TDR Targets

Basic information

Technical information

TDR Targets ID: 1367737
Name: 2-[3-(cyclohexanecarbonyl)indol-1-yl]-N-(2,3- dimethylphenyl)acetamide
MW: 388.502 | Formula: C25H28N2O2
H donors: 1 H acceptors: 2 LogP: 5.5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1cc(c2c1cccc2)C(=O)C1CCCCC1)Nc1cccc(c1C)C
InChi: 1S/C25H28N2O2/c1-17-9-8-13-22(18(17)2)26-24(28)16-27-15-21(20-12-6-7-14-23(20)27)25(29)19-10-4-3-5-11-19/h6-9,12-15,19H,3-5,10-11,16H2,1-2H3,(H,26,28)
InChiKey: BFURPHZLTDPQFF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[3-(cyclohexyl-oxomethyl)-1-indolyl]-N-(2,3-dimethylphenyl)acetamide
2-(3-cyclohexylcarbonylindol-1-yl)-N-(2,3-dimethylphenyl)ethanamide
NCGC00101780-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0125	0.0163
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0125	0.0185
Schistosoma mansoni	hypothetical protein	0.0044	0.0248	0.0415
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0248	0.0204
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Schistosoma mansoni	hypothetical protein	0.0072	0.0602	0.114
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0218	0.2445	0.8871
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0248	0.0415
Loa Loa (eye worm)	thioredoxin reductase	0.0096	0.09	0.1411
Trichomonas vaginalis	glutathione reductase, putative	0.0033	0.0111	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0199	0.0474
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0044	0.0248	0.0216
Schistosoma mansoni	opsin-like receptor	0.0044	0.0248	0.0415
Echinococcus granulosus	Polycystic kidney disease protein	0.0064	0.05	0.0457
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0125	0.008
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0187	0.2046	0.2128
Echinococcus granulosus	neuropeptide receptor A26	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Schistosoma mansoni	loxhd1	0.0064	0.05	0.0932
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0044	0.0248	0.0367
Onchocerca volvulus		0.0044	0.0248	0.0694
Brugia malayi	Doublecortin family protein	0.0064	0.05	0.0741
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0033	0.0111	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0044	0.0248	0.0694
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0033	0.0111	0.0917
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0028	0.0045	0.0067
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0072	0.0602	0.0592
Schistosoma mansoni	coup transcription factor	0.0034	0.0125	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0064	0.05	0.0752
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0248	0.0216
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Onchocerca volvulus		0.0058	0.0427	0.1308
Loa Loa (eye worm)	TYRA-2 protein	0.0044	0.0248	0.0335
Echinococcus granulosus	allatostatin A receptor	0.0044	0.0248	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Onchocerca volvulus		0.0044	0.0248	0.0694
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0125	0.0163
Plasmodium falciparum	glutathione reductase	0.0096	0.09	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0248	0.0216
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0033	0.0111	0.007
Brugia malayi	Dopamine receptor	0.0044	0.0248	0.0367
Brugia malayi	larval opioid receptor	0.0044	0.0248	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0028	0.0045	0.0067
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0125	0.008
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.2963	1
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0125	0.0273
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus granulosus	7tm_1 domain containing protein	0.0044	0.0248	0.0204
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.024	0.0196
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0125	0.0131
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0033	0.0111	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0237	0.0604
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0044	0.0248	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0125	0.0185
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0125	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0125	0.0185
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0377	0.0679
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0125	0.0185
Echinococcus multilocularis	serotonin transporter	0.0102	0.0974	0.0988
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0248	0.0335
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0044	0.0248	0.0415
Echinococcus multilocularis	somatostatin receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Onchocerca volvulus		0.0044	0.0248	0.0694
Plasmodium falciparum	thioredoxin reductase	0.0096	0.09	1
Echinococcus multilocularis	orexin receptor type 2	0.0044	0.0248	0.0216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0125	0.0085
Onchocerca volvulus		0.0259	0.2963	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Echinococcus multilocularis	sex peptide receptor	0.0044	0.0248	0.0216
Brugia malayi	Melatonin receptor type 1A	0.0044	0.0248	0.0367
Onchocerca volvulus		0.0044	0.0248	0.0694
Onchocerca volvulus	Putative nachr subunit	0.0187	0.2046	0.6857
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0187	0.2046	0.3304
Schistosoma mansoni	hypothetical protein	0.0064	0.05	0.0932
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0072	0.0602	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0427	0.0782
Brugia malayi	beta-NAC-like protein	0.004	0.0199	0.0295
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0033	0.0111	0.035
