TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 239.273 | Formula: C14H13N3O
H donors: 1 H acceptors: 3 LogP: 2.77 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc(C)c2c(n1)n(nc2)Cc1ccccc1
InChi: 1S/C14H13N3O/c1-10-7-13(18)16-14-12(10)8-15-17(14)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,16,18)
InChiKey: NJQHKGVCXFASGF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Rattus norvegicus	Inositol monophosphatase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Echinococcus granulosus	inositol monophosphatase 1	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania donovani	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	extragenic suppressor protein SuhB	Get druggable targets OG5_126810	All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Trichomonas vaginalis	myo inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	inositol monophosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	inositol monophosphatase 1	Get druggable targets OG5_126810	All targets in OG5_126810
Brugia malayi	Inositol-1	Get druggable targets OG5_126810	All targets in OG5_126810
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Entamoeba histolytica	myo-inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Loa Loa (eye worm)	inositol-1	Get druggable targets OG5_126810	All targets in OG5_126810
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	myo inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	inositol monophosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma brucei gambiense	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania infantum	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma congolense	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Neospora caninum	hypothetical protein	Get druggable targets OG5_126810	All targets in OG5_126810
Trichomonas vaginalis	inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania braziliensis	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	Get druggable targets OG5_126810	All targets in OG5_126810

