Detailed information for compound 13363

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 272.344 | Formula: C19H16N2
  • H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)c1[nH]ccc2c1nc1c2cccc1
  • InChi: 1S/C19H16N2/c1-12-7-8-14(13(2)11-12)18-19-16(9-10-20-18)15-5-3-4-6-17(15)21-19/h3-11,20H,1-2H3
  • InChiKey: POCJKIKKCWWKRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Onchocerca volvulus 0.0079 0.0686 0.2122
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0465
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0043 0.0298 0.0258
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0244 0.0999
Entamoeba histolytica recQ family helicase, putative 0.002 0.005 0.0133
Plasmodium falciparum protein kinase 7 0.0628 0.6602 0.6588
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0075 0.0438
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.022 0.0225
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.029 0.1184
Onchocerca volvulus 0.0036 0.022 0.0587
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0673 0.3936
Trypanosoma cruzi hexose transporter, putative 0.0174 0.171 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.022 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0244 0.0333
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0244 0.1429
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0015 0.0015
Leishmania major glucose transporter/membrane transporter D2, putative 0.0174 0.171 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0114 0.1061 0.1804
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0402 0.0683
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0402 0.0683
Onchocerca volvulus Putative transporter 0.0079 0.0686 0.2122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0015 0.0015
Onchocerca volvulus 0.0036 0.022 0.0587
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.002 0.005 0.0293
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.037 0.063
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Schistosoma mansoni amine GPCR 0.0403 0.4177 0.7103
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Plasmodium falciparum proline--tRNA ligase 0.0078 0.0673 0.0634
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0174 0.171 0.2848
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0244 0.1429
Schistosoma mansoni flap endonuclease-1 0.0025 0.0103 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Brugia malayi G-protein coupled receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0569 0.053
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.002 0.005 0.0293
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.022 0.0374
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Giardia lamblia Sgs1 DNA helicase, putative 0.0041 0.0273 0.0598
Brugia malayi Serotonin receptor 0.0036 0.022 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trypanosoma brucei telomerase reverse transcriptase 0.0082 0.0721 0.4214
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.002 0.005 0.0085
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.002 0.005 0.0008
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0244 0.0333
Onchocerca volvulus 0.0036 0.022 0.0587
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.022 0.0225
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.022 0.0225
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0067 0.0554 0.1465
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.002 0.005 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0174 0.171 0.2848
Echinococcus granulosus geminin 0.0179 0.1759 0.1796
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0067 0.0554 0.0942
Brugia malayi putative neuropeptide receptor 0.0036 0.022 0.0374
Echinococcus multilocularis GPCR, family 2 0.0017 0.0015 0.0015
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0041 0.0273 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Brugia malayi neuropeptide F receptor 0.0036 0.022 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Trypanosoma brucei sugar transporter, putative 0.0079 0.0686 0.4009
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.022 0.0374
Giardia lamblia Sugar-proton symporter 0.0079 0.0686 0.1703
Brugia malayi Dopamine receptor protein 1 0.0036 0.022 0.0374
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1457 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0554 0.0942
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.022 0.0225
Toxoplasma gondii ABC1 family protein 0.0038 0.0244 0.0297
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni amine GPCR 0.0036 0.022 0.0374
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.022 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0244 0.0999
Brugia malayi AKH receptor 0.0036 0.022 0.0374
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0156 0.1515 0.2577
Schistosoma mansoni lipoxygenase 0.008 0.0697 0.1186
Brugia malayi major facilitator superfamily protein 0.0079 0.0686 0.1166
Echinococcus multilocularis transcription factor eb 0.0114 0.1061 0.1083
Brugia malayi hypothetical protein 0.0019 0.0042 0.0071
Schistosoma mansoni protein kinase 0.0068 0.0569 0.0968
Loa Loa (eye worm) hypothetical protein 0.048 0.5007 0.8515
Schistosoma mansoni opsin-like receptor 0.0036 0.022 0.0374
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0673 0.3936
Echinococcus multilocularis serotonin receptor 0.0171 0.1675 0.171
Echinococcus multilocularis neuropeptide receptor 0.0036 0.022 0.0225
Toxoplasma gondii sugar transporter ST3 0.0079 0.0686 0.097
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.002 0.005 0.0051
Loa Loa (eye worm) hypothetical protein 0.048 0.5007 0.8515
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.022 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0085
Brugia malayi hypothetical protein 0.0079 0.0686 0.1166
Brugia malayi Flap endonuclease-1 0.0027 0.0131 0.0223
Echinococcus multilocularis fmrfamide receptor 0.0036 0.022 0.0225
Brugia malayi Bloom's syndrome protein homolog 0.0069 0.0575 0.0979