Brugia malayi	hypothetical protein	0.0064	0.05	0.0741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0062	0.0002
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0125	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Brugia malayi	MH2 domain containing protein	0.0144	0.151	0.2237
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0974	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Echinococcus multilocularis	serotonin receptor	0.0044	0.0248	0.0216
Treponema pallidum	NADH oxidase	0.0033	0.0111	0.0845
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0033	0.0111	0.0293
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0044	0.0248	0.0216
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0096	0.0896	0.1328
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0237	0.0604
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0044	0.0248	0.0415
Echinococcus granulosus	expressed protein	0.0429	0.5097	0.5074
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0105	0.0122
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0248	0.0335
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0033	0.0111	0.035
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0125	0.008
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0377	0.152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0125	0.0131
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0383	0.4522	0.4763
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0248	0.0415
Entamoeba histolytica	hypothetical protein	0.0043	0.024	0.6051
Loa Loa (eye worm)	hypothetical protein	0.011	0.1081	0.1711
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0248	0.0415
Plasmodium vivax	glutathione reductase, putative	0.0096	0.09	1
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0125	0.0185
Echinococcus granulosus	serotonin receptor	0.0044	0.0248	0.0204
Brugia malayi	steroid hormone receptor	0.0034	0.0125	0.0185
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0248	0.0415
Brugia malayi	ecdysteroid receptor	0.0034	0.0125	0.0185
Schistosoma mansoni	histamine h1 receptor	0.0044	0.0248	0.0415
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0125	0.0185
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0125	0.0085
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0125	0.008
Toxoplasma gondii	NADPH-glutathione reductase	0.0033	0.0111	0.0917
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0125	0.0185
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0105	0.0847
Onchocerca volvulus		0.0096	0.0896	0.2918
Echinococcus multilocularis	transcription factor btf3	0.004	0.0199	0.0164
Onchocerca volvulus		0.0033	0.0105	0.0205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Trypanosoma brucei	trypanothione reductase	0.0096	0.09	1
Schistosoma mansoni	amine GPCR	0.0044	0.0248	0.0415
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus multilocularis	allatostatin A receptor	0.0044	0.0248	0.0216
Brugia malayi	putative neuropeptide receptor	0.0044	0.0248	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0187	0.2046	0.2128
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0228	0.2566	0.3802
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1657	0.2662
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Brugia malayi	Pre-SET motif family protein	0.0228	0.2566	0.3801
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus granulosus	tm gpcr rhodopsin	0.0586	0.7074	0.7061
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Schistosoma mansoni	lipoxygenase	0.0268	0.3069	0.6192
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0102	0.0138
Schistosoma mansoni	hypothetical protein	0.0072	0.0602	0.114
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0044	0.0248	0.0204
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0125	0.0085
Onchocerca volvulus		0.0044	0.0248	0.0694
Schistosoma mansoni	hypothetical protein	0.0058	0.0427	0.0782
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0377	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	G protein-coupled receptor F59B2.13	0.0044	0.0248	0.0367
Brugia malayi	GnHR receptor homolog	0.0044	0.0248	0.0367
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0044	0.0248	0.0367
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0248	0.0415
Mycobacterium tuberculosis	Probable reductase	0.0218	0.2445	0.8871
Schistosoma mansoni	amine GPCR	0.0044	0.0248	0.0415
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0033	0.0111	0.0917
Plasmodium falciparum	glutathione reductase	0.0033	0.0111	0.0917
Brugia malayi	ORL1-like opioid receptor	0.0044	0.0248	0.0367
Entamoeba histolytica	transcription factor BTF3, putative	0.004	0.0199	0.4853
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0383	0.4522	0.4497
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Brugia malayi	hypothetical protein	0.0064	0.05	0.0741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0062	0.0002
Brugia malayi	Dopamine receptor protein 1	0.0044	0.0248	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus granulosus	fmrfamide receptor	0.0044	0.0248	0.0204
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0125	0.0163
Toxoplasma gondii	NAC domain-containing protein	0.004	0.0199	0.1931
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0033	0.0111	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0152	0.031
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0248	0.0216
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0377	0.0353
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0248	0.0415
Trypanosoma cruzi	ion transport protein, putative	0.0207	0.2304	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0125	0.0185
