Detailed information for compound 1335240

Basic information

Technical information
  • TDR Targets ID: 1335240
  • Name: 5-[(2-chlorophenyl)methyl]-4-oxo-6,7-dihydrop yrazolo[5,1-c]pyrazine-2-carboxylic acid
  • MW: 305.716 | Formula: C14H12ClN3O3
  • H donors: 1 H acceptors: 4 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCn2c1cc(n2)C(=O)O)Cc1ccccc1Cl
  • InChi: 1S/C14H12ClN3O3/c15-10-4-2-1-3-9(10)8-17-5-6-18-12(13(17)19)7-11(16-18)14(20)21/h1-4,7H,5-6,8H2,(H,20,21)
  • InChiKey: ZZKFZXZEBKGYEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(2-chlorobenzyl)-4-keto-6,7-dihydropyrazolo[5,1-c]pyrazine-2-carboxylic acid
  • MLS000755267
  • SMR000338139
  • 11M-301S
  • Oprea1_416334
  • 5-(2-chlorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0124 0.0124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0499 0.1507
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0149
Onchocerca volvulus 0.0502 0.14 1
Entamoeba histolytica phosphofructokinase, putative 0.0053 0.0094 0.6306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.015
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0015 0.1021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0128 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0098 0.0799
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0052 0.0423
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1001 0.8163
Leishmania major ATP-dependent phosphofructokinase 0.0053 0.0094 0.0765
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0149 0.0149
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Brugia malayi hypothetical protein 0.0121 0.0292 0.239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0128 0.0387
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0098 0.0251
Brugia malayi MAP kinase sur-1 0.0054 0.0098 0.0802
Echinococcus granulosus 6 phosphofructokinase 0.0053 0.0094 0.0094
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0633 0.0633
Schistosoma mansoni single-minded 0.0052 0.0091 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0089 0.0729
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0098 0.0098
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1159 0.3312 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0053 0.0094 0.0768
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0102 0.0833
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0015 0.0109
Brugia malayi Smad1 0.0025 0.0013 0.0104
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0098 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.0292 0.1783
Echinococcus multilocularis smad 0.0025 0.0013 0.0013
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0015 0.0015
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0015 0.0015
Brugia malayi 6-phosphofructokinase 0.0053 0.0094 0.0768
Schistosoma mansoni hypothetical protein 0.0072 0.0149 0.0149
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0015 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0013 0.0104
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0015 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0098 0.07
Schistosoma mansoni 6-phosphofructokinase 0.0053 0.0094 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0169 0.1386
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0128 0.0387
Trichomonas vaginalis set domain proteins, putative 0.0502 0.14 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0124 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0013 0.0013
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0128 0.0128
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0098 0.0799
Brugia malayi Pre-SET motif family protein 0.0063 0.0124 0.1016
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0442 0.1227 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0124 0.0124
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.1004 0.821
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.0665 0.5436
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0098 0.07
Brugia malayi MH2 domain containing protein 0.0025 0.0013 0.0104
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0018 0.0009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1001 0.8163
Trichomonas vaginalis chaperonin, putative 0.0026 0.0015 0.0109
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0098 0.0802
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0098 0.07
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.0407 0.3325
Trichomonas vaginalis phosphofructokinase, putative 0.0053 0.0094 0.0671
Leishmania major polypeptide deformylase-like protein, putative 0.0442 0.1227 1
Entamoeba histolytica hypothetical protein 0.0072 0.0149 1
Leishmania major hypothetical protein, conserved 0.0027 0.0018 0.0149
Brugia malayi phosphofructokinase 0.0053 0.0094 0.0768
Loa Loa (eye worm) hypothetical protein 0.0121 0.0292 0.239
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0149 0.0149
Brugia malayi Cytochrome P450 family protein 0.0056 0.0102 0.0833
Loa Loa (eye worm) 6-phosphofructokinase 0.0053 0.0094 0.0768
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0015 0.0124
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0011 0.0089
Mycobacterium ulcerans 6-phosphofructokinase 0.0053 0.0094 0.0284
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0053 0.0094 0.0284
Echinococcus granulosus GPCR family 2 0.0079 0.0169 0.0169
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0633 0.0633
Brugia malayi hypothetical protein 0.0027 0.0018 0.015
Schistosoma mansoni hypothetical protein 0.0049 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0063 0.0124 0.1016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0124 0.0124
Onchocerca volvulus 0.0049 0.0081 0.0221
Schistosoma mansoni 6-phosphofructokinase 0.0053 0.0094 0.0094
Toxoplasma gondii hypothetical protein 0.0059 0.0111 0.0292
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0128 0.0128
Entamoeba histolytica phosphofructokinase, putative 0.0053 0.0094 0.6306
Mycobacterium ulcerans hypothetical protein 0.0192 0.0499 0.1507
Entamoeba histolytica hypothetical protein 0.0072 0.0149 1
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0015 0.155
Echinococcus multilocularis Smad4 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0121 0.0292 0.239
Entamoeba histolytica hypothetical protein 0.0072 0.0149 1
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0435 0.3561
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0053 0.0094 0.0671
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0098 0.0098
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0091 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.0665 0.5436
Leishmania major cytochrome p450-like protein 0.0024 0.0011 0.0088
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0011 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0128 0.0387
Onchocerca volvulus Huntingtin homolog 0.0121 0.0292 0.1783
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0015 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0011 0.0088
Brugia malayi 6-phosphofructokinase 0.0053 0.0094 0.0768
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0124 0.0124
