Detailed information for compound 1335188

Basic information

Technical information
  • TDR Targets ID: 1335188
  • Name: 4-methyl-2-[[2-(phenoxy)acetyl]amino]-N-pheny l-1,3-thiazole-5-carboxamide
  • MW: 367.422 | Formula: C19H17N3O3S
  • H donors: 2 H acceptors: 3 LogP: 3.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1sc(c(n1)C)C(=O)Nc1ccccc1)COc1ccccc1
  • InChi: 1S/C19H17N3O3S/c1-13-17(18(24)21-14-8-4-2-5-9-14)26-19(20-13)22-16(23)12-25-15-10-6-3-7-11-15/h2-11H,12H2,1H3,(H,21,24)(H,20,22,23)
  • InChiKey: WEQYSAYUKCUIJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methyl-2-[[2-(phenoxy)acetyl]amino]-N-phenyl-thiazole-5-carboxamide
  • 4-methyl-2-[[1-oxo-2-(phenoxy)ethyl]amino]-N-phenyl-5-thiazolecarboxamide
  • 4-methyl-2-[2-(phenoxy)ethanoylamino]-N-phenyl-1,3-thiazole-5-carboxamide
  • Oprea1_465189
  • MLS000551924
  • SMR000172994
  • 4-Methyl-2-(2-phenoxy-acetylamino)-thiazole-5-carboxylic acid phenylamide
  • ASN 05021012
  • ZINC01378897

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.084 0.2495
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0007 0.0016 0.0049
Leishmania major carnitine/choline acetyltransferase, putative 0.0018 0.041 0.1177
Echinococcus granulosus beta tubulin 0.0015 0.0283 0.0283
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.084 0.2495
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0007 0.0016 0.0049
Trichomonas vaginalis tubulin gamma chain, putative 0.0015 0.0283 0.081
Echinococcus multilocularis Tubulin beta 2C chain 0.0015 0.0283 0.0283
Echinococcus granulosus tubulin beta 4A class IVa 0.0015 0.0283 0.0283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.173 0.173
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0099 0.3318 0.9868
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Echinococcus multilocularis proteasome subunit alpha type 6 0.0007 0.0016 0.0016
Trypanosoma cruzi beta tubulin, putative 0.0015 0.0283 0.0799
Echinococcus multilocularis splicing factor 3b subunit 3 0.0019 0.0445 0.0445
Leishmania major carnitine palmitoyltransferase-like protein 0.0018 0.041 0.1177
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0007 0.0016 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.173 0.173
Onchocerca volvulus 0.0018 0.041 0.223
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0007 0.0016 0.0016
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0018 0.041 0.1193
Onchocerca volvulus 0.0058 0.1838 1
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0099 0.3318 1
Giardia lamblia Beta tubulin 0.0015 0.0283 0.081
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0101 0.3362 0.3362
Onchocerca volvulus 0.0018 0.041 0.223
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0018 0.041 0.1193
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Echinococcus multilocularis proteasome subunit alpha type 2 0.0007 0.0016 0.0016
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0101 0.3362 0.3362
Loa Loa (eye worm) proteasome subunit beta type 2 0.0007 0.0016 0.0016
Toxoplasma gondii beta tubulin 0.0015 0.0283 0.081
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0007 0.0016 0.0016
Loa Loa (eye worm) PAS-3 protein 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0099 0.3318 0.9868
Loa Loa (eye worm) proteasome subunit beta type 1 0.0007 0.0016 0.0016
Entamoeba histolytica tubulin family protein 0.0015 0.0283 0.081
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.084 0.2495
Brugia malayi beta-tubulin, identical 0.0015 0.0283 0.0283
Echinococcus granulosus proteasome subunit beta type 6 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Echinococcus multilocularis proteasome subunit beta type 6 0.0007 0.0016 0.0016
Echinococcus granulosus Tubulin beta 2C chain 0.0015 0.0283 0.0283
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0099 0.3318 1
Brugia malayi Proteasome subunit alpha type 7-1 0.0007 0.0016 0.0016
Brugia malayi Proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0445 0.0445
Echinococcus granulosus tubulin beta 1 chain 0.0015 0.0283 0.0283
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0018 0.041 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.041 0.1177
Trichomonas vaginalis tubulin, putative 0.0015 0.0283 0.081
Loa Loa (eye worm) hypothetical protein 0.003 0.084 0.084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.173 0.173
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0007 0.0016 0.0049
Echinococcus granulosus tubulin subunit beta 0.0015 0.0283 0.0283
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0018 0.041 0.1177
Giardia lamblia Beta tubulin 0.0015 0.0283 0.081
Leishmania major proteasome beta 5 subunit, putative 0.0099 0.3318 0.9868
Echinococcus granulosus Tubulin beta 2C chain 0.0015 0.0283 0.0283
Plasmodium falciparum tubulin beta chain 0.0015 0.0283 0.081
Echinococcus multilocularis choline O acetyltransferase 0.0018 0.041 0.041
Onchocerca volvulus 0.0018 0.041 0.223
Brugia malayi proteasome subunit alpha type 2 0.0007 0.0016 0.0016
Echinococcus multilocularis Tubulin beta 2C chain 0.0015 0.0283 0.0283
Trypanosoma brucei beta tubulin 0.0015 0.0283 0.081
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0007 0.0016 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.173 0.5216
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.084 0.2462
Echinococcus granulosus Proteasome subunit alpha beta 0.0007 0.0016 0.0016
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0018 0.041 0.1177
Echinococcus granulosus proteasome subunit beta t family 0.0007 0.0016 0.0016