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0925 0.9795 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0131 0.0218
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.022 0.0374
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.022 0.0374
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0059 0.0343
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.022 0.0225
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.037 0.2054
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.002 0.005 0.0293
Brugia malayi hypothetical protein 0.0019 0.0042 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0189 0.0321
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0302 0.1554
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.0569 0.053
Echinococcus granulosus solute carrier family 22 0.0079 0.0686 0.07
Leishmania major DNA polymerase delta catalytic subunit, putative 0.002 0.005 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus neuropeptide receptor 0.0036 0.022 0.0225
Brugia malayi G-protein coupled receptor 0.0036 0.022 0.0374
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0079 0.0686 0.1166
Brugia malayi larval opioid receptor 0.0036 0.022 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0244 0.0416
Echinococcus multilocularis solute carrier family 22 0.0079 0.0686 0.07
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.022 0.0374
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.002 0.005 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Brugia malayi DNA polymerase family B containing protein 0.002 0.005 0.0085
Plasmodium falciparum hexose transporter 0.0561 0.588 0.5863
Onchocerca volvulus 0.0079 0.0686 0.2122
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0024 0.014
Echinococcus granulosus RUN 0.0019 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0366 0.3782 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Echinococcus multilocularis General substrate transporter 0.0482 0.5031 0.5136
Schistosoma mansoni biogenic amine receptor 0.0036 0.022 0.0374
Echinococcus multilocularis g protein coupled receptor 0.0036 0.022 0.0225
Schistosoma mansoni glucose transporter 0.0079 0.0686 0.1166
Entamoeba histolytica hypothetical protein 0.005 0.037 0.0979
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.022 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Echinococcus granulosus GPCR family 2 0.0017 0.0015 0.0015
Schistosoma mansoni DNA helicase recq5 0.0041 0.0273 0.0465
Entamoeba histolytica recQ family helicase, putative 0.0046 0.0336 0.0888
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.002 0.005 0.0132
Leishmania major hypothetical protein, conserved 0.0079 0.0686 0.4009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0554 0.0942
Onchocerca volvulus 0.0036 0.022 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0686 0.109
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0042 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.022 0.0225
Onchocerca volvulus 0.0038 0.0244 0.0668
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.002 0.005 0.0051
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.022 0.0225
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1068 0.109
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0569 0.0968
Echinococcus granulosus g protein coupled receptor 0.0036 0.022 0.0225
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0025
Echinococcus granulosus somatostatin receptor 0.0036 0.022 0.0225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0302 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Schistosoma mansoni biogenic amine (5HT) receptor 0.0171 0.1675 0.2848
Schistosoma mansoni glucose transport protein 0.0561 0.588 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0569 0.0968
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Onchocerca volvulus 0.0036 0.022 0.0587
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.022 0.0374
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.022 0.0374
Brugia malayi sulfakinin receptor protein 0.0036 0.022 0.0374
Brugia malayi Major Facilitator Superfamily protein 0.0079 0.0686 0.1166
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.022 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Leishmania major protein kinase, putative 0.0068 0.0569 0.3327
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.022 0.0374
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.022 0.0225
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0042 0.0043
Schistosoma mansoni hypothetical protein 0.0179 0.1759 0.2992
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.0569 0.0793
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0089 0.0099
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0131 0.0223
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis sugar transport protein, putative 0.0079 0.0686 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trypanosoma cruzi hexose transporter, putative 0.0174 0.171 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0042 0.0043
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Schistosoma mansoni glucose transport protein 0.0561 0.588 1
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0041 0.0273 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0025
Schistosoma mansoni hypothetical protein 0.0179 0.1759 0.2992
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.022 0.0587
Loa Loa (eye worm) hypothetical protein 0.0171 0.1675 0.2848
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.0569 0.053
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0079 0.0686 0.2802
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0304 0.0436
Onchocerca volvulus 0.0079 0.0686 0.2122
Echinococcus granulosus Sugar transporter ERD6 protein 0.0079 0.0686 0.07
Echinococcus multilocularis RUN 0.0019 0.0042 0.0043
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3154 0.8338
Trichomonas vaginalis DNA helicase recq, putative 0.0069 0.0575 0.0901
