Detailed information for compound 1396513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.928 | Formula: C24H17ClFN3OS
  • H donors: 2 H acceptors: 2 LogP: 8.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)[n+]1nc(sc1c1c(O)ccc2c1cccc2)Nc1ccccc1.[Cl-]
  • InChi: 1S/C24H16FN3OS.ClH/c25-17-11-13-19(14-12-17)28-23(30-24(27-28)26-18-7-2-1-3-8-18)22-20-9-5-4-6-16(20)10-15-21(22)29;/h1-15H,(H,26,27);1H
  • InChiKey: QCABNNYIVHKUDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0038 0.0133 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0017 0.0017
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0133 0.0133
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0038 0.0133 0.0125
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0101 0.0093
Plasmodium vivax unspecified product 0.0026 0.0061 0.0025
Echinococcus multilocularis histone deacetylase 3 0.0515 0.2972 0.2967
Trypanosoma cruzi histone deacetylase, putative 0.0242 0.1346 0.3959
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0133 0.0125
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.0858 0.0851
Echinococcus multilocularis gamma secretase subunit aph 1 0.1484 0.8737 0.8736
Loa Loa (eye worm) cysteine protease 0.0047 0.0186 0.0179
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0038 0.0133 0.0125
Schistosoma mansoni myosin xvIII 0.0038 0.0133 0.0125
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.4967 0.4963
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0133 0.0125
Brugia malayi AKH receptor 0.0038 0.0133 0.0133
Brugia malayi RE15519p 0.0038 0.0133 0.0133
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0101 0.0101
Echinococcus multilocularis cpg binding protein 0.0037 0.0122 0.0115
Echinococcus granulosus 7TM GPCR rhodopsin 0.0038 0.0133 0.0125
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0133 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0186 0.0455
Echinococcus granulosus geminin 0.0344 0.1952 0.1946
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Leishmania major histone deacetylase, putative 0.0515 0.2972 1
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Toxoplasma gondii kringle domain-containing protein 0.0036 0.0117 0.019
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0365 0.0358
Onchocerca volvulus 0.0568 0.3286 0.3281
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0484 0.2784 0.2779
Onchocerca volvulus Histone deacetylase 10 homolog 0.0242 0.1346 0.1339
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0186 0.0458
Echinococcus granulosus caspase 2 0.0568 0.3286 0.3281
Plasmodium vivax vivapain-3 0.0026 0.0061 0.0025
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Schistosoma mansoni histone deacetylase hda2 0.0395 0.2258 0.2252
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0551 0.3186 0.3181
Echinococcus granulosus prolyl endopeptidase 0.0134 0.0701 0.0694
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0061 0.0076
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0064 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Schistosoma mansoni opsin-like receptor 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0568 0.3286 0.3281
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus 7tm_1 domain containing protein 0.0038 0.0133 0.0125
Toxoplasma gondii cathepsin B 0.0052 0.0215 0.0484
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0186 0.0179
Trypanosoma cruzi prolyl endopeptidase 0.0134 0.0701 0.2011
Echinococcus granulosus cathepsin l1 0.0033 0.0101 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0221 0.056
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0051 0.0205 0.0198
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0404 0.0397
Echinococcus granulosus dro:myosuppressin receptor 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Schistosoma mansoni histone deacetylase 4 5 0.0383 0.2185 0.2179
Schistosoma mansoni histone deacetylase 0.0515 0.2972 0.2967
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0186 0.0179
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0133 0.0125
Entamoeba histolytica histone deacetylase, putative 0.0515 0.2972 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0038 0.0133 0.0125
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0133 0.0125
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0053
Plasmodium falciparum histone deacetylase 2 0.0383 0.2185 0.7304
Plasmodium vivax histone deacetylase 1, putative 0.0515 0.2972 0.8675
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0196 0.1071 0.1064
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0221 0.056
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0133 0.0133
Trichomonas vaginalis hypothetical protein 0.0041 0.0148 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0196 0.1071 0.1064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Plasmodium vivax histone deacetylase, putative 0.0383 0.2185 0.6336
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.0701 0.0694
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Echinococcus multilocularis somatostatin receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0133 0.0125
Trypanosoma cruzi Aph-1 protein, putative 0.0578 0.3346 1
Loa Loa (eye worm) fibroinase 0.0047 0.0186 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Leishmania major histone deacetylase, putative 0.0383 0.2185 0.7304
Toxoplasma gondii histone deacetylase HDAC1 0.0383 0.2185 0.6336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Echinococcus granulosus histone deacetylase 6 0.0383 0.2185 0.2179