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0377	1
Trichomonas vaginalis	mercuric reductase, putative	0.0033	0.0111	0.017
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0377	0.0558
Echinococcus multilocularis	neuropeptide s receptor	0.0044	0.0248	0.0216
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0187	0.2046	0.201
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0125	0.0085
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus granulosus	G protein coupled receptor 139	0.0044	0.0248	0.0204
Echinococcus granulosus	dro:myosuppressin receptor	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0974	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0028	0.0045	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0377	0.1087
Entamoeba histolytica	hypothetical protein	0.004	0.0199	0.4853
Trypanosoma cruzi	trypanothione reductase, putative	0.0096	0.09	0.3596
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0377	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0125	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2778	0.4513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0102	0.0974	0.1535
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0427	0.0633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0033	0.0111	0.0164
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0125	0.008
Echinococcus granulosus	neuropeptide s receptor	0.0044	0.0248	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0062	0.0002
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Entamoeba histolytica	hypothetical protein	0.0043	0.024	0.6051
Schistosoma mansoni	transcription factor btf3	0.004	0.0199	0.0315
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0248	0.0216
Schistosoma mansoni	hypothetical protein	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0044	0.0248	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0125	0.0185
Schistosoma mansoni	neuropeptide f receptor 76f	0.0044	0.0248	0.0415
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0044	0.0248	0.0335
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.0199	0.0401
Plasmodium vivax	basic transcription factor 3b, putative	0.004	0.0199	0.1931
Brugia malayi	Cation transporter family protein	0.0028	0.0045	0.0067
Schistosoma mansoni	amine GPCR	0.0044	0.0248	0.0415
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0125	0.0085
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0102	0.0974	0.1443
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0044	0.0248	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0125	0.0185
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0187	0.2046	0.201
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0228	0.2566	0.3802
Loa Loa (eye worm)	doublecortin family protein	0.0064	0.05	0.0752
Brugia malayi	G-protein coupled receptor	0.0044	0.0248	0.0367
Echinococcus granulosus	RUN	0.0064	0.05	0.0457
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.009	0.0045
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.2566	0.4163
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0072	0.0602	0.0559
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0248	0.0216
Plasmodium vivax	multidomain scavenger receptor, putative	0.0064	0.05	0.54
Echinococcus granulosus	g-protein coupled receptor	0.0044	0.0248	0.0204
Echinococcus granulosus	sex peptide receptor	0.0044	0.0248	0.0204
Brugia malayi	Thioredoxin reductase	0.0096	0.09	0.1333
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0125	0.0185
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0033	0.0111	0.0917
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0125	0.0273
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0187	0.2046	0.2128
Schistosoma mansoni	opsin-like receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0248	0.0415
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0044	0.0248	0.0204
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0044	0.0248	0.0367
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.024	0.04
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0896	0.1406
Echinococcus granulosus	neuropeptide FF receptor 2	0.0044	0.0248	0.0204
Plasmodium vivax	thioredoxin reductase, putative	0.0096	0.09	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0064	0.05	0.0457
Brugia malayi	hypothetical protein	0.0043	0.024	0.0356
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0044	0.0248	0.0415
Loa Loa (eye worm)	ICD-1 protein	0.004	0.0199	0.0254
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0377	0.152
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0044	0.0248	0.0216
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0033	0.0111	0.0917
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0248	0.0216
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0243	0.2753	1
Schistosoma mansoni	calcium-activated potassium channel	0.0233	0.2627	0.5287
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.024	0.0208
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0125	0.0085
Onchocerca volvulus		0.0044	0.0248	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Onchocerca volvulus		0.0044	0.0248	0.0694
Schistosoma mansoni	hypothetical protein	0.0044	0.0248	0.0415
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0028	0.0045	0.0067
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0028	0.0045	0.0067
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0248	0.0204
Schistosoma mansoni	rab6-interacting	0.0064	0.05	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0044	0.0248	0.0216
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0033	0.0111	0.0917