Schistosoma mansoni blooms syndrome DNA helicase 0.0048 0.0352 0.0599
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0078 0.0673 0.0951
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.3154 0.8316
Schistosoma mansoni neuropeptide receptor 0.0036 0.022 0.0374
Toxoplasma gondii sugar transporter ST2 0.0079 0.0686 0.097
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.022 0.0225
Onchocerca volvulus 0.0036 0.022 0.0587
Plasmodium falciparum lysine--tRNA ligase 0.005 0.037 0.033
Echinococcus granulosus solute carrier family 22 0.0079 0.0686 0.07
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0336 0.1963
Schistosoma mansoni hypothetical protein 0.0019 0.0042 0.0071
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0059 0.01
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Onchocerca volvulus 0.0036 0.022 0.0587
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.022 0.0374
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.022 0.0225
Entamoeba histolytica protein kinase, putative 0.0068 0.0569 0.1504
Giardia lamblia Telomerase catalytic subunit 0.0082 0.0721 0.1797
Onchocerca volvulus 0.0079 0.0686 0.2122
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.037 1
Leishmania major glucose transporter, lmgt3 0.0174 0.171 1
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0569 0.089
Onchocerca volvulus 0.0079 0.0686 0.2122
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Leishmania major glucose transporter, lmgt2 0.0174 0.171 1
Onchocerca volvulus 0.0036 0.022 0.0587
Onchocerca volvulus 0.0079 0.0686 0.2122
Schistosoma mansoni neuropeptide receptor 0.0036 0.022 0.0374
Giardia lamblia DINP protein human, muc B family 0.0022 0.0075 0.0067
Onchocerca volvulus 0.0038 0.0244 0.0668
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0524 0.0535
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0042 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Brugia malayi hypothetical protein 0.0079 0.0686 0.1166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0015 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.022 0.0225
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0079 0.0686 0.5
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0082 0.0721 0.4214
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0067 0.0554 0.2555
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0024 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0223 0.0378
Echinococcus multilocularis sex peptide receptor 0.0036 0.022 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0244 0.0416
Loa Loa (eye worm) hypothetical protein 0.0053 0.0402 0.0683
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.037 0.033
Schistosoma mansoni opsin-like receptor 0.0036 0.022 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.002 0.005 0.0085
Loa Loa (eye worm) RecQ helicase 0.0069 0.0575 0.0979
Plasmodium vivax DNA polymerase alpha, putative 0.002 0.005 0.0008
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.022 0.0374
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0042 0.0071
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.022 0.0374
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0041 0.0273 0.0232
Echinococcus granulosus serotonin receptor 0.0036 0.022 0.0225
Onchocerca volvulus 0.0036 0.022 0.0587
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.022 0.0225
Trypanosoma brucei glucose transporter 1E 0.0174 0.171 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0075 0.0438
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Onchocerca volvulus 0.0079 0.0686 0.2122
Trypanosoma brucei THT1 - hexose transporter, putative 0.0174 0.171 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Mycobacterium ulcerans hypothetical protein 0.0038 0.0244 0.1133
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.022 0.0225
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.022 0.0225
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0079 0.0686 0.0647
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Onchocerca volvulus 0.0036 0.022 0.0587
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus g protein coupled receptor 0.0036 0.022 0.0225
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.002 0.005 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trypanosoma cruzi hexose transporter, putative 0.0079 0.0686 0.4009
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Brugia malayi lysyl-tRNA synthetase 0.005 0.037 0.063
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.022 0.0225
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Toxoplasma gondii transporter, major facilitator family protein 0.0079 0.0686 0.097
Brugia malayi G protein-coupled receptor 0.0036 0.022 0.0374
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.022 0.0225
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0131 0.0768
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.022 0.0587
Leishmania major telomerase reverse transcriptase, putative 0.0082 0.0721 0.4214
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.002 0.005 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.171 0.2848
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0336 0.1963
Loa Loa (eye worm) major facilitator superfamily transporter 0.0079 0.0686 0.1166
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Trypanosoma cruzi hexose transporter 0.0174 0.171 1
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0301 0.3076 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.002 0.005 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Echinococcus granulosus tm gpcr rhodopsin 0.0925 0.9795 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0302 0.1765
Schistosoma mansoni protein kinase 0.0068 0.0569 0.0968
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.002 0.005 0.0293
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.002 0.005 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0569 0.0968
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Giardia lamblia DNA repair protein RAD52 0.0366 0.3782 1
