Detailed information for compound 1386805

Basic information

Technical information
  • TDR Targets ID: 1386805
  • Name: T5230503
  • MW: 402.464 | Formula: C20H22N2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.28 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](NC(=O)c1cccs1)Cc1ccccc1)OCC(=O)N1CCOCC1
  • InChi: 1S/C20H22N2O5S/c23-18(22-8-10-26-11-9-22)14-27-20(25)16(13-15-5-2-1-3-6-15)21-19(24)17-7-4-12-28-17/h1-7,12,16H,8-11,13-14H2,(H,21,24)/t16-/m0/s1
  • InChiKey: IQFDKZQAYOXWMZ-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC02635038
  • MLS001005124
  • SMR000378018

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major casein kinase II, putative 0.039 0.9874 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.2425 0.2425
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0737 0.0737
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0071 0.0072
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.2425 0.2425
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0737 0.0746
Echinococcus multilocularis casein kinase ii subunit alpha 0.039 0.9874 0.9874
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0737 0.0737
Entamoeba histolytica protein kinase domain containing protein 0.0395 1 1
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0395 1 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0866 0.0866
Schistosoma mansoni serine/threonine protein kinase 0.0395 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0802 0.0802
Plasmodium vivax unspecified product 0.039 0.9874 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0395 1 1
Entamoeba histolytica casein kinase, putative 0.039 0.9874 0.9874
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0249 0.0252
Echinococcus granulosus snurportin 1 0.0372 0.9376 0.9376
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.2425 0.2425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0802 0.0802
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0737 0.0737
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0115 0.2425 0.2456
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0737 0.0746
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0737 0.0746
Schistosoma mansoni importin beta-1 0.0035 0.0249 0.0249
Plasmodium falciparum casein kinase 2, alpha subunit 0.039 0.9874 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0737 0.0737
Giardia lamblia Kinase, CMGC GSK 0.0115 0.2425 0.2456
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1082 0.1082
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0249 0.0252
Echinococcus granulosus protein kinase shaggy 0.0115 0.2425 0.2425
Trypanosoma brucei protein kinase, putative 0.0115 0.2425 0.2456
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0115 0.2425 0.2425
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0737 0.0746
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1082 0.1082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.0249
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0866 0.0866
Brugia malayi Protein kinase domain containing protein 0.0053 0.0737 0.0737
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.2425 0.2456
Plasmodium vivax protein kinase Crk2 0.0053 0.0737 0.0746
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0866 0.0866
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0737 0.0746
Schistosoma mansoni hypothetical protein 0.035 0.8792 0.8792
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0737 0.0746
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0802 0.0802
Echinococcus granulosus importin subunit beta 1 0.0035 0.0249 0.0249
Plasmodium falciparum importin beta, putative 0.0035 0.0249 0.0252
Echinococcus multilocularis snurportin 1 0.0372 0.9376 0.9376
Plasmodium vivax importin-beta 2, putative 0.0035 0.0249 0.0252
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0866 0.0866
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.039 0.9874 1
Brugia malayi RNA, U transporter 1 0.0099 0.1988 0.1988
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0115 0.2425 0.2425
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0737 0.0746
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0071 0.0072
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0249 0.0249
Plasmodium falciparum glycogen synthase kinase 3 0.0115 0.2425 0.2456
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.5455 0.5455
Brugia malayi Casein kinase II, alpha chain 0.039 0.9874 0.9874
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0737 0.0737
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.9376 0.9376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0866 0.0866
Plasmodium falciparum protein kinase 5 0.0053 0.0737 0.0746
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0866 0.0866
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0048 0.0593 0.0593
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0115 0.2425 0.2425
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Loa Loa (eye worm) MBCTL1 0.0066 0.1082 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0737 0.0746
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0395 1 1
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0737 0.0737
Trypanosoma cruzi casein kinase II, putative 0.039 0.9874 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0071 0.0072
Leishmania major importin beta-1 subunit, putative 0.0028 0.0071 0.0072
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1082 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0737 0.0746
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1082 0.1082
Entamoeba histolytica protein kinase domain containing protein 0.039 0.9874 0.9874
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.5455 0.5455
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0115 0.2425 0.2456
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.039 0.9874 0.9874
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0737 0.0737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0802 0.0802
Schistosoma mansoni hypothetical protein 0.0372 0.9376 0.9376
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0737 0.0746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0802 0.0802
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0866 0.0866
Entamoeba histolytica protein kinase, putative 0.0115 0.2425 0.2425
Plasmodium vivax glycogen synthase kinase 3, putative 0.0115 0.2425 0.2456
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0737 0.0737
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0866 0.0866
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0737 0.0746
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1082 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Onchocerca volvulus 0.0115 0.2425 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0737 0.0737
Entamoeba histolytica hypothetical protein 0.0028 0.0071 0.0071
Giardia lamblia Kinase, CMGC CK2 0.039 0.9874 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0737 0.0746
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0802 0.0802
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0071 0.0072
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0866 0.0866
Brugia malayi mbt repeat family protein 0.0058 0.0866 0.0866
Brugia malayi cell division control protein 2 homolog 0.0053 0.0737 0.0737
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0737 0.0737
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0802 0.0802
Schistosoma mansoni protein kinase 0.039 0.9874 0.9874
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0115 0.2425 0.2456
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0737 0.0737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0802 0.0802
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0802 0.0802
Echinococcus multilocularis protein kinase shaggy 0.0115 0.2425 0.2425
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1082 0.1082
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0737 0.0737
Brugia malayi mbt repeat family protein 0.0058 0.0866 0.0866
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0737 0.0746
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.2425 0.2456
Giardia lamblia Kinase, CMGC GSK 0.0115 0.2425 0.2456
Toxoplasma gondii CMGC kinase, CK2 family 0.039 0.9874 1
Trypanosoma brucei Casein kinase II 0.039 0.9874 1
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.1082 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.039 0.9874 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0737 0.0746
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0249 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0737 0.0737
Echinococcus granulosus casein kinase ii subunit alpha 0.039 0.9874 0.9874
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.2425 0.2425
Brugia malayi intracellular kinase 0.0115 0.2425 0.2425
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0737 0.0737

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2332 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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