Detailed information for compound 1358233

Basic information

Technical information
  • TDR Targets ID: 1358233
  • Name: 2-furan-3-yl-4-morpholin-4-ylquinazoline
  • MW: 281.309 | Formula: C16H15N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O1CCN(CC1)c1nc(nc2c1cccc2)c1cocc1
  • InChi: 1S/C16H15N3O2/c1-2-4-14-13(3-1)16(19-6-9-20-10-7-19)18-15(17-14)12-5-8-21-11-12/h1-5,8,11H,6-7,9-10H2
  • InChiKey: UJUDVTFDRDPLOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-furyl)-4-morpholino-quinazoline
  • 2-(3-furyl)-4-morpholinoquinazoline
  • 2-furan-3-yl-4-morpholin-4-yl-quinazoline
  • NCGC00011664
  • PCOP-569276

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major protein kinase, putative 0.0073 0.0117 0.9944
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.003 0.0024 0.1226
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0118 1
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0024 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0118 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0117 1
Loa Loa (eye worm) dynactin 5 0.0024 0.0011 0.09
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0011 0.09
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0073 0.0117 0.1111
Brugia malayi hypothetical protein 0.0024 0.0011 0.09
Leishmania major serine acetyltransferase 0.0024 0.0011 0.0895
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.003 0.0024 0.1234
Leishmania major hypothetical protein, conserved 0.0024 0.0011 0.0895
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.003 0.0024 0.1226
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0011 0.09
Echinococcus multilocularis 0.0072 0.0116 0.9825
Leishmania major protein kinase, putative 0.0073 0.0117 0.9944
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0073 0.0117 1
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.003 0.0024 0.2023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.09
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0011 0.09
Leishmania major hypothetical protein, conserved 0.0024 0.0011 0.0895
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0073 0.0117 1
Trypanosoma cruzi serine acetyltransferase, putative 0.0024 0.0011 0.09
Brugia malayi Protein kinase domain containing protein 0.0073 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0116 0.9897
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.003 0.0024 0.1234
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0118 1
Loa Loa (eye worm) nucleotidyl transferase 0.003 0.0024 0.2023
Giardia lamblia Kinase, CMGC CLK 0.0073 0.0117 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0118 0.1118
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.003 0.0024 0.1226
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.09
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0073 0.0117 1
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.003 0.0024 0.1226
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0073 0.0117 1
Trypanosoma cruzi hypothetical protein 0.0024 0.0011 0.09
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0073 0.0117 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0118 0.0108
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0465 0.0972 0.0972
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0073 0.0117 1
Leishmania major hypothetical protein, conserved 0.0024 0.0011 0.0895
Mycobacterium ulcerans serine acetyltransferase CysE 0.0024 0.0011 0.0011
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0024 0.0011 0.09
Brugia malayi zgc:92842 0.0024 0.0011 0.09
Trypanosoma cruzi serine acetyltransferase, putative 0.0024 0.0011 0.09
Echinococcus granulosus hypothetical protein 0.0072 0.0116 0.9825
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.003 0.0024 0.2023
Leishmania major GDP-mannose pyrophosphorylase 0.003 0.0024 0.2012
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.003 0.0024 1
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.003 0.0024 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0117 0.9938
Brugia malayi Nucleotidyl transferase family protein 0.003 0.0024 0.2023
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0118 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0073 0.0117 0.9938
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.003 0.0024 0.2023
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.4612 1 1
Brugia malayi hypothetical protein 0.0024 0.0011 0.09
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0024 0.0011 0.09
Mycobacterium ulcerans hypothetical protein 0.0465 0.0972 0.0972
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0118 1
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.4612 1 1
Treponema pallidum licC protein (licC) 0.0465 0.0972 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0465 0.0972 0.0962
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.4612 1 1
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0465 0.0972 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0073 0.0117 1
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.003 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0011 0.09
Plasmodium falciparum protein serine/threonine kinase-1 0.0073 0.0117 1
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.003 0.0024 0.2023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0465 0.0972 0.0962
Plasmodium vivax serine/threonine kinase-1, putative 0.0073 0.0117 1
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0024 0.0011 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0011 0.09
Brugia malayi GDP-mannose pyrophosphorylase B 0.003 0.0024 0.2023
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.003 0.0024 0.1226
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0118 1
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.003 0.0024 0.1234
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.003 0.0024 0.1226
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0011 0.09
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0024 0.0011 0.5
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.003 0.0024 0.1226
Mycobacterium ulcerans hypothetical protein 0.0024 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0117 0.9938
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.003 0.0024 0.1234
Brugia malayi hypothetical protein 0.0024 0.0011 0.09
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0118 0.0118
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.003 0.0024 0.2023
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0011 0.09
Brugia malayi hypothetical protein 0.0024 0.0011 0.09
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0118 0.0118
Trypanosoma brucei nucleotidyl transferase, putative 0.003 0.0024 0.2023
Mycobacterium ulcerans hypothetical protein 0.0465 0.0972 0.0972
Echinococcus multilocularis dual specificity protein kinase clk2 0.0073 0.0117 0.9938
Mycobacterium ulcerans transferase 0.0024 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.258925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-FP Assay). (Class of assay: confirmatory) [Related pubchem assays: 1771, 1770 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.