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	hypothetical protein	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0044	0.0248	0.0694
Entamoeba histolytica	hypothetical protein	0.0043	0.024	0.6051
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0028	0.0045	0.0067
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0044	0.0248	0.0415
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0125	0.0185
Echinococcus multilocularis	Polycystic kidney disease protein	0.0064	0.05	0.0484
Plasmodium vivax	SET domain protein, putative	0.0033	0.0105	0.0847
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus multilocularis	dro:myosuppressin receptor	0.0044	0.0248	0.0216
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0125	0.0163
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus multilocularis	expressed protein	0.0429	0.5097	0.5374
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0033	0.0111	0.1072
Mycobacterium tuberculosis	Probable oxidoreductase	0.0243	0.2753	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0044	0.0248	0.0415
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0125	0.008
Brugia malayi	Dopamine receptor protein 2	0.0044	0.0248	0.0367
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0033	0.0111	0.0135
Echinococcus multilocularis	conserved hypothetical protein	0.0774	0.9445	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0125	0.0085
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0102	0.0974	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0237	0.0604
Trypanosoma cruzi	ion transport protein, putative	0.0207	0.2304	1
Brugia malayi	AKH receptor	0.0044	0.0248	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0105	0.0099
Schistosoma mansoni	hypothetical protein	0.0072	0.0602	0.114
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0028	0.0045	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0125	0.0185
Schistosoma mansoni	hypothetical protein	0.0245	0.2778	0.5595
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0248	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0377	0.1087
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0044	0.0248	0.0415
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0125	0.0185
Toxoplasma gondii	thioredoxin reductase	0.0096	0.09	1
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.3292	0.3261
Schistosoma mansoni	amine GPCR	0.0415	0.4929	1
Leishmania major	trypanothione reductase	0.0096	0.09	0.382
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0974	0.1535
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Echinococcus multilocularis	neuropeptide receptor A26	0.0044	0.0248	0.0216
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0064	0.05	0.0484
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0033	0.0111	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0218	0.2445	0.8871
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0044	0.0248	0.0694
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0125	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0044	0.0248	0.0335
Schistosoma mansoni	hypothetical protein	0.0072	0.0602	0.114
Mycobacterium tuberculosis	Probable dehydrogenase	0.0218	0.2445	0.8871
Echinococcus granulosus	lipoxygenase domain containing protein	0.0064	0.05	0.0457
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0248	0.0204
Schistosoma mansoni	myosin xvIII	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0044	0.0248	0.0694
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0044	0.0248	0.0694
Brugia malayi	sulfakinin receptor protein	0.0044	0.0248	0.0367
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0125	0.0273
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0072	0.0602	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0033	0.0111	0.1072
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0218	0.2445	0.8871
Treponema pallidum	sodium- and chloride- dependent transporter	0.0102	0.0974	1
Schistosoma mansoni	adenoreceptor	0.0044	0.0248	0.0415
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0377	0.4082
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.151	0.2419
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus multilocularis	G protein coupled receptor 139	0.0044	0.0248	0.0216
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0125	0.0085
Brugia malayi	Latrophilin receptor protein 2	0.0072	0.0602	0.0892
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.3292	0.3454
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Leishmania major	ion transport protein-like protein	0.0207	0.2304	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0125	0.0163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0137	0.0259
Brugia malayi	hypothetical protein	0.0286	0.3292	0.4877
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0105	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0602	0.092
Plasmodium falciparum	LCCL domain-containing protein	0.0064	0.05	0.54
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0044	0.0248	0.0367
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0248	0.0204
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0248	0.0415
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0187	0.2046	0.201
Echinococcus granulosus	7TM GPCR rhodopsin	0.0044	0.0248	0.0204
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0586	0.7074	0.7478
Loa Loa (eye worm)	norepinephrine transporter	0.0102	0.0974	0.1535
Schistosoma mansoni	hypothetical protein	0.0043	0.024	0.04
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0125	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0237	0.0604
Echinococcus multilocularis	g-protein coupled receptor	0.0044	0.0248	0.0216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0248	0.0204