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0007 0.0016 0.0016
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.041 0.1177
Echinococcus granulosus beta tubulin 0.0015 0.0283 0.0283
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.084 0.2495
Loa Loa (eye worm) BEN-1 protein 0.0015 0.0283 0.0283
Echinococcus multilocularis Tubulin beta 2C chain 0.0015 0.0283 0.0283
Brugia malayi proteasome subunit alpha type 3 0.0007 0.0016 0.0016
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.041 0.1177
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0007 0.0016 0.0049
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0101 0.3362 1
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0007 0.0016 0.0049
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0007 0.0016 0.0016
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0099 0.3318 1
Onchocerca volvulus 0.0018 0.041 0.223
Echinococcus granulosus Tubulin beta 2C chain 0.0015 0.0283 0.0283
Schistosoma mansoni survival motor neuron protein 0.0058 0.1838 0.5541
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0018 0.041 0.041
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0007 0.0016 0.0049
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Loa Loa (eye worm) beta-tubulin 0.0015 0.0283 0.0283
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0099 0.3318 1
Leishmania major hypothetical protein, conserved 0.003 0.084 0.2462
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0101 0.3362 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.173 0.5216
Loa Loa (eye worm) tubulin beta-4 chain 0.0015 0.0283 0.0283
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0018 0.041 0.041
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Echinococcus multilocularis proteasome subunit beta type 7 0.0007 0.0016 0.0016
Mycobacterium ulcerans proteasome PrcB 0.0099 0.3318 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0015 0.0283 0.0283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.173 0.173
Trypanosoma brucei beta tubulin 0.0015 0.0283 0.081
Toxoplasma gondii beta-tubulin, putative 0.0015 0.0283 0.081
Loa Loa (eye worm) tubulin beta-1 chain 0.0015 0.0283 0.0283
Toxoplasma gondii proteasome subunit beta type, putative 0.0099 0.3318 1
Brugia malayi proteasome subunit beta type 3 0.0007 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.041 0.1177
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Brugia malayi Proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Entamoeba histolytica CPSF A subunit region protein, putative 0.0019 0.0445 0.1298
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0007 0.0016 0.0016
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0018 0.041 0.1193
Loa Loa (eye worm) hypothetical protein 0.0101 0.3362 0.3362
Brugia malayi proteasome subunit alpha type 4 0.0007 0.0016 0.0016
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0007 0.0016 0.0049
Echinococcus granulosus subfamily T1A non peptidase ue 0.0007 0.0016 0.0016
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0007 0.0016 0.0016
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0007 0.0016 0.0049
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0018 0.041 0.1177
Plasmodium vivax proteasome subunit beta type-5, putative 0.0099 0.3318 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.173 0.173
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0018 0.041 0.041
Brugia malayi Choline O-acetyltransferase 0.0018 0.041 0.041
Entamoeba histolytica tubulin family protein 0.0015 0.0283 0.081
Schistosoma mansoni choline o-acyltransferase 0.0018 0.041 0.1236
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.084 0.2462
Giardia lamblia Beta tubulin 0.0015 0.0283 0.081
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Schistosoma mansoni choline o-acyltransferase 0.0018 0.041 0.1236
Echinococcus multilocularis tubulin subunit beta 0.0015 0.0283 0.0283
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0018 0.041 0.1193
Echinococcus multilocularis beta tubulin 0.0015 0.0283 0.0283
Trichomonas vaginalis spliceosomal protein sap, putative 0.0019 0.0445 0.1298
Echinococcus granulosus choline O acetyltransferase 0.0018 0.041 0.041
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0099 0.3318 0.3318
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Brugia malayi proteasome subunit beta type 2 0.0007 0.0016 0.0016
Toxoplasma gondii beta-1 tubulin, putative 0.0015 0.0283 0.081
Brugia malayi Tubulin beta-1 chain 0.0015 0.0283 0.0283
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0007 0.0016 0.0016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1838 0.1838
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0018 0.041 0.1177
Trypanosoma brucei beta tubulin 0.0015 0.0283 0.081
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0007 0.0016 0.5
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0007 0.0016 0.0016
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0007 0.0016 0.0016
Loa Loa (eye worm) proteasome subunit beta type 3 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0007 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.173 0.5216
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0007 0.0016 0.0049
Brugia malayi splicing factor 3B subunit 3 0.0019 0.0445 0.0445
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Trypanosoma brucei beta tubulin 0.0015 0.0283 0.081
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.041 0.1193