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.171 0.2848
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.022 0.0374
Toxoplasma gondii sugar transporter ST1 0.0079 0.0686 0.097
Onchocerca volvulus 0.0036 0.022 0.0587
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.037 0.2165
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.022 0.0225
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0244 0.0999
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0113 0.1055 0.1794
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.002 0.005 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Plasmodium falciparum flap endonuclease 1 0.0027 0.0131 0.009
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus neuropeptide receptor 0.0036 0.022 0.0225
Entamoeba histolytica hypothetical protein 0.0104 0.0959 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.0561 0.588 1
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.037 0.2165
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0302 0.0308
Loa Loa (eye worm) hypothetical protein 0.0171 0.1675 0.2848
Schistosoma mansoni adenoreceptor 0.0036 0.022 0.0374
Plasmodium falciparum mitogen-activated protein kinase 2 0.0359 0.3705 0.3679
Brugia malayi hypothetical protein 0.0079 0.0686 0.1166
Onchocerca volvulus 0.0079 0.0686 0.2122
Echinococcus granulosus dna polymerase kappa 0.0043 0.0302 0.0308
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.022 0.0374
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0025
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0673 0.3936
Onchocerca volvulus 0.0036 0.022 0.0587
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.0569 0.053
Schistosoma mansoni biogenic amine receptor 0.0036 0.022 0.0374
Schistosoma mansoni histamine h1 receptor 0.0036 0.022 0.0374
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0067 0.0554 0.0566
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.037 0.0378
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.037 0.1038
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0079 0.0686 0.4361
Echinococcus multilocularis solute carrier family 22 0.0079 0.0686 0.07
Brugia malayi Telomerase reverse transcriptase 0.0219 0.2191 0.3726
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.037 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Brugia malayi ORL1-like opioid receptor 0.0036 0.022 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Echinococcus multilocularis orexin receptor type 2 0.0036 0.022 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Plasmodium vivax hexose transporter 0.0561 0.588 0.5863
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.022 0.0374
Echinococcus multilocularis allatostatin A receptor 0.0036 0.022 0.0225
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.002 0.005 0.0293
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0673 0.3936
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0189 0.1102
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni rab6-interacting 0.0019 0.0042 0.0071
Onchocerca volvulus 0.0036 0.022 0.0587
Echinococcus multilocularis solute carrier family 22 0.0079 0.0686 0.07
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.037 0.2165
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0042 0.029 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0686 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Onchocerca volvulus 0.0036 0.022 0.0587
Brugia malayi Melatonin receptor type 1A 0.0036 0.022 0.0374
Schistosoma mansoni sugar transporter 0.0079 0.0686 0.1166
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.002 0.005 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0302 0.1765
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.0569 0.053
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Schistosoma mansoni rab6-interacting 0.0019 0.0042 0.0071
Onchocerca volvulus DNA polymerase homolog 0.002 0.005 0.0027
Brugia malayi Dopamine receptor 0.0036 0.022 0.0374
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.002 0.005 0.0085
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Brugia malayi Major Facilitator Superfamily protein 0.0079 0.0686 0.1166
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.005 0.0085
Echinococcus multilocularis fmrfamide receptor 0.0036 0.022 0.0225
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.037 0.0549
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Schistosoma mansoni neuropeptide receptor 0.0036 0.022 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Plasmodium vivax CDK-related protein kinase 6, putative 0.0944 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.022 0.0225
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Loa Loa (eye worm) beta-lactamase 0.0038 0.0244 0.0416
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0561 0.588 0.6004
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Mycobacterium ulcerans beta-lactamase 0.0038 0.0244 0.1133
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0554 0.0942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Echinococcus granulosus General substrate transporter 0.0482 0.5031 0.5136
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0673 0.3936
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni protein kinase 0.0068 0.0569 0.0968
Plasmodium vivax proline--tRNA ligase, putative 0.0078 0.0673 0.0634
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0227 0.1327
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Giardia lamblia Hexose transporter 0.0079 0.0686 0.1703
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.022 0.0225
Schistosoma mansoni hypothetical protein 0.0036 0.0223 0.0378
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Brugia malayi major facilitator superfamily protein 0.0079 0.0686 0.1166
Schistosoma mansoni sugar transporter 0.0079 0.0686 0.1166
Schistosoma mansoni amine GPCR 0.0036 0.022 0.0374
Brugia malayi beta-lactamase family protein 0.0038 0.0244 0.0416
