Detailed information for compound 1365709

Basic information

Technical information
  • TDR Targets ID: 1365709
  • Name: N-[2,5-diethoxy-4-[(3-methoxyphenyl)carbamoth ioylamino]phenyl]cyclopropanecarboxamide
  • MW: 429.532 | Formula: C22H27N3O4S
  • H donors: 2 H acceptors: 1 LogP: 3.8 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(NC(=O)C2CC2)c(cc1N=C(Nc1cccc(c1)OC)S)OCC
  • InChi: 1S/C22H27N3O4S/c1-4-28-19-13-18(25-22(30)23-15-7-6-8-16(11-15)27-3)20(29-5-2)12-17(19)24-21(26)14-9-10-14/h6-8,11-14H,4-5,9-10H2,1-3H3,(H,24,26)(H2,23,25,30)
  • InChiKey: BSWXKCCDMXURJJ-UHFFFAOYSA-N  


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Synonyms

  • N-[2,5-diethoxy-4-[[[(3-methoxyphenyl)amino]-thioxomethyl]amino]phenyl]cyclopropanecarboxamide
  • N-[2,5-diethoxy-4-[(3-methoxyphenyl)thiocarbamoylamino]phenyl]cyclopropanecarboxamide
  • ASN 04375558
  • Cyclopropanecarboxylic acid {2,5-diethoxy-4-[3-(3-methoxy-phenyl)-thioureido]-phenyl}-amide
  • MLS000556075
  • SMR000172782