Schistosoma mansoni hypothetical protein 0.0568 0.3286 0.3281
Brugia malayi G protein-coupled receptor 0.0038 0.0133 0.0133
Schistosoma mansoni histone deacetylase 1 2 3 0.0242 0.1346 0.1339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.017 0.0163
Echinococcus multilocularis serotonin receptor 0.016 0.0858 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.017 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0061 0.0076
Leishmania major histone deacetylase, putative 0.0383 0.2185 0.7304
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0358
Plasmodium falciparum cysteine repeat modular protein 1 0.0036 0.0117 0.0219
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.1381 0.1374
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0186 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.0618 1
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0295 0.0721
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0186 0.0179
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0186 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0051
Echinococcus granulosus neuropeptide receptor 0.0038 0.0133 0.0125
Schistosoma mansoni amine GPCR 0.0038 0.0133 0.0125
Schistosoma mansoni adenoreceptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0017 0.001
Echinococcus multilocularis cathepsin b 0.0142 0.0751 0.0744
Trypanosoma brucei Aph-1 protein, putative 0.0578 0.3346 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.001
Loa Loa (eye worm) ctsf protein 0.0047 0.0186 0.0179
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.0117 0.0109
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0038 0.0133 0.0125
Loa Loa (eye worm) histone deacetylase 0.0383 0.2185 0.2179
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0133 0.0125
Schistosoma mansoni gamma-secretase subunit aph-1 0.1484 0.8737 0.8736
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0186 0.0179
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0133 0.0125
Echinococcus granulosus fmrfamide receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0649 0.0642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.017 0.0163
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0133 0.0125
Brugia malayi G-protein coupled receptor 0.0038 0.0133 0.0133
Schistosoma mansoni neuropeptide receptor 0.0038 0.0133 0.0125
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0365 0.0929
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0365 0.0358
Schistosoma mansoni amine GPCR 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0494 0.2845 0.2839
Trypanosoma brucei prolyl endopeptidase 0.0134 0.0701 0.2011
Plasmodium falciparum histone deacetylase 1 0.0515 0.2972 1
Brugia malayi Protein kinase domain containing protein 0.0036 0.0117 0.0117
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0038 0.0133 0.0125
Echinococcus granulosus apoptotic protease activating factor 1 0.0568 0.3286 0.3281
Toxoplasma gondii cathepsin CPL 0.0047 0.0186 0.0397
Trypanosoma brucei histone deacetylase 2 0.0242 0.1346 0.3959
Onchocerca volvulus 0.0047 0.0186 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.0163
Brugia malayi putative neuropeptide receptor 0.0038 0.0133 0.0133
Onchocerca volvulus Prolyl endopeptidase homolog 0.0134 0.0701 0.0694
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Echinococcus multilocularis cysteine protease 0.0047 0.0186 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Loa Loa (eye worm) histone deacetylase 7A 0.0383 0.2185 0.2179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0262 0.0255
Brugia malayi Trypsin family protein 0.0017 0.0008 0.0008
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0038 0.0133 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus gamma secretase subunit aph 1 0.1484 0.8737 0.8736
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0133 0.0125
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0063 0.003
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0133 0.0133
Brugia malayi histone deacetylase 1 (HD1) 0.0515 0.2972 0.2972
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0186 0.0179
Brugia malayi Dopamine receptor protein 1 0.0038 0.0133 0.0133
Brugia malayi histone deacetylase 11 0.059 0.3418 0.3418
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0186 0.0179
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0025 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0061 0.0076
Giardia lamblia Histone deacetylase 0.0515 0.2972 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.017 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0205 0.0205
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis serotonin receptor 0.016 0.0858 0.0851
Echinococcus granulosus tachykinin peptides receptor 99D 0.0038 0.0133 0.0125
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0221 0.0358
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0186 0.043
Trypanosoma brucei histone deacetylase, putative 0.0383 0.2185 0.6493
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0484 0.2784 0.2784
Onchocerca volvulus 0.0047 0.0186 0.0179
Schistosoma mansoni hypothetical protein 0.0051 0.0205 0.0198
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0186 0.0455
Loa Loa (eye worm) hypothetical protein 0.0134 0.0701 0.0694
Brugia malayi sulfakinin receptor protein 0.0038 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0125
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Toxoplasma gondii histone deacetylase HDAC5 0.0242 0.1346 0.3844