Brugia malayi	follicle stimulating hormone receptor	0.0302	0.3499	0.5184
Echinococcus multilocularis	serotonin receptor	0.0044	0.0248	0.0216
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0237	0.0576
Brugia malayi	G-protein coupled receptor	0.0044	0.0248	0.0367
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0033	0.0111	0.1072
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0064	0.05	0.0484
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0096	0.0896	0.0906
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0072	0.0602	0.092
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0096	0.09	0.319
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2566	0.4164
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0237	0.0907
Schistosoma mansoni	amine GPCR	0.0044	0.0248	0.0415
Brugia malayi	Pre-SET motif family protein	0.0033	0.0105	0.0155
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0218	0.2445	0.8871
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0125	0.0163
Brugia malayi	putative neuropeptide receptor NPR1	0.0044	0.0248	0.0367
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1239	0.1973
Brugia malayi	neuropeptide F receptor	0.0044	0.0248	0.0367
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0028	0.0045	0.0067
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0031	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0125	0.0131
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0033	0.0111	0.035
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0033	0.0111	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0105	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0033	0.0111	1
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0105	0.006
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0125	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.0248	0.0204
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0045	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0062	0.0002
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0044	0.0248	0.0204
Echinococcus granulosus	orexin receptor type 2	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0044	0.0248	0.0216
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0248	0.0415
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0044	0.0248	0.0204
Brugia malayi	latrophilin 2 splice variant baaae	0.0156	0.1657	0.2455
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.0248	0.0415
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0125	0.0131
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0248	0.0216
Echinococcus granulosus	GPCR family 2	0.0072	0.0602	0.0559
Trypanosoma brucei	transcription factor BTF3, putative	0.004	0.0199	0.2069
Echinococcus granulosus	serotonin transporter	0.0102	0.0974	0.0933
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0248	0.0216
Echinococcus multilocularis	GPCR, family 2	0.0072	0.0602	0.0592
Echinococcus multilocularis	small conductance calcium activated potassium	0.0245	0.2778	0.2907
Brugia malayi	Cation transporter family protein	0.0028	0.0045	0.0067
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Echinococcus granulosus	small conductance calcium activated potassium	0.0245	0.2778	0.2745
Brugia malayi	G protein-coupled receptor	0.0044	0.0248	0.0367
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0248	0.0415
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0125	0.0185
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.0199	0.0401
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.0248	0.0415
Brugia malayi	excitatory GABA receptor EXP-1A	0.0028	0.0045	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0064	0.05	0.0752
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0102	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0508	0.6099	1
Brugia malayi	Serotonin receptor	0.056	0.6749	1
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0248	0.0204
Echinococcus granulosus	transcription factor btf3	0.004	0.0199	0.0154
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0125	0.0085
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0228	0.2566	0.4164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0125	0.0131
Entamoeba histolytica	hypothetical protein	0.0043	0.024	0.6051
Schistosoma mansoni	hypothetical protein	0.0156	0.1657	0.33
Schistosoma mansoni	opsin-like receptor	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0064	0.05	0.156
Brugia malayi	RE15519p	0.0044	0.0248	0.0367
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0202	0.196
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0248	0.0335
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0243	0.2753	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0097	0.0124
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0187	0.2046	0.3031
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0248	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0125	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0102	0.0138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0202	0.0482
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0125	0.0131
Echinococcus granulosus	somatostatin receptor	0.0044	0.0248	0.0204
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0044	0.0248	0.0367
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0377	0.0548
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Onchocerca volvulus		0.0034	0.0125	0.0273
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0237	0.2503
Echinococcus granulosus	thioredoxin glutathione reductase	0.0096	0.0906	0.0865
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0248	0.0216
