0.0523 0.2879
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0066 0.0138
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.011 0.0318
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0446 0.2549 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.011 0.0318
Onchocerca volvulus 0.0027 0.0097 0.0533
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0108 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0066 0.0066
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.0095
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0162 0.0162
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0066 0.0365
Brugia malayi hypothetical protein 0.0041 0.0179 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0797 0.8855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0066 0.026
Echinococcus granulosus solute carrier family 5 0.0038 0.0162 0.0338
Giardia lamblia Cathepsin B precursor 0.0158 0.0864 0.4268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0066 0.026
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0052 0.0107
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0066 0.0365
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0292 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.0523 0.258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.011 0.0318
Brugia malayi hypothetical protein 0.0011 0.0007 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0066 0.0138
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0277 0.0692
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0292 0.0607
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0162 0.0162
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0355 0.1663
Brugia malayi GH02984p 0.0344 0.1949 0.7648
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.011 0.0318
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0052 0.0107
Treponema pallidum fructose-bisphosphate aldolase 0.0331 0.1878 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.011 0.0431
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0179 0.0373
Echinococcus granulosus cathepsin L 0.0029 0.011 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0203
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0052 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0523 0.258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.011 0.0318
Schistosoma mansoni inositol transporter 0.0038 0.0162 0.0338
Brugia malayi Cathepsin L-like precursor 0.01 0.0523 0.2051
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0052 0.0052

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.