TDR Targets

Basic information

Technical information

TDR Targets ID: 1359342
Name: UPCMLD16BSDN001082:001
MW: 427.493 | Formula: C23H29N3O5
H donors: 0 H acceptors: 4 LogP: 1.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN1CC(=O)N2[C@](C1=O)(C)[C@H]1C(=O)N(C(=O)[C@H]1[C@H]2c1ccc(cc1)OC)CC
InChi: 1S/C23H29N3O5/c1-5-7-12-24-13-16(27)26-19(14-8-10-15(31-4)11-9-14)17-18(23(26,3)22(24)30)21(29)25(6-2)20(17)28/h8-11,17-19H,5-7,12-13H2,1-4H3/t17-,18-,19-,23-/m1/s1
InChiKey: BWECENGRGJPPJI-FZONSQQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0161	0.0138
Echinococcus granulosus	histone deacetylase 8	0.0761	0.4282	0.4269
Onchocerca volvulus		0.0058	0.0161	0.0324
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0063	0.019	0.0167
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0063	0.019	0.0171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Toxoplasma gondii	histone deacetylase HDAC3	0.1652	0.951	0.9703
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0208	0.0189
Loa Loa (eye worm)	histone deacetylase	0.1702	0.98	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0535	0.0524
Trypanosoma cruzi	cruzipain precursor, putative	0.0121	0.0535	0.0524
Brugia malayi	Bromodomain containing protein	0.0091	0.0355	0.0362
Plasmodium vivax	histone deacetylase 1, putative	0.1652	0.951	0.9703
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0121	0.0535	0.0524
Leishmania major	histone deacetylase, putative	0.1652	0.951	0.9703
Entamoeba histolytica	cysteine proteinase 2	0.0063	0.019	0.0176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Trypanosoma cruzi	histone deacetylase, putative	0.0761	0.4282	0.4356
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0161	0.0141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.004	0.0059	0.0037
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Schistosoma mansoni	hypothetical protein	0.035	0.1876	0.1857
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1652	0.951	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0081	0.03	0.0278
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0208	0.0185
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Echinococcus granulosus	cysteine protease	0.0063	0.019	0.0167
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0034	0.0023	0.0024
Toxoplasma gondii	histone deacetylase HDAC5	0.0761	0.4282	0.4356
Echinococcus multilocularis	histone deacetylase 7	0.1702	0.98	0.98
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Toxoplasma gondii	histone deacetylase HDAC4	0.0761	0.4282	0.4356
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.0161	0.0324
Loa Loa (eye worm)	histone deacetylase 1	0.1652	0.951	0.9703
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.03	0.0292
Brugia malayi	histone deacetylase 11	0.0761	0.4282	0.4369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Plasmodium vivax	histone deacetylase, putative	0.0761	0.4282	0.4356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.019	0.0176
Trypanosoma brucei	histone deacetylase, putative	0.1702	0.98	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0063	0.019	0.0167
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0161	0.0138
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.004	0.0059	0.006
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0535	0.054
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0078	0.0055
Plasmodium vivax	histone deacetylase, putative	0.1702	0.98	1
Loa Loa (eye worm)	histone deacetylase 11	0.0761	0.4282	0.4356
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0095	0.0074
Echinococcus granulosus	histone deacetylase 1	0.1652	0.951	0.9509
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Loa Loa (eye worm)	histone deacetylase 3	0.1652	0.951	0.9703
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Schistosoma mansoni	histone deacetylase hda2	0.1736	1	1
Onchocerca volvulus		0.0081	0.03	0.065
Loa Loa (eye worm)	hypothetical protein	0.004	0.0059	0.0037
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Plasmodium vivax	vivapain-2	0.0121	0.0535	0.0524
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0034	0.0023	0.0024
Trypanosoma cruzi	histone deacetylase, putative	0.1702	0.98	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.1652	0.951	0.9703
Schistosoma mansoni	cathepsin F (C01 family)	0.0121	0.0535	0.0513
Trypanosoma brucei	histone deacetylase 3	0.1702	0.98	1
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Brugia malayi	Histone deacetylase 1	0.1652	0.951	0.9704
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Onchocerca volvulus	Cathepsin L homolog	0.0121	0.0535	0.1203
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0761	0.4282	1
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0535	0.054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus granulosus	histone deacetylase	0.1702	0.98	0.98
Trypanosoma brucei	histone deacetylase 4	0.1702	0.98	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0246	0.0224
Trypanosoma cruzi	histone deacetylase 1, putative	0.1652	0.951	0.9703
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Onchocerca volvulus		0.0121	0.0535	0.1203
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Plasmodium vivax	vivapain-2	0.0121	0.0535	0.0524
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0272	0.0249