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0248	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0248	0.0204
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0125	0.0163
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0033	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3292	0.5363
Schistosoma mansoni	sodium/chloride dependent transporter	0.0102	0.0974	0.1902
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0243	0.2753	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0044	0.0248	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0377	0.1212
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0033	0.0111	0.035
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0125	0.008
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0248	0.0204
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0105	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0248	0.0216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0277	0.0742
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0044	0.0248	0.0335
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0248	0.0216
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0248	0.0216
Echinococcus multilocularis	RUN	0.0064	0.05	0.0484
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0248	0.0415
Onchocerca volvulus		0.0064	0.05	0.156
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0044	0.0248	0.0415
Plasmodium falciparum	thioredoxin reductase	0.0033	0.0111	0.0917
Brugia malayi	Cation transporter family protein	0.0028	0.0045	0.0067
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0072	0.0602	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Loa Loa (eye worm)	glutathione reductase	0.0096	0.09	0.1411
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0044	0.0248	0.0335
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Loa Loa (eye worm)	serotonin transporter b	0.0102	0.0974	0.1535
Schistosoma mansoni	lipoxygenase	0.0383	0.4522	0.9167
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0248	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	glutathione reductase	0.0096	0.09	0.1333
Schistosoma mansoni	calcium-activated potassium channel	0.0245	0.2778	0.5595
Onchocerca volvulus		0.0102	0.0974	0.3185
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0044	0.0248	0.0415
Schistosoma mansoni	rab6-interacting	0.0064	0.05	0.0932
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0248	0.0204
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0044	0.0248	0.0367
Echinococcus granulosus	L aminoadipate semialdehyde	0.0096	0.0896	0.0855
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0218	0.2445	0.8871
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0377	0.1087
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0096	0.0896	0.1743
Loa Loa (eye worm)	melatonin receptor type 1A	0.0044	0.0248	0.0335
Leishmania major	basic transcription factor 3a, putative	0.004	0.0199	0.0738
Schistosoma mansoni	polycystin 1-related	0.0064	0.05	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0248	0.0335
Brugia malayi	neuropeptide F receptor	0.0044	0.0248	0.0367
Plasmodium falciparum	basic transcription factor 3b, putative	0.004	0.0199	0.1931
Onchocerca volvulus		0.0044	0.0248	0.0694
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0105	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0097	0.0124
Giardia lamblia	GTOR	0.0054	0.0377	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.2046	0.3304
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.151	0.2419
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0248	0.0415
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0125	0.0131
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0377	0.1212
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0105	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0248	0.0204
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0125	0.0163
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0044	0.0248	0.0216
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0248	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0237	0.0604
Brugia malayi	Serotonin receptor	0.0044	0.0248	0.0367
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0028	0.0045	0.0067
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0199	0.0474
Brugia malayi	hypothetical protein	0.0044	0.0248	0.0367
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0248	0.0216
Brugia malayi	nuclear hormone receptor	0.0034	0.0125	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0199	0.0474
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0096	0.0906	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0508	0.6099	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0248	0.0335
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0033	0.0111	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0125	0.0163
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0377	0.0333
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0302	0.3499	0.5704
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0125	0.008

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.0399 uM	PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.9953 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	2.6122 uM	PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.8048 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	5.8048 uM	PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.0918 uM	PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.0918 uM	PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1495165

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1367737