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.2447 1
Onchocerca volvulus 0.0079 0.0686 0.2122
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0059 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0244 0.0333
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.022 0.0374
Echinococcus granulosus solute carrier family 22 0.0079 0.0686 0.07
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.002 0.005 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.037 0.063
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.022 0.0374
Onchocerca volvulus 0.0079 0.0686 0.2122
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Trypanosoma cruzi glucose transporter, putative 0.0079 0.0686 0.4009
Leishmania major glucose transporter, lmgt1 0.0174 0.171 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.022 0.0374
Brugia malayi RE15519p 0.0036 0.022 0.0374
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.002 0.005 0.0027
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1068 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Brugia malayi Doublecortin family protein 0.0019 0.0042 0.0071
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.002 0.005 0.0293
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0015 0.0015
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0554 0.0942
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.022 0.0225
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.022 0.0374
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1457 0.5952
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0273 0.0341
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0131 0.0768
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Brugia malayi follicle stimulating hormone receptor 0.0036 0.022 0.0374
Schistosoma mansoni neuropeptide receptor 0.0036 0.022 0.0374
Brugia malayi Sugar transporter family protein 0.0079 0.0686 0.1166
Onchocerca volvulus 0.0079 0.0686 0.2122
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0244 0.1133
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Onchocerca volvulus 0.0036 0.022 0.0587
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.022 0.0225
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.022 0.0225
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.022 0.0225
Schistosoma mansoni sugar transporter 0.0079 0.0686 0.1166
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0131 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0171 0.1675 0.171
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0015 0.0025
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0302 0.0432
Brugia malayi neuropeptide F receptor 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Onchocerca volvulus 0.0036 0.022 0.0587
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0075 0.0306
Brugia malayi hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis esterase, putative 0.0038 0.0244 0.0333
Echinococcus granulosus flap endonuclease 1 0.0027 0.0131 0.0134
Schistosoma mansoni amine GPCR 0.0036 0.022 0.0374
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0131 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0302 0.1554
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Echinococcus multilocularis g protein coupled receptor 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0244 0.0999
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Loa Loa (eye worm) hypothetical protein 0.0054 0.0419 0.0713
Schistosoma mansoni DNA helicase recq1 0.0041 0.0273 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.022 0.0225
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0041 0.0273 0.0279
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.022 0.0225
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0273 0.0465
Mycobacterium tuberculosis Conserved protein 0.0038 0.0244 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0067 0.0554 0.0865
Schistosoma mansoni lipoxygenase 0.0114 0.1068 0.1816
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0067 0.0554 0.0566
Toxoplasma gondii protein kinase, putative 0.0628 0.6602 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.002 0.005 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0686 0.109
Onchocerca volvulus 0.0079 0.0686 0.2122
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.002 0.005 0.0085
Schistosoma mansoni amine GPCR 0.0036 0.022 0.0374
Loa Loa (eye worm) sugar transporter 0.0561 0.588 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0079 0.0686 0.07
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0244 0.025
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.022 0.0225
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0131 0.0768
Trichomonas vaginalis sugar transporter, putative 0.0174 0.171 0.2848
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.3154 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.002 0.005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Plasmodium vivax sugar transporter, putative 0.0079 0.0686 0.0647
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0273 0.0341
Brugia malayi Sugar transporter family protein 0.0079 0.0686 0.1166
Echinococcus granulosus orexin receptor type 2 0.0036 0.022 0.0225
Schistosoma mansoni myosin xvIII 0.0036 0.022 0.0374
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.029 0.0373
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0359 0.3705 0.5579
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.0569 0.0793
Echinococcus granulosus neuropeptide s receptor 0.0036 0.022 0.0225
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.0569 0.053
Leishmania major myo-inositol/proton symporter (MIT) 0.0079 0.0686 0.4009
Echinococcus granulosus g-protein coupled receptor 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0079 0.0686 0.2802
Mycobacterium tuberculosis Conserved protein 0.0038 0.0244 0.0999
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0042 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.9041 0.9231
