Detailed information for compound 1352855

Basic information

Technical information
  • TDR Targets ID: 1352855
  • Name: 1-[7-acetyl-3-cyclohexyl-6-(3-methoxyphenyl)- [1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl] ethanone
  • MW: 412.505 | Formula: C21H24N4O3S
  • H donors: 0 H acceptors: 4 LogP: 4.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1c(sc2n(n1C(=O)C)c(nn2)C1CCCCC1)C(=O)C
  • InChi: 1S/C21H24N4O3S/c1-13(26)19-18(16-10-7-11-17(12-16)28-3)24(14(2)27)25-20(22-23-21(25)29-19)15-8-5-4-6-9-15/h7,10-12,15H,4-6,8-9H2,1-3H3
  • InChiKey: OTYMZPNOICEQHD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[3-cyclohexyl-7-ethanoyl-6-(3-methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl]ethanone
  • NCGC00137294-01
  • G857-1458

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0074 0.0664 0.4355
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0126 0.1299 0.8518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0699 1
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0692 0.0692
Brugia malayi DOMON domain containing protein 0.0024 0.0048 0.0312
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Schistosoma mansoni acetylcholine receptor-related 0.0034 0.0172 0.0172
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0034 0.0172 0.113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Brugia malayi hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Onchocerca volvulus 0.0074 0.0664 1
Plasmodium vivax vivapain-2 0.002 0 0.5
Brugia malayi TAR-binding protein 0.0076 0.0692 0.454
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0168 0.1821 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.1299 0.8518
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.004 0.0243 0.1593
Loa Loa (eye worm) DOMON domain-containing protein 0.0024 0.0048 0.0312
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0617 0.8824
Loa Loa (eye worm) ACC-1 protein 0.0074 0.0664 0.4355
Onchocerca volvulus 0.0034 0.0172 0.2595
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0692 0.0692
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0074 0.0664 0.0664
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0074 0.0664 0.0664
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0172 0.0172
Onchocerca volvulus 0.0034 0.0172 0.2595
Loa Loa (eye worm) hypothetical protein 0.0126 0.1299 0.8518
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0074 0.0664 0.4355
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0074 0.0664 0.4355
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0243 0.1593
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0692 0.0692
Brugia malayi Cation transporter family protein 0.0074 0.0664 0.4355
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0 0.5
Plasmodium vivax vivapain-2 0.002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0126 0.1299 0.8518
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0074 0.0664 0.4355
Onchocerca volvulus 0.0074 0.0664 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0074 0.0664 0.4355
Onchocerca volvulus Putative nachr subunit 0.0074 0.0664 1
Onchocerca volvulus 0.0074 0.0664 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0034 0.0172 0.0172
Brugia malayi hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) GABA receptor subunit 0.004 0.0243 0.1593
Onchocerca volvulus 0.0074 0.0664 1
Echinococcus granulosus glycine receptor subunit beta 0.0074 0.0664 0.0664
Onchocerca volvulus 0.004 0.0243 0.3659
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0074 0.0664 0.4355
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0243 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Echinococcus granulosus nAChR subunit 0.004 0.0243 0.0243
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0074 0.0664 0.0664
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0 0.5
Loa Loa (eye worm) ACC-1 protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) DOMON domain-containing protein 0.0024 0.0048 0.0312
Schistosoma mansoni nAChR subunit 0.0034 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.0172 0.113
Brugia malayi Cation transporter family protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Schistosoma mansoni dopamine-beta-monooxygenase 0.0238 0.2681 0.2681
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Brugia malayi DOMON domain containing protein 0.0024 0.0048 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0692 0.454
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0126 0.1299 0.1299
Echinococcus granulosus glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Echinococcus multilocularis nAChR subunit 0.0074 0.0664 0.0664
Echinococcus granulosus tumor protein p63 0.0408 0.477 0.477
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Leishmania major cathepsin L-like protease 0.0077 0.0699 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0243 0.0243
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0074 0.0664 0.4355
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0074 0.0664 0.4355
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0064 0.0536 0.3519
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0692 0.0692
Echinococcus granulosus glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Brugia malayi MH2 domain containing protein 0.0144 0.1524 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0074 0.0664 0.4355
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0172 0.113
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0074 0.0664 0.0664
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0034 0.0172 0.0172
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0243 0.1593
Echinococcus multilocularis glycine receptor subunit beta 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0486 0.0486