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0047 0.0324 0.1029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0014 0.0298
Echinococcus granulosus calpain A 0.0114 0.1156 0.1145
Schistosoma mansoni lipoxygenase 0.0142 0.1503 0.1492
Plasmodium vivax calpain, putative 0.004 0.0243 0.4131
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.0763
Loa Loa (eye worm) hypothetical protein 0.0073 0.0644 0.2087
Trypanosoma brucei calpain-like protein, putative 0.004 0.0243 0.1319
Trichomonas vaginalis peptide N-glycanase, putative 0.0036 0.0188 0.2134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.3037 0.3029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.3037 0.3029
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.1319
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0061 0.05 0.8859
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0395 0.4612 0.4606
Mycobacterium ulcerans hypothetical protein 0.0036 0.0188 0.3714
Loa Loa (eye worm) hypothetical protein 0.0078 0.0711 0.231
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.0763
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0482 0.3451
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.1903
Giardia lamblia Transglutaminase/protease, putative 0.0036 0.0188 0.2134
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.1903
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0267 0.3037 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0104
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0482 0.047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0006
Leishmania major histone deacetylase, putative 0.0066 0.0568 0.4218
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0243 0.0763
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.033 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0103 0.1635
Brugia malayi hypothetical protein 0.0024 0.0044 0.0104
Schistosoma mansoni calpain (C02 family) 0.004 0.0243 0.0231
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0072
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0106 0.1055 0.1044
Echinococcus multilocularis geminin 0.0205 0.2268 0.2258
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0044 0.0032
Loa Loa (eye worm) cathepsin B 0.0088 0.0836 0.2721
Plasmodium falciparum histone deacetylase 1 0.0066 0.0568 1
Brugia malayi histone deacetylase 1 (HD1) 0.0066 0.0568 0.1837
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.03
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0188 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0088 0.0836 0.6604
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.03
Echinococcus granulosus calpain 5 0.004 0.0243 0.0231
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0119 0.1216 0.1205
Loa Loa (eye worm) prolyl oligopeptidase 0.0061 0.05 0.1613
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0044 0.0032
Trypanosoma cruzi kinesin, putative 0.0028 0.0095 0.0274
Giardia lamblia Cathepsin B precursor 0.0088 0.0836 1
Echinococcus granulosus histone deacetylase 1 0.0066 0.0568 0.0556
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0482 0.047
Loa Loa (eye worm) hypothetical protein 0.0267 0.3037 1
Giardia lamblia Cathepsin B precursor 0.0088 0.0836 1
Echinococcus multilocularis Transglutaminase 0.0036 0.0188 0.0176
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.0763
Mycobacterium tuberculosis Hypothetical protein 0.0036 0.0188 0.3901
Mycobacterium ulcerans transglutaminase family protein 0.0036 0.0188 0.3714
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.033 0.0318
Trypanosoma cruzi histone deacetylase 1, putative 0.0066 0.0568 0.1837
Echinococcus multilocularis cathepsin b 0.0267 0.3037 0.3029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0103 0.2144
Echinococcus granulosus Transglutaminase 0.0036 0.0188 0.0176
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0103 0.1903
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.1903
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1503 0.1492
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0044 0.0032
Trypanosoma brucei histone deacetylase 1 0.0066 0.0568 0.4218
Schistosoma mansoni hypothetical protein 0.0036 0.0188 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0006
Schistosoma mansoni histone deacetylase 0.0066 0.0568 0.0556
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0044 0.0537
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0103 0.1903
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.3037 0.3029
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.1319
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0482 0.047
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0243 0.0231
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0044 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0243 0.0763
Echinococcus granulosus histone deacetylase 3 0.0066 0.0568 0.0556
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0044 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.033 0.0318
Echinococcus multilocularis histone deacetylase 3 0.0066 0.0568 0.0556
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.033 0.1051
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0119 0.1216 0.398
Trypanosoma brucei antigen, putative 0.004 0.0243 0.1319
Brugia malayi cathepsin B-like cysteine proteinase 0.0267 0.3037 1
Toxoplasma gondii histone deacetylase HDAC3 0.0066 0.0568 0.6751
Brugia malayi hypothetical protein 0.0047 0.0324 0.1029
Toxoplasma gondii cathepsin B 0.0088 0.0836 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0243 0.0763
Loa Loa (eye worm) calpain family protein 1 0.0106 0.1055 0.3447
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Trypanosoma brucei calpain-like protein, putative 0.004 0.0243 0.1319
Echinococcus granulosus cathepsin b 0.0267 0.3037 0.3029
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1503 0.1492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0243 0.0763
Echinococcus granulosus RUN 0.0024 0.0044 0.0032
Echinococcus multilocularis RUN 0.0024 0.0044 0.0032
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.0243 0.0763
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.1154 0.1143
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0114 0.1154 0.1143
Echinococcus granulosus calpain 7 C02 family 0.004 0.0243 0.0231
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0267 0.3037 0.3029
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.1319
Giardia lamblia Hypothetical protein 0.0036 0.0188 0.2134
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0061 0.05 0.0489
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0014 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0836 1
Toxoplasma gondii histone deacetylase HDAC2 0.0066 0.0568 0.6751
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0568 0.6751
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0482 1
Loa Loa (eye worm) calpain 5 0.0028 0.0095 0.0274
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Schistosoma mansoni rab6-interacting 0.0024 0.0044 0.0032
Echinococcus granulosus cathepsin b 0.0267 0.3037 0.3029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0103 0.1903
Onchocerca volvulus 0.0024 0.0044 0.0574
