TDR Targets

Basic information

Technical information

TDR Targets ID: 1403840
Name: 1,3-benzothiazol-6-yl-[4-(1,3-benzothiazol-2- yl)piperazin-1-yl]methanone
MW: 380.487 | Formula: C19H16N4OS2
H donors: 0 H acceptors: 3 LogP: 4.22 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)scn2)N1CCN(CC1)c1nc2c(s1)cccc2
InChi: 1S/C19H16N4OS2/c24-18(13-5-6-14-17(11-13)25-12-20-14)22-7-9-23(10-8-22)19-21-15-3-1-2-4-16(15)26-19/h1-6,11-12H,7-10H2
InChiKey: XPSLWRBYQMNCIE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,3-benzothiazol-6-yl-[4-(1,3-benzothiazol-2-yl)-1-piperazinyl]methanone
Oprea1_827596
ZINC04088577

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	adenoreceptor	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	neuropeptide F receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.0366	0.0366
Brugia malayi	ORL1-like opioid receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	amine GPCR	0.0086	0.0366	0.0366
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Brugia malayi	larval opioid receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	somatostatin receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	orexin receptor type 2	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine receptor	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0079	0.0325	0.0325
Schistosoma mansoni	neuropeptide F-like receptor	0.0086	0.0366	0.0366
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.009	0.039	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0368	0.0368
Echinococcus granulosus	dro:myosuppressin receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0026	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	G-protein coupled receptor	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0026	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0026	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0026	0.0018	0.5
Schistosoma mansoni	hypothetical protein	0.0043	0.0119	0.0119
Brugia malayi	Serotonin receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	g protein coupled receptor	0.0086	0.0366	0.0366
Entamoeba histolytica	hypothetical protein	0.0043	0.0119	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0311	0.0311
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Echinococcus granulosus	orexin receptor type 2	0.0086	0.0366	0.0366
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	G protein coupled receptor 139	0.0086	0.0366	0.0366
Echinococcus granulosus	fmrfamide receptor	0.0086	0.0366	0.0366
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0086	0.0366	0.0366
Brugia malayi	putative neuropeptide receptor NPR1	0.0086	0.0366	0.0366
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	fmrfamide receptor	0.0086	0.0366	0.0366
Brugia malayi	GnHR receptor homolog	0.0086	0.0366	0.0366
Schistosoma mansoni	amine GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0119	0.0119
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	neuropeptide F receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0079	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptide receptor	0.0086	0.0366	0.0366
Brugia malayi	follicle stimulating hormone receptor	0.0086	0.0366	0.0366
Brugia malayi	Dopamine receptor protein 1	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	melatonin receptor type 1A	0.0086	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0026	0.0018	0.0018
Echinococcus multilocularis	allatostatin A receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide Y receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	myosin xvIII	0.0086	0.0366	0.0366
Schistosoma mansoni	opsin-like receptor	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0026	0.0018	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0026	0.0018	0.5
Brugia malayi	G-protein coupled receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	opsin-like receptor	0.0086	0.0366	0.0366
Brugia malayi	neuropeptide F receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	CYP4Cod1	0.009	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0239	0.0239
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0079	0.0325	0.0325
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	g-protein coupled receptor	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0086	0.0366	0.0366
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0086	0.0366	0.0366
Schistosoma mansoni	opsin-like receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0119	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0106	0.0106
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0026	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0026	0.0018	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	7tm_1 domain containing protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	dro:myosuppressin receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0018	0.0018
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0026	0.0018	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptide s receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	neuropeptide receptor	0.0086	0.0366	0.0366
Trypanosoma brucei	cytochrome P450, putative	0.009	0.039	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptide Y receptor	0.0086	0.0366	0.0366
Brugia malayi	AKH receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0041	0.0106	0.0106
Echinococcus multilocularis	neuropeptides capa receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0086	0.0366	0.0366
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0086	0.0366	0.0366
Loa Loa (eye worm)	neuropeptide F receptor	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0026	0.0018	0.5
Echinococcus granulosus	allatostatin A receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide Y receptor	0.0086	0.0366	0.0366
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0026	0.0018	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide receptor A26	0.0086	0.0366	0.0366
Echinococcus multilocularis	somatostatin receptor	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	neuropeptide f receptor 76f	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	g-protein coupled receptor	0.0086	0.0366	0.0366
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0018	0.0018
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0086	0.0366	0.0366
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptides capa receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide FF receptor 2	0.0086	0.0366	0.0366
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0311	0.0311
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	biogenic amine 5HT receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0216	0.0216
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0086	0.0366	0.0366
Echinococcus granulosus	sex peptide receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0086	0.0366	0.0366