Echinococcus granulosus neuropeptide s receptor 0.0038 0.0133 0.0125
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0186 0.0455
Toxoplasma gondii histone deacetylase HDAC2 0.0515 0.2972 0.8675
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0206 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.006 0.0262 0.0255
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0196 0.1071 0.1064
Schistosoma mansoni opsin-like receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0248 0.1381 0.1374
Toxoplasma gondii histone deacetylase HDAC3 0.0515 0.2972 0.8675
Echinococcus granulosus cathepsin b 0.0142 0.0751 0.0744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus multilocularis histone deacetylase 7 0.0383 0.2185 0.2179
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.001
Toxoplasma gondii histone deacetylase HDAC4 0.059 0.3418 1
Loa Loa (eye worm) hypothetical protein 0.0568 0.3286 0.3281
Schistosoma mansoni histone deacetylase 4 5 0.0383 0.2185 0.2179
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0125
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0365 0.0929
Brugia malayi Histone deacetylase family protein 0.0383 0.2185 0.2185
Schistosoma mansoni cpg binding protein 0.0037 0.0122 0.0115
Onchocerca volvulus 0.0038 0.0133 0.0125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.001
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0017 0.0008 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0133 0.0125
Echinococcus granulosus g protein coupled receptor 0.0038 0.0133 0.0125
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0342 0.0334
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0186 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0568 0.3286 0.3286
Echinococcus multilocularis cysteine protease 0.0047 0.0186 0.0179
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0186 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Trypanosoma brucei histone deacetylase 4 0.0383 0.2185 0.6493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0061 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0515 0.2972 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.1484 0.8737 0.8736
Loa Loa (eye worm) hypothetical protein 0.0196 0.1071 0.1064
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus multilocularis geminin 0.0344 0.1952 0.1946
Schistosoma mansoni hypothetical protein 0.0041 0.0149 0.0141
Brugia malayi Cathepsin L-like precursor 0.0033 0.0101 0.0101
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Brugia malayi larval opioid receptor 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus histone deacetylase 8 0.0242 0.1346 0.1339
Loa Loa (eye worm) hypothetical protein 0.0568 0.3286 0.3281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Schistosoma mansoni neuropeptide receptor 0.0038 0.0133 0.0125
Brugia malayi Cell death protein 3 precursor 0.0568 0.3286 0.3286
Brugia malayi ORL1-like opioid receptor 0.0038 0.0133 0.0133
Onchocerca volvulus 0.0047 0.0186 0.0179
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0515 0.2972 1
Brugia malayi neuropeptide F receptor 0.0038 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0037 0.0122 0.0115
Echinococcus multilocularis neuropeptide FF receptor 2 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi Trypsin family protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Schistosoma mansoni biogenic amine receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Schistosoma mansoni amine GPCR 0.0038 0.0133 0.0125
Brugia malayi Trypsin-like protease protein 5 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0215 0.053
Leishmania major hypothetical protein, conserved 0.0036 0.0117 0.0219
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0133 0.0125
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0186 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0186 0.0455
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0133 0.0125
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0061 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.011 0.0103
Brugia malayi CXXC zinc finger family protein 0.0035 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0133 0.0125
Echinococcus multilocularis max protein X 0.0484 0.2784 0.2779
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0038 0.0133 0.0125
Echinococcus multilocularis histone deacetylase 6 0.0383 0.2185 0.2179
Echinococcus multilocularis histone deacetylase 0.0383 0.2185 0.2179
Loa Loa (eye worm) hypothetical protein 0.0242 0.1346 0.1339
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.0858 0.0851
Plasmodium vivax vivapain-1 0.0026 0.0061 0.0025
Onchocerca volvulus 0.0047 0.0186 0.0179
Schistosoma mansoni biogenic amine receptor 0.0038 0.0133 0.0125
Echinococcus granulosus g protein coupled receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) histone deacetylase 1 0.0515 0.2972 0.2967
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi Dopamine receptor protein 2 0.0038 0.0133 0.0133
Toxoplasma gondii prolyl endopeptidase 0.0134 0.0701 0.1928
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0061 0.0076
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis G-protein coupled receptor, putative 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0093
Plasmodium vivax histone deacetylase, putative 0.059 0.3418 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0133 0.0125
Brugia malayi cathepsin B-like cysteine proteinase 0.0142 0.0751 0.0751
