Detailed information for compound 1376834

Basic information

Technical information
  • TDR Targets ID: 1376834
  • Name: 2-[4-(4-chlorophenyl)-3-cyano-6-thiophen-2-yl pyridin-2-yl]sulfanylacetic acid
  • MW: 386.875 | Formula: C18H11ClN2O2S2
  • H donors: 1 H acceptors: 4 LogP: 4.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(SCC(=O)O)nc(cc1c1ccc(cc1)Cl)c1cccs1
  • InChi: 1S/C18H11ClN2O2S2/c19-12-5-3-11(4-6-12)13-8-15(16-2-1-7-24-16)21-18(14(13)9-20)25-10-17(22)23/h1-8H,10H2,(H,22,23)
  • InChiKey: UQCLCESEXBRIHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-(4-chlorophenyl)-3-cyano-6-(2-thienyl)-2-pyridyl]sulfanyl]acetic acid
  • 2-[[4-(4-chlorophenyl)-3-cyano-6-(2-thienyl)-2-pyridyl]thio]acetic acid
  • 2-[4-(4-chlorophenyl)-3-cyano-6-thiophen-2-yl-pyridin-2-yl]sulfanylethanoic acid
  • AK-777/11656049
  • STOCK4S-39448
  • 2-[4-(4-chlorophenyl)-3-cyano-6-thiophen-2-ylpyridin-1-ium-2-yl]sulfanylacetate
  • 2-[4-(4-chlorophenyl)-3-cyano-6-(2-thienyl)pyridin-1-ium-2-yl]sulfanylacetate
  • 2-[[4-(4-chlorophenyl)-3-cyano-6-(2-thienyl)-2-pyridin-1-iumyl]thio]acetate
  • 2-[[4-(4-chlorophenyl)-3-cyano-6-(2-thienyl)pyridin-1-ium-2-yl]thio]acetate
  • 2-[4-(4-chlorophenyl)-3-cyano-6-thiophen-2-yl-pyridin-1-ium-2-yl]sulfanylethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens SUMO1 activating enzyme subunit 1 No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin-like modifier activating enzyme 2 Starlite/ChEMBL No references
Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme Starlite/ChEMBL No references
Homo sapiens eukaryotic translation initiation factor 4H Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania mexicana serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132232 All targets in OG5_132232
Leishmania major ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium falciparum serine/threonine protein phosphatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein phosphatase 1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Echinococcus multilocularis SUMO activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium knowlesi serine/threonine protein phosphatase PP1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma brucei ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) serine/threonine-protein phosphatase PP1-beta Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ThiF family protein Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium yoelii related to ubiquitin-activating enzyme homolog UBA2-related Get druggable targets OG5_127838 All targets in OG5_127838
Babesia bovis ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Candida albicans potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium vivax SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania braziliensis ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium berghei serine/threonine protein phosphatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium vivax ubiquitin activating enzyme, putative Get druggable targets OG5_128859 All targets in OG5_128859
Neospora caninum hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium vivax serine/threonine protein phosphatase PP1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis SUMO-1 activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium parvum serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Toxoplasma gondii serine/threonine phosophatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni ubiquitin-activating enzyme E1b Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei protein phosphatase 1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania mexicana ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei gambiense serine/threonine protein phosphatase catalytic subunit, putative,serine/threonine protein phosphatase PP1-gamma Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum AFR138Wp, related Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis protein phosphatase-1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus serine:threonine protein phosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative Get druggable targets OG5_126821 All targets in OG5_126821
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Toxoplasma gondii ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium falciparum SUMO-activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis protein phosphatase, caeel, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni protein phosphatase type 1 Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium berghei SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum SUMO-1 activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K10685 ubiquitin-like 1-activating enzyme E1 B, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium berghei SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus sumo-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Plasmodium yoelii serine/threonine protein phosphatase alpha-3 isoform Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Leishmania donovani serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis protein phosphatase 2A, caeel, putative Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma mansoni protein phosphatase type 1 Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma cruzi ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum SUMO-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Eukaryotic translation initiation factor 4H, putative Get druggable targets OG5_132232 All targets in OG5_132232
Leishmania infantum serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis conserved hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Giardia lamblia Ubiquitin-activating enzyme E1 1 Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Neospora caninum hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Giardia lamblia Phosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium yoelii SUMO-1 activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma mansoni protein phosphatase-1 Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Brugia malayi ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Babesia bovis Ser/Thr protein phosphatase family protein Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII Get druggable targets OG5_126821 All targets in OG5_126821
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni protein phosphatase-1 Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA binding protein Get druggable targets OG5_132232 All targets in OG5_132232
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus eukaryotic translation initiation factor 4b:4h eukaryotic translation initiation factor 4H 248 aa 217 aa 26.3 %
Plasmodium falciparum protein phosphatase containing kelch-like domains protein phosphatase 1, catalytic subunit, alpha isozyme 341 aa 331 aa 41.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.1114 0.1997
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0012 0.0183 0.0477
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.0028
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.1828 0.305
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0012 0.0183 0.0158
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.1114 0.2908
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0576 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.5579 0.6373
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3832 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0317 0.0827
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0012 0.0183 0.0477
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0012 0.0183 0.0158
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0008 0.0025 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.1828 1
Trypanosoma brucei protein phosphatase 1 0.0008 0.0025 0.0065
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0018 0.0392 0.0964
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0008 0.0025 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3832 1
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0008 0.0025 0.0028
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0576 0.0553
Loa Loa (eye worm) hypothetical protein 0.01 0.3335 0.3809
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0012 0.0183 0.0999
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Leishmania major DNA polymerase eta, putative 0.0023 0.0576 0.1504
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0576 1
Schistosoma mansoni protein phosphatase-1 0.0008 0.0025 0.0045
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Echinococcus granulosus dna polymerase eta 0.0023 0.0576 0.073
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Schistosoma mansoni protein phosphatase-1 0.0008 0.0025 0.0045
Schistosoma mansoni protein phosphatase type 1 0.0012 0.0183 0.0327
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0012 0.0183 0.0999
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.1033 0.1577