Trypanosoma brucei calpain-like protein, putative 0.004 0.0243 0.1319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0188 0.3901
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma brucei calpain-like protein, putative 0.004 0.0243 0.1319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.03
Loa Loa (eye worm) histone deacetylase 3 0.0066 0.0568 0.1837
Entamoeba histolytica histone deacetylase, putative 0.0066 0.0568 1
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0044 0.0104
Schistosoma mansoni rab6-interacting 0.0024 0.0044 0.0032
Onchocerca volvulus 0.0024 0.0044 0.0574
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0119 0.1216 0.1205
Schistosoma mansoni calpain C (C02 family) 0.004 0.0243 0.0231
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0395 0.4612 0.4606
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0395 0.4612 0.4606
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0243 0.0763
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.033 0.1051
Onchocerca volvulus 0.0029 0.0103 0.165
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.0243 0.0231
Echinococcus multilocularis calpain A 0.0114 0.1156 0.1145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.0763
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0061 0.05 0.5928
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0119 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0907 0.2958
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0188 1
Echinococcus granulosus calpain A 0.004 0.0243 0.0231
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0482 1
Schistosoma mansoni hypothetical protein 0.0205 0.2268 0.2258
Giardia lamblia Cathepsin B precursor 0.0088 0.0836 1
Brugia malayi Histone deacetylase 1 0.0066 0.0568 0.1837
Loa Loa (eye worm) calpain 0.004 0.0243 0.0763
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0072
Leishmania major histone deacetylase, putative 0.0066 0.0568 0.4218
Mycobacterium ulcerans hypothetical protein 0.0029 0.0103 0.1903
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0243 0.0231
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0103 0.1635
Brugia malayi calpain 7 0.004 0.0243 0.0763
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0243 0.1319
Plasmodium vivax histone deacetylase 1, putative 0.0066 0.0568 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.033 0.0318
Echinococcus granulosus geminin 0.0205 0.2268 0.2258
Loa Loa (eye worm) calpain family protein 1 0.0078 0.0711 0.231
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0482 0.047
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0568 0.6751
Loa Loa (eye worm) hypothetical protein 0.0066 0.0563 0.1821
Brugia malayi Doublecortin family protein 0.0024 0.0044 0.0104
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0188 0.3901
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0119 0.1216 0.398
Echinococcus granulosus calpain 0.004 0.0243 0.0231
Mycobacterium ulcerans putative transglutaminase-like protein 0.0036 0.0188 0.3714
Trypanosoma cruzi kinesin, putative 0.0028 0.0095 0.0274
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0114 0.1154 0.1143
Brugia malayi prolyl oligopeptidase family protein 0.0119 0.1216 0.398
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0072
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0095 0.149
Schistosoma mansoni loxhd1 0.0024 0.0044 0.0032
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0119 0.1216 1
Echinococcus multilocularis hypothetical protein 0.004 0.0243 0.0231
Trypanosoma cruzi histone deacetylase 1, putative 0.0066 0.0568 0.1837
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0006
Giardia lamblia Histone deacetylase 0.0066 0.0568 0.6751
Brugia malayi prolyl oligopeptidase family protein 0.0061 0.05 0.1613
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0119 0.1216 0.1205
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0044 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.033 0.0318
Echinococcus multilocularis calpain 5 0.004 0.0243 0.0231
Onchocerca volvulus 0.0066 0.0563 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0482 0.5706
Echinococcus multilocularis calpain 0.004 0.0243 0.0231
Brugia malayi calpain 5 0.0028 0.0095 0.0274
Schistosoma mansoni hypothetical protein 0.0024 0.0044 0.0032
Schistosoma mansoni histone deacetylase 0.0066 0.0568 0.0556
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0061 0.05 0.0489
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0061 0.05 0.0489
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0568 0.6751
Schistosoma mansoni lipoxygenase 0.01 0.0976 0.0965
Brugia malayi Thioredoxin family protein 0.0036 0.0188 0.0581
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0103 0.1903
Brugia malayi calpain family protein 1 0.0106 0.1055 0.3447
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0836 0.0824
Brugia malayi calpain family protein 1 0.0106 0.1055 0.3447
Entamoeba histolytica protein kinase, putative 0.0028 0.0095 0.149
Brugia malayi histone deacetylase 3 (HD3) 0.0066 0.0568 0.1837
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0104
Brugia malayi hypothetical protein 0.0024 0.0044 0.0104
Schistosoma mansoni hypothetical protein 0.0205 0.2268 0.2258
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.03
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0088 0.0836 0.6604
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0044 0.0537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.033 0.0318
Onchocerca volvulus 0.0036 0.0188 0.3188
Mycobacterium tuberculosis Long conserved protein 0.0036 0.0188 0.3901
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.03
Mycobacterium ulcerans hypothetical protein 0.0036 0.0188 0.3714
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0103 0.1635
Loa Loa (eye worm) hypothetical protein 0.0066 0.0568 0.1837
Loa Loa (eye worm) histone deacetylase 1 0.0066 0.0568 0.1837
Echinococcus multilocularis cathepsin b 0.0267 0.3037 0.3029
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.1154 0.1143
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0088 0.0836 0.2721
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0568 0.6751
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0482 1
Echinococcus multilocularis histone deacetylase 1 0.0066 0.0568 0.0556
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0119 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1055 0.3447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.033 0.0318
Echinococcus multilocularis calpain family protein 1, d 0.0078 0.0711 0.07
Mycobacterium tuberculosis Conserved protein 0.0036 0.0188 0.3901
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.03
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0006
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.0243 0.0231
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.0243 0.1319
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0103 0.2144
Schistosoma mansoni polycystin 1-related 0.0024 0.0044 0.0032

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0586 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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