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.022 0.0225
Echinococcus multilocularis geminin 0.0179 0.1759 0.1796
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.022 0.0374
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.022 0.0225
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0059 0.0013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.022 0.0374
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.029 0.1184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.022 0.0374
Entamoeba histolytica protein kinase, putative 0.0068 0.0569 0.1504
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.022 0.0225
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.0569 0.053
Echinococcus multilocularis neuropeptide receptor 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0071
Trypanosoma brucei THT1 - hexose transporter, putative 0.0174 0.171 1
Brugia malayi polk-prov protein 0.0033 0.0189 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Trypanosoma cruzi sugar transporter, putative 0.0079 0.0686 0.4009
Echinococcus multilocularis bloom syndrome protein 0.0069 0.0575 0.0587
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0569 0.0581
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.022 0.0374
Schistosoma mansoni opsin-like receptor 0.0036 0.022 0.0374
Schistosoma mansoni biogenic amine receptor 0.0036 0.022 0.0374
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.022 0.0225
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.0068 0.0569 0.0968
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0063 0.0513 0.0473
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0244 0.0416
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.002 0.005 0.0027
Trypanosoma cruzi hexose transporter, putative 0.0174 0.171 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0402 0.0683
Echinococcus granulosus solute carrier family 22 0.0079 0.0686 0.07
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0686 0.109
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Onchocerca volvulus 0.0079 0.0686 0.2122
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.002 0.005 0.0008
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.022 0.0374
Schistosoma mansoni loxhd1 0.0019 0.0042 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trichomonas vaginalis glucose transporter, putative 0.0174 0.171 0.2848
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0686 0.109
Mycobacterium ulcerans sugar transporter 0.0079 0.0686 0.4361
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Brugia malayi beta-lactamase 0.0038 0.0244 0.0416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.022 0.0225
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.0569 0.053
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0131 0.0347
Echinococcus granulosus hypothetical protein 0.0036 0.022 0.0225
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.022 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0273 0.0465
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0067 0.0554 0.0942
Brugia malayi Dopamine receptor protein 2 0.0036 0.022 0.0374
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0244 0.0416
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.022 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0374
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0131 0.0134
Onchocerca volvulus 0.0036 0.022 0.0587
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Mycobacterium ulcerans lipase LipD 0.0038 0.0244 0.1133
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.022 0.0225
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0336 0.1963
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3154 0.5323
Echinococcus multilocularis serotonin receptor 0.0171 0.1675 0.171
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.01
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.022 0.0374
Echinococcus granulosus allatostatin A receptor 0.0036 0.022 0.0225
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.022 0.0225
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.002 0.005 0.0051
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.002 0.005 0.0293
Toxoplasma gondii RNA-directed DNA polymerase 0.0082 0.0721 0.1024
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0524 0.0535
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.002 0.005 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0024 0.014
Schistosoma mansoni sugar transporter 0.0079 0.0686 0.1166
Onchocerca volvulus 0.0079 0.0686 0.2122
Trichomonas vaginalis glucose transporter, putative 0.0079 0.0686 0.109
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.022 0.0374
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0244 0.0204
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0244 0.0999
Echinococcus granulosus sex peptide receptor 0.0036 0.022 0.0225
Echinococcus granulosus transcription factor eb 0.0114 0.1061 0.1083
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.022 0.0225
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0244 0.025
Echinococcus multilocularis synaptic vesicle 2 protein 0.0079 0.0686 0.07
Mycobacterium ulcerans integral membrane transport protein 0.0079 0.0686 0.4361
Entamoeba histolytica recQ family DNA helicase 0.0021 0.0059 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Loa Loa (eye worm) sugar transporter 0.0079 0.0686 0.1166
Brugia malayi DNA polymerase delta catalytic subunit 0.002 0.005 0.0085
Plasmodium vivax telomerase reverse transcriptase, putative 0.0082 0.0721 0.0682
Toxoplasma gondii lysine-tRNA ligase 0.005 0.037 0.0489
Echinococcus multilocularis somatostatin receptor 0.0036 0.022 0.0225
Echinococcus granulosus g protein coupled receptor 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0079 0.0686 0.4009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Onchocerca volvulus 0.0079 0.0686 0.2122
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.022 0.0225
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0131 0.0124