Echinococcus granulosus nAChR subunit 0.0074 0.0664 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Entamoeba histolytica hypothetical protein 0.004 0.0243 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0034 0.0172 0.113
Brugia malayi RNA binding protein 0.0076 0.0692 0.454
Onchocerca volvulus 0.0074 0.0664 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0074 0.0664 0.0664
Schistosoma mansoni nAChR subunit 0.0034 0.0172 0.0172
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0074 0.0664 0.4355
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0034 0.0172 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1524 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0074 0.0664 0.4355
Echinococcus multilocularis glycine receptor subunit beta 0.0074 0.0664 0.0664
Brugia malayi DOMON domain containing protein 0.0024 0.0048 0.0312
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0168 0.1821 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0692 0.454
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) DOMON domain-containing protein 0.0024 0.0048 0.0312
Echinococcus multilocularis tumor protein p63 0.0408 0.477 0.477
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0699 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0074 0.0664 0.0664
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Onchocerca volvulus 0.0024 0.0048 0.0716
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0074 0.0664 0.4355
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0074 0.0664 0.0664
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0074 0.0664 0.0664
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0034 0.0172 0.113
Onchocerca volvulus 0.006 0.0486 0.7319
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0074 0.0664 0.0664
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0074 0.0664 0.0664
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0126 0.1299 0.1299
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0074 0.0664 0.0664
Brugia malayi Cation transporter family protein 0.0074 0.0664 0.4355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0172 0.113
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0074 0.0664 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0172 0.0172
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) LGC-31 protein 0.0074 0.0664 0.4355
Schistosoma mansoni acetylcholine receptor subunit beta 0.0034 0.0172 0.0172
Onchocerca volvulus 0.0034 0.0172 0.2595
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0692 0.454
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0168 0.1821 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0699 1
Leishmania major cathepsin L-like protease 0.0077 0.0699 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0074 0.0664 0.4355
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.004 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0034 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0074 0.0664 0.4355
Toxoplasma gondii cathepsin CPL 0.002 0 0.5
Schistosoma mansoni peptidylglycine monooxygenase 0.0126 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0692 0.454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Brugia malayi excitatory GABA receptor EXP-1A 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Leishmania major cathepsin L-like protease 0.0077 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.3187
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0074 0.0664 0.0664
Echinococcus granulosus glycine receptor subunit beta 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Brugia malayi hypothetical protein 0.0034 0.0172 0.113
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.1593
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0074 0.0664 0.0664
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0083 0.0778 0.5
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0062 0.0513 0.3368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0699 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0074 0.0664 0.0664
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0074 0.0664 0.4355
Onchocerca volvulus 0.004 0.0243 0.3659
Echinococcus granulosus tar DNA binding protein 0.0076 0.0692 0.0692
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0172 0.113
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1524 1
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0126 0.1299 0.1299
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0692 0.0692
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0074 0.0664 0.0664
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0496 0.7098
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Echinococcus multilocularis nAChR subunit 0.004 0.0243 0.0243
Brugia malayi hypothetical protein 0.0034 0.0172 0.113
Onchocerca volvulus 0.0074 0.0664 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0074 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Brugia malayi hypothetical protein 0.0034 0.0172 0.113
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0034 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.113
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0692 0.0692
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0034 0.0172 0.113
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Onchocerca volvulus 0.0024 0.0048 0.0716
Loa Loa (eye worm) hypothetical protein 0.0074 0.0664 0.4355
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0699 1
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0083 0.0778 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0074 0.0664 0.0664
Schistosoma mansoni nAChR subunit 0.0074 0.0664 0.0664
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0243 0.1593
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0034 0.0172 0.113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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