Brugia malayi	Papain family cysteine protease containing protein	0.0063	0.019	0.0194
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.019	0.0171
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Trypanosoma brucei	histone deacetylase 1	0.1652	0.951	0.9703
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0112	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0121	0.0535	0.0524
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0121	0.0535	0.0524
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0535	0.0524
Echinococcus multilocularis	histone deacetylase 3	0.1652	0.951	0.9509
Echinococcus multilocularis	histone deacetylase 6	0.1736	1	1
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Onchocerca volvulus	Cathepsin F homolog	0.0121	0.0535	0.1203
Schistosoma mansoni	histone deacetylase 4 5	0.1702	0.98	0.98
Loa Loa (eye worm)	hypothetical protein	0.004	0.0059	0.0037
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.019	0.0176
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0208	0.0185
Giardia lamblia	Histone deacetylase	0.1652	0.951	1
Brugia malayi	histone deacetylase 1 (HD1)	0.1652	0.951	0.9704
Toxoplasma gondii	histone deacetylase HDAC1	0.1702	0.98	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Entamoeba histolytica	cysteine proteinase, putative	0.0081	0.03	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0081	0.03	0.0283
Entamoeba histolytica	histone deacetylase, putative	0.1652	0.951	1
Trypanosoma cruzi	cysteine peptidase, putative	0.004	0.0059	0.0037
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Loa Loa (eye worm)	hypothetical protein	0.1652	0.951	0.9703
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.1154	0.1134
Brugia malayi	Bromodomain containing protein	0.0046	0.0095	0.0097
Echinococcus granulosus	cathepsin L	0.0063	0.019	0.0167
Toxoplasma gondii	histone deacetylase HDAC2	0.1652	0.951	0.9703
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Leishmania major	histone deacetylase, putative	0.1652	0.951	0.9703
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0161	0.0141
Loa Loa (eye worm)	ctsf protein	0.0121	0.0535	0.0524
Brugia malayi	Cathepsin L-like precursor	0.004	0.0059	0.006
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0208	0.0185
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.019	0.0176
Plasmodium falciparum	histone deacetylase 1	0.1652	0.951	0.9703
Echinococcus granulosus	histone deacetylase 7	0.1702	0.98	0.98
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.019	0.0176
Onchocerca volvulus		0.0121	0.0535	0.1203
Loa Loa (eye worm)	hypothetical protein	0.004	0.0059	0.0037
Brugia malayi	Cathepsin L-like precursor	0.0081	0.03	0.0306
Trypanosoma cruzi	cysteine proteinase, putative	0.0063	0.019	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0126	0.0105
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Echinococcus multilocularis	histone deacetylase 6	0.1702	0.98	0.98
Leishmania major	cysteine peptidase A (CPA)	0.0121	0.0535	0.0524
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0063	0.019	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0081	0.03	0.0283
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0081	0.03	0.0283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0161	0.0138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0121	0.0535	0.054
Onchocerca volvulus	Cathepsin L homolog	0.0121	0.0535	0.1203
Toxoplasma gondii	cathepsin CPL	0.0121	0.0535	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0324	0.0308
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0063	0.019	0.0167
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0078	0.0055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0121	0.0535	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.019	0.0171
Brugia malayi	mbt repeat family protein	0.0058	0.0161	0.0165
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0208	0.0212
Trypanosoma cruzi	histone deacetylase, putative	0.1702	0.98	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Schistosoma mansoni	cathepsin s	0.004	0.0059	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.03	0.0292
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0121	0.0535	0.0513
Trypanosoma cruzi	cysteine protease, putative	0.0063	0.019	0.0171
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Loa Loa (eye worm)	MBCTL1	0.0066	0.0208	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Leishmania major	histone deacetylase, putative	0.1702	0.98	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Brugia malayi	histone deacetylase 3 (HD3)	0.1652	0.951	0.9704
Trypanosoma brucei	histone deacetylase 2	0.0761	0.4282	0.4356
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.019	0.0171
Echinococcus granulosus	histone deacetylase 6	0.1702	0.98	0.98
Trypanosoma cruzi	histone deacetylase, putative	0.1702	0.98	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus granulosus	cathepsin l1	0.0081	0.03	0.0278
Plasmodium vivax	unspecified product	0.004	0.0059	0.0037
Schistosoma mansoni	histone deacetylase 1 2 3	0.0761	0.4282	0.4269
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Schistosoma mansoni	histone deacetylase	0.1652	0.951	0.9509
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0121	0.0535	0.0513
Echinococcus multilocularis	cysteine protease	0.0121	0.0535	0.0513