Onchocerca volvulus 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0133 0.0125
Echinococcus granulosus sex peptide receptor 0.0038 0.0133 0.0125
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0047 0.0186 0.0179
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0186 0.0458
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0053 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Echinococcus multilocularis neuropeptide receptor A26 0.0038 0.0133 0.0125
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0649 0.0642
Schistosoma mansoni tsg101-related 0.007 0.032 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0033 0.0101 0.0093
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0133 0.0125
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0515 0.2972 1
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis caspase 2 0.0568 0.3286 0.3281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Schistosoma mansoni biogenic amine receptor 0.0038 0.0133 0.0125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0215 0.0208
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0751 0.0744
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0093
Echinococcus granulosus g protein coupled receptor 0.0038 0.0133 0.0125
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis histone deacetylase 8 0.0242 0.1346 0.1339
Trypanosoma brucei cysteine peptidase C (CPC) 0.0052 0.0215 0.0543
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0093
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0551 0.3186 0.3181
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Onchocerca volvulus 0.0047 0.0186 0.0179
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0142 0.0751 0.0744
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0133 0.0125
Echinococcus granulosus max protein X 0.0484 0.2784 0.2779
Echinococcus granulosus histone deacetylase 6 0.0383 0.2185 0.2179
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0133 0.0125
Brugia malayi MH2 domain containing protein 0.0125 0.0649 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Entamoeba histolytica cysteine protease, putative 0.0047 0.0186 0.043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0206 0.4744
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0484 0.2784 0.2779
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.001
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0061 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus multilocularis G protein coupled receptor 139 0.0038 0.0133 0.0125
Echinococcus multilocularis prolyl endopeptidase 0.0134 0.0701 0.0694
Schistosoma mansoni cpg binding protein 0.0035 0.011 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0134 0.0701 0.2222
Trypanosoma cruzi histone deacetylase 1, putative 0.0515 0.2972 0.8871
Echinococcus granulosus somatostatin receptor 0.0038 0.0133 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.0163
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0141 0.0743 0.0736
Echinococcus granulosus GPCR family 2 0.0019 0.0017 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0038 0.0133 0.0125
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0186 0.0179
Echinococcus granulosus alpha 1A adrenergic receptor 0.0038 0.0133 0.0125
Plasmodium vivax histone deacetylase 2, putative 0.0383 0.2185 0.6336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Plasmodium vivax vivapain-2 0.0047 0.0186 0.0397
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0186 0.0455
Onchocerca volvulus Neuropeptide F receptor homolog 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0133 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0149 0.0149
Brugia malayi Histone deacetylase 1 0.0515 0.2972 0.2972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0133 0.0125
Schistosoma mansoni histone deacetylase 0.0515 0.2972 0.2967
Echinococcus granulosus histone deacetylase 1 0.0515 0.2972 0.2967
Onchocerca volvulus 0.0179 0.0967 0.096
Echinococcus multilocularis g-protein coupled receptor 0.0038 0.0133 0.0125
Echinococcus granulosus histone deacetylase 7 0.0383 0.2185 0.2179
Loa Loa (eye worm) histone deacetylase 3 0.0515 0.2972 0.2967
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0344 0.1952 0.1946
Schistosoma mansoni histone deacetylase hda2 0.0242 0.1346 0.1339
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0186 0.0179
Loa Loa (eye worm) hypothetical protein 0.016 0.0858 0.0851
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0186 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0036 0.0117 0.0109
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.0221 0.5231
Brugia malayi hypothetical protein 0.0084 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0244 0.0629
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0133 0.0125
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0133 0.0125
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0186 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0133 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Loa Loa (eye worm) cathepsin B 0.0052 0.0215 0.0208
Echinococcus multilocularis neuropeptide s receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.001
Brugia malayi Kringle domain containing protein 0.0036 0.0117 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Echinococcus granulosus neuropeptide receptor 0.0038 0.0133 0.0125
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0365 0.0929
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0404 0.0397