Giardia lamblia DINP protein human, muc B family 0.0023 0.0576 0.1504
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0576 0.1033
Brugia malayi Pre-SET motif family protein 0.0251 0.8755 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0018 0.0392 0.1023
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.5579 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trichomonas vaginalis protein phosphatase-1, putative 0.0012 0.0183 0.0158
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0576 0.0658
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0576 0.1504
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3832 0.4377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1722 0.3086
Toxoplasma gondii ThiF family protein 0.0038 0.1114 0.6095
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0576 0.1504
Schistosoma mansoni DNA polymerase eta 0.0023 0.0576 0.1033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0923 0.2408
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.1637 0.2933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1722 0.2852
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0008 0.0025 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Brugia malayi ThiF family protein 0.0038 0.1114 0.1273
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3832 0.6762
Trypanosoma brucei unspecified product 0.0016 0.0317 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.3335 0.8694
Loa Loa (eye worm) hypothetical protein 0.0058 0.1828 0.2089
Schistosoma mansoni protein phosphatase type 1 0.0012 0.0183 0.0327
Echinococcus granulosus dna polymerase kappa 0.0023 0.0576 0.073
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0576 0.073
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.1828 0.3277
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.1114 0.6095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1033 0.1852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1722 0.2852
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0576 0.1504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0183 0.0209
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0576 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1722 0.3086
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0183 0.0158
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0008 0.0025 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.1033 0.5652
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0576 0.073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0576 0.5
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.1114 0.6095
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0576 0.073
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0576 0.1504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1722 0.2852
Loa Loa (eye worm) hypothetical protein 0.0023 0.0576 0.0658
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0008 0.0025 0.0028
Plasmodium vivax SET domain protein, putative 0.0036 0.1033 0.5652
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0012 0.0183 0.0209
Leishmania major DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0163 0.5579 1
Schistosoma mansoni protein phosphatase-1 0.0012 0.0183 0.0327
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0018 0.0392 0.0368
Echinococcus multilocularis dna polymerase eta 0.0023 0.0576 0.073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1033 0.1852
Brugia malayi RNA binding protein 0.0163 0.5579 0.6373
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0576 0.0658
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1722 0.1967
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3832 0.4377
Toxoplasma gondii hypothetical protein 0.0058 0.1828 1
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Brugia malayi Pre-SET motif family protein 0.0036 0.1033 0.1181
Loa Loa (eye worm) hypothetical protein 0.0036 0.1033 0.1181
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.5579 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3832 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.3335 0.8694
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.1114 0.1726
Loa Loa (eye worm) ThiF family protein 0.0038 0.1114 0.1273
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3832 1
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0183 0.0158
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.1828 0.305
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0018 0.0392 0.1023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1722 0.3086
Trypanosoma brucei protein phosphatase 1, putative 0.0012 0.0183 0.0477
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Schistosoma mansoni protein phosphatase type 1 0.0008 0.0025 0.0045
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3832 0.3121
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0012 0.0183 0.0209
Trypanosoma brucei unspecified product 0.0016 0.0317 0.0827
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3832 0.6868
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8755 1
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0008 0.0025 0.0028
Giardia lamblia Kinase, PLK 0.0114 0.3832 1
Schistosoma mansoni kinase 0.0058 0.182 0.3262
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0012 0.0183 0.0209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1722 0.2852
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.5579 1
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0008 0.0025 0.0065
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0576 0.1033
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.1114 0.2908
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0317 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0576 0.1449
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.1033 0.1577
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0012 0.0183 0.0477
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1722 0.1967
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.1828 1
Brugia malayi putative serine/threonine phosphatase 0.0008 0.0025 0.0028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.1033 0.1577
Trypanosoma brucei protein phosphatase 1 0.0008 0.0025 0.0065
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0576 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0576 0.1504
Trypanosoma brucei polo-like protein kinase 0.0114 0.3832 1
Schistosoma mansoni protein phosphatase-1 0.0012 0.0183 0.0327
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0576 0.1504
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0008 0.0025 0.0065
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0163 0.5579 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1766 0.1745
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.1033 0.1852
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0576 0.0658
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0008 0.0025 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1033 0.1852
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.1114 0.1726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0986 0.1488
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0317 0.0827
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0008 0.0025 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3832 0.6762
Brugia malayi ThiF family protein 0.0058 0.1828 0.2089
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3832 0.3816
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1766 0.1745
Toxoplasma gondii serine/threonine phosophatase PP1 0.0012 0.0183 0.0999
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.1114 0.2908
Trypanosoma brucei unspecified product 0.0023 0.0576 0.1504
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0008 0.0025 0.0028
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0183 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0576 0.1504

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.656 um PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Protein Phosphatase 1 (PP1). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (Primary screen (PP5 inhibitors)), 2235 (Screening assay (PP1 inhibitors in singlate))] ChEMBL. No reference
IC50 (functional) = 8.73 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (binding) = 10.675 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2014, AID2028, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (binding) = 39.68 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2030, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (binding) > 67.047 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of PP1: fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Protein Phosphatase 5 (PP5). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (PP5 inhibitors in singlate), 2235 (PP1 inhibitors in singlate)] ChEMBL. No reference
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2011, AID2018, AID2069, AID2614, AID2658] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.