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0007 0.0016 0.0016
Echinococcus multilocularis proteasome (prosome, macropain) 0.0099 0.3318 0.3318
Brugia malayi hypothetical protein 0.002 0.0453 0.0453
Brugia malayi Proteasome subunit alpha type 1 0.0007 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.041 0.041
Echinococcus granulosus Proteasome subunit alpha type 7 0.0007 0.0016 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.084 0.2495
Echinococcus multilocularis Tubulin beta 2C chain 0.0015 0.0283 0.0283
Trichomonas vaginalis tubulin beta chain, putative 0.0015 0.0283 0.081
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0007 0.0016 0.0016
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0101 0.3362 1
Schistosoma mansoni hypothetical protein 0.0014 0.0237 0.0715
Trichomonas vaginalis tubulin epsilon chain, putative 0.0015 0.0283 0.081
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Brugia malayi Proteasome A-type and B-type family protein 0.0007 0.0016 0.0016
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0007 0.0016 0.0049
Plasmodium vivax splicing factor 3B subunit 3, putative 0.0019 0.0445 0.1298
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0007 0.0016 0.0049
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0015 0.0283 0.0283
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0007 0.0016 0.0016
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0007 0.0016 0.0016
Brugia malayi Proteasome A-type and B-type family protein 0.0099 0.3318 0.3318
Echinococcus multilocularis beta tubulin 0.0015 0.0283 0.0283
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0101 0.3362 0.3362
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0099 0.3318 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.173 0.173
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0018 0.041 0.1177
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Plasmodium falciparum splicing factor 3B subunit 3, putative 0.0019 0.0445 0.1298
Loa Loa (eye worm) choline O-acetyltransferase 0.0018 0.041 0.041
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0007 0.0016 0.0049
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0007 0.0016 0.0016
Trichomonas vaginalis tubulin alpha chain, putative 0.0015 0.0283 0.081
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Echinococcus multilocularis tubulin beta 1 chain 0.0015 0.0283 0.0283
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0007 0.0016 0.0049
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0007 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.041 0.1177
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0015 0.0283 0.0283
Toxoplasma gondii splicing factor 3b, subunit 3, putative 0.0019 0.0445 0.1298
Trichomonas vaginalis tubulin epsilon chain, putative 0.0015 0.0283 0.081
Brugia malayi proteasome subunit alpha type 6 0.0007 0.0016 0.0016
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0018 0.041 0.041
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0237 0.0237
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0015 0.0283 0.0283
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Echinococcus granulosus proteasome subunit alpha type 2 0.0007 0.0016 0.0016
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Echinococcus granulosus proteasome prosome macropain 0.0099 0.3318 0.3318
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0007 0.0016 0.0049
Brugia malayi proteasome subunit beta type 1 0.0007 0.0016 0.0016
Loa Loa (eye worm) tubulin beta chain 0.0015 0.0283 0.0283
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0018 0.041 0.1177
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0007 0.0016 0.0016
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0007 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Echinococcus granulosus splicing factor 3b subunit 3 0.0019 0.0445 0.0445
Brugia malayi Choline O-acetyltransferase 0.0018 0.041 0.041
Onchocerca volvulus Notchless protein homolog 0.0007 0.0016 0.0088
Loa Loa (eye worm) BEN-1 protein 0.0015 0.0283 0.0283
Plasmodium falciparum proteasome subunit beta type-5 0.0099 0.3318 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0237 0.0237
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0018 0.041 0.041
Plasmodium vivax tubulin beta chain, putative 0.0015 0.0283 0.081
Echinococcus granulosus proteasome subunit alpha type 6 0.0007 0.0016 0.0016
Echinococcus granulosus Tubulin beta 2C chain 0.0015 0.0283 0.0283
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0099 0.3318 1
Brugia malayi proteasome subunit alpha type 1 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Brugia malayi hypothetical protein 0.003 0.084 0.084
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0007 0.0016 0.0016
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0099 0.3318 1
Schistosoma mansoni hypothetical protein 0.0058 0.1838 0.5541
Onchocerca volvulus 0.0019 0.0445 0.242
Schistosoma mansoni tubulin subunit beta 0.0015 0.0283 0.0854
Echinococcus granulosus proteasome subunit beta type 7 0.0007 0.0016 0.0016
Brugia malayi 20S proteasome alpha5 subunit 0.0007 0.0016 0.0016
Leishmania major beta tubulin 0.0015 0.0283 0.0799
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0007 0.0016 0.0049
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0007 0.0016 0.0016
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0007 0.0016 0.0049

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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