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.1154	0.1134
Echinococcus granulosus	histone deacetylase 3	0.1652	0.951	0.9509
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Entamoeba histolytica	cysteine proteinase 1, putative	0.0063	0.019	0.0176
Leishmania major	cathepsin L-like protease	0.0121	0.0535	0.0524
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0063	0.019	0.0171
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0063	0.019	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.019	0.0176
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1652	0.951	1
Onchocerca volvulus		0.0121	0.0535	0.1203
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0034	0.0023	0.0024
Plasmodium falciparum	histone deacetylase 2	0.1702	0.98	1
Onchocerca volvulus		0.0121	0.0535	0.1203
Plasmodium vivax	histone deacetylase 2, putative	0.1702	0.98	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1652	0.951	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0121	0.0535	0.0513
Schistosoma mansoni	cathepsin F (C01 family)	0.0121	0.0535	0.0513
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0246	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0081	0.03	0.0306
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0208	0.0185
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0535	0.0546
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.019	0.0176
Trypanosoma cruzi	cruzipain precursor, putative	0.004	0.0059	0.0037
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0535	0.0546
Loa Loa (eye worm)	cysteine protease	0.0121	0.0535	0.0524
Loa Loa (eye worm)	fibroinase	0.0121	0.0535	0.0524
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Plasmodium vivax	vivapain-3	0.0063	0.019	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0941	0.5342	0.544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Brugia malayi	Cathepsin L-like precursor	0.0081	0.03	0.0306
Brugia malayi	mbt repeat family protein	0.0058	0.0161	0.0165
Brugia malayi	BRCA1-associated protein 2 containing protein	0.0034	0.0023	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0161	0.0138
Echinococcus multilocularis	cathepsin L cysteine protease	0.0121	0.0535	0.0513
Leishmania major	histone deacetylase, putative	0.1702	0.98	1
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0161	0.0138
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0535	0.054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0121	0.0535	0.0513
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0121	0.0535	0.0524
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0161	0.0138
Onchocerca volvulus		0.0121	0.0535	0.1203
Echinococcus granulosus	histone deacetylase 6	0.1702	0.98	0.98
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0208	0.0185
Trichomonas vaginalis	histone deacetylase, putative	0.1652	0.951	1
Loa Loa (eye worm)	hypothetical protein	0.0761	0.4282	0.4356
Brugia malayi	Histone deacetylase family protein	0.1702	0.98	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0535	0.0524
Plasmodium falciparum	histone deacetylase, putative	0.1702	0.98	1
Echinococcus multilocularis	histone deacetylase	0.1702	0.98	0.98
Onchocerca volvulus		0.0121	0.0535	0.1203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Plasmodium vivax	unspecified product	0.0063	0.019	0.0171
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0535	0.0524
Entamoeba histolytica	cysteine protease, putative	0.0063	0.019	0.0176
Brugia malayi	Papain family cysteine protease containing protein	0.0063	0.019	0.0194
Echinococcus multilocularis	histone deacetylase 6	0.1702	0.98	0.98
Echinococcus granulosus	cathepsin l1	0.0121	0.0535	0.0513
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0121	0.0535	0.0513
Brugia malayi	cathepsin L-like precursor	0.0081	0.03	0.0306
Plasmodium vivax	vivapain-1	0.0063	0.019	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0975	0.5541	0.5644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus multilocularis	histone deacetylase 1	0.1652	0.951	0.9509
Echinococcus multilocularis	histone deacetylase 8	0.0761	0.4282	0.4269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Loa Loa (eye worm)	histone deacetylase 7A	0.1702	0.98	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.03	0.0283
Brugia malayi	Histone deacetylase family protein	0.1702	0.98	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0535	0.054
Onchocerca volvulus		0.0121	0.0535	0.1203
Trypanosoma cruzi	histone deacetylase, putative	0.0761	0.4282	0.4356
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0535	0.0524
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0535	0.0524
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0121	0.0535	0.054
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0161	0.0138
Echinococcus multilocularis	cysteine protease	0.0121	0.0535	0.0513
Schistosoma mansoni	histone deacetylase hda2	0.0761	0.4282	0.4269
Echinococcus multilocularis	cathepsin L	0.0063	0.019	0.0167
Schistosoma mansoni	histone deacetylase 4 5	0.1702	0.98	0.98
Brugia malayi	cathepsin F-like cysteine proteinase	0.004	0.0059	0.006
Schistosoma mansoni	histone deacetylase	0.1652	0.951	0.9509

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.631 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1474332

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1359342