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	306 aa	22.5 %
Trichomonas vaginalis	inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	268 aa	22.4 %
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	Inositol monophosphatase 1	277 aa	263 aa	24.0 %
Dictyostelium discoideum	3',5'-bisphosphate nucleotidase	Inositol monophosphatase 1	277 aa	230 aa	25.2 %
Trichomonas vaginalis	diphosphonucleoside phosphohydrolase, putative	Inositol monophosphatase 1	277 aa	263 aa	21.7 %
Schistosoma mansoni	pap-inositol-14-phosphatase	Inositol monophosphatase 1	277 aa	279 aa	22.9 %
Trypanosoma brucei gambiense	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	309 aa	27.8 %
Trypanosoma congolense	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	304 aa	28.9 %
Onchocerca volvulus	Putative 28S ribosomal protein S10, mitochondrial	Inositol monophosphatase 1	277 aa	271 aa	46.1 %
Brugia malayi	Inositol monophosphatase family protein	Inositol monophosphatase 1	277 aa	238 aa	21.8 %
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	307 aa	22.5 %
Trichomonas vaginalis	myo inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	276 aa	21.4 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Schistosoma japonicum	ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative	Inositol monophosphatase 1	277 aa	275 aa	21.5 %
Trypanosoma cruzi	inositol polyphosphate 1-phosphatase, putative	Inositol monophosphatase 1	277 aa	291 aa	23.7 %
Loa Loa (eye worm)	hypothetical protein	Inositol monophosphatase 1	277 aa	298 aa	23.8 %
Trypanosoma cruzi	myo-inositol-1 phosphatase, putative	Inositol monophosphatase 1	277 aa	284 aa	30.6 %
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	300 aa	22.0 %
Trypanosoma brucei	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	304 aa	27.3 %
Onchocerca volvulus		Inositol monophosphatase 1	277 aa	238 aa	22.7 %
Dictyostelium discoideum	3',5'-bisphosphate nucleotidase 1	Inositol monophosphatase 1	277 aa	275 aa	22.2 %
Trichomonas vaginalis	inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	258 aa	21.7 %
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	Inositol monophosphatase 1	277 aa	287 aa	22.3 %
Onchocerca volvulus	Putative trans-2-enoyl-CoA reductase 1, mitochondrial	Inositol monophosphatase 1	277 aa	278 aa	23.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.002	0.0357	0.0357
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0264	1	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.002	0.0357	0.0357
Loa Loa (eye worm)	LGC-31 protein	0.002	0.0357	0.0357
Brugia malayi	Cation transporter family protein	0.002	0.0357	0.0357
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.004	0.1161	0.5
Schistosoma mansoni	inositol monophosphatase	0.0045	0.1346	0.7621
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0045	0.1346	0.5
Loa Loa (eye worm)	inositol-1	0.0045	0.1346	0.1346
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.004	0.1161	0.5
Onchocerca volvulus		0.0048	0.1494	1
Trypanosoma brucei	carnitine O-palmitoyltransferase, putative	0.0048	0.1494	1
Onchocerca volvulus		0.002	0.0357	0.2387
Brugia malayi	Choline O-acetyltransferase	0.0048	0.1494	0.1494
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.002	0.0357	0.0357
Brugia malayi	Choline O-acetyltransferase	0.0048	0.1494	0.1494
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.1346	0.5
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.0264	1	1
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0048	0.1494	0.0171
Onchocerca volvulus		0.002	0.0357	0.2387
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.002	0.0357	0.0357
Echinococcus granulosus	choline O acetyltransferase	0.0048	0.1494	0.1494
Leishmania major	carnitine/choline acetyltransferase, putative	0.0048	0.1494	0.0171
Onchocerca volvulus		0.0048	0.1494	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0357	0.202
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.002	0.0357	0.202
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0048	0.1494	0.1494
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0048	0.1494	0.0171
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Onchocerca volvulus	Putative nachr subunit	0.002	0.0357	0.2387
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.002	0.0357	0.0357
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Brugia malayi	Cation transporter family protein	0.002	0.0357	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.1494	0.0171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1766	1
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Schistosoma mansoni	inositol monophosphatase	0.0045	0.1346	0.7621
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0264	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.002	0.0357	0.202
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0357	0.0357
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1766	0.1766
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0357	0.0357
Schistosoma mansoni	choline o-acyltransferase	0.0048	0.1494	0.8461
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.0264	1	1
Trypanosoma cruzi	carnitine O-palmitoyltransferase II, putative	0.0048	0.1494	0.0171
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.1494	0.0171
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0357	0.0357
Brugia malayi	Inositol-1	0.0045	0.1346	0.1346
Echinococcus granulosus	nAChR subunit	0.002	0.0357	0.0357
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.1346	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.1494	0.0171
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.002	0.0357	0.0357
Leishmania major	choline/Carnitine o-acyltransferase-like protein	0.0264	1	1
Onchocerca volvulus		0.0048	0.1494	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0048	0.1494	0.0171
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0048	0.1494	0.1494
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.002	0.0357	0.0357
Onchocerca volvulus		0.0048	0.1494	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0048	0.1494	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.002	0.0357	0.0357
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0357	0.0357
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1766	0.1766
Loa Loa (eye worm)	choline O-acetyltransferase	0.0048	0.1494	0.1494
Schistosoma mansoni	choline o-acyltransferase	0.0048	0.1494	0.8461
Trypanosoma brucei	carnitine O-acetyltransferase, putative	0.0048	0.1494	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.002	0.0357	0.0357
Echinococcus multilocularis	choline O acetyltransferase	0.0048	0.1494	0.1494
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0357	0.0357
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.002	0.0357	0.0357
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1766	0.1766
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Leishmania major	carnitine palmitoyltransferase-like protein	0.0048	0.1494	0.0171
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1766	0.1766
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0357	0.0357
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0357	0.202
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.002	0.0357	0.0357
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Trypanosoma cruzi	choline/carnitine O-acetyltransferase, putative	0.0048	0.1494	0.0171
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Onchocerca volvulus		0.002	0.0357	0.2387
Echinococcus multilocularis	inositol monophosphatase 1	0.0045	0.1346	0.1346
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0048	0.1494	0.1494
Onchocerca volvulus		0.002	0.0357	0.2387
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0357	0.0357
Echinococcus granulosus	inositol monophosphatase 1	0.0045	0.1346	0.1346
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.002	0.0357	0.202
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0048	0.1494	0.1494
Echinococcus multilocularis	nAChR subunit	0.002	0.0357	0.0357
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1766	1
Echinococcus multilocularis	carnitine O palmitoyltransferase 2	0.0048	0.1494	0.1494
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Onchocerca volvulus		0.002	0.0357	0.2387
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0357	0.0357
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0357	0.0357
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1766	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0045	0.1346	0.5
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0045	0.1346	0.5
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Trypanosoma brucei	hypothetical protein, conserved	0.0048	0.1494	1
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0357	0.0357
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1766	0.1766
Schistosoma mansoni	nAChR subunit	0.002	0.0357	0.202
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1494	0.1494
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.002	0.0357	0.0357
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Trypanosoma cruzi	carnitine O-acetyltransferase, putative	0.0048	0.1494	0.0171
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.002	0.0357	0.0357
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.002	0.0357	0.0357
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.1494	0.0171
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0357	0.0357
Onchocerca volvulus		0.002	0.0357	0.2387
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.002	0.0357	0.0357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0357	0.0357
Brugia malayi	Cation transporter family protein	0.002	0.0357	0.0357
Echinococcus granulosus	carnitine O palmitoyltransferase 2	0.0048	0.1494	0.1494
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0357	0.0357
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1766	0.1766
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0045	0.1346	0.5
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.002	0.0357	0.0357
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0048	0.1494	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0357	0.202
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0357	0.0357
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0045	0.1346	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0357	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.1494	0.0171

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0063 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1481268

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1362048