Giardia lamblia Prolyl-tRNA synthetase 0.0067 0.0554 0.1351
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0079 0.0686 0.4361
Loa Loa (eye worm) hypothetical protein 0.0079 0.0686 0.1166
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.022 0.0374
Brugia malayi Sugar transporter family protein 0.0561 0.588 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0174 0.171 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.037 0.2054
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0131 0.009
Echinococcus granulosus fmrfamide receptor 0.0036 0.022 0.0225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0113 0.1055 0.1794
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.022 0.0225
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0244 0.0999
Trichomonas vaginalis glucose transporter, putative 0.0174 0.171 0.2848
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0244 0.0333
Brugia malayi beta-lactamase family protein 0.0038 0.0244 0.0416
Echinococcus granulosus bloom syndrome protein 0.0069 0.0575 0.0587
Echinococcus granulosus synaptic vesicle 2 protein 0.0079 0.0686 0.07
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0416
Brugia malayi GnHR receptor homolog 0.0036 0.022 0.0374
Trichomonas vaginalis myo-inositol transporter, putative 0.0079 0.0686 0.109
Trypanosoma brucei unspecified product 0.0036 0.0227 0.1327
Brugia malayi Cam kinase protein 1 0.0068 0.0569 0.0968
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.022 0.0374
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.0569 0.0793
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0075 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0041 0.0273 0.0465
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0359 0.3705 0.3679
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Trichomonas vaginalis DNA helicase recq1, putative 0.0069 0.0575 0.0901
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0244 0.1429
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.022 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Brugia malayi DNA polymerase alpha catalytic subunit 0.002 0.005 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0079 0.0686 0.109
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0336 0.049
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.022 0.0225
Echinococcus multilocularis g protein coupled receptor 0.0036 0.022 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.022 0.0225
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.037 0.0858
Schistosoma mansoni hypothetical protein 0.0561 0.588 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0561 0.588 0.6004
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.037 0.0378
Trypanosoma brucei glucose transporter, putative 0.0174 0.171 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3154 0.8338
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0378
Trypanosoma brucei glucose transporter 2A 0.0174 0.171 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0959 0.2534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.022 0.0225
Plasmodium falciparum telomerase reverse transcriptase 0.0082 0.0721 0.0682
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.022 0.0374
Brugia malayi Serotonin receptor 0.0036 0.022 0.0374
Mycobacterium tuberculosis Conserved protein 0.0038 0.0244 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.022 0.0225
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0041 0.0273 0.0279
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1457 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0244 0.1133
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0244 0.0999
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.022 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Loa Loa (eye worm) major facilitator superfamily transporter 0.0079 0.0686 0.1166
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0569 0.0968
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0015 0.0025
Onchocerca volvulus 0.0079 0.0686 0.2122
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0374
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.002 0.005 0.0085
Echinococcus multilocularis solute carrier family 22 0.0079 0.0686 0.07
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.022 0.0225
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0082 0.0721 0.4214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0302 0.1765
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0244 0.0333
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0374
Onchocerca volvulus 0.0038 0.0244 0.0668
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0569 0.0581
Toxoplasma gondii facilitative glucose transporter GT1 0.0561 0.588 0.8899
Schistosoma mansoni glucose transport protein 0.0561 0.588 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0189 0.1102
Trypanosoma cruzi hexose transporter, putative 0.0095 0.086 0.5031
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.022 0.0225
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0569 0.3327
Brugia malayi Major Facilitator Superfamily protein 0.0079 0.0686 0.1166
Leishmania major hypothetical protein, conserved 0.0038 0.0244 0.1429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.022 0.0374
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.0569 0.053

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 1 % Percentage inhibition against cyclin dependent kinase 5 (CDK 5) at a concentration of 50 uM ChEMBL. 11909733
Inhibition (binding) = 1 % Percentage inhibition against cyclin dependent kinase 5 (CDK 5) at a concentration of 50 uM ChEMBL. 11909733
Inhibition (binding) = 5 % Percentage inhibition against cyclin dependent kinase 2 (CDK 2) at a concentration of 50 uM ChEMBL. 11909733
Inhibition (binding) = 5 % Percentage inhibition against cyclin dependent kinase 2 (CDK 2) at a concentration of 50 uM ChEMBL. 11909733

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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