Detailed information for compound 1383957

Basic information

Technical information
  • TDR Targets ID: 1383957
  • Name: MLS000335144
  • MW: 428.44 | Formula: C24H20N4O4
  • H donors: 1 H acceptors: 4 LogP: 4.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nn(cc1CNC(=O)c1cccc(c1)[N+](=O)[O-])c1ccccc1
  • InChi: 1S/C24H20N4O4/c1-32-22-12-10-17(11-13-22)23-19(16-27(26-23)20-7-3-2-4-8-20)15-25-24(29)18-6-5-9-21(14-18)28(30)31/h2-14,16H,15H2,1H3,(H,25,29)
  • InChiKey: XQCSLUPAGUKJLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000249902
  • T5270355

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 0.0019 0.054 0.054
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0366 0.0366
Onchocerca volvulus Cathepsin L homolog 0.0023 0.116 0.116
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0079 1 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.116 0.116
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.197 0.197
Brugia malayi hypothetical protein 0.0043 0.4415 0.4415
Schistosoma mansoni tar DNA-binding protein 0.0076 0.956 0.956
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.197 0.197
Loa Loa (eye worm) CYP4Cod1 0.0028 0.197 0.197
Schistosoma mansoni tar DNA-binding protein 0.0076 0.956 0.956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Onchocerca volvulus 0.0023 0.116 0.116
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.197 0.197
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.116 0.116
Treponema pallidum ATP-dependent RNA helicase 0.0079 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.2721 0.2721
Schistosoma mansoni hypothetical protein 0.0019 0.054 0.054
Brugia malayi RNA binding protein 0.0076 0.956 0.956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Loa Loa (eye worm) ctsf protein 0.0023 0.116 0.116
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0366 0.0366
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4415 0.4415
Echinococcus multilocularis lamin dm0 0.0033 0.2721 0.2649
Onchocerca volvulus 0.0023 0.116 0.116
Plasmodium vivax RNA helicase-1, putative 0.0079 1 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0079 1 1
Echinococcus granulosus intermediate filament protein 0.0033 0.2721 0.2721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.116 0.116
Onchocerca volvulus 0.0023 0.116 0.116
Echinococcus multilocularis 0.0019 0.054 0.0447
Trypanosoma brucei cytochrome P450, putative 0.0028 0.197 0.1512
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Entamoeba histolytica hypothetical protein 0.0043 0.4415 0.4415
Onchocerca volvulus Cathepsin F homolog 0.0023 0.116 0.116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.6771 0.6771
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0079 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Plasmodium falciparum eukaryotic initiation factor 4A 0.0079 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Echinococcus granulosus lamin 0.0033 0.2721 0.2721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0079 1 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Leishmania major cysteine peptidase A (CPA) 0.0023 0.116 0.0656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Echinococcus granulosus eukaryotic initiation factor 4A 0.0079 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.4415 0.4415
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0079 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.116 0.116
Loa Loa (eye worm) TAR-binding protein 0.0076 0.956 0.956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Brugia malayi TAR-binding protein 0.0076 0.956 0.956
Echinococcus multilocularis cysteine protease 0.0023 0.116 0.1074
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Brugia malayi intermediate filament protein 0.0033 0.2721 0.2721
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Onchocerca volvulus 0.0033 0.2721 0.2721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Loa Loa (eye worm) cysteine protease 0.0023 0.116 0.116
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0079 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Onchocerca volvulus 0.0023 0.116 0.116
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0079 1 1
Leishmania major cytochrome p450-like protein 0.0028 0.197 0.1512
Schistosoma mansoni tar DNA-binding protein 0.0076 0.956 0.956
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.116 0.1074
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4415 0.436
Leishmania major eukaryotic initiation factor 4a, putative 0.0079 1 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Entamoeba histolytica hypothetical protein 0.0043 0.4415 0.4415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Schistosoma mansoni tar DNA-binding protein 0.0076 0.956 0.956
Loa Loa (eye worm) RNA binding protein 0.0076 0.956 0.956
Echinococcus granulosus cathepsin l1 0.0023 0.116 0.116
Brugia malayi cytochrome P450 0.0019 0.054 0.054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0097 0.0097
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.116 0.116
Leishmania major eukaryotic initiation factor 4a, putative 0.0079 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Echinococcus multilocularis tar DNA binding protein 0.0076 0.956 0.9556
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.2721 0.2721
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0079 1 1
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Echinococcus multilocularis musashi 0.0033 0.2721 0.2649
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0079 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.956 0.956
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Mycobacterium leprae putative cytochrome p450 0.0019 0.054 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.116 0.116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4415 0.4415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.2721 0.2721
Loa Loa (eye worm) hypothetical protein 0.0079 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.956 0.956
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.116 0.1074
Onchocerca volvulus 0.0033 0.2721 0.2721
Brugia malayi Cytochrome P450 family protein 0.0028 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0023 0.116 0.116
Loa Loa (eye worm) fibroinase 0.0023 0.116 0.116
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.116 0.116
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.054 0.054
Brugia malayi Cytochrome P450 family protein 0.0019 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0032 0.2628 0.2628
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.956 0.956
Onchocerca volvulus 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.116 0.116
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.197 0.197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Echinococcus granulosus tar DNA binding protein 0.0076 0.956 0.956
Schistosoma mansoni lamin 0.0033 0.2721 0.2721
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0079 1 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0079 1 1
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0079 1 1
Onchocerca volvulus Cathepsin L homolog 0.0023 0.116 0.116
Schistosoma mansoni intermediate filament proteins 0.0033 0.2721 0.2721
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.116 0.116
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.116 0.1074
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.197 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.197 0.197
Brugia malayi Cytochrome P450 family protein 0.0059 0.6771 0.6771
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Entamoeba histolytica hypothetical protein 0.0043 0.4415 0.4415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.116 0.116
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0079 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.054 0.054
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0079 1 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.116 0.116
Schistosoma mansoni cytochrome P450 0.0019 0.054 0.054
Echinococcus granulosus lamin dm0 0.0033 0.2721 0.2721
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.116 0.116
Loa Loa (eye worm) intermediate filament protein 0.0033 0.2721 0.2721
Schistosoma mansoni lamin 0.0033 0.2721 0.2721
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0079 1 1
Onchocerca volvulus 0.0023 0.116 0.116
Toxoplasma gondii cathepsin CPL 0.0023 0.116 0.0656
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Schistosoma mansoni hypothetical protein 0.0043 0.4415 0.4415
Echinococcus multilocularis cysteine protease 0.0023 0.116 0.1074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0079 1 1
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Leishmania major cathepsin L-like protease 0.0023 0.116 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Brugia malayi Cathepsin L-like precursor 0.0023 0.116 0.116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.116 0.0656
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.116 0.116
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.116 0.1074
Echinococcus multilocularis lamin 0.0033 0.2721 0.2649
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.054 0.5
Onchocerca volvulus 0.0023 0.116 0.116
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.054 0.054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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