Brugia malayi histone deacetylase 3 (HD3) 0.0515 0.2972 0.2972
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0133 0.0125
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.0117 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus cpg binding protein 0.0037 0.0122 0.0115
Onchocerca volvulus 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0196 0.1071 0.1064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Trypanosoma brucei oligopeptidase b 0.0053 0.0221 0.056
Loa Loa (eye worm) hypothetical protein 0.016 0.0858 0.0851
Brugia malayi hypothetical protein 0.0017 0.0008 0.0008
Onchocerca volvulus 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0133 0.0125
Leishmania major oligopeptidase b 0.0053 0.0221 0.0577
Echinococcus granulosus histone deacetylase 0.0383 0.2185 0.2179
Loa Loa (eye worm) hypothetical protein 0.0515 0.2972 0.2967
Leishmania major hypothetical protein, conserved 0.0027 0.0064 0.0038
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0701 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Brugia malayi neuropeptide F receptor 0.0038 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Onchocerca volvulus 0.0036 0.0117 0.0109
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0365 0.0358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.017 0.0163
Echinococcus multilocularis orexin receptor type 2 0.0038 0.0133 0.0125
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0133 0.0125
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0133 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0061 0.0061
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0133 0.0125
Echinococcus granulosus cathepsin L 0.0026 0.0061 0.0053
Loa Loa (eye worm) hypothetical protein 0.0348 0.1976 0.1969
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0133 0.0125
Echinococcus multilocularis cathepsin L 0.0026 0.0061 0.0053
Brugia malayi hypothetical protein 0.0248 0.1381 0.1381
Schistosoma mansoni amine GPCR 0.0038 0.0133 0.0125
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0142 0.0751 0.2161
Onchocerca volvulus 0.0047 0.0186 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0101 0.0137
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0221 0.056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus multilocularis cathepsin b 0.0142 0.0751 0.0744
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Brugia malayi Trypsin family protein 0.0196 0.1071 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0221 0.0577
Loa Loa (eye worm) hypothetical protein 0.0153 0.0816 0.0809
Brugia malayi Melatonin receptor type 1A 0.0038 0.0133 0.0133
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0404 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0036 0.0117 0.019
Schistosoma mansoni survival motor neuron protein 0.0051 0.0205 0.0198
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0117 0.0244
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0061 0.0053
Onchocerca volvulus 0.0038 0.0133 0.0125
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0186 0.043
Trichomonas vaginalis histone deacetylase, putative 0.0515 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0017 0.0017
Brugia malayi Serotonin receptor 0.0038 0.0133 0.0133
Plasmodium falciparum histone deacetylase, putative 0.0383 0.2185 0.7304
Schistosoma mansoni opsin-like receptor 0.0038 0.0133 0.0125
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0186 0.0458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0751 0.0744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0101 0.0137
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0133 0.0125
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.1381 0.1374
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0186 0.0186
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0061 0.0061
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.0221 0.5966
Echinococcus granulosus cysteine protease 0.0026 0.0061 0.0053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.017 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.0142 0.0751 0.0744
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Echinococcus granulosus histone deacetylase 6 0.0395 0.2258 0.2252
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0133 0.0125
Schistosoma mansoni caspase-7 (C14 family) 0.0568 0.3286 0.3281
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0133 0.0125
Schistosoma mansoni tsg101-related 0.0057 0.0244 0.0236
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0038 0.0133 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0206 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0033 0.0101 0.0197
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Trypanosoma brucei histone deacetylase 3 0.0383 0.2185 0.6493
Brugia malayi Serotonin receptor 0.0038 0.0133 0.0133
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0035 0.011 0.0103
Onchocerca volvulus 0.0038 0.0133 0.0125
Echinococcus granulosus G protein coupled receptor 139 0.0038 0.0133 0.0125
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0186 0.0179
Echinococcus granulosus hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0117 0.0109
Brugia malayi Trypsin family protein 0.0017 0.0008 0.0008
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Schistosoma mansoni tsg101-related 0.007 0.032 0.0313
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0262 0.0262
Onchocerca volvulus 0.0038 0.0133 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Onchocerca volvulus Cell death protein 3 homolog 0.0568 0.3286 0.3281