Echinococcus granulosus	g protein coupled receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	G-protein coupled receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	neuropeptide receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptide receptor	0.0086	0.0366	0.0366
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0086	0.0366	0.0366
Brugia malayi	G protein-coupled receptor F59B2.13	0.0086	0.0366	0.0366
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0086	0.0366	0.0366
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	G protein-coupled receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0026	0.0018	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0119	0.5
Schistosoma mansoni	histamine h1 receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.5543	0.5543
Echinococcus granulosus	neuropeptide receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0311	0.0311
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0311	0.0311
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0311	0.0311
Schistosoma mansoni	cytochrome P450	0.0026	0.0018	0.0018
Schistosoma mansoni	amine GPCR	0.0086	0.0366	0.0366
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0079	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptides capa receptor	0.0086	0.0366	0.0366
Brugia malayi	RE15519p	0.0086	0.0366	0.0366
Entamoeba histolytica	hypothetical protein	0.0043	0.0119	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0311	0.0311
Brugia malayi	sulfakinin receptor protein	0.0086	0.0366	0.0366
Brugia malayi	Cytochrome P450 family protein	0.009	0.039	0.039
Brugia malayi	RNA binding protein	0.0076	0.0311	0.0311
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0026	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.006	0.0216	0.0216
Brugia malayi	Dopamine receptor	0.0086	0.0366	0.0366
Trypanosoma cruzi	cytochrome P450, putative	0.009	0.039	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	cytochrome P450 family protein	0.009	0.039	0.039
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0086	0.0366	0.0366
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0106
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0026	0.0018	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0216	0.0216
Echinococcus granulosus	cytochrome P450 2K1	0.0026	0.0018	0.0018
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0026	0.0018	0.5
Echinococcus granulosus	serotonin receptor	0.0086	0.0366	0.0366
Brugia malayi	Melatonin receptor type 1A	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0026	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.0366	0.0366
Schistosoma mansoni	neuropeptide receptor	0.0086	0.0366	0.0366
Brugia malayi	TAR-binding protein	0.0076	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	sex peptide receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	cytochrome P450 family protein	0.009	0.039	0.039
Echinococcus multilocularis	neuropeptide Y receptor	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0026	0.0018	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0026	0.0018	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0026	0.0018	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0086	0.0366	0.0366
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0026	0.0018	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Leishmania major	cytochrome p450-like protein	0.009	0.039	1
Schistosoma mansoni	hypothetical protein	0.0086	0.0366	0.0366
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.0295	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	amine GPCR	0.0086	0.0366	0.0366
Giardia lamblia	Ceramide glucosyltransferase	0.0792	0.4461	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.0366	0.0366
Brugia malayi	cytochrome P450	0.0026	0.0018	0.0018
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	biogenic amine 5HT receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.0366	0.0366
Entamoeba histolytica	hypothetical protein	0.0043	0.0119	0.5
Schistosoma mansoni	neuropeptide receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	serotonin receptor	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0086	0.0366	0.0366
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	TYRA-2 protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus granulosus	neuropeptide s receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0311	0.0311
Echinococcus multilocularis	fmrfamide receptor	0.0086	0.0366	0.0366
Trypanosoma cruzi	cytochrome P450, putative	0.009	0.039	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	G-protein coupled receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	G protein coupled receptor 139	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.0295	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0368	0.0368
Brugia malayi	Serotonin receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	Cytochrome P450 family protein	0.009	0.039	0.039
Brugia malayi	hypothetical protein	0.0043	0.0119	0.0119
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0311	0.0311
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.0366	0.0366
Schistosoma mansoni	neuropeptide F-like receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Brugia malayi	Dopamine receptor protein 2	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	amine GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0086	0.0366	0.0366
Echinococcus granulosus	g protein coupled receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis		0.0026	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Echinococcus multilocularis	neuropeptides capa receptor	0.0086	0.0366	0.0366
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0026	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0026	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0265	0.0265
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0311	0.0311
Mycobacterium leprae	putative cytochrome p450	0.0026	0.0018	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0086	0.0366	0.0366
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0086	0.0366	0.0366
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.0366	0.0366
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.0366	0.0366
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0119	0.0119
Echinococcus multilocularis	neuropeptide receptor A26	0.0086	0.0366	0.0366
Loa Loa (eye worm)	cytochrome P450	0.0026	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366
Brugia malayi	putative neuropeptide receptor	0.0086	0.0366	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0086	0.0366	0.0366
Echinococcus multilocularis	serotonin receptor	0.0086	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0366	0.0366

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.3048 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5774 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1562296

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1403840