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0013 0.0104
Toxoplasma gondii hypothetical protein 0.1159 0.3312 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0442 0.1227 1
Brugia malayi MH1 domain containing protein 0.0025 0.0013 0.0104
Plasmodium vivax SET domain protein, putative 0.0063 0.0124 0.033
Schistosoma mansoni hypothetical protein 0.0079 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0079 0.0169 0.0169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0169 0.1386
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0013 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0169 0.0169
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0098 0.0799
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0015 0.0124
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0053 0.0094 0.0765
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0089 0.0729
Plasmodium vivax peptide deformylase, putative 0.1159 0.3312 1
Loa Loa (eye worm) phosphofructokinase 0.0053 0.0094 0.0768
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0098 0.0098
Brugia malayi Pre-SET motif family protein 0.0441 0.1223 1
Entamoeba histolytica phosphofructokinase, putative 0.0053 0.0094 0.6306
Loa Loa (eye worm) hypothetical protein 0.0174 0.0446 0.3645
Schistosoma mansoni smad 0.0025 0.0013 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.1223 1
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0011 0.0088
Loa Loa (eye worm) hypothetical protein 0.0238 0.0633 0.5175
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0169 0.0169
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0089 0.0729
Echinococcus multilocularis microtubule associated protein 2 0.3457 1 1
Schistosoma mansoni hypothetical protein 0.0079 0.0169 0.0169
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0442 0.3607
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0009
Brugia malayi PAS domain containing protein 0.0052 0.0091 0.0743
Brugia malayi Cytochrome P450 family protein 0.0024 0.0011 0.0089
Trypanosoma brucei Polypeptide deformylase 1 0.0442 0.1227 1
Schistosoma mansoni hypothetical protein 0.017 0.0435 0.0435
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1001 0.8163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0169 0.1386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0149 0.0149
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0015 0.0124
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0124 0.033
Brugia malayi hypothetical protein 0.0174 0.0446 0.3645
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0128 0.0387
Echinococcus multilocularis tumor protein p63 0.034 0.093 0.093
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0018 0.0149
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0098 0.07
Loa Loa (eye worm) hypothetical protein 0.0249 0.0665 0.5436
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0098 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0117 0.0117
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0013 0.0013
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0053 0.0094 0.0765
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0098 0.0799
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0085 0.0085
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0011 0.0089
Echinococcus multilocularis GPCR, family 2 0.0079 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0072 0.0149 1
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0052 0.0156
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0011 0.0033
Trypanosoma cruzi Peptide deformylase 2, putative 0.0442 0.1227 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0122 0.0995
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1159 0.3312 1
Trichomonas vaginalis phosphofructokinase, putative 0.0053 0.0094 0.0671
Trypanosoma brucei protein kinase, putative 0.0054 0.0098 0.0799
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0089 0.0729
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0098 0.0799
Loa Loa (eye worm) Smad1 0.0025 0.0013 0.0104
Echinococcus granulosus single minded 2 0.0038 0.0052 0.0052
Mycobacterium ulcerans peptide deformylase 0.1159 0.3312 1
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0169 0.1386
Brugia malayi MH1 domain containing protein 0.0025 0.0013 0.0104
Plasmodium falciparum peptide deformylase 0.1159 0.3312 1
Schistosoma mansoni microtubule-associated protein tau 0.3457 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0442 0.3607
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1159 0.3312 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.1004 0.821
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.0665 0.5436
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0128 0.0128
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0149
Echinococcus granulosus tumor protein p63 0.034 0.093 0.093
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0128 0.1046
Loa Loa (eye worm) hypothetical protein 0.005 0.0085 0.0696
Schistosoma mansoni hypothetical protein 0.0079 0.0169 0.0169
Onchocerca volvulus 0.0063 0.0124 0.0537
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0169 0.0169
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0015 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0128 0.0343
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0442 0.3607
Chlamydia trachomatis peptide deformylase 0.1159 0.3312 0.5
Brugia malayi hypothetical protein 0.0238 0.0633 0.5175
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0052 0.0052
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0442 0.1227 1
Brugia malayi MH2 domain containing protein 0.0365 0.1004 0.821
Treponema pallidum polypeptide deformylase (def) 0.1159 0.3312 1
Trichomonas vaginalis phosphofructokinase, putative 0.0053 0.0094 0.0671
Echinococcus granulosus smad 0.0025 0.0013 0.0013
Brugia malayi hypothetical protein 0.0072 0.0149 0.1218
Loa Loa (eye worm) hypothetical protein 0.017 0.0435 0.3561
Echinococcus multilocularis 6 phosphofructokinase 0.0053 0.0094 0.0094
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0124 0.0124
Onchocerca volvulus 0.005 0.0085 0.0247
Trypanosoma brucei Peptide deformylase 2 0.0442 0.1227 1
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0011 0.0089
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0015 0.0124
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0098 0.0799
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0018 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0098 0.0799
Echinococcus granulosus Smad4 0.0025 0.0013 0.0013
Schistosoma mansoni Smad4 0.0025 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.0025 0.0013 0.0104
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0124 0.0124
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1001 0.8163
Brugia malayi Cytochrome P450 family protein 0.0024 0.0011 0.0089
Brugia malayi hypoxia-induced factor 1 0.016 0.0407 0.3325
Schistosoma mansoni survival motor neuron protein 0.0049 0.0081 0.0081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0081 0.0666

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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