Echinococcus granulosus allatostatin A receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Brugia malayi hypothetical protein 0.0038 0.0133 0.0133
Echinococcus multilocularis GPCR, family 2 0.0019 0.0017 0.001
Trypanosoma cruzi oligopeptidase b 0.0053 0.0221 0.056
Schistosoma mansoni histamine h1 receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0133 0.0125
Brugia malayi Probable ClpP-like protease 0.0077 0.0365 0.0365
Echinococcus multilocularis histone deacetylase 6 0.0383 0.2185 0.2179
Echinococcus granulosus serotonin receptor 0.0038 0.0133 0.0125
Echinococcus multilocularis sex peptide receptor 0.0038 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Loa Loa (eye worm) histone deacetylase 11 0.059 0.3418 0.3413
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0133 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0149 0.0141
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0133 0.0133
Trypanosoma cruzi histone deacetylase, putative 0.0383 0.2185 0.6493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Brugia malayi Dopamine receptor 0.0038 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0047 0.0186 0.0458
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.5
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0064 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0101 0.0137
Schistosoma mansoni neuropeptide receptor 0.0038 0.0133 0.0125
Brugia malayi Cathepsin L-like precursor 0.0047 0.0186 0.0186
Echinococcus multilocularis histone deacetylase 6 0.0395 0.2258 0.2252
Trypanosoma cruzi oligopeptidase b 0.0053 0.0221 0.056
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0221 0.0358
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0063 0.0035
Echinococcus granulosus cathepsin b 0.0142 0.0751 0.0744
Brugia malayi G-protein coupled receptor 0.0038 0.0133 0.0133
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0133 0.0125
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0365 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2845 0.2839
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0133 0.0125
Schistosoma mansoni neuropeptide receptor 0.0038 0.0133 0.0125
Trypanosoma cruzi histone deacetylase, putative 0.0242 0.1346 0.3959
Toxoplasma gondii hypothetical protein 0.0027 0.0063 0.003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0133 0.0133
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0221 0.056
Trypanosoma brucei histone deacetylase 1 0.0515 0.2972 0.8871
Leishmania major histone deacetylase, putative 0.0515 0.2972 1
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0133 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0751 0.0744
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0061 0.0076
Schistosoma mansoni hypothetical protein 0.0344 0.1952 0.1946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0186 0.043
Echinococcus granulosus histone deacetylase 3 0.0515 0.2972 0.2967
Plasmodium vivax vivapain-2 0.0047 0.0186 0.0397
Echinococcus multilocularis histone deacetylase 1 0.0515 0.2972 0.2967
Echinococcus granulosus cathepsin l1 0.0047 0.0186 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0186 0.0455
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0053
Trypanosoma cruzi histone deacetylase 1, putative 0.0515 0.2972 0.8871
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0052 0.0215 0.0557
Brugia malayi gamma-secretase subunit aph-1 0.1484 0.8737 0.8737
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2845 0.2839
Trypanosoma cruzi histone deacetylase, putative 0.0383 0.2185 0.6493
Echinococcus multilocularis allatostatin A receptor 0.0038 0.0133 0.0125
Brugia malayi GnHR receptor homolog 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0133 0.0125
Schistosoma mansoni amine GPCR 0.0038 0.0133 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0133 0.0125
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0186 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.0163
Onchocerca volvulus 0.0038 0.0133 0.0125
Brugia malayi cathepsin L-like precursor 0.0033 0.0101 0.0101
Brugia malayi Histone deacetylase family protein 0.0383 0.2185 0.2185
Echinococcus granulosus peptide allatostatin:somatostatin 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0052 0.0215 0.0543
Trypanosoma cruzi histone deacetylase, putative 0.0383 0.2185 0.6493
Echinococcus granulosus orexin receptor type 2 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0133 0.0125
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0133 0.0125
Onchocerca volvulus 0.0038 0.0133 0.0125
Echinococcus granulosus g-protein coupled receptor 0.0038 0.0133 0.0125
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.0701 0.0694
Brugia malayi Cathepsin L-like precursor 0.0033 0.0101 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0133 0.0125
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0484 0.2784 0.2779
Trypanosoma cruzi Aph-1 protein, putative 0.0578 0.3346 1
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0125

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
IC50 (binding) = 23.673 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 31.979 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 46.789 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10.3